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Mapk7 deletion in chondrocytes causes vertebral defects by reducing MEF2C/PTEN/AKT signaling

Genes & Diseases 2024年第2期11卷 964-977页

作者： chengzhi wu Hengyu Liu Dongmei Zhong Xiaoming Yang Zhiheng Liao Yuyu Chen Shun Zhang Deying Su Baolin Zhang Chuan Li Liru Tian Caixia Xu Peiqiang Su Guangdong Provincial Key Laboratory of Orthopedics and Traumatology Department of Spine SurgeryThe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510080China Research Center for Translational Medicine The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510080China Precision Medicine Institute The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510080China Department of Orthopedics Renmin Hospital of Wuhan UniversityWuhanHubei 430060China Guangdong Provincial Key Laboratory of Proteomics and State Key Laboratory of Organ Failure Research School of Basic Medical SciencesSouthern Medical UniversityGuangzhouGuangdong 510515China

Mutation of the MAPK7 gene was related to human scoliosis.Mapk7 regulated the development of limb bones and skulls in mice.However,the role of MAPK7 in vertebral development is still unclear.In this study,we constructed Col2a1-cre;Mapk7 f/f transgenic mouse model to delete Mapk7 in cartilage,which displayed kyphosis and osteopenia.Mechanistically,Mapk7 loss decreased MEF2C expression and thus activated PTEN to oppose PI3K/AKT signaling in vertebral growth plate chondrocytes,which impaired chondrocyte hypertrophy and attenuated vertebral ossification.In vivo,systemic pharmacological activation of AKT rescued impaired chondrocyte hypertrophy and alleviated mouse vertebral defects caused by Mapk7 deficiency.Our study firstly clarified the mechanism by which MAPK7 was involved in vertebral development,which might contribute to understanding the pathology of spinal deformity and provide a basis for the treatment of developmental disorders of the spine.

关键词： Chondrocyte hypertrophy Growth plate Kyphosis MAPK7 MEF2C Osteopenia PI3K/AKT PTEN

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A supplementary assessment system of AQI-V for comprehensive management and control of air quality in chemical industrial parks

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Journal of Environmental Sciences 2023年第8期130卷 114-125页

作者： Qiaoli Wang Dongping Sheng chengzhi wu Deji Jing Nana Cheng Xingnong Cai Sujing Li Jingkai Zhao Wei Li Jianmeng Chen College of Environment Zhejiang University of TechnologyHangzhou 310032China Key Laboratory of Biomass Chemical Engineering of the Ministry of Education Institute of Industrial Ecology and EnvironmentCollege of Chemical and Biological EngineeringZhejiang University(Yuquan Campus)Hangzhou 310027China Trinity Consultants Inc.(China office)Hangzhou 310012China Zhejiang Ocean University ZhoushanZhejiang Province 316022China

Volatile organic compounds(VOCs)are the dominant pollutants in industrial parks.However,they are not generally considered as part of the air quality index(AQI)system,which leads to a biased assessment of pollution in industrial parks.In this study,a supplementary assessment system of AQI-V was established by analyzing VOCs characteristics with vehicle-mounted PTR-TOFMS instrument,correlation analysis and the standards analysis.Three hourly and daily scenarios were considered,and the hierarchical parameter setting was further optimized by field application.The hourly and daily assessments revealed the evaluation factors for the discriminability of different air quality levels,practiced value for regional air quality improvement,and the reservation of general dominant pollutants.Finally,the universality testing in ZPIP successfully recognized most of the peaks,with 54.76%,38.39%and 6.85%for O_(3),VOCs and NO_(2) as the dominant pollutant,and reflected the daily ambient air quality condition,togetherwith the dominant pollutant.The AQI-V systemwith VOCs sub-index is essential for air quality evaluation in industrial parks,which can further provide scientific support to control the pollution of VOCs and the secondary pollutant,therefore significantly improve the air quality in local industrial parks.

