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Edible prