检索结果-南通市图书馆

Molecular Plant 2024年第2期17卷 215-218页

作者： Wanchao Zhu Rui Han Xiaoyang Shang Tao Zhou chengyong liang Xiaomeng Qin Hong Chen Zaiwen Feng Hongwei Zhang Xingming Fan Weifu Li Lin Li National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070China Key Laboratory of Biology and Genetic Improvement of Maize in Arid Area of Northwest Region College of AgronomyNorthwest A&F UniversityYanglingShaanxi712100China College of Informatics Huazhong Agricultural UniversityWuhan 430070China State Key Laboratory of Crop Gene Resources and Breeding Institute of Crop ScienceChinese Academy of Agricultural SciencesBeijing 100081China institute of Food Crops Sciences Yunnan Academy of Agricultural Sciences2238 Beijing RoadKunmingYunnan 650200China Hubei Hongshan Laboratory Wuhan 430070China Shenzhen Institute of Nutrition and Health Huazhong Agricultural UniversityWuhan 430070China Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China

Since the beginning of humanity,people have been seeking practical solutions to meet their most basic need:*** advent of agriculture greatly increased the food supply and led to a rapid increase in the human *** food production via agriculture can be attributed to both improved crop management practices and crop breeding through ***(crop)breeding has been categorized into four major stages based on the techniques employed(Wallace et al.,2018).

关键词： breeding seeking Wallace

浅谈广州国际会议展览中心工程+16m楼面的钢筋安装施工

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

房材与应用 2005年第3期33卷 17-18页

作者：梁成勇广州市建筑集团有限公司广东广州510030

在大型工程和超大型工程施工中,钢筋安装特别是大跨度高层楼面的钢筋安装是关键工程。施工准备时期应熟悉设计图纸,掌握施工重点、难点,结合现场环境,做好施工前的钢筋抽料、制作、运输及安装等工作。特别要注重钢筋安装,熟悉各工艺,保... 详细信息

在大型工程和超大型工程施工中,钢筋安装特别是大跨度高层楼面的钢筋安装是关键工程。施工准备时期应熟悉设计图纸,掌握施工重点、难点,结合现场环境,做好施工前的钢筋抽料、制作、运输及安装等工作。特别要注重钢筋安装,熟悉各工艺,保证抓好工程进度和质量。。

关键词：钢筋安装直螺纹连接后浇带

Rational design and crystallographic analysis of novel isoform-selective TRKA inhibitors for cancer therapy

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2023年第1期13卷 440-443页

作者： Guan Wang Yongya Wu chengyong Wu Wen Shuai Tingting Jiang Aoxue Wang Faqian Bu Qiu Sun liang Ouyang State Key Laboratory of Biotherapy and Cancer Center Innovation Center of Nursing Research Nursing Key Laboratory of Sichuan ProvinceNational Clinical Research Center for GeriatricsWest China Hospitaland Collaborative Innovation Center of BiotherapySichuan UniversityChengdu 610041China

To the Editor:Tropomyosin receptor kinase A/B/C(TRKA/B/C)are encoded by neurotrophic tyrosine receptor kinase 1/2/3(NTRK1/2/3),*** gene fusions are the most common drivers of ***,TRKA is the most common oncogene in TR... 详细信息

关键词： Cancer therapy Co-crystal structure Drugdiscovery Selective inhibitor TRKA

Two alkynyl functionalized Co（Ⅱ）-MOFs as fluorescent sensors exhibiting selectivity and sensitivity for Fe3+ and nitroaromatic compounds

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2019年第7期30卷 1440-1444页

作者： Yue Li Xia Wang chengyong Xing Xiurong Zhang Zelong liang Xiaokang Wang Kai Zhang Yutong Wang Di Liu Weidong Fan Fangna Dai School of Materials Science and Engineering College of Science China University of Petroleum(East China) Qingdao 266580 China College of Chemical Engineering China University of Petroleum(East China) Qingdao 266580 China College of Chemical and Environmental Engineering Shandong University of Science and Technology Qingdao 266590 China

