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Mepanipyrim induces visual developmental toxicity and vision-guided behavioral alteration in zebrafish larvae

Journal of Environmental Sciences 2023年第2期124卷 76-88页

作者： Chao Shen Yimei Cai Jialing Li Chengyong He Zhenghong Zuo State Key Laboratory of Cellular Stress Biology School of Life SciencesXiamen UniversityXiamen 361005China State Key Laboratory of Marine Environmental Science Xiamen UniversityXiamen 361005China

Mepanipyrim,an anilinopyrimidine fungicide,has been extensively used to prevent fungal diseases in fruit culture.Currently,research on mepanipyrim-induced toxicity in organisms is still very scarce,especially visual developmental toxicity.here,zebrafish larvae were employed to investigate mepanipyrim-induced visual developmental toxicity.Intense light andmonochromatic light stimuli-evoked escape experiments were used to investigate vision-guided behaviors.Meanwhile,transcriptomic sequencing and real-time quantitative PCR assays were applied to assess the potential mechanisms of mepanipyrim-induced visual developmental toxicity and vision-guided behavioral alteration.Our results showed that mepanipyrim exposure could induce retinal impairment and vision-guided behavioral alteration in larval zebrafish.In addition,the grk1b gene of the phototransduction signaling pathway was found to be a potential aryl hydrocarbon receptor(AhR)-regulated gene.Mepanipyrim-induced visual developmental toxicity was potentially related to the AhR signaling pathway.Furthermore,mepanipyrim-induced behavioral alteration was guided by the visual function,and the effects of mepanipyrim on long and middle wavelength light-sensitive opsins may be the main cause of vision-guided behavioral alteration.Our results provide insights into understanding the relationship between visual development and vision-guided behaviors induced by mepanipyrim exposure.

关键词： Danio rerio mepanipyrim visual developmental toxicity vision-guided behaviors phototransduction signaling pathway grk1b

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Mepanipyrim induces cardiotoxicity of zebrafish(Danio rerio) larvae via promoting AhR-regulated COX expression pathway

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Journal of Environmental Sciences 2023年第3期125卷 650-661页

作者： Chao Shen Jing he Kongyang Zhu Naying Zheng Yue Yu Chengyong He Chunyan Yang Zhenghong Zuo State Key Laboratory of Cellular Stress Biology School of Life SciencesXiamen UniversityXiamen 361005China State Key Laboratory of Marine Environmental Science Xiamen UniversityXiamen 361005China

The wide use of pesticides has seriously threatened human health and the survival of beneficial organisms. The fungicide mepanipyrim is widely used in viticulture practices. Studies of mepanipyrim-induced toxicity in organisms are still scarce, especially studies on cardiotoxicity. In this study, we aimed to investigate mepanipyrim-induced cardiotoxicity in zebrafish(Danio rerio) larvae. We found that mepanipyrim could induce cardiotoxicity by altering the heart rate and cardiomyocyte diameter of larvae. Meanwhile, RNA sequencing and RT-qPCR data indicated that mepanipyrim exposure could dramatically alter the m RNA expression of calcium signaling pathway-, cardiac muscle contraction-, and oxidative respiratory chain-related genes. Interestingly, by the CALUX cell bioassay, we found that most cytochrome c oxidase(COX) family genes exhibited potential AhR-regulated activity, suggesting that mepanipyrim induced cardiotoxicity via a novel AhR-regulated manner in larvae.Additionally, the AhR antagonist CH_(2)23191 could effectively prevent mepanipyrim-induced cardiotoxicity in zebrafish larvae. In conclusion, the AhR agonist mepanipyrim could induce cardiotoxicity in a novel unreported AhR-regulated manner, which could specifically affect the expression of COX family genes involved in the mitochondrial oxidative respiratory chain. Our data will help explain the toxic effects of mepanipyrim on organisms and provide new insight into the AhR agonistic activity pesticide-induced cardiotoxicity.

关键词： Zebrafish(Danio rerio) Mepanipyrim AhR agonist Cardiotoxicity CH_(2)23191 Cytochrome coxidase

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Comparison of developmental toxicity of different surface modified CdSe/ZnS QDs in zebrafish embryos

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Journal of Environmental Sciences 2021年第2期33卷 240-249页

作者： Naying Zheng Jinhui Yan Wang Qian Chao Song Zhenghong Zuo Chengyong He State Key Laboratory of Cellular Stress Biology School of Life SciencesXiamen UniversityXiamen 361005China Freshwater Fisheries Research Center Chinese Academy of Fishery SciencesWixi 214081China