关键词： Air quality index Industrial parks,VOCs sub-index AQI-V system Scenario analysis

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长白山天池火山晚更新世以来岩浆房系统的压力探讨

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岩石学报 2024年第7期40卷 2075-2086页

作者：周秉锐潘波颜丽丽徐丹武成智中国地震局地质研究所吉林长白山火山国家野外科学观测研究站北京100029 吉林省长白山天池火山监测站安图133613

长白山天池火山是一座大型的复合式活火山,由于其曾剧烈的喷发活动(946~947AD)和2002-2006年的扰动事件而备受瞩目。自晚更新世以来,天池火山有过多次剧烈的爆炸式喷发活动,其岩浆主要为高分异的碱流质与粗面质岩浆,SiO_(2)>65%。地球... 详细信息

长白山天池火山是一座大型的复合式活火山,由于其曾剧烈的喷发活动(946~947AD)和2002-2006年的扰动事件而备受瞩目。自晚更新世以来,天池火山有过多次剧烈的爆炸式喷发活动,其岩浆主要为高分异的碱流质与粗面质岩浆,SiO_(2)>65%。地球物理探测表明天池火山地下在浅部地壳存在岩浆房,但却未能对历史喷发活动的岩浆系统进行约束。本文利用晚更新世以来喷发物的电子探针数据,运用Qz-Ab-Or系统投图、单斜辉石机器学习压力计以及rhyolite-MELTS压力计对各期喷发的岩浆驻存压力条件进行计算,认为天文峰期(TWF)碱流岩压力约246~444MPa、气象站期(QXZ)碱流岩压力约184~344MPa、千年大喷发(ME-I)碱流岩压力约162~314MPa,千年大喷发(ME-II)粗面岩压力约438~540MPa。通过压力与深度换算后发现上述喷发岩浆贮存位置均对应中上地壳深度的岩浆房,并且三期碱流岩压力随喷发时间逐渐降低,暗示天池碱流质岩浆房在万年尺度内逐渐向浅部地壳演化的趋势;而粗面质岩浆可能来自另一个更深的岩浆房。该发现将有助于提高对天池火山岩浆房系统演化的认识,并为火山监测数据解释和灾害预警等工作提供依据。

关键词：长白山天池火山地质压力计高分异岩浆岩浆贮存压力岩浆演化岩浆房系统

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浅埋超近接上下重叠隧道开挖面合理间距研究

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铁道工程学报 2024年第3期41卷 73-79页

作者：徐前卫蒋承志叶颜伟吴祥松覃早张骏同济大学上海201804 中铁二局第五工程有限公司成都610091 嘉兴南湖学院嘉兴314001 沪杭城际铁路股份有限公司上海200040

研究目的:重庆鸡公咀上下层隧道近距离平行重叠,施工中存在相互扰动问题。针对上层隧道施工对下层隧道的扰动影响,本文采用数值模拟的方法研究上下层隧道开挖面合理间距,以降低近接隧道施工的相互影响,并达到缩短隧道施工总工期的目的... 详细信息

研究目的:重庆鸡公咀上下层隧道近距离平行重叠,施工中存在相互扰动问题。针对上层隧道施工对下层隧道的扰动影响,本文采用数值模拟的方法研究上下层隧道开挖面合理间距,以降低近接隧道施工的相互影响,并达到缩短隧道施工总工期的目的。研究结论:(1)沿隧道纵向平面内,在上下层隧道开挖面水平净距为0跨时,上层隧道对下层隧道扰动最大,为最不利净距;(2)当隧道开挖面的间距在50 m以上时,随着间距的增加,上层隧道对下层隧道的扰动有较为明显的减小;(3)当上下层隧道开挖面的间距在50 m以下时,随着间距的变化,上层隧道对下层隧道的扰动变化并不明显;(4)当上下层隧道开挖面的间距为125~150 m时,下层隧道的竖向位移值稳定在13 mm左右;(5)本研究成果可为今后类似工程的设计与施工提供参考。

