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A Novel mRNA Signature Related to Immunity to Predict Survival and Immunotherapy Response in Hepatocellular Carcinoma

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Journal of Clinical and Translational Hepatology 2022年第5期10卷 925-938页

作者： chenhao zhou Jialei Weng Yuan Gao Chunxiao Liu Xiaoqiang Zhu Qiang zhou Chia-Wei Li Jialei Sun Manar Atyah Yong Yi Qinghai Ye Yi Shi Qiongzhu Dong Yingbin Liu Mien-Chie Hung Ning Ren Department of Liver Surgery Liver Cancer InstituteZhongshan Hospitaland Key Laboratory of Carcinogenesis and Cancer Invasion(Ministry of Education)Fudan UniversityShanghaiChina Department of Molecular and Cellular Oncology The University of Texas MD Anderson Cancer CenterHoustonTXUSA Department of Biliary-Pancreatic Surgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina School of Biomedical Sciences Li Ka Shing Faculty of MedicineThe University of Hong KongPok Fu LamHong Kong SARChina Biomedical Research Center Zhongshan HospitalFudan UniversityShanghaiChina Institute of Fudan Minhang Academic Health System and Key Laboratory of Whole-period Monitoring and Precise Intervention of Digestive Cancer(SMHC)Minhang Hospital&AHSFudan UniversityShanghaiChina Institutes of Biomedical Sciences Fudan UniversityShanghaiChina Graduate Institute of Biomedical Sciences and Center for Molecular Medicine China Medical UniversityTaichung

Background and Aims:Hepatocellular carcinoma(HCC)is the most common primary liver cancer and the incidence and mortality rates are *** the limited treatments of HCC and promising application of immunotherapy for cancer,we aimed to identify an immune-related prognostic signature that can predict overall survival(OS)rates and immunotherapy response in ***:The initial signature development was conducted using a training dataset from the Cancer Genome Atlas followed by independent internal and external validations from that resource and the Gene Expression Omnibus.A signature based nomogram was generated using multivariate Cox regression *** associations of signature score with tumor immune phenotype and response to immunotherapy were analyzed using single-sample gene set enrichment analysis and tumor immune dysfunction and exclusion algorithm.A cohort from Zhongshan Hospital was employed to verify the pre dictive robustness of the signature regarding prognostic risk and immunotherapy ***:The prognostic signature,IGS_(HCC),consisting of 22 immune-related genes,had independent prognostic ability,with training and validation ***,IGS_(HCC)stratified HCC patients with different outcomes in *** prognostic accuracy of IGS_(HCC)was better than three reported prognostic *** IGS_(HCC)-based nomogram had high accuracy and significant clinical benefits in predicting 3-and 5-year ***_(HCC)reflected distinct immunosuppressive phenotypes in low-and high-score *** with low IGS_(HCC)scores were more likely than those with high scores to benefit from ***:IGS_(HCC)predicted HCC prognosis and response to immunotherapy,and contributed to individualized clinical management.

关键词： Hepatocellular carcinoma Gene signature Immune microenvironment Prognosis Immunotherapy

Connecting the Belt and Road through sea-rail collaboration

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Frontiers of Engineering Management 2017年第3期4卷 315-324页

作者： chenhao zhou Haobin LI Wencheng WANG Loo Hay LEE Ek Peng CHEW Industrial Systems Engineering and Management National University of Singapore School of Management Shanghai University

As part of China's "the Belt and Road"strategy, China Railway Express provides alternative shipping routes and transportation modes from Asia to Europe and creates new opportunities for intermodal transportation in the shipping industry. A time–distancebased cost(time cost) function was proposed to compare China Railway Express with traditional transportation modes. Time cost was related to different types of cargoes,which exhibit distinct sensitivity to time. Using the proposed cost function as basis, we identified the cost indifference area where total costs are equal. Further analysis was performed for selecting the transportation mode and supply area for a specific cargo. This study provides various parties, such as business owners, the government, and the shipping industry, with many valuable insights.