Quantum dots(QDs)are new types of nanomaterials.Few studies have focused on the effect of different surface modified QDs on embryonic development.herein,we compared the in vivo toxicity of Cd Se/Zn S QDs with carboxyl(-COOH)and amino(-NH 2)modification using zebrafish embryos.After exposure,the two Cd Se/Zn S QDs decreased the survival rate,hatching rate,and embryo movement of zebrafish.Moreover,we found QDs attached to the embryo membrane before hatching and the eyes,yolk and heart after hatching.The attached amount of carboxyl QDs was more.Consistently,the Cd content in embryos and larvae was higher in carboxyl QD-treatment.We further observed that the two QDs caused zebrafish pericardial edema and cardiac dysfunction.In line with it,both carboxyl and amino QDs upregulated the transcription levels of cardiac development-related genes,and the levels were higher in carboxyl QD-treated groups.Furthermore,the chelator of Cd^2+diethylene triamine pentacetate acid could partially rescued the developmental toxicity caused by the two types of QDs suggesting that both the nature of QDs and the release of Cd^2+contribute to the developmental toxicity.In conclusion,the two Cd Se/ZnS QDs have developmental toxicity and affect the cardiac development,and the carboxyl QDs is more toxic possibly due to the higher affinity and more release to embryos and larvae.Our study provides new knowledge that the surface functional modification of QDs is critical on the development on aquatic species,which is beneficial to develop and applicate QDs more safely and environmentfriendly.

关键词： Quantum dots Surface modification Fish Cardiac development Developmental toxicity

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Emerging paradigms in exploring the interactions among diet,probiotics,and cancer immunotherapeutic response

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The Innovation 2023年第4期4卷 11-12页

作者： Shi Huang Chengyong He Jiufeng Li Yi-Zhou Gao Zuoyun Wang Yongjun Wei Faculty of Dentistry The University of Hong KongHong Kong SARChina State Key Laboratory of Cellular Stress Biology School of Life SciencesFaculty of Medicine and Life SciencesXiamen UniversityXiamen 361102China Department of Environment health School of Public HealthFudan UniversityShanghai 200032China The Center for Microbes Development and HealthKey Laboratory of Molecular Virology and ImmunologyChinese Academy of SciencesShanghai 200031China Department of Human Anatomy and Histoembryology School of Basic Medical Sciences and Shanghai Xuhui Central HospitalFudan UniversityShanghai 200031China School of Pharmaceutical Sciences Laboratory of Synthetic BiologyFood Laboratory of ZhongyuanZhengzhou UniversityZhengzhou 450001China

In the new issue of Cell,Dr.Meisel’s teamcharacterized how the orally administrated probiotic bacteria Lactobacillus reuteri(Lr)translocated from the gut to tumors in mice with melanoma.1 Furthermore,its production of a compound called indole-3-aldehyde(I3A)derived fromdietary tryptophan directly stimulates immune cells to make cancer immunotherapy more effective(Figure 1A).

关键词： cancer melanoma therapeutic

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Safety profile of two-dimensional Pd nanosheets for photothermal therapy and photoacoustic imaging

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Nano Research 2017年第4期10卷 1234-1248页

作者： Mei Chen Shuzhen Chen Chengyong He Shiguang Mo Xiaoyong Wang Gang Liu Nanfeng Zheng State Key Laboratory for Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materials and Engineering Research Center for Nano-Preparation Technology of Fujian Province College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University Xiamen 361005 China Department of Microbiology and Immunology Xiamen Medical College Xiamen 361008 China

Two-dimensional （2D） nanosheets have emerged as an important class of nanomaterial with great potential in the field of biomedicines, particularly in cancer theranostics. However, owing to the lack of effective methods that synthesize uniform 2D nanomaterials with controlled size, systematic evaluation of size-dependent bio-behaviors of 2D nanomaterials is rarely reported. To the best of our knowledge, we are the first to report a systematic evaluation of the influence of size of 2D nanomaterials on their bio-behaviors. 2D Pd nanosheets with diameters ranging from 5 to 80 nm were synthesized and tested in cell and animal models to assess their size-dependent bioapplication, biodistribution, elimination, toxicity, and genomic gene expression profiles. Our results showed size significantly influences the biological behaviors of Pd nanosheets, including their photothermal and photoacoustic effects, pharmacokinetics, and toxicity. Compared to larger-sized Pd nanosheets, smaller-sized Pd nanosheets exhibited more advanced photoacoustic imaging and photothermal effects upon ultralow laser irradiation. Moreover, in vivo results indicated that 5-nm Pd nanosheets escape from the reticuloendothelial system with a longer blood half-life and can be cleared by renal excretion, while Pd nanosheets with larger sizes mainly accumulate in the liver and spleen. The 30-nm Pd nanosheets exhibited the highest tumor accumulation. Although Pd nanosheets did not cause any appreciable toxicity at the cellular level, we observed slight lipid accumulation in the liver and inflammation in the spleen. Genomic gene expression analysis showed that 80-nm Pd nanosheets interacted with more cellular components and affected more biological processes in the liver, as compared to 5-nm Pd nanosheets. We believe this work will provide valuable information and insights into the clinical application of 2D Pd nanosheets as nanomedicines.