关键词：隧道工程围岩扰动变形加固数值模拟

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Modeling the multi-level plumbing system of the Changbaishan caldera from geochemical, mineralogical, Sr-Nd isotopic and integrated geophysical data

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Geoscience Frontiers 2021年第5期12卷 17-36页

作者： Jian Yi Pujun Wang Xuanlong Shan Guido Ventura chengzhi wu Jiannan Guo Pencheng Liu Jiahui Li College of Earth Science Jilin UniversityJianshe Street 2199Changchun 130061China Key Laboratory for Evolution of Past Life and Environment in Northeast Asia(Jilin University) Ministry of EducationChangchun 130026China Istituto Nazionale di Geofisica e Vulcanologia Via di Vigna Murata605Roma 00143Italy Istituto per lo Studio degli impatti Antropici e Sostenibilitàin ambiente marino(IAS) Capo Granitola(TP)91021Italy Changbai Mountain Tianchi Volcano Observatory Chibei DistrictAntu 133613China

Changbaishan,an intraplate volcano,is characterized by an approximately 6 km wide summit caldera and last erupted in 1903.Changbaishan experienced a period of unrest between 2002 and 2006.The activity developed in three main stages,including shield volcano(basalts),cone-construction(trachyandesites to trachytes with minor basalts),and caldera-forming stages(trachytes to comendites).This last stage is associated with one of the more energetic eruptions of the last millennium on Earth,the 946 CE,VEI 7 Millennium Eruption(ME),which emitted over 100 km^(3) of pyroclastics.Compared to other active calderas,the plumbing system of Changbaishan and its evolution mechanisms remain poorly constrained.Here,we merge new whole-rock,glass,mineral,isotopic,and geobarometry data with geophysical data and present a model of the plumbing system.The results show that the volcano is characterized by at least three main magma reservoirs at different depths:a basaltic reservoir at the Moho/lower crust depth,an intermediate reservoir at 10-15 km depth,and a shallower reservoir at 0.5-3 km depth.The shallower reservoir was involved in the ME eruption,which was triggered by a fresh trachytic melt entering a shallower reservoir where a comenditic magma was stored.The trachytes and comendites originate from fractional crystallization processes and minor assimilation of upper crust material,while the less evolved melts assimilate lower crust material.Syn-eruptive magma mingling occurred during the ME eruption phase.The magma reservoirs of the caldera-forming stage partly reactivate those of the cone-construction stage.The depth of the magma storage zones is controlled by the layering of the crust.The plumbing system of Changbaishan is vertically extensive,with crystal mush reservoirs renewed by the replenishment of new trachytic to trachyandesitic magma from depth.Unlike other volcanoes,evidence of a basaltic recharge is lacking.The interpretation of the signals preceding possible future eruptions should consider the multi-level nature of t

关键词： Changbaishan volcano Caldera Plumbing system Triggering mechanism Storage depth

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跨学科知识发现及其生长路径挖掘研究——基于国家自然科学基金的跨学科申请视角

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科技情报研究 2024年第2期6卷 58-71页

作者：吴小兰章成志南京师范大学新闻与传播学院网络与新媒体系南京210024 南京师范大学融媒传播与舆情治理研究中心南京210024 南京理工大学经济管理学院信息管理系南京210094

[目的/意义]在国家自然科学基金项目申请中,同一个学者在不同时间使用不同学科基金代码,这在一定程度上促进了跨学科知识的融合与生长。为此,文章基于国家自然科学基金跨学科申请视角,挖掘跨学科知识及其融合生长路径。[方法/过程]首先... 详细信息

