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Science China(Information Sciences) 2018年第1期61卷 136-149页

作者： Jingyu ZHANG Minyi GUO chentao wu Yuanyi CHEN Department of Computer Science and Engineering Shanghai Jiao Tong University

With the emerging of 3 D-stacking technology, the dynamic random-access memory(DRAM)can be stacked on chips to architect the DRAM last level cache(LLC). Compared with static randomaccess memory(SRAM), DRAM is larger but slower. In the existing research papers, a lot of work has been devoted to improving the workload performance using SRAM and stacked DRAM together, ranging from SRAM structure improvement, to optimizing cache tag and data access. Instead, little attention has been paid to designing an LLC scheduling scheme for multi-programmed workloads with different memory footprints. Motivated by this, we propose a self-adaptive LLC scheduling scheme, which allows us to utilize SRAM and 3 D-stacked DRAM efficiently, achieving better workload performance. This scheduling scheme employs(1) an evaluation unit, which is used to probe and evaluate the cache information during the process of programs being executed; and(2) an implementation unit, which is used to self-adaptively choose SRAM or DRAM. To make the scheduling scheme work correctly, we develop a data migration policy. We conduct extensive experiments to evaluate the performance of our proposed scheme. Experimental results show that our method can improve the multi-programmed workload performance by up to 30% compared with the state-of-the-art methods.

关键词： 3D-stacking technology cache architecture cache scheduling multi-programmed workloads memory system performance optimization

PAM: an efficient power-aware multilevel cache policy to reduce energy consumption of storage systems

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Frontiers of Computer Science 2019年第4期13卷 850-863页

作者： Xiaodong MENG chentao wu Minyi GUO Long ZHENG Jingyu ZHANG Shanghai Key Laboratory of Scalable Computing and Systems Department of Computer Science & Engineering Shanghai Jiao Tong University Shanghai 200240 China

Energy consumption is one of the most significant aspects of large-scale storage systems where multilevel caches are widely used. In a typical hierarchical storage structure, upper-level storage serves as a cache for the lower level, forming a distributed multilevel cache system. In the past two decades, several classic LRU-based multilevel cache policies have been proposed to improve the overall I/O performance of storage systems. However, few power-aware multilevel cache policies focus on the storage devices in the bottom level, which consume more than 27% of the energy of the whole system [1]. To address this problem, we propose a novel power-aware multilevel cache (PAM) policy that can reduce the energy consumption of high-performance and I/O bandwidth storage devices. In our PAM policy, an appropriate number of cold dirty blocks in the upper level cache are identified and selected to flush directly to the storage devices, providing high probability extension of the lifetime of disks in standby mode. To demonstrate the effectiveness of our proposed policy, we conduct several simulations with real-world traces. Compared to existing popular cache schemes such as PA? LRU, PB-LRU, and Demote, PAM reduces power consumption by up to 15% under different I/O workloads, and improves energy efficiency by up to 50.5%.

关键词： storage system multilevel cache energy consumption I/O performance hint

HSCS:a hybrid shared cache scheduling scheme for multiprogrammed workloads

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Frontiers of Computer Science 2018年第6期12卷 1090-1104页

作者： Jingyu ZHANG chentao wu Dingyu YANG Yuanyi CHEN Xiaodong MENG Liting XU Minyi GUO Department of Computer Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Hunan Provincial Key Laboratory of Intelligent Processing of Big Data on Transportation School of Computer and Communication EngineeringChangsha University of Science and TechnologyChangsha 410004China School of Electronics and Information Shanghai Dianji UniversityShanghai 200240China