关键词： Pd nanosheets photothermal therapy photoacoustic imaging toxicity evaluation genomic gene expression

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Incidence,genomic diversity,and evolution of strawberry mottle virus in China

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BIOCELL 2021年第4期45卷 1137-1151页

作者： LINGJIAO FAN Chengyong He MENGMENG WU DEHANG GAO ZheNFEI DONG SheNGFAN HOU ZEKUN FENG HONGQING WANG College of Horticulture China Agricultural UniversityBeijing100193China

Strawberry mottle virus(SMoV)is one of the most common viruses infecting strawberries,causing losses to fruit yield and quality.In this study,165 strawberry leaf samples were collected from six provinces of China,46 of which tested positive for SMoV.The complete genome sequences of 11 SMoV isolates were obtained from Liaoning(DGHY3,DGHY16-2,DGHY17,DGHY20-2,DGHY21,DGHY26-2),Shandong(SDHY1,SDHY5,SDHY31-2,SDHY33-2),and Beijing(BJMX7).The RNA1 and RNA2 nucleotide identities between the 11 Chinese isolates were 95.4-99.3%and 96.3-99.6%,respectively,and they shared 78.4-96.6%and 84.8-93.5%identities with the available SMoV isolates in GenBank.Recombination analysis revealed that Chinese isolate SDHY33-2 and Canadian isolates Ontario and Simcoe were recombinants,and recombination events frequently occurred in the 3’UTR of SMoV.Phylogenetic analysis showed that in an RNA1 tree,most Chinese isolates clustered into the same group while isolate DGHY17 clustered into another group together with Czech isolate C and three Canadian isolates.In an RNA2 tree,all Chinese isolates clustered into a single group.The phylogenetic analysis based on nucleotide sequences was consistent with the results based on coat protein(CP)and RNA-dependent RNA polymerase(RdRp).Further evolutionary analysis indicated that negative selection drives SMoV evolution,and gene flow plays a major role in genetic differentiation.Additionally,reassortment and recombination also influence the evolution of SMoV.To our knowledge,this is the first report of the complete genome of SMoV isolates from China and a detailed analysis of the SMoV population structure.

关键词： Viral occurrence Complete genome Molecular variation Genetic structure

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Review of theoretical methods and research aspects for detecting leaf water content using terahertz spectroscopy and imaging

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International Journal of Agricultural and Biological Engineering 2018年第5期11卷 27-34页

作者： Fangfang Qu Pengcheng Nie Lei Lin chengyong Cai Yong he College of Biosystems Engineering and Food Science Zhejiang UniversityHangzhou 310058China Key Laboratory of Spectroscopy Sensing Ministry of Agriculture and Rural AffairsHangzhou 310058China State Key Laboratory of Modern Optical Instrumentation College of Optical Science and EngineeringZhejiang UniversityHangzhou 310058China

The water content in vegetative leaves is an important indicator to plant science.It reveals the physiological status of plants and provides valuable information in irrigation management.Terahertz(THz)as a state-of-the-art technology shows great potential in measuring and monitoring the water status in plant leaves.This paper reviewed the theoretical models for calculating water content in the plant leaves,the methods for eliminating the scattering loss caused by the surface roughness of leaf,the applications of THz spectroscopy and THz imaging for monitoring leaf water content and describing leaf water distribution.The survey of the researches presents the considerable advantages of this emerging and promising THz technology in agriculture.

关键词： terahertz(THz)spectroscopy terahertz imaging leaf water content leaf water distribution theoretical models eliminating scattering loss agriculture

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An iridium(Ⅲ)-palladium(Ⅱ) metal-organic cage for efficient mitochondria-targeted photodynamic therapy

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Chinese Chemical Letters 2020年第5期31卷 1183-1187页

作者： Chaojie Li Yaping Wang Yulin Lu Jing Guo Chengyi Zhu Haozhe he Xiaohui Duan Mei Pan chengyong Su MOE Laboratory of Bioinorganic and Synthetic Chemistry Lehn Institute of Functional MaterialsSchool of ChemistrySun Yat-Sen UniversityGuangzhou 510275China School of Materials Science and Engineering and School of Chemistry Sun Yat-Sen University.Guangzhou 510275China Sun Yat-Sen Memorial Hospital Sun Yat-Sen UniversityGuangzhou 510120China