关键词： China Railway Express the Belt and Road shipping industry combined transportation

基于深度学习的下行大规模MIMO OFDM系统的1比特预编码算法

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电子与信息学报 2024年第3期46卷 886-894页

作者：周宸颢温利嫄钱骅康凯中国科学院上海高等研究院上海201210 中国科学院大学北京100049 上海科技大学信息科学与技术学院上海201210

大规模多输入多输出(MIMO)系统中通过在基站端配备数百根天线,在提高频谱利用效率的同时,也带来了系统成本的增加。本课题组之前提出了一种适用于下行大规模MIMO正交频分复用(OFDM)系统的收敛保证的多载波1比特预编码算法(CG-MC1bit),... 详细信息

大规模多输入多输出(MIMO)系统中通过在基站端配备数百根天线,在提高频谱利用效率的同时,也带来了系统成本的增加。本课题组之前提出了一种适用于下行大规模MIMO正交频分复用(OFDM)系统的收敛保证的多载波1比特预编码算法(CG-MC1bit),能够获得较优的系统性能,但相应的计算复杂度较高,阻碍了其在实时系统中的应用。为进一步解决大规模MIMO系统中的成本和功耗问题,该文提出了一个模型驱动的神经网络,在CG-MC1bit算法的基础上迭代展开(Unfolding)得到了一种更加高效的CG-MC1bit-Net算法。具体而言,将迭代算法展开为一个神经网络,并引入可训练的参数来替代前向传播中的高复杂性操作。实验结果表明,该方法能够自动更新参数,与传统的预编码算法相比,收敛速度更快,计算复杂度更低。

关键词：大规模多输入多输出预编码正交频分复用(OFDM) 迭代展开神经网络

Development and Validation of a Metabolic Gene-Based Prognostic Signature for Hepatocellular Carcinoma

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Development and Validation of a Metabolic Gene-Based Prognos...

Synergistically enhanced ORR and HER performance on Co-N-C coupled in-situ generated PtCo intermetallic

2022CCTB中国肿瘤标志物学术大会暨中国整合肿瘤学大会暨第十六届肿瘤标志物青年科学家论坛暨中国肿瘤标志物产业创新大会

作者： Jialei Weng chenhao zhou Qiang zhou Wanyong Chen Yirui Yin Manar Atyah Qiongzhu Dong Yi Shi Ning Ren Zhongshan Hospital Fudan University Department of Molecular and Cellular Oncology The University of Texas MD Anderson Cancer Center Institute of Fudan Minhang Academic Health System Minhang Hospitaland Key Laboratory of Shanghai Municipal Health CommissionFudan University Institutes of Biomedical Sciences Fudan University Biomedical Research Centre Zhongshan HospitalFudan University

Background:Hepatocellular carcinoma(HCC) is a malignant tumor with great variation in prognosis among *** in metabolism influence disease progression and clinical *** objective of this study was to determine the overall survival(OS) risk of HCC patients from a metabolic *** and Methods:The model was constructed using the least absolute shrinkage and selection operator(LASSO) COX regression based on The Cancer Genome Atlas(TCGA,n=342) *** International Cancer Genome Consortium(ICGC,n=232),GSE14520(n=242) datasets,and a clinical cohort(n=64) were then used to assess the prognostic value of the ***:A 10 metabolic gene-based signature was constructed and verified as a robust and independent prognostic classifier in public and real-world validation ***,the signature enabled the identification of HCC molecular subtypes,yielding an AUC value of0.678 [95%CI:0.592-0.763].Besides,the signature was associated with metabolic processes like glycolysis,supported by a clear correlation between the risk score and expression of rate-limiting ***,high-risk tumor was likely to have a high tumor infiltration status of immunosuppressive cells,as well as elevated expression of some immune checkpoint *** final clinical translation,a nomogram integrating the signature and tumor stage was established,and showed improved predictive accuracy of 3-and 5-year OS and brought more net benefit to ***:We developed a prognostic signature based on 10 metabolic genes,which has proven to be an independent and reliable prognostic predictor for HCC and reflects the metabolic and immune characteristics of tumors.

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Journal of Energy Chemistry 2025年第1期100卷 721-729页

作者： Guanyu Luo Min Song Lulu An Xiao Huang Qian Zhang chenhao Zhang Tao Shen Shuang Wang Deli Wang Key Laboratory of Material Chemistry for Energy Conversion and Storage (Huazhong University of Science and Technology) Ministry of Education School of Chemistry and Chemical Engineering Huazhong University of Science and Technology

Integrating multi-scale sites in a composite catalyst is vital to realize efficient ***,a synergistic composite catalyst consisting of Co atomic sites and in-situ generated PtCo intermetallic compounds （IMCs）(o-PtCo@CoNC) is proposed through Co pre-anchoring and subsequent impregnation-reduction *** loading of Co atoms provides a chance for in-situ generating PtCo ordered intermetallic *** remaining Co single atoms and PtCo IMCs construct synergistic electrocatalytic *** from the ordered structure,synergistic effect of Pt Co IMCs and Co single atoms,o-PtCo@CoNC exhibits excellent electrocatalytic performance for oxygen reduction reaction （ORR） and hydrogen evolution reaction （HER） with mass activity of 1.21 A mgPt-1（at 0.9 V） and5.70 A mgPt-1（at an overpotential of 100 mV）,***,o-PtCo@CoNC delivers negligible loss of half-wave potential and overpotential during long-term stability test in acid solutions,with 13 mV decay after 50,000 potential cycles for ORR and a 2.7 mV decay after 20,000 potential cycles for *** integration strategy of single-atomic sites coupled IMCs paves the way for enhancing the activity and durability of Pt-based electrocatalysts.

关键词： Synergistic effect Intermetallics Single atomic sites Oxygen reduction reaction Hydrogen evolution reaction

极间柔性多孔物充填型活动掩膜电解加工微坑技术

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中国科学：技术科学 2016年第10期46卷 1005-1015页

作者：明平美周维海赵晨昊周红梅秦歌张新民河南理工大学机械与动力工程学院焦作454000

针对常规掩膜电解加工极难在非平面工件上高效制取表面织构的难题,在设计开发出进液、排液、导流等功能结构合为一体的特殊工具阴极的基础上,本文提出一种极间柔性多孔物充填型活动掩膜电解加工微坑技术,数值仿真并优化设计了极间流场,... 详细信息

针对常规掩膜电解加工极难在非平面工件上高效制取表面织构的难题,在设计开发出进液、排液、导流等功能结构合为一体的特殊工具阴极的基础上,本文提出一种极间柔性多孔物充填型活动掩膜电解加工微坑技术,数值仿真并优化设计了极间流场,试验分析了掩膜厚度、极间电压、压紧力、脉冲参数等核心工艺参数对微坑几何特征及其分布特性的影响.基于优选工艺条件,分别在不锈钢平面与圆柱面上加工出几何特征尺寸分布较均匀的微坑阵列.极间柔性多孔物充填型活动掩膜电解加工对平面与曲面工件均能展现出较强的表面织构制备能力和适应性.

关键词：掩膜电解加工微坑柔性多孔物表面织构活动掩膜

预应力轴心受拉钢构件抗火性能研究(Ⅲ):实用设计方法

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防灾减灾工程学报 2016年第3期36卷 350-356页

作者：周焕廷周晨昊张健李国强武汉理工大学土木工程与建筑学院湖北武汉430070 同济大学土木工程防灾国家重点实验室上海200092

为研究预应力轴心受拉钢构件的抗火性能,利用传热学原理对火灾下预应力轴心受拉钢构件的温度分布进行了理论分析,得出了任意爆火时刻预应力索温度的差分计算式。分析表明:火灾下拉索升温随拉索的等效直径增加而降低,随预应力钢管的温度... 详细信息