Two Co(II)-MOFs with different structures were successfully synthesized under the premise of designing two ligands containing alkynyl functional groups. Complexes 1 ([Co(TEPA)(TPT)2/3]·2DMF·H2O) and 2 ([Co(EPA)(TPT)]·1.5DMF·1.5H2O) show excellent luminescence properties. Meanwhile, as fluorescent sensors, complexes 1 and 2 exhibit selectivity and sensitivity for Fe3+ with the Ksv of 1.520 ×104 L/mol and 3.543 ×104 L/mol, which can rapidly detect nitroaromatic compounds in methanol and ethanol, especially for 2,4-NPH through fluorescence quenching with high quenching efficiency. In particular, the Ksv value of complexes 1 and 2 towards 2,4-NPH can reach up to 1.627 ×105 L/mol and 9.600 ×104 L/mol, demonstrating that complexes 1 and 2 are good candidates for the identification and detection of Fe3+and nitroaromatic compounds.

关键词： Metal-organic frameworks Alkynyl functionalized Fluorescence sensor Fe3+ ion Nitroaromatic compounds

DCLK1 autoinhibition and activation in tumorigenesis

在线全文

学校读者我要写书评

暂无评论

The Innovation 2022年第1期3卷 46-53页

作者： Linna Cheng Zejing Yang Wenhao Guo chengyong Wu Shufang liang Aiping Tong Zhongwei Cao Rick F.Thorne Sheng-Yong Yang Yamei Yu Qiang Chen State Key Laboratory of Biotherapy and Cancer Center West China HospitalSichuan Universityand Collaborative Innovation Center of BiotherapyChengdu 610041China Institute of Hematology Henan Key Laboratory of Stem Cell Differentiation and ModificationHenan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityPeople’s Hospital of Henan UniversityZhengzhou 450003China Department of Abdominal Oncology Cancer Center and State Key Laboratory of BiotherapyWest China HospitalWest China Medical SchoolSichuan UniversityChengdu 610041China Translational Research Institute Henan Provincial People’s HospitalAcademy of Medical ScienceZhengzhou UniversityZhengzhou 450003China

Doublecortin-like kinase 1(DCLK1)is upregulated in many tumors and is a marker for tumor stem *** evidence suggests DCLK1 constitutes a promising drug target for cancer ***,the regulation of DCLK1 kinase activity is poorly understood,particularly the function of its autoinhibitory domain(AID),and,moreover,no physiological activators of DCLK1 have presently been *** we determined the first DCLK1 kinase structure in the autoinhibited state and identified the neuronal calcium sensor HPCAL1 as an activator of *** C-terminal AID functions to block the ATP-binding site and is competitive with ***1 binds directly to the AID in a Ca^(2+)-dependent manner,which releases the *** also analyzed cancer-associated mutations occurring in the AID and elucidate how these mutations disrupt DCLK1 autoinhibition to elicit kinase activity *** results present a molecular mechanism for autoinhibition and activation of DCLK1 kinase activity and provide insights into DCLK1-associated tumorigenesis.

关键词： inhibited tumorigenesis DCL

The R2R3-MYB transcription factor GhMYB1a regulates flavonol and anthocyanin accumulation in Gerbera hybrida

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Horticulture Research 2020年第1期7卷 1783-1795页

作者： Chunmei Zhong Yi Tang Bin Pang Xukun Li Yuping Yang Jing Deng chengyong Feng Lingfei Li Guiping Ren Yaqin Wang Jianzong Peng Shulan Sun Shan liang Xiaojing Wang College of Forestry and Landscape Architecture Key Laboratory of Energy Plants Resource and UtilizationMinistry of AgricultureP.R.ChinaSouth China Agricultural UniversityGuangzhou 510642China Guangdong Provincial Key Laboratory of Biotechnology for Plant Development School of Life SciencesSouth China Normal UniversityGuangzhou 510631China Key Laboratory of Plant Resources and Beijing Botanical Garden Institute of BotanyChinese Academy of SciencesBeijing 100093China Key Laboratory of Southern Subtropical Plant Diversity Fairy Lake Botanical GardenShenzhen&Chinese Academy of SciencesShenzhenGuangdong 518004China

