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基于磁-固-路双向耦合的电机电磁振动分析方法

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机械工程学报 2024年第11期60卷 156-168页

作者：徐晨期祝长生浙江大学电气工程学院杭州310027

电机的电磁振动是由电机的电磁场与结构场之间的相互作用产生的,研究电机的电磁振动就必须考虑这种磁-固双向耦合的影响。结合电机驱动与控制系统,提出了一种磁-固-路双向耦合的电机电磁振动分析方法。首先建立了电机转子及定子在磁-固... 详细信息

电机的电磁振动是由电机的电磁场与结构场之间的相互作用产生的,研究电机的电磁振动就必须考虑这种磁-固双向耦合的影响。结合电机驱动与控制系统,提出了一种磁-固-路双向耦合的电机电磁振动分析方法。首先建立了电机转子及定子在磁-固双向耦合条件下的动力学模型,基于场路耦合方程建立了电机驱动与控制系统和电磁场之间的联系。然后提出了电机电磁振动的磁-固-路双向耦合循环迭代方法,分析了多场路双向耦合分析中需要解决的关键问题。接着提出了一种多场耦合分析的节点标记方法,实现了电机电磁场与结构场间数据的快速、准确传递和交换。最后以一台1 MW-4极72槽永磁同步电机为例,进行了电机振动的分析及试验测试,对电机电磁振动磁-固-路双向耦合循环迭代分析方法的可行性和准确性进行了验证。结果表明,提出的节点标记及磁-固-路双向耦合循环迭代分析方法能够实现不同场网格节点间信息的准确传递,能考虑转子偏心、结构、轴承、驱动及控制系统等对电机电磁振动特性的影响,为精确预测电机的电磁振动和噪声提供了一种可行的方法。

关键词：电机电磁振动磁-固双向耦合场路耦合

Hcy、叶酸及心肌酶水平在酒依赖伴抑郁症患者中的水平变化及临床意义

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中国基层医药 2024年第8期31卷 1126-1132页

作者：徐陈骐汤锦磊林蒙蜜翁晓璐温州市第七人民医院检验科温州325000 温州市第七人民医院行为医学科温州325000 温州医科大学附属第二医院内分泌科温州325027

目的:分析同型半胱氨酸(Hcy)、叶酸及心肌酶水平在酒依赖伴抑郁症患者中的水平变化及临床意义。方法:选取2022年1月至2023年6月在温州市第七人民医院收治的酒依赖伴抑郁症患者102例为观察组。使用密西根酒依赖筛查表(MAST)对观察组患者... 详细信息