[目的/意义]在国家自然科学基金项目申请中,同一个学者在不同时间使用不同学科基金代码,这在一定程度上促进了跨学科知识的融合与生长。为此,文章基于国家自然科学基金跨学科申请视角,挖掘跨学科知识及其融合生长路径。[方法/过程]首先,结合自然科学基金学科申请代码的层级结构,改进并优化了跨学科性测度指标,识别最具有跨学科性的跨学科知识。随后,构建跨学科知识与一级学科的二类型异质网络,并基于RankClus实现了跨学科知识社区发现与生长路径挖掘。[结果/结论]研究发现,存在显著的12个跨学科知识主题与6个明显的知识生长路径,其知识生长路径分别是生命科学部-医学科学部(C-H)、化学科学部-工程与材料科学部(B-E)、生命科学部—地理科学部(C-D)、数理科学部—信息科学部—管理科学部(A-FG)、数理科学部—地理科学部—工程与材料科学部(A-D-E)、化学科学部—管理科学部(B-G)。

关键词：跨学科知识国家自然科学基金知识生长路径跨学科测度指标

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Kernel broken smooth particle hydrodynamics method for crack propagation simulation applied in layered rock cells and tunnels

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Underground Space 2023年第3期10卷 55-75页

作者： chengzhi Xia Zhenming Shi Hongchao Zheng Xiaohan wu School of Civil Engineering Tongji UniversityShanghai 200092China College of Environmental Science and Engineering Tongji UniversityShanghai 200092China

Understanding the cracking process of layered tunnels requires a high-fidelity method.Improved smooth particle hydrodynamics(SPH),termed kernel broken SPH(KBSPH),was implemented to simulate the crack propagation and deformation of layered rock cells and field layered tunnels with dip angles of 0°–90°,and the results were compared with those of the laboratory tests.Three attempts,including the bedding angle,interlayer distance,and lateral pressure coefficient,were made to investigate the crack propagation and deformation of layered tunnels.Finally,the pros and cons of the KBSPH method applied in the rock field were compared with those of other methods.The results indicate that the KBSPH can explicitly reproduce crack propagation by improving the kernel function with a totally damaged symbol,and the deformation responses have been captured reasonably.We infer that this method is effective and rapid in crack propagation and large deformation simulation for other types of rock tunnels.

关键词： Smooth particle hydrodynamics Kernel broken Layered rock tunnel Crack propagation

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基于流域系统模拟一情景优化的精细治理决策支持方法

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地理学报 2024年第1期79卷 58-75页

作者：秦承志朱良君申申吴彤肖桂荣吴升陈芸芝汪小钦冯险峰朱阿兴陆锋中国科学院地理科学与资源研究所资源与环境信息系统国家重点实验室北京100101 中国科学院大学资源与环境学院北京100049 数字中国研究院(福建) 福州350108 福州大学空间数据挖掘与信息共享教育部重点实验室福州350108 南京师范大学地理科学学院南京210023 威斯康星大学麦迪逊分校地理系美国麦迪逊WI 53706

面向美丽中国生态文明建设所需,亟待有效实现流域精细治理的科学决策,以根据流域综合治理愿景目标,优化流域管理措施(BMP)的空间布局方案(即BMP情景)、制定符合实际需求的实施路线图。对此,“流域系统模拟—情景优化”方法框架近年展现... 详细信息

面向美丽中国生态文明建设所需,亟待有效实现流域精细治理的科学决策,以根据流域综合治理愿景目标,优化流域管理措施(BMP)的空间布局方案(即BMP情景)、制定符合实际需求的实施路线图。对此,“流域系统模拟—情景优化”方法框架近年展现出广阔应用前景。本文介绍了该框架在应对实际应用需求中尚存的一系列问题,开展了体系性的方法研究:①提出新的流域过程建模框架,以兼顾建模灵活性和高性能计算、高效实现流域系统模拟;②提出以坡位单元作为BMP空间配置单元、并在情景优化过程中可进行单元边界动态调整的BMP情景优化方法,可有效考虑流域综合治理的经验知识,保障优化结果合理性;③提出考虑分阶段投资约束的BMP情景实施次序优化方法,可推荐出符合实际落地需求的实施路线图;④设计研发用户友好的参与式流域规划系统,供各方利益相关者协商决策。通过典型小流域应用案例验证了上述新方法、工具和原型系统的有效性和实用价值。