An Ir8 Pd4-heteronuclear metal-organic cage(MOC-51)was assembled from bipodal metalloligand[Ir(ppy)2(qpy)(BF4)](qpy=4,4′:2′,2″:4″,4′′′-quaterpyridine;ppy-2-phenylpridine)with Pd(Ⅱ)salt.The cubic barrel shaped MOC shows one-photon and two-photon excited deep-red emission,as well as large singlet oxygen quantum yields under visible light irradiation,therefore exhibiting great potentials in organelles-targeted cell imaging and photodynamic therapy(PDT).Compared with the Ir(Ⅲ)metalloligand,the Ir8 Pd4-MOC showed less dark toxicity and higher mitochondria-targeting efficiency.The localization in mitochondria overco mes the limitation of short lifetime and diffusion distance of ROS in cell,thus improved PDT effect can be obtained in low light dose usage of the MOC.This study presents the first case of Ir-based metal-organic cages for bio-applications in successful integration of imaging diagnosis and photodynamic therapy.

关键词： Metal-organic cage Photodynamic therapy Mitochondria-targeted Ir(Ⅲ)metalloligand Two-photon

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Drilling Force and Temperature of Bone under Dry and Physiological Drilling Conditions

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Chinese Journal of Mechanical Engineering 2014年第6期27卷 1240-1248页

作者： XU Linlin WANG chengyong JIANG Min he Huiyu SONG Yuexian CheN Hanyuan SheN Jingnan ZHANG Jiayong School of Electromechanical Engineering Guangdong University of Technology Guangzhou Aquila Precise Tools LTD The First Affiliated Hospital Sun Yat-sen University National Engineering Research Center for healthcare Devices

Many researches on drilling force and temperature have been done with the aim to reduce the labour intensiveness of surgery, avoid unnecessary damage and improve drilling quality. However, there has not been a systematic study of mid- and high-speed drilling under dry and physiological conditions（injection of saline）. Furthermore, there is no consensus on optimal drilling parameters. To study these parameters under dry and physiological drilling conditions, pig humerus bones are drilled with medical twist drills operated using a wide range of drilling speeds and feed rates. Drilling force and temperature are measured using a YDZ-II01W dynamometer and a NEC TVS-500EX thermal infrared imager, respectively, to evaluate internal bone damage. To evaluate drilling quality, bone debris and hole morphology are observed by SEM（scanning electron microscopy）. Changes in drilling force and temperature give similar results during drilling such that the value of each parameter peaks just before the drill penetrates through the osteon of the compact bone into the trabeculae of the spongy bone. Drilling temperatures under physiological conditions are much lower than those observed under dry conditions, while a larger drilling force occurs under physiological conditions than dry conditions. Drilling speed and feed rate have a significant influence on drilling force, temperature, bone debris and hole morphology. The investigation of the effect of drilling force and temperature on internal bone damage reveals that a drilling speed of 4500 r/min and a feed rate of 50 mm/min are recommended for bone drilling under physiological conditions. Drilling quality peaks under these optimal parameter conditions. This paper proposes the optimal drilling parameters under mid- and high-speed surgical drilling, considering internal bone damage and drilling quality, which can be looked as a reference for surgeons performing orthopedic operations.

关键词： drilling bone medical twist drill drilling force drilling temperature internal bone damage

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Orbitally driven giant thermal conductance associated with abnormal strain dependence in hydrogenated graphene-like borophene

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npj Computational Materials 2019年第1期5卷 752-759页

作者： Jia he Dengfeng Li Yan Ying Chunbao Feng Junjie he chengyong Zhong Hangbo Zhou Ping Zhou Gang Zhang School of Science Chongqing University of Posts and TelecommunicationsChongqing 400065China Institute of High Performance Computing A*STARSingapore 138632Singapore

heat energy in solids is carried by phonons and electrons.However,in most two-dimensional(2D)materials,the contribution from electrons to total thermal conduction is much lower than that for phonons.In this work,through first-principles calculations combined with non-equilibrium Green’s function theory,we studied electron and phonon thermal conductance in recently synthesized 2D hydrogen boride.The hexagonal boron network with bridging hydrogen atoms is suggested to exhibit comparable lattice thermal conductance(4.07 nWK−1 nm−2)as graphene(4.1 nWK−1 nm−2),and similar electron thermal conductance(3.6 nWK−1 nm−2),which is almost ten times that of graphene.As a result,total thermal conductance of 2D hydrogen boride is about two-fold of graphene,being the highest value in all known 2D materials.Moreover,tensile strain along the armchair direction leads to an increase in carrier density,significantly increasing electron thermal conductance.The increase in electron thermal conductance offsets the reduction in phonon thermal conductance,contributing to an abnormal increase in thermal conductance.We demonstrate that the high electron density governs extraordinarily high thermal conductance in 2D hydrogen boride,distinctive among 2D materials.

关键词： strain thermal Orbital

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