Anthocyanins and flavonols have vital roles in flower coloration,plant development,and *** anthocyanins and flavonols share the same subcellular localization and common biosynthetic substrates,these pathways may compete for ***,the mechanism regulating this potential competition remains ***,we identified GhMYB1a,an R2R3-MYB transcription factor involved in the regulation of anthocyanin and flavonol accumulation in gerbera(Gerbera hybrida).GhMYB1a shares high sequence similarity with that of other characterized regulators of flavonol *** addition,GhMYB1a is also phylogenetically grouped with these *** overexpression of GhMYB1a in gerbera and tobacco(Nicotiana tabacum)resulted in decreased anthocyanin accumulation and increased accumulation of flavonols by upregulating the structural genes involved in flavonol *** further found that GhMYB1a functions as a homodimer instead of interacting with basic helix-loop-helix *** results suggest that GhMYB1a is involved in regulating the anthocyanin and flavonol metabolic pathways through precise regulation of gene *** functional characterization of GhMYB1a provides insight into the biosynthesis and regulation of flavonols and anthocyanins.

关键词： precise similarity insight

Immobilization of metal-organic molecular cage on g-C3N4 semiconductor for enhancement of photocatalytic H2 generation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Catalysis 2019年第8期40卷 1198-1204页

作者： Yuanpu Wang liang Liu DongJun Wu Jing Guo Jianying Shi Junmin Liu chengyong Su MOE Laboratory of Bioinorganic and Synthetic Chemistry Lehn Institute of Functional MaterialsSchool of Chemistryand School of Materials Science and EngineeringSun Yat-sen UniversityGuangzhou 510275GuangdongChina State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

A new compound based on immobilizing of Pd6(RuL3)8(BF4)28 (L=2-(pyridin-3-yl)-1H-imidazo [4,5-f][1,10]-phenanthroline) cage (MOC-16) on g-C3N4 was synthesized. Infrared spectrum and powder X-ray diffraction were used to characterize structure of hybrid MOC-16/g-C3N4, as well as UV-vis absorption spectrum and X-ray photoelectron spectroscopy were carried out to unveil photocatalytic mechanism. With the introduction of MOC-16, the absorption edge of MOC-16/g-C3N4 in UV-vis spectrum extended apparently to long-wavelength region compared with pristine g-C3N4. H2 evolution yielded with MOC-16/g-C3N4 in aqueous solution containing TEOA was much higher than that with RuL3/g-C3N4, Pd/RuL3/g-C3N4 and mixture of MOC-16 and g-C3N4, showing that the octahedral cage structure with high-efficient electron transfer and the interface interaction between MOC-16 and g-C3N4 were significant for improvement of H2 evolution.

关键词： g-C3N4 Metal-organic cage Photocatalytic H2 evolution Visible light Stability

双转台五轴机床旋转轴位置无关几何误差的辨识

在线全文

学校读者我要写书评

暂无评论

中国机械工程 2023年第21期34卷 2585-2591页

作者：梁小冰卢耀安王成勇广东工业大学机电工程学院广州510006 广东工业大学广东省微创手术器械设计与精密制造重点实验室广州510006 高性能工具全国重点实验室广州510006

旋转轴的位置无关几何误差(PIGEs)是影响五轴机床加工精度的重要因素。以AC双转台五轴机床为研究对象,提出一种基于差分演化算法的旋转轴PIGEs辨识方法。首先,建立机床旋转轴PIGEs和球杆仪杆长变化的关系模型,使用已有的辨识方法获得机... 详细信息

旋转轴的位置无关几何误差(PIGEs)是影响五轴机床加工精度的重要因素。以AC双转台五轴机床为研究对象,提出一种基于差分演化算法的旋转轴PIGEs辨识方法。首先,建立机床旋转轴PIGEs和球杆仪杆长变化的关系模型,使用已有的辨识方法获得机床旋转轴PIGEs初始解,然后定义优化目标函数,通过差分演化算法整体优化求解旋转轴PIGEs,提高旋转轴PIGEs辨识准确性。实验与仿真的结果表明提出的旋转轴PIGEs辨识方法可有效提高辨识准确性。