The traditional dynamic random-access memory (DRAM) storage medium can be integrated on chips via modern emerging 3D-stacking technology to architect a DRAM shared cache in multicore systems. Compared with static random-access memory (SRAM), DRAM is larger but slower. In the existing research, a lot of work has been devoted to improving the workload performance using SRAM and stacked DRAM together in shared cache systems, ranging from SRAM structure improvement to optimizing cache tags and data access. However, little attention has been paid to designing a shared cache scheduling scheme for multiprogrammed workloads with different memory footprints in multicore systems. Motivated by this, we propose a hybrid shared cache scheduling scheme that allows a multicore system to utilize SRAM and 3D-stacked DRAM efficiently, thus achieving better workload performance. This scheduling scheme employs (1) a cache monitor, which is used to collect cache statistics; (2) a cache evaluator, which is used to evaluate the cache information during the process of programs being executed; and (3) a cache switcher, which is used to self-adaptively choose SRAM or DRAM shared cache modules. A cache data migration policy is naturally developed to guarantee that the scheduling scheme works correctly. Extensive experiments are conducted to evaluate the workload performance of our proposed scheme. The experimental results showed that our method can improve the multiprogrammed workload performance by up to 25% compared with state-of-the-art methods (including conventional and DRAM cache systems).

关键词： multicore system shared cache workload performance

蒲地蓝药渣氮掺杂碳点制备及对Fe^(3+)检测分析

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淮阴工学院学报 2024年第2期33卷 28-34页

作者：吴晨涛于诗源马成欣张婷阙子淼喻春皓淮阴工学院化学工程学院江苏淮安223003

基于生物质碳点(carbon dots,CDs)作为新型的荧光碳纳米材料,因其具备较好的生物相容性、低细胞毒性等优点,在荧光成像、环境检测等领域受到广泛关注。利用煎煮后的蒲地蓝原材料制备CDs,其市场需求量大导致大量残渣被浪费,且当前将多种... 详细信息

基于生物质碳点(carbon dots,CDs)作为新型的荧光碳纳米材料,因其具备较好的生物相容性、低细胞毒性等优点,在荧光成像、环境检测等领域受到广泛关注。利用煎煮后的蒲地蓝原材料制备CDs,其市场需求量大导致大量残渣被浪费,且当前将多种中药组合制备成CDs的文章鲜有报道。针对上述问题,以蒲地蓝残渣作为碳源,三乙胺为氮源,采用水热法制备氮掺杂CDs(Nitrogen doped carbon dots,N-CDs)。首先,结合单因素试验与正交试验,最终确定N-CDs的最佳工艺条件为蒲地蓝药渣1.2 g、反应温度220℃、三乙胺0.4 mL、反应时间8 h;其次,将该条件下的N-CDs进行紫外和荧光光谱的检测,N-CDs紫外吸收峰位于268 nm处,最佳激发和发射峰分别位于320 nm和412 nm,量子产率为6.48%;最后,利用红外、XRD、TEM对N-CDs进行形貌分析,结果表明N-CDs属于无定形碳,且表面富含羟基、羰基等官能团,平均粒径为7.08 nm。此外,将N-CDs用于Fe3+检测,N-CDs的荧光猝灭程度与0.2~20μmol/L的Fe^(3+)浓度呈良好的线性关系,线性方程为y=0.00598c+0.00792(R2=0.9969),检出限为0.31μmol/L。该检测方法操作简单,成本低,选择性好。

关键词：蒲地蓝碳点离子检测荧光猝灭

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飞行器地面运输载荷分析算法及软件设计

空天技术 2023年第2期2023卷 58-65页

作者：武晨滔邓忠民北京航空航天大学宇航学院

地面运输过程中空天飞行器总体呈水平状态，载荷状态具有弯剪载荷结合、动静载荷结合的特点。研究了飞行器地面运输载荷的工程算法。基于解析算法分析了弹性支承对空天飞行器载荷分布的影响；基于谱密度方法进行了随机路面数据重构，并... 详细信息

地面运输过程中空天飞行器总体呈水平状态，载荷状态具有弯剪载荷结合、动静载荷结合的特点。研究了飞行器地面运输载荷的工程算法。基于解析算法分析了弹性支承对空天飞行器载荷分布的影响；基于谱密度方法进行了随机路面数据重构，并基于Duhamel积分对飞行器动载荷进行了求解。设计并开发了专门用于飞行器地面运输环境的载荷分析软件，软件可以对数据进行分析并建立结构支承模型；仿真地面不平度传导至结构的动静载荷并求解响应以及飞行器结构各部位所受弯矩、剪力、挠度等载荷数据。与商业软件分析结果对比，软件设计合理，结果准确。

