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Glucose metabolism and pancreatic beta cell function in patients with obstructive sleep apnea-hypopnea syndrome

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Glucose metabolism and pancreatic beta cell function in pati...

中华医学会呼吸病学年会——2011（第十二次全国呼吸病学学术会议）

作者： chenjuan gu,Qingyun li,min li department of respiratory medicine,shanghai ruijin hospital,medical school of shanghai jiaotong university

The objective of this study was to determine the impact of obstructive sleep apnea hypopnea syndrome(OSAHS) on glucose metabolism and pancreatic beta cell function. A total of 179 subjects who recorded all-night polysomnography in our sleep laboratory during the period from January 2005 to December 2010 were enrolled in this study and were divided into

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Chronic intermittent hypoxia increases beta cell mass and activates mTOR/HIF1/VEGF-A pathway in mice islet

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Chronic intermittent hypoxia increases beta cell mass and ac...

中华医学会呼吸病学年会——2011（第十二次全国呼吸病学学术会议）

作者： chenjuan gu,min li,Qingyun li,Ning li department of respiratory medicine,shanghai ruijin hospital,medical school of shanghai jiaotong university

The objective of this study was to determine changes in pancreatic beta cell mass and islet mTOR/HIF1/VEGF-A pathway in mice subjected to chronic intermittent hypoxia,which was probably related to CIH-induced impaired glucose metabolism and beta cell dysfunction. A gas control delivery system was designed to regulate the flow of nitrogen and oxygen into a customized

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ROLE OF TOLL-liKE RECEPTOR 4 IN AIRWAY INFLAMMATION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASES

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Journal of shanghai Second medical university(Foreign Language Edition) 2008年第1期20卷 38-41页

作者：周敏戎霞君万欢英黄绍光李彪李敏 department of respiratory Disease Ruijin Hospital School of Medicine Shanghai Jiaotong University

Objective To confirm if pulmonary epithelial cells express Toll-like receptor 4 （TLR4） and investigate the role of TLR4 in airway inflammation of chronic obstructive pulmonary diseases （COPD）. Methods The expressions of TLR4, IL-8 mRNA and NF-KB activation stimulated by differen factors E lipopolysacharides （LPS）, interleukin-lβ, cigarette smoking extract （CSE）] in pulmonary epithelial cells were investigated. Results LPS, CSE and IL-lβ induced the production of IL-8 and activation of NF-KB. The levels of 1L-8 mRNA and NF-KB protein in E1A ＋ cell were markedly higher than E1A- cell and A549 cell （ P 〈0. 05）. The TLR4 mRNA of all the cells increased along with the increase of LPS＇ stimulated time. There was significant difference among different LPS＇ doses （ 12 h： P = O. 039 ; 24 h ： P = O. 013 ）. The TLR4 mRNA of E1A ＋ cell was higher than the other two groups （ P 〈0. 05）. IL-lβ induced all the cells expressing TLR4 mRNA. CSE had no effect on the expression of TLR4 mRNA. Conclusion Pulmonary epithelial cells express TLR4. LPS and IL-lβ up-regulate IL-8 mediated via the activation of NF-KB induced by TLR4. But CSE up-regulates IL-8 mediated via the activation of NF-KB, which has no relation to TLR4 and may have another signal transduction pathway.

关键词： Toll-like receptor 4 pulmonary epithelial cells chronic airway inflammation

Access block and prolonged length of stay in the emergency department are associated with a higher patient mortality rate

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World Journal of Emergency medicine 2022年第1期13卷 59-64页

作者： Ting Cheng Qian Peng Ya-qing Jin Hong-jie Yu Pei-song Zhong Wei-min gu Xiao-shan Wang yi-ming Lu li Luo department of respiratory and Critical Care medicine Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China Institute of respiratory Diseases Shanghai Jiaotong University School of MedicineShanghai 200025China shanghai Key Laboratory of Emergency Prevention Diagnosis and Treatment of Respiratory Infectious DiseasesShanghai 200025China school of Public Health Fudan UniversityShanghai 200032China Jiading District Center for Disease Control and Prevention Shanghai 201800China department of Statistical Information Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 201801China department of Emergency Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China Key Laboratory of Public Health Safety of the ministry of Education and Key Laboratory of Health Technology Assessment of the ministry of Health Fudan UniversityShanghai 200032China

Access block,known as exit block or boarding,is defined as a situation in which patients who are admitted or planned for admission remain in the emergency department(ED)as they are unable to be transferred to an inpatient unit within a reasonable time frame(no longer than 8 hours).[1,2]Access block often occurs due to insufficient hospital capacity and is a major issue in emergency medicine.[3]

关键词： Access admitted transferred

Strategies and recommendations for the management of gastrointestinal surgery during the COVID-19 pandemic:experience shared by Chinese surgeons

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Gastroenterology Report 2020年第3期8卷 167-174,I0001页

