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Journal of Environmental Sciences 2024年第2期136卷 547-558页

作者： Yong Wang Cheng Liu Haoyun Hu Qiujun lu Haiyan Wang chenxi Zhao Fuyou Du Ningli Tang Guangxi Key Laboratory of Electrochemical and Magnetochemical Functional Materials College of Chemistry and BioengineeringGuilin University of TechnologyGuilin 541004China College of Biological and Environmental Engineering Changsha UniversityChangsha 410022China

The construction and application of novel highly efficient photocatalysts have been the focus in the field of environmental pollutant removal.In this work,a novel CuFe_(2)O_(4)/Bi_(12)O_(17)Cl_(2)photocatalysts were synthesized by simple hydrothermal and chemical precipitation method.The fabricated CuFe_(2)O_(4)/Bi_(12)O_(17)Cl_(2)composite exhibited much higher photocatalytic activity than pristine CuFe_(2)O_(4)and Bi_(12)O_(17)Cl_(2)in the removal of bisphenol A(BPA)under visible-light illumination,which ascribed to the intrinsic p-n junction of CuFe_(2)O_(4)and Bi_(12)O_(17)Cl_(2).The photocatalytic degradation rate of BPA on CuFe_(2)O_(4)/Bi_(12)O_(17)Cl_(2)with an optimized CuFe_(2)O_(4)content(1.0 wt.%)reached 93.0%within 30 min.The capture experiments of active species confirmed that the hydroxyl radicals(·OH)and superoxide radicals(·O_(2)^(-))played crucial roles in photocatalytic BPA degradation process.Furthermore,the possible degradation mechanism and pathways of BPA was proposed according to the detected intermediates in photocatalytic reaction process.

关键词： Bi_(12)O_(17)Cl_(2) CuFe_(2)O_(4) Heterojunction Bisphenol A Photocatalytic degradation

Neddylation is a novel therapeutic target for lupus by regulating double negative T cell homeostasis

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Signal Transduction and Targeted Therapy 2024年第2期9卷 738-750页

作者： Yun Zhang Lijun Du chenxi Wang Zhangsheng Jiang Qingchi Duan Yiping Li Zhijun Xie Zhixing He Yi Sun Lin Huang Liwei lu Chengping Wen Key Laboratory of Chinese medicine rheumatology of Zhejiang Province Research Institute of Chinese Medical Clinical Foundation and ImmunologyCollege of Basic Medical ScienceZhejiang Chinese Medical UniversityHangzhou 310053China Department of General Surgery Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)of the Second Affiliated Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Cancer Center of Zhejiang University Hangzhou 310029China Department of Pathology and Shenzhen Institute of Research and Innovation The University of Hong KongHong KongChina Chongqing International Institute for Immunology Chongqing 400038China

Systemic lupus erythematosus(SLE),a severe autoimmune disorder,is characterized by systemic inflammatory response,autoantibody accumulation and damage to organs.The dysregulation of double-negative(DN)T cells is considered as a crucial commander during SLE.Neddylation,a significant type of protein post-translational modification(PTM),has been well-proved to regulate T cell-mediated immune response.However,the function of neddylation in SLE is still unknown.Here,we reported that neddylation inactivation with MLN4924,a specific inhibitor of NEDD8-activating enzyme E1(NAE1),or genetic abrogation of Ube2m in T cells decreased DN T cell accumulation and attenuated murine lupus development.Further investigations revealed that inactivation of neddylation blocked Bim ubiquitination degradation and maintained Bim level in DN T cells,contributing to the apoptosis of the accumulated DN T cells in lupus mice.Then double knockout(KO)lupus-prone mice(Ube2m-/-Bim-/-lpr)were generated and results showed that loss of Bim reduced Ube2m deficiency-induced apoptosis in DN T cells and reversed the alleviated lupus progression.Our findings identified that neddylation inactivation promoted Bim-mediated DN T cell apoptosis and attenuated lupus progression.Clinically,we also found that in SLE patients,the proportion of DN T cells was raised and their apoptosis was reduced.Moreover,compared to healthy groups,SLE patients exhibited decreased Bim levels and elevated Cullin1 neddylation levels.Meantime,the inhibition of neddylation induced Bim-dependent apoptosis of DN T cells isolated from SLE patients.Altogether,our findings provide the direct evidence about the function of neddylation during lupus,suggesting a promising therapeutic approach for this disease.

关键词： inactivation double finding

Architectural Design and Additive Manufacturing of Mechanical Metamaterials:A Review

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Engineering 2022年第10期17卷 44-63页

作者： chenxi lu Mengting Hsieh Zhifeng Huang Chi Zhang Yaojun Lin Qiang Shen Fei Chen Lianmeng Zhang State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Department of Mechanical and Aerospace Engineering University of CaliforniaIrvineCA 90095USA

Mechanical metamaterials can be defined as a class of architected materials that exhibit unprecedented mechanical properties derived from designed artificial architectures rather than their constituent materials.While macroscale and simple layouts can be realized by conventional top-down manufacturing approaches,many of the sophisticated designs at various length scales remain elusive,due to the lack of adequate manufacturing methods.Recent progress in additive manufacturing(AM)has led to the realization of a myriad of novel metamaterial concepts.AM methods capable of fabricating microscale architectures with high resolution,arbitrary complexity,and high feature fidelity have enabled the rapid development of architected meta materials and drastically reduced the design-computation and experimental-validation cycle.This paper first provides a detailed review of various topologies based on the desired mechanical properties,including stiff,strong,and auxetic(negative Poisson’s ratio)metamaterials,followed by a discussion of the AM technologies capable of fabricating these metamaterials.Finally,we discuss current challenges and recommend future directions for AM and mechanical metamaterials.

关键词： Mechanical metamaterials Auxetic materials Architectural design Additive manufacturing

Near-Real-Time Carbon Emission Accounting Technology Toward Carbon Neutrality

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Engineering 2022年第7期8卷 44-51页

作者： Zhu Liu Taochun Sun Ying Yu Piyu Ke Zhu Deng chenxi lu Da Huo Xiang Ding Department of Earth System Science Tsinghua UniversityBeijing 100084China Gillings School of Global Public Health University of North Carolina at Chapel HillChapel HillNC 27599USA College of Urban and Environmental Sciences Peking UniversityBeijing 100871China

Climate change is the greatest environmental threat to humans and the planet in the 21st century.Global anthropogenic greenhouse gas emissions are one of the main causes of the increasing number of extreme climate events.Cumulative carbon dioxide(CO_(2))emissions showed a linear relationship with cumulative temperature rise since the pre-industrial stage,and this accounts for approximately 80%of the total anthropogenic greenhouse gases.Therefore,accurate and reliable carbon emission data are the foundation and scientific basis for most emission reduction policymaking and target setting.Currently,China has made clear the ambitious goal of achieving the peak of carbon emissions by 2030 and achieving carbon neutrality by 2060.The development of a finer-grained spatiotemporal carbon emission database is urgently needed to achieve more accurate carbon emission monitoring for continuous implementation and the iterative improvement of emission reduction policies.Near-real-time carbon emission monitoring is not only a major national demand but also a scientific question at the frontier of this discipline.This article reviews existing annual-based carbon accounting methods,with a focus on the newly developed real-time carbon emission technology and its current application trends.We also present a framework for the latest near-real-time carbon emission accounting technology that can be widely used.The development of relevant data and methods will provide strong database support to the policymaking for China’s“carbon neutrality”strategy.Finally,this article provides an outlook on the future of real-time carbon emission monitoring technology.

关键词： Carbon neutrality Carbon accounting Carbon monitoring

Liquid exfoliation of stanene as degradable nanoagents for NIR-II photothermal therapy

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Journal of Materials Science & Technology 2023年第17期148卷 186-198页

作者： Xueqiao Li Weijian Li Zhaohua Miao chenxi lu Hongna Ma Yan Xu Deyan Gong Cheng-Yan Xu Zhengbao Zha School of Food and Biological Engineering Hefei University of TechnologyHefei 230009China College of Nuclear Equipment and Nuclear Engineering Yantai UniversityYantai 264005China School of Materials Science and Engineering Harbin Institute of Technology(Shenzhen)Shenzhen 518055China Shenzhen Bay Laboratory Shenzhen 518052China

Stanene,the two-dimensional form of elemental tin(Sn),is easily oxidized in the ambient environ-ment,significantly hindering its applications in biomedical fields.However,the degradation mechanism of stanene remains unclear.Herein,combined DFT calculations and proof-of-concept experiments were conducted to elucidate the underlying degradation mechanism of stanene.The results reveal that the degradation of stanene in an oxygenated water environment is a water-accelerated oxidation process.H_(2) O molecules could not only facilitate the electron transfer from stanene to O_(2) because of the polarization effect of H_(2) O,but also directly react with the defect sites of stanene due to enhanced absorption energy.Moreover,several protective strategies like alcohol protection were proposed to avoid or mitigate the oxidation of stanene for further applications.Finally,stanene was explored as the second near-infrared(NIR-II)photonic agents for ablation of 4T1 tumor,depicting a tumor-growth inhibition ratio up to 96.7%,much better than that of the first near-infrared(NIR-I)group(65.5%).This work reveals the degradation mechanism of stanene and demonstrates its biomedical applications in the NIR-II region.

关键词： Stanene Degradation mechanism DFT calculations Photothermal therapy NIR-II

基于传感器标记的野生动物追踪技术在中国的应用现状与展望

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生物多样性 2024年第5期32卷 169-191页

作者：鲁彬悦李坤王晨溪李晟北京大学生命科学学院北京100871 中国科学院地理科学与资源研究所北京100101

对动物的标记、定位与追踪是研究其空间运动的重要途径。自20世纪80年代起,以动物个体佩戴的传感器为核心的野生动物追踪技术被引入我国,广泛用于野生动物行为与生态研究。为全面地了解中国野生动物追踪技术的应用现状,本研究系统检索了... 详细信息

对动物的标记、定位与追踪是研究其空间运动的重要途径。自20世纪80年代起,以动物个体佩戴的传感器为核心的野生动物追踪技术被引入我国,广泛用于野生动物行为与生态研究。为全面地了解中国野生动物追踪技术的应用现状,本研究系统检索了1970–2022年间在中国开展的野生动物追踪研究论文,统计并汇总了基于传感器的追踪技术类别、应用动物类群、研究领域及研究地点等信息。本研究共收集到论文519篇,涵盖了分属7纲32目的共计185个物种。动物追踪研究地点覆盖我国34个省(直辖市、自治区、特别行政区),其中最为集中的区域主要包括青藏高原东缘及周边山地、长江中下游区域、华东至华南沿海以及东北地区。所使用的技术类别包括5类:无线电遥测(RT)技术(占总研究数量的47.7%)、无线射频识别(RFID)技术(3.2%)、光敏全球定位传感器(GLS)技术(0.6%)、基于Argos系统(ASS)的卫星追踪技术(9.3%)、基于全球定位导航系统(GNSS)的卫星追踪技术(39.3%)。在各类技术中,甚高频(VHF)RT技术是我国使用历史较长、数量较大的技术;ASS和GNSS技术引入较晚,但增长迅速,其中GNSS技术在近5年来已经成为应用最多的技术。RT技术在大中型哺乳动物、小型哺乳动物、陆禽鸟类以及两栖、爬行动物追踪中应用最多,游禽与涉禽鸟类的追踪以GNSS技术为主,鱼类追踪研究中ASS技术应用较多,而无脊椎动物的追踪研究则主要使用RFID技术。不同的研究领域中所使用的技术类别存在差异,其中迁徙研究主要应用GNSS和ASS卫星追踪技术。本研究的结果表明,基于传感器的野生动物标记、定位与追踪技术在我国的应用规模正在快速扩大,标记动物数量、累积数据量快速增加。今后,中国的野生动物追踪研究应进一步扩展研究深度和广度,加强多学科合作与技术创新,倡导并推动数据共享与合作,并进一步推动国产追踪设备及技术的研发与完善,从而为我国野生动物生态研究与资源保护管理提供可靠的科学支持。

关键词：动物追踪无线电遥测卫星追踪野生动物监测运动生态学

中性粒细胞的训练免疫在多种疾病中的作用及进展

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中国医学前沿杂志（电子版） 2024年第3期16卷 62-66页

作者：吴晨曦陆培华南京医科大学无锡医学中心无锡市人民医院南京医科大学附属无锡人民医院肿瘤科江苏无锡214000

免疫系统通常被分为先天免疫系统和适应性免疫系统。最近的研究表明,与以前认为只有适应性免疫存在免疫记忆的观点相反,先天免疫系统也有先天免疫记忆,称为“训练免疫”。先天免疫细胞的骨髓祖细胞和外周成熟细胞可以受到各种内源性或... 详细信息

免疫系统通常被分为先天免疫系统和适应性免疫系统。最近的研究表明,与以前认为只有适应性免疫存在免疫记忆的观点相反,先天免疫系统也有先天免疫记忆,称为“训练免疫”。先天免疫细胞的骨髓祖细胞和外周成熟细胞可以受到各种内源性或外源性刺激,引发持续的、主要由表观遗传学介导的变化,从而增加先天免疫系统对再刺激的反应。中性粒细胞是先天免疫系统的重要组成部分,可以被诱导出训练免疫特性,并在组织平衡、再生和慢性炎症中发挥复杂作用。本文回顾了中性粒细胞产生中枢和外周先天免疫记忆的机制,以及它们在多种疾病中的特点和作用。

关键词：训练免疫先天免疫系统中性粒细胞

ESG表现对实体企业金融化的影响研究——基于中国制造业上市公司的实证

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中国证券期货 2024年第1期 73-80页

作者：陆晨晰云南民族大学管理学院(会计学院) 昆明650000

本文以2011—2021年中国沪深A股制造业上市公司为研究对象,实证制造企业ESG表现对企业金融化的影响。结果显示:制造企业ESG表现以及环境、社会、公司治理表现均与金融化显著正相关。通过替换解释变量、工具变量法、倾向性得分匹配(PSM)... 详细信息

本文以2011—2021年中国沪深A股制造业上市公司为研究对象,实证制造企业ESG表现对企业金融化的影响。结果显示:制造企业ESG表现以及环境、社会、公司治理表现均与金融化显著正相关。通过替换解释变量、工具变量法、倾向性得分匹配(PSM)等方法进行稳健性检验,结论依然成立。异质性分析表明,制造企业ESG表现对金融化的影响与制造企业权力结构有关,但与制造企业产权性质无关。两职分离的制造企业中ESG表现与金融化显著正相关,而两职合一的制造企业中此种关系并不显著。

关键词： ESG表现企业金融化制造业实体企业

气相色谱-离子迁移谱结合多元统计学分析不同包装对香椿粉品质的影响

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食品科学 2024年第7期45卷 252-262页

作者：赵丽丽王继红卢晨曦史冠莹张乐蒋鹏飞王赵改河南省农业科学院农副产品加工研究中心河南郑州450002 河南工业大学粮油食品学院河南郑州450001

为延长真空冷冻干燥香椿粉的货架期,分别采用聚乙烯(polyethylene,PE)密封袋、铝箔密封袋、复合真空袋、铝箔真空袋对香椿粉进行包装,在(55±1)℃高温、(40±3)%相对湿度条件下进行加速实验,研究香椿粉贮藏期间感官、水分、色泽、风味... 详细信息

为延长真空冷冻干燥香椿粉的货架期,分别采用聚乙烯(polyethylene,PE)密封袋、铝箔密封袋、复合真空袋、铝箔真空袋对香椿粉进行包装,在(55±1)℃高温、(40±3)%相对湿度条件下进行加速实验,研究香椿粉贮藏期间感官、水分、色泽、风味成分及菌落总数的变化。结果表明:随着贮藏时间延长,采用PE密封包装贮藏的香椿粉吸潮、褐变严重,菌落总数显著上升;而铝箔真空包装贮藏的香椿粉中水分含量、色泽及菌落总数未发生明显变化;不同包装贮藏的香椿粉中共鉴定出56种挥发性化合物,包括醇类13种、醛类11种、酸类3种、萜烯类3种、酮类7种、酯类9种、醚类1种、含硫类2种、烷烃类3种、杂环类4种;挥发性化合物的主成分分析表明,不同包装贮藏的香椿粉样品可显著区分;通过正交偏最小二乘判别分析,结合变量投影重要性(variable importance in projection,VIP),共筛选出14种差异挥发性化合物(VIP>1),其聚类热图也可对不同包装贮藏样品进行较好分类。以铝箔真空包装形式效果最佳,铝箔密封、复合真空包装次之,PE密封包装的香椿粉水分、色泽、风味及微生物品质变化最大。

关键词：香椿粉包装材料贮藏品质气相色谱-离子迁移谱

全固态锂硫电池电极及电解质膜的制备及性能研究

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电源技术 2024年第4期48卷 622-627页

作者：吕忠伟彭锦雪郑陈熙龚正良厦门大学能源学院福建厦门361102

全固态锂硫电池(ASSLSBs)兼具高能量密度与高安全性,被认为是最具潜力的下一代储能体系候选者之一,然而目前实验室使用的粉末冷压技术并不适合实际应用。因此,开发合适的工艺大规模制备固态电解质膜以及复合正极对促进全固态锂硫电池的... 详细信息

全固态锂硫电池(ASSLSBs)兼具高能量密度与高安全性,被认为是最具潜力的下一代储能体系候选者之一,然而目前实验室使用的粉末冷压技术并不适合实际应用。因此,开发合适的工艺大规模制备固态电解质膜以及复合正极对促进全固态锂硫电池的实际化应用具有重要意义。以二甲苯作为溶剂,苯乙烯-乙烯-丁烯-苯乙烯嵌段共聚物(SEBS)作为粘结剂,通过浆料涂布工艺制备了具有高离子电导率(4.7×10^(-4) S/cm)的自支撑硫化物固态电解质膜以及高硫含量(50%质量分数)、高硫载量(4~5 mg/cm^(2))的复合硫正极极片,并研究了其性能。研究表明:SEBS质量分数为3%时,电解质膜兼具柔性及高离子电导率;SEBS质量分数为1%的复合硫正极极片表现出良好的电化学性能。使用固态电解质膜与复合正极极片组装的全固态锂硫电池首次放电比容量可达742.9 mAh/g。

关键词：全固态锂硫电池自支撑硫化物电解质膜硫正极极片