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Characteristics of novel Ti-10Mo-xCu alloy by powder metallurgy for potential biomedical implant applications

Bioactive Materials 2020年第3期5卷 659-666页

作者： Wei Xu chenjin hou Yuxuan Mao Lei Yang Maryam Tamaddon Jianliang Zhang Xuanhui Qu Chaozong Liu Bo Su Xin Lu Beijing Advanced Innovation Center for Materials Genome Engineering State Key Laboratory for Advanced Metals and MaterialsInstitute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijingChina Institute of Orthopaedic&Musculoskeletal Science University College LondonRoyal National Orthopaedic HospitalStanmoreHA74LPUK Center for Health Science and Engineering Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control TechnologySchool of Materials Science and EngineeringHebei University of TechnologyTianjin300130China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China Bristol Dental School University of BristolBristolBS12LYUK

When biomaterials are implanted in the human body,the surfaces of the implants become favorable sites for microbial adhesion and biofilm formation,causing peri-implant infection which frequently results in the failure of prosthetics and revision ***-Mo alloy is one of the commonly used implant materials for load-bearing bone replacement,and the prevention of infection of Ti-Mo implants is therefore *** this study,bacterial inhibitory copper(Cu)was added to Ti-Mo matrix to develop a novel Ti-Mo-Cu alloy with bacterial inhibitory *** effects of Cu content on microstructure,tensile properties,cytocompatibility,and bacterial inhibitory ability of Ti-Mo-Cu alloy were systematically *** revealed that Ti-10Mo-1Cu alloy consisted ofαandβphases,while there were a few Ti2Cu intermetallic compounds existed for Ti-10Mo-3Cu and Ti-10Mo-5Cu alloys,in addition toαandβ*** tensile strength of Ti-10Mo-xCu alloy increased with Cu content while elongation ***-10Mo-3Cu alloy exhibited an optimal tensile strength of 1098.1 MPa and elongation of 5.2%.Cytocompatibility study indicated that none of the Ti-10Mo-xCu alloys had a negative effect on MC3T3-E1 cell *** inhibitory rates against *** and *** increased with the increase in Cu content of Ti-10Mo-xCu alloy,within the ranges of 20-60%and 15-50%,*** together,this study suggests that Ti-10Mo-3Cu alloy with high strength,acceptable elongation,excellent cytocompatibility,and the bacterial inhibitory property is a promising candidate for biomedical implant applications.

关键词： Ti-10Mo-xCu alloy Microstructure Mechanical properties Cytocompatibility Bacterial inhibitory property

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