目的:分析同型半胱氨酸(Hcy)、叶酸及心肌酶水平在酒依赖伴抑郁症患者中的水平变化及临床意义。方法:选取2022年1月至2023年6月在温州市第七人民医院收治的酒依赖伴抑郁症患者102例为观察组。使用密西根酒依赖筛查表(MAST)对观察组患者的酒依赖程度进行评价,将其分为轻度酒依赖组(33例)、中度酒依赖组(37例)、较重酒依赖组(15例)、严重酒依赖组(17例)。使用汉密尔顿抑郁症评定量表(HAMD)对观察组患者的疾病严重程度进行评价,将其分为轻度抑郁组(43例)、中度抑郁组(34例)、重度抑郁组(25例)。采用蒙特利尔认知评估量表(MoCA)评估观察组患者认知功能,将其分为认知功能正常组(73例)、认知功能障碍组(29例)。并选择同一时期该院30例健康志愿者为对照组。比较各组Hcy、叶酸及心肌酶水平。并采用Pearson法分析Hcy、叶酸及心肌酶水平与HAMD、MoCA、MAST评分的相关性。结果:观察组Hcy水平为(15.21±1.99)μg/L,显著高于对照组的(11.38±1.46)μg/L(t=-9.80,P<0.001),叶酸、乳酸脱氢酶(LDH)及肌酸激酶(CK)水平分别为(4.82±1.77)μg/L、(122.69±33.98)IU/L、(87.83±16.52)IU/L,均显著低于对照组的(6.27±1.35)μg/L、(150.56±38.78)IU/L、(98.67±20.29)IU/L(t=4.16、3.82、2.99,均P<0.05)。轻度、中度、较重及严重酒依赖组Hcy水平[(13.16±1.23)μg/L、(15.35±0.82)μg/L、(16.79±1.38)μg/L、(17.63±1.22)μg/L]依次升高,叶酸[(6.11±1.51)μg/L、(4.95±1.40)μg/L、(4.04±0.99)μg/L、(2.70±0.99)μg/L]、LDH[(153.35±27.47)IU/L、(123.29±16.59)IU/L、(109.83±14.41)IU/L、(73.24±16.86)IU/L]及CK水平[(104.14±12.78)IU/L、(86.48±9.15)IU/L、(78.11±7.85)IU/L、(67.71±9.00)IU/L]依次降低,差异均有统计学意义(F=73.24、26.53、59.08、53.86,均P<0.001)。轻度、中度及重度抑郁组Hcy水平[(13.75±1.54)μg/L、(15.46±1.17)μg/L、(17.39±1.31)μg/L]依次升高,叶酸[(5.83±1.77)μg/L、(4.67±1.12)μg/L、(3.28±1.26)μg/L]、LDH[(138.09±33.67)IU/L、(119.73±26.39)IU/L、(100.24±30.88)IU/L]及CK水平[(96.35±15.24)IU/L、(86.73±15.62)IU/L、(74.69±9.71)IU/L]依次降低,差异均有统计学意义(F=56.57、24.36、12.23、18.44,均P<0.001)。认知功能障碍组Hcy水平为(17.01±1.63)μg/L,显著高于认知功能正常组的(14.50±1.64)μg/L(t=-6.97,P<0.001),叶酸、LDH及CK水平分别为(3.76±1.78)μg/L、(102.71±31.08)IU/L、(76.00±13.37)IU/L,显著低于认知功能正常组的(5.24±1.58)μg/L、(130.63±31.92)IU/L、(92.52±15.31)IU/L(t=4.11、4.01、5.09,均P<0.001)。Hcy水平与HAMD、MAST评分均呈正相关(r=0.854、0.846,均P<0.05),与MoCA评分呈负相关(r=-0.648,P<0.001))。叶酸、LDH及CK水平与HAMD、MAST评分均呈负相关(r=-0.644、-0.701;r=-0.551、-0.696;r=-0.505、-0.673;均P<0.001),与MoCA评分均呈正相关(r=0.514、0.436、0.448,均P<0.001)。结论:酒依赖伴抑郁症患者Hcy、叶酸及心肌酶表达出现异常,且这些指标与患者酒依赖程度、抑郁程度及认知功能有关。

关键词：抑郁症精神病酒精中毒性半胱氨酸叶酸 L-乳酸脱氢酶肌酸激酶

Structural understanding of T cell receptor triggering

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Cellular & Molecular Immunology 2020年第3期17卷 193-202页

作者： Xinyi xu Hua Li chenqi xu State Key Laboratory of Molecular Biology Shanghai Science Research CenterCAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesUniversity of Chinese Academy of Sciences320 Yueyang Road200031 ShanghaiChina School of Life Science and Technology ShanghaiTech University100 Haike Road201210 ShanghaiChina

The T cell receptor(TCR)is one of the most complicated receptors in mammalian cells,and its triggering mechanism remains *** an octamer complex,TCR comprises an antigen-binding subunit(TCRαβ)and three CD3 signaling subunits(CD3ζζ,CD3δε,and CD3γε).Engagement of TCRαβwith an antigen peptide presented on the MHC leads to tyrosine phosphorylation of the immunoreceptor tyrosine-based activation motif(ITAM)in CD3 cytoplasmic domains(CDs),thus translating extracellular binding kinetics to intracellular signaling *** conformational change plays an important role in the transmembrane signal transduction of TCR is under *** by the complexity and functional importance of TCR,many groups have been studying TCR structure and triggering for decades using diverse biochemical and biophysical ***,we synthesize these structural studies and discuss the relevance of the conformational change model in TCR triggering.