作者： Jia Ke Nan Lan Ting Wang Jin-Jie Wu Zhen He Xiao-Sheng He Kai-Xiong Tao Qun Qian Ping-Hong Zhou guo-Xin li min-Hua Zheng Zhong-Tao Zhang Jia-Fu Ji Ping Lan department of Colorectal Surgery The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China guangdong Institute of Gastroenterology Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesGuangzhouGuangdongP.R.China department of Gastrointestinal Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiP.R.China department of General Surgery Zhongnan Hospital of Wuhan UniversityWuhanHubeiP.R.China Endoscopy Center Zhongshan HospitalFudan UniveristyShanghaiP.R.China department of General Surgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China department of Gastrointestinal Surgery Ruijin HospitalShanghai Jiaotong University School of MedicineShanghaiP.R.China department of General Surgery Beijing Friendship HospitalCapital Medical UniversityNational Clinical Research Center for Digestive DiseasesBeijingP.R.China department of Gastrointestinal Cancer Center Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer Hospital&InstituteBeijingP.R.China

Novel coronavirus disease-2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is an ongoing public-health pandemic *** SARS-CoV-2 has been known to spread primarily through respiratory droplets,recent evidence also supports fecal/oral as an additional route of transmission,raising concerns over gastrointestinal(GI)transmission of the ***,we,as the front-line Chinese GI surgeons,would like to share our experience and lessons in the combat against *** is essential to create science-based,rational,and practical strategies during the outbreak of ***,we provide multi-institutional consensus on minimizing disease transmission while continuing to provide care from all aspects for patients in GI surgery,including outpatient clinics,inpatient units,gastrointestinal endoscopy centers,and adjustments in perioperative *** experiences and recommendations are worth sharing and may help to establish specific infection-control and outcome measures.

关键词： gastroenterological surgery novel coronavirus disease-2019 perioperative care severe acute respiratory syndrome coronavirus 2

Genetic polymorphisms of XPD and CDA genes and lung cancer risk in a Chinese population

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Genetic polymorphisms of XPD and CDA genes and lung cancer r...

中华医学会呼吸病学年会——2013（第十四次全国呼吸病学学术会议）

作者： min ZHOU WAN Huan ying GAO Bei li DING Yong jie Rong xia jun department of respiratory Ruijin HospitalShanghai Jiaotong University School of Medicine

Objective To investigate the relationships between CDA,XPD gene polymorphism and susceptibility to lung cancer and its pathological types,and explore the influence of the interaction between smoking and gene polymorphisms to the risk of lung cancer. Methods A case - control study was performed on 103 lung cancer patients and 103 healthy controls,we determined the genotypes distribution of XPDexon 10 G→A(Asp312Asn) and 23T→G(Lys751Gln) of the two

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慢性阻塞性肺疾病急性加重住院患者呼吸道病毒感染与炎症细胞因子的相关性

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中华结核和呼吸杂志 2018年第12期41卷 942-948页

作者：赵春柳黄靓雯张利张秋蕊李庆民周敏瑞金医院卢湾分院呼吸科上海交通大学医学院附属瑞金医院呼吸与危重症医学科上海交通大学医学院呼吸病研究所 200025 河南省人民医院阜外华中心血管病医院

目的探讨慢性阻塞性肺疾病(慢阻肺)急性加重期呼吸道病毒感染疾病特点及其与炎症细胞因子的相关性。方法前瞻性纳入2015年10月至2017年9月上海交通大学医学院附属瑞金医院慢阻肺急性加重患者,共纳入慢阻肺急性加重期患者99例,其中男81例... 详细信息

目的探讨慢性阻塞性肺疾病(慢阻肺)急性加重期呼吸道病毒感染疾病特点及其与炎症细胞因子的相关性。方法前瞻性纳入2015年10月至2017年9月上海交通大学医学院附属瑞金医院慢阻肺急性加重患者,共纳入慢阻肺急性加重期患者99例,其中男81例,女18例,年龄54~93岁,平均(74±10)岁。收集所有患者的痰液,使用多通道实时荧光定量PCR检测15种呼吸道病毒,分析病毒阳性结果相关的临床特点;使用EliSA法检测患者血清中IL-6、IL-8、可溶性IL-2受体(sIL-2R)、干扰素-γ、干扰素诱导蛋白(IP-10)、调节活化正常T细胞表达和趋化因子(RANTES)及肿瘤坏死因子-α(TNF-α)等炎症因子水平,评估与呼吸道病毒感染的相关性,并建立判别模型。结果99例患者中病毒检测阳性34例(34%),其中流感A型病毒阳性率最高(38%,13/34),其次为鼻病毒(35%,12/34)。多因素logistic回归分析显示,发热、稳定期慢阻肺评估测试(CAT)评分、血清IP-10和TNF-α水平与慢阻肺急性加重期呼吸道病毒感染相关(OR值分别为19.146、1.211、1.010和1.086,均P<0.05)。血清IP-10及sIL-2R水平在流感A型病毒阳性患者中显著升高。结论呼吸道病毒感染在慢阻肺急性加重期常见,流感A型病毒和鼻病毒检出率最高;发热是常见症状;稳定期呼吸道症状严重者对病毒易感。呼吸道病毒感染导致系统性炎症水平升高,流感病毒尤为显著。由发热、稳定期CAT评分、血清IP-10和TNF-α水平组成的判别模型对提示慢阻肺急性加重期呼吸道病毒感染有意义。

关键词：肺疾病慢性阻塞胜急性加重呼吸道病毒感染炎症因子