关键词：位置无关几何误差旋转轴误差辨识五轴机床球杆仪

Disruption of PABPN1 phase separation by SNRPD2 drives colorectal cancer cell proliferation and migration through promoting alternative polyadenylation of CTNNBIP1

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第6期67卷 1212-1225页

作者： Zhijie Hu Mengxia Li Yufeng Chen Liutao Chen Yuting Han chengyong Chen Xin Lu Nan You Yawen Lou Yingye Huang Zhanfeng Huo Chao Liu Cheng liang Susu Liu Ke Deng liangfu Chen Shangwu Chen Guohui Wan Xiaojian Wu Yonggui Fu Anlong Xu State Key Laboratory of Biocontrol Guangdong Province Key Laboratory of Pharmaceutical Functional GenesDepartment of BiochemistrySchool of Life SciencesSun Yat-sen UniversityGuangzhou 510275China Department of General Surgery(Colorectal Surgery)&Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases&Biomedical Innovation Center The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655China National-Local Joint Engineering Laboratory of Druggability and New Drug Evaluation National Engineering Research Center for New Drug and Druggability(cultivation)Guangdong Province Key Laboratory of New Drug Design and EvaluationSchool of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhou 510006China School of Life Sciences Beijing University of Chinese MedicineBeijing 100029China

Generally shortened 3′UTR due to alternative polyadenylation(APA)is widely observed in cancer,but its regulation mechanisms for cancer are not well ***,with profiling of APA in colorectal cancer tissues and poly(A)signal editing,we firstly identified that the shortened 3′UTR of CTNNIBP1 in colorectal cancer promotes cell proliferation and *** found that liquid-liquid phase separation(LLPS)of PABPN1 is reduced albeit with higher expression in cancer,and the reduction of LLPS leads to the shortened 3′UTR of CTNNBIP1and promotes cell proliferation and ***,the splicing factor SNRPD2 upregulated in colorectal cancer,can interact with glutamic-proline(EP)domain of PABPN1,and then disrupt LLPS of PABPN1,which attenuates the repression effect of PABPN1 on the proximal poly(A)*** results firstly reveal a new regulation mechanism of APA by disruption of LLPS of PABPN1,suggesting that regulation of APA by interfering LLPS of 3′end processing factor may have the potential as a new way for the treatment of cancer.

关键词： alternative polyadenylation colorectal cancer CTNNBIP1 PABPN1 liquid-liquid phase separation SNRPD2

在线全文

学校读者我要写书评

暂无评论

VSC-HVDC系统控制体系框架

电工技术学报 2009年第5期24卷 141-147页

作者：梁海峰李庚银王松赵成勇华北电力大学电力系统保护与动态安全监控教育部重点实验室北京102206

控制系统是VSC-HVDC系统的核心之一。目前虽已有许多研究者在该领域做了大量的工作,但多数成果集中在VSC-HVDC控制器的设计和控制方法的研究上,对整个VSC-HVDC系统控制体系框架的研究并不多见。本文在介绍VSC-HVDC系统结构的基础上,阐述... 详细信息

控制系统是VSC-HVDC系统的核心之一。目前虽已有许多研究者在该领域做了大量的工作,但多数成果集中在VSC-HVDC控制器的设计和控制方法的研究上,对整个VSC-HVDC系统控制体系框架的研究并不多见。本文在介绍VSC-HVDC系统结构的基础上,阐述了VSC-HVDC控制系统的基本功能,指出采用多重化配置和分层控制结构设计的必要性,具体提出建立四层结构的VSC-HVDC系统控制体系框架的观点,即直流系统控制层、换流器控制层、阀组控制层和独立控制层。文章在讲述各层配置原则的基础上,详细阐述了每个控制层次的控制功能和范围以及各层次之间的相互关系,并进一步介绍了控制系统和保护功能的协调配合问题,为VSC-HVDC控制系统的开发奠定了基础。

关键词： VSC-HVDC 电压源换流器(VSC) 直流输电(HVDC) 控制体系