关键词： T Cell Receptor Structure Conformational change Triggering

氯氮平对精神分裂症患者内分泌激素水平影响及并发代谢异常的因素分析

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中国基层医药 2024年第8期31卷 1154-1159页

作者：林蒙蜜陈丽玲郑存庆徐陈骐温州市第七人民医院检验科温州325000

目的:探讨氯氮平对精神分裂症患者内分泌激素水平影响,并分析影响患者并发代谢异常的相关因素。方法:回顾性分析2021年1月至2023年1月到温州市第七人民医院治疗的精神分裂症患者102例的临床资料,所有患者采用氯氮平治疗,并根据患者治疗... 详细信息

目的:探讨氯氮平对精神分裂症患者内分泌激素水平影响,并分析影响患者并发代谢异常的相关因素。方法:回顾性分析2021年1月至2023年1月到温州市第七人民医院治疗的精神分裂症患者102例的临床资料,所有患者采用氯氮平治疗,并根据患者治疗后是否发生代谢异常,分为代谢正常组(n=76)和代谢异常组(n=26)。记录并比较两组患者糖脂代谢水平、甲状腺功能及性腺激素水平,采用logistic回归分析影响患者并发代谢异常的相关因素。结果:治疗后,患者三酰甘油(TG)、低密度脂蛋白(LDL)、糖化血红蛋白(HbAlc)、三碘甲状腺原氨酸(T 3)及催乳素(PRL)水平均高于治疗前,雌二醇(E 2)水平低于治疗前,差异均有统计学意义(t=2.84、3.36、25.35、3.26、4.88,-5.76,均P<0.05)。代谢异常组身体质量指数(BMI)、病程、TG、HbAlc、T 3及PRL水平均高于代谢正常组,LDL、FT 4及E 2水平均低于代谢正常组,差异均有统计学意义(t=4.41、5.67、3.20、4.71、3.49、3.97、-4.84、-4.51、-4.25,均P<0.05)。logistic回归分析结果显示,BMI水平偏高(OR=7.410,95%CI=1.485~36.988)、病程较长(OR=1.385,95%CI=1.088~1.764)、LDL水平偏低(OR=0.003,95%CI=0.000~0.453)、HbAlc水平偏高(OR=4.222,95%CI=1.067~16.706)、FT 4水平偏低(OR=0.238,95%CI=0.086~0.655)及E 2水平偏低(OR=0.845,95%CI=0.726~0.984)均为影响患者并发代谢异常的相关因素(均P<0.05)。结论:采用氯氮平治疗精神分裂症,将对患者糖脂代谢、甲状腺及性腺激素水平造成影响,同时发现BMI水平偏高、病程较长、LDL水平偏低、HbAlc水平偏高、FT 4水平偏低及E 2水平偏低将提高患者并发代谢异常风险,因此应根据实际情况进行针对性干预。

关键词：精神分裂症氯氮平碳水化合物代谢脂类代谢甲状腺功能试验性腺激素类危险因素 Logistic模型因素分析统计学

1106例万古霉素血药浓度监测及影响因素分析

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医药导报 2024年第2期43卷 184-189页

作者：潘坤明李艳丽徐辰祺李然宜许青李晓宇复旦大学附属中山医院药剂科上海200032 复旦大学附属中山医院肾脏内科上海200032

目的分析住院患者万古霉素血药浓度达标情况及影响因素,为万古霉素临床合理使用及治疗药物监测(TDM)开展提供参考。方法选取复旦大学附属中山医院2016年1月—2019年6月住院并接受万古霉素TDM的患者。收集病历资料,万古霉素血药浓度,急... 详细信息

目的分析住院患者万古霉素血药浓度达标情况及影响因素,为万古霉素临床合理使用及治疗药物监测(TDM)开展提供参考。方法选取复旦大学附属中山医院2016年1月—2019年6月住院并接受万古霉素TDM的患者。收集病历资料,万古霉素血药浓度,急性肾损伤(AKI)发生情况等。根据药物浓度是否达标分组,使用Logistic回归分析药物浓度达标的影响因素。分析药物浓度与急性肾损伤发生的相关性。结果共纳入患者1106例。70.7%为男性,年龄中位数为60.0(IQR=20)岁。科室分布以外科为主,占比76.4%。万古霉素疗程中位天数为10.8(IQR=9.0)。仅有21.6%患者首次浓度监测为给药第4或5剂前。46.8%患者药物浓度监测结果在10~20μg·mL^(-1),达到目标浓度范围。万古霉素相关AKI发生率为25.9%。不同万古霉素药物浓度的患者AKI发生率不同:20μg·mL^(-1)时,AKI发生率分别为15.8%、20.5%、25.8%和39.4%。多元Logistic回归分析显示:相比于用药疗程≤7 d,用药疗程>7~14 d(OR=1.688,P=0.001)以及用药疗程>14 d(OR=1.744,P=0.002)均更可能达到目标浓度。相比于接受非常规日剂量的患者,接受常规日剂量患者更可能达到目标浓度(OR=1.540,P=0.003)。结论我国万古霉素TDM现状依然存在监测时机延迟、目标浓度达标率低等不足。较高的万古霉素浓度与AKI显著相关,影响万古霉素浓度达标的因素主要包括用药疗程和用药方案的复杂性。