关键词：流域系统模拟流域管理措施情景分析智能优化决策支持

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Demulsification performance and mechanism of oil droplets by electrocoagulation: Role of surfactant

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Journal of Environmental Sciences 2022年第8期34卷 171-180页

作者： Liang Wang Ben Zhang Bin Zhao Saiguo Yang Kun wu Jingqiu Sun chengzhi Hu State Key Laboratory of Separation Membranes and Membrane Processes School of Environmental Science and EngineeringTiangong UniversityTianjin 300387China State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China School of Environmental and Municipal Engineering Xi’an University of Architecture and TechnologyXi’an 710055China Jiangsu Collaborative Innovation Center of Technology and Material of Water Treatment Suzhou University of Science and TechnologySuzhou 215009China

Surfactants are widely used to improve the solubility of oil in water in petrochemical,making it more difficult to remove oil–water emulsions during the water treatment process.Electrocoagulation(EC) is an appropriate method for treating oily wastewater and destabilizing emulsions. However, the demulsification mechanism of oil–water droplets emulsified by surfactants with different charges have not been investigated systematically. The demulsification performance of electrocoagulation on emulsions wastewater containing cationic,non-ionic, and anionic surfactants was studied. The results showed that the removal rate of total organic carbon(TOC) in oily wastewater with anionic surfactant by EC reached92.98% ± 0.40% at a current density of 1 mA/cm^(2), while that of the non-ionic surfactant was 84.88% ± 0.63%. The characterization of flocs showed that EC has the highest coagulation and demulsification of oil droplets with a negative charge on the surface(-70.50 ± 10.25mV), which indicated that the charge neutralization of oil droplets was beneficial for the destabilization of the formed oily flocs. However, when the zeta potential of the oil droplets reached 75.50 ± 1.25 mV, the TOC removal efficiency was only 11.80% ± 1.43%. The TOC removal could achieve 33.23% ± 3.21% when the current density improved from 1 mA/cm^(2)to 10 mA/cm^(2). The enhanced removal was due to the sweep coagulation rather than charge neutralization. This study provides a fundamental basis for the electrochemical treatment of oily wastewater.

关键词： Charge neutralization Electrostatic repulsion Flotation Surfactant

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基于CNN-Swin Transformer Network的LPI雷达信号识别

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现代雷达 2024年第3期46卷 59-65页

作者：苏琮智杨承志邴雨晨吴宏超邓力洪空军航空大学航空作战勤务学院吉林长春130022 解放军94891部队江苏苏州215159

针对在低信噪比(SNR)条件下,低截获概率雷达信号调制方式识别准确率低的问题,提出一种基于Transformer和卷积神经网络(CNN)的雷达信号识别方法。首先,引入Swin Transformer模型并在模型前端设计CNN特征提取层构建了CNN+Swin Transforme... 详细信息

针对在低信噪比(SNR)条件下,低截获概率雷达信号调制方式识别准确率低的问题,提出一种基于Transformer和卷积神经网络(CNN)的雷达信号识别方法。首先,引入Swin Transformer模型并在模型前端设计CNN特征提取层构建了CNN+Swin Transformer网络(CSTN),然后利用时频分析获取雷达信号的时频特征,对图像进行预处理后输入CSTN模型进行训练,由网络的底部到顶部不断提取图像更丰富的语义信息,最后通过Softmax分类器对六类不同调制方式信号进行分类识别。仿真实验表明:在SNR为-18 dB时,该方法对六类典型雷达信号的平均识别率达到了94.26%,证明了所提方法的可行性。

关键词：低截获概率雷达信号调制方式识别 Swin Transformer网络卷积神经网络时频分析

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