关键词：飞行器地面运输载荷分析超静定梁路面仿真

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1780 mm热轧精轧机工作辊断辊分析

一重技术 2023年第2期 49-52页

作者：吴晨涛广西钢铁集团有限公司广西防城港538000

针对某厂1780 mm生产线精轧机F2工作辊在生产过程中从工作辊扁头卡环处断裂的事故,通过有限元和金相组织分析,找出轧辊断裂的具体原因。

关键词：有限元分析金相组织工作辊断裂高铬铁

Cobalt doping amount determines dominant reactive species in peroxymonosulfate activation via porous carbon catalysts co-doped by cobalt and nitrogen

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Journal of Environmental Sciences 2024年第4期138卷 212-226页

作者： Xiang Li Limeng wu Aiqin Zhang Shaohua wu Yan Lin Chunping Yang Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle Nanchang Hangkong UniversityNanchang 330063China Academy of Environmental and Resource Sciences School of Environmental Science and EngineeringGuangdong University of Petrochemical TechnologyMaoming 525000China College of Environmental Science and Engineering Hunan University and Key Laboratory of Environmental Biology and Pollution Control(Hunan University)Ministry of EducationChangsha 410082China

Switching the reaction routes in peroxymonosulfate(PMS)-based advanced oxidation processes have attracted much attention but remain challenging.Herein,a series of Co-N/C catalysts with different compositions and structures were prepared by using bimetallic zeolitic imidazolate frameworks based on ZIF-8 and ZIF-67(x Zn/Co-ZIFs).Results show that Co doping amount could mediate the transformation of the activation pathway of PMS over CoN/C.When Co doping amount was less than 10%,the constructed x Co-N/C/PMS system(x≤10%)was singlet oxygen-dominated reaction;however further increasing Co doping amount would lead to the generation and coexistence of sulfate radicals and high-valent cobalt,besides singlet oxygen.Furthermore,the nitrogen-coordinated Co(Co-NX)sites could serve as main catalytically active sites to generate singlet oxygen.While excess Co doping amount caused the formation of Co nanoparticles from which leached Co ions were responsible for the generation of sulfate radicals and high-valent cobalt.Compared to undoped N/C,Co doping could significantly enhance the catalytic performance.The 0.5%Co-N/C could achieve the optimum degradation(0.488 min^(-1))and mineralization abilities(78.4%)of sulfamethoxazole among the investigated Co-N/C catalysts,which was superior to most of previously reported catalysts.In addition,the application prospects of the two systems in different environmental scenarios(pH,inorganic anions and natural organic matter)were assessed and showed different degradation behaviors.This study provides a strategy to regulate the reactive species in PMS-based advanced oxidation process.

关键词： Peroxymonosulfate Sulfate radical Singlet oxygen Cobalt Zeolitic imidazolate framework Advanced oxidation process

The physiological role of the unfolded protein response in the nervous system

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Neural Regeneration Research 2024年第11期19卷 2411-2420页

作者： Shuangchan wu Wensheng Lin Department of Neuroscience University of MinnesotaMinneapolisMNUSA Institute for Translational Neuroscience University of MinnesotaMinneapolisMNUSA

The unfolded protein response(UPR)is a cellular stress response pathway activated when the endoplasmic reticulum,a crucial organelle for protein folding and modification,encounters an accumulation of unfolded or misfolded proteins.The UPR aims to restore endoplasmic reticulum homeostasis by enhancing protein folding capacity,reducing protein biosynthesis,and promoting protein degradation.It also plays a pivotal role in coordinating signaling cascades to determine cell fate and function in response to endoplasmic reticulum stress.Recent research has highlighted the significance of the UPR not only in maintaining endoplasmic reticulum homeostasis but also in influencing various physiological processes in the nervous system.Here,we provide an overview of recent findings that underscore the UPR’s involvement in preserving the function and viability of neuronal and myelinating cells under physiological conditions,and highlight the critical role of the UPR in brain development,memory storage,retinal cone development,myelination,and maintenance of myelin thickness.