为研究预应力轴心受拉钢构件的抗火性能,利用传热学原理对火灾下预应力轴心受拉钢构件的温度分布进行了理论分析,得出了任意爆火时刻预应力索温度的差分计算式。分析表明:火灾下拉索升温随拉索的等效直径增加而降低,随预应力钢管的温度升高而升高。利用索温度的差分计算式以及抗火设计基本思路,推导出预应力轴心受拉钢构件临界温度的简化计算方法,并采用试验研究、有限元方法对计算方法进行了验证。该计算方法表明构件的临界温度随着约束刚度比的增加而升高,随着荷载比的增加而降低。

关键词：预应力轴心受拉钢构件抗火性能设计方法

结合多光束光学应力传感器与改进的Canny算法求曲率半径的方法研究

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电子测量与仪器学报 2022年第7期36卷 82-90页

作者：周陈昊凌晓杨连乔张建华上海大学材料科学与工程学院上海200072

利用多光束光学应力传感器(MOSS)求薄膜曲率需要测量出光束在反射前后的间距,根据相邻入射(折射)光束间距即可计算出薄膜的曲率半径。光束的间距可由接收到的光斑中心点确定。提取光斑的中心点主要利用Canny边缘检测算法和椭圆拟合算法... 详细信息

利用多光束光学应力传感器(MOSS)求薄膜曲率需要测量出光束在反射前后的间距,根据相邻入射(折射)光束间距即可计算出薄膜的曲率半径。光束的间距可由接收到的光斑中心点确定。提取光斑的中心点主要利用Canny边缘检测算法和椭圆拟合算法。用CMOS传感器得到的光斑阵列图像,在光斑周围参杂有很大的椒盐噪声,对于传统的Canny算法,无法准确的检测出光斑的边缘。利用一种改进的Canny边缘检测算法,可有效的消除光斑周围的噪声,并较好的保留光斑边缘。最后利用椭圆拟合算法对边缘进行拟合,求得光斑阵列的所有中心点。实验最后选用标准件进行验证,用测得的间距算出曲率半径与实际进行对比,误差结果在2%~4%,证明该方法可行。

关键词：光束间距薄膜曲率边缘检测椭圆拟合

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基于5阶B样条的避障泊车路径规划

厦门大学学报（自然科学版） 2024年第4期63卷 670-678页

作者：周辰昊刘中华吴新烨厦门大学建筑与土木工程学院福建厦门361005

[目的]为实现安全泊车,针对自动泊车路径规划方法中泊车环境存在障碍物的情况进行路径规划研究.[方法]提出基于5阶B样条曲线的双步式避障泊车路径规划方法,建立泊车环境避障及障碍物避障约束函数,以B样条路径曲线控制点为主要变量,以泊... 详细信息

[目的]为实现安全泊车,针对自动泊车路径规划方法中泊车环境存在障碍物的情况进行路径规划研究.[方法]提出基于5阶B样条曲线的双步式避障泊车路径规划方法,建立泊车环境避障及障碍物避障约束函数,以B样条路径曲线控制点为主要变量,以泊车完成时车辆在车位内且车身平行于车位为目标,建立含有多个非线性约束的泊车路径函数,并进行求解.[结果]数值仿真结果表明,基于5阶B样条曲线的避障泊车路径规划方法,可得到同时满足环境避障约束、障碍物避障约束及车辆参数约束的泊车轨迹曲线,能够实现当泊车环境存在障碍物时的路径规划.[结论]本文提出的5阶B样条曲线双步式避障泊车路径规划方法适用于平行泊车与垂直泊车,能够有效规划出一条可行的避障泊车路径,且保证行驶过程中车辆转向角速度连续,车辆与障碍物保持一定安全距离.该方法能够应用在较多泊车场景,具有较好的理论意义与工程价值.

关键词：自动泊车路径规划车辆避障 B样条曲线