关键词：万古霉素治疗药物监测谷浓度浓度达标急性肾损伤

Upper ocean response to typhoon Kujira(2015) in the South China Sea by multiple means of observation

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Journal of Oceanology and Limnology 2020年第2期38卷 314-333页

作者： GUO Jie ZHANG Tianlong xu chenqi XIE Qiang Key Laboratory of Coastal Environmental Processes and Ecological Remediation Yantai Institute of Coastal Zone Research(YIC)Chinese Academy of Sciences(CAS)Yantai 264003China Shandong Key Laboratory of Coastal Environmental Processes YICCASYantai 264003China Center for Ocean Mega-Science CASQingdao 266071China University of Chinese Academy of Sciences Beijing 100049China Institute of Deep-sea Science and Engineering CASSanya 572000China

The impact of typhoon Kujira(2015)on the ocean environment around Yongxing Island in the South China Sea was observed using multiple-satellite sensors and on-site data.A subsurface buoy and Agro float were located to the left and lower right of the track of the *** observations revealed sea surface cooling of up to 2.5℃,a maximum decrease in sea surface salinity of 2 in the main study area because of heavy rain,and increases in the chlorophyll concentration induced by the slow-moving typhoon with a maximum observed instantaneous wind speed of 35.1 m/*** sea surface temperature to the right of the typhoon track changed more than that on the left owing to a right bias of the typhoon associated with coupling of the typhoon with wind stress on the sea *** the ocean interior,there was obvious downwelling at 24.7 m and upwelling at a depth of 35.7 m with the vertical entrainment and agitation of the typhoon,and the ef fects extended to different depths of up to more than 1000 *** the typhoon passed through the main study area,the maximum flow velocity change at depths of 51 and 660 m was about 0.44 and 0.04 m/s,*** typhoon af fected the flow field to a depth of 660 m as it formed and decayed in 11 h,moved at an average speed of 60 m/h,and af fected the sea surface over a range exceeding 700 km as it moved slowly and stayed at sea for 2 *** entrainment and agitation generated by the typhoon,as well as rainfall,cooled the sea *** inhibited the strengthening of the typhoon,but the energy transmitted to the ocean led to divergence-convergence flow from a shallow to deep layer.

关键词： typhoon Kujira(2015) downwelling upwelling flow field wind field salinity temperature

A new oil spill detection algorithm based on Dempster-Shafer evidence theory

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Journal of Oceanology and Limnology 2022年第2期40卷 456-469页

作者： Tianlong ZHANG Jie GUO chenqi xu Xi ZHANG Chuanyuan WANG Baoquan LI Yantai Institute of Coastal Zone Research(YIC) Chinese Academy of Sciences(CAS)CAS Key Laboratory of Coastal Environmental Processes and Ecological RemediationYantai 264003China Shandong Key Laboratory of Coastal Environmental Processes Yantai Institute of Coastal Zone ResearchChinese Academy of SciencesYantai 264003China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China University of the Chinese Academy of Sciences Beijing 100049China Frist Institute of Oceanography(FIO) Ministry of Natural Resources(MNR)Qingdao 266061China

Features of oil spills and look-alikes in polarimetric synthetic aperture radar(SAR)images always play an important role in oil spill *** oil spill detection algorithms have been implemented based on these *** environmental factors such as wind speed are important to distinguish oil spills and look-alikes,some oil spill detection algorithms do not consider the environmental *** distinguish oil spills and look-alikes more accurately based on environmental factors and image features,a new oil spill detection algorithm based on Dempster-Shafer evidence theory was *** process of oil spill detection taking account of environmental factors was modeled using the subjective Bayesian *** Faster-region convolutional neural networks(RCNN)model was used for oil spill detection based on the convolution *** detection results of the two models were fused at decision level using Dempster-Shafer evidence *** establishment and test of the proposed algorithm were completed based on our oil spill and look-alike sample database that contains 1798 image samples and environmental information records related to the image *** analysis and evaluation of the proposed algorithm shows a good ability to detect oil spills at a higher detection rate,with an identifi cation rate greater than 75%and a false alarm rate lower than 19%from experiments.A total of 12 oil spill SAR images were collected for the validation and evaluation of the proposed *** evaluation result shows that the proposed algorithm has a good performance on detecting oil spills with an overall detection rate greater than 70%.

关键词： synthetic aperture radar(SAR)data oil spill detection subjective Bayesian Faster-region convolutional neural networks(RCNN) Dempster-Shafer evidence theory

Experimental research on oil fi lm thickness and its microwave scattering during emulsifi cation

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Journal of Oceanology and Limnology 2022年第4期40卷 1361-1376页

作者： Jie GUO chenqi xu Genwang LIU Xi ZHANG Junmin MENG Guangbo REN Yantai Institute of Coastal Zone Research Chinese Academy of Sciences(CAS)CAS Key Laboratory of Coastal Environmental Processes and Ecological RemediationYantai 264003China Shandong Key Laboratory of Coastal Environmental Processes Yantai Institute of Coastal Zone ResearchCASYantai 264003China Center for Ocean Mega-Science CASQingdao 266071China University of Chinese Academy of Sciences Beijing 100049China First Institute of Oceanography Ministry of Natural ResourcesQingdao 266061China

Synthetic Aperture Radar(SAR) plays a major role in identifying oil spills on the sea ***,obtaining information of oil spill thickness(volume) is still a *** is an important process affecting the thickness and normalized radar cross section(NRCS) of oil *** of crude oil emulsification with C-band fully-polarized scatterometer were conducted combining airborne hyperspectral imaging spectrometer and 3 D laser scanner observation data,to provide experimental parameters and method to support accurate remote sensing monitoring on marine oil *** is further proved that through quantitative homogeneous emulsified oil spill experiments,to a certain extent,the NRCS of oil film increased during the emulsification process of crude *** backscattering mechanism of crude oil emulsification was explored using a semi-empirical model(SEM);the change of oil film NRCS was modulated by its dielectric constant and surface roughness,in which the dielectric constant showed a dominant *** relationship between thickness and NRCS of oil film was studied under two experimental *** differences of NRCS between oil film and adjacent seawater(Δσ~0) and the damping ratio(DR) were found to have a linear relationship with oil thickness,which were best in the vertical polarization mode(VV) at 45° incident angle during the quantitative crude oil homogeneous emulsification *** the natural emulsification process of continuous oil spill in which oil film was mixed with both crude oil and emulsified oil,an empirical equation of oil film thickness is preliminarily *** Δσ~0,DR,and the empirical equation of oil film thickness were applied to the marine continuous oil spill incident on a 19-3 oil platform with spaceborne SAR image and successfully explained the distribution of the relative thickness of the oil film.

关键词： crude oil emulsifi cation normalized radar cross section(NRCS) moisture content oil fi lm thickness damping ratio 1

Lipid metabolism in tumor-infiltrating T cells: mechanisms and applications

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Life Metabolism 2022年第3期1卷 211-223页

作者： Xin-Yu Ke Miaowen Zou chenqi xu State Key Laboratory of Molecular Biology Shanghai Science Research CenterCAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesShanghai 200031China

As an essential part of adaptive immunity,T cells coordinate the immune responses against pathogens and cancer *** metabolism has emerged as a key regulator for the activation,differentiation,and effector functions of T ***,uncovering the molecular mechanisms by which lipid metabolism dictates T cell biology is of vital *** tumor microenvironment is a hostile milieu,*** characterized by nutrient *** this environment,various cells,such as T cells and cancer cells,reprogram their metabolism,including their lipid metabolism,to meet their energy and functional ***,we review the participation of fatty acid and cholesterol metabolism homeostasis in orchestrating T cell *** demonstrate how the tumor microenvironment reshapes the lipid metabolism in T ***,we highlight the current cancer therapeutic interventions that target fatty acid and cholesterol metabolism of T *** offering a holistic understanding of how lipid metabolic adaption by T cells facilitates their immunosurveillance in the tumor microenvironment,we believe this review and the future studies might inspire the next-generation immunotherapies.

关键词： T cells lipid metabolism fatty acid metabolism cholesterol metabolism tumor microenvironment cancer immunotherapies