关键词： myelin neuron oligodendrocyte Schwann cell unfolded protein response

LONP1 ameliorates liver injury and improves gluconeogenesis dysfunction in acute-on-chronic liver failure

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Chinese Medical Journal 2024年第2期137卷 190-199页

作者： Muchen wu Jing wu Kai Liu Minjie Jiang Fang Xie Xuehong Yin Jushan wu Qinghua Meng Department of Liver Disease Beijing You-An HospitalCapital Medical UniversityBeijing 100069China Beijing Institute of Hepatology Beijing You-An HospitalCapital Medical UniversityBeijing 100069China Department of General Surgery Beijing You-An HospitalCapital Medical UniversityBeijing 100069China

Background:Acute-on-chronic liver failure(ACLF)is a severe liver disease with complex pathogenesis.Clinical hypoglycemia is common in patients with ACLF and often predicts a worse prognosis.Accumulating evidence suggests that glucose metabolic disturbance,especially gluconeogenesis dysfunction,plays a critical role in the disease progression of ACLF.Lon protease-1(LONP1)is a novel mediator of energy and glucose metabolism.However,whether gluconeogenesis is a potential mechanism through which LONP1 modulates ACLF remains unknown.Methods:In this study,we collected liver tissues from ACLF patients,established an ACLF mouse model with carbon tetrachloride(CCl 4),lipopolysaccharide(LPS),and D-galactose(D-gal),and constructed an in vitro hypoxia and hyperammonemia-triggered hepatocyte injury model.LONP1 overexpression and knockdown adenovirus were used to assess the protective effect of LONP1 on liver injury and gluconeogenesis regulation.Liver histopathology,biochemical index,mitochondrial morphology,cell viability and apoptosis,and the expression and activity of key gluconeogenic enzymes were detected to explore the underlying protective mechanisms of LONP1 in ACLF.Results:We found that LONP1 and the expressions of gluconeogenic enzymes were downregulated in clinical ACLF liver tissues.Furthermore,LONP1 overexpression remarkably attenuated liver injury,which was characterized by improved liver histopathological lesions and decreased serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST)in ACLF mice.Moreover,mitochondrial morphology was improved upon overexpression of LONP1.Meanwhile,the expression and activity of the key gluconeogenic enzymes were restored by LONP1 overexpression.Similarly,the hepatoprotective effect was also observed in the hepatocyte injury model,as evidenced by improved cell viability,reduced cell apoptosis,and improved gluconeogenesis level and activity,while LONP1 knockdown worsened liver injury and gluconeogenesis disorders.Conclusion:We demonstrated that gluconeogenesis dysfunc

关键词： Acute-on-chronic liver failure Lon protease-1 Gluconeogenesis disturbance Mitochondrial dysfunction Metabolism

Ballistic performances of the hourglass lattice sandwich structures under high-velocity fragments

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Defence Technology（防务技术） 2024年第1期31卷 312-325页

作者： He-xiang wu Jia Qu Lin-zhi wu Key Laboratory of Advanced Ship Materials and Mechanics College of Aerospace and Civil EngineeringHarbin Engineering UniversityHarbin150001China School of Civil Engineering Northeast Forestry UniversityHarbin150040China

In this paper,the numerical simulation method is used to study the ballistic performances of hourglass lattice sandwich structures with the same mass under the vertical incidence of fragments.Attention is paid to elucidating the influences of rod cross-section dimensions,structure height,structure layer,and rod inclination angle on the deformation mode,ballistic performances,and ability to change the ballistic direction of fragments.The results show that the ballistic performances of hourglass lattice sandwich structures are mainly affected by their structural parameters.In this respect,structural parameters optimization of the hourglass lattice sandwich structures enable one to effectively improve their ballistic limit velocity and,consequently,ballistic performances.

关键词： Hourglass lattice sandwich structures Ballistic performances high-velocity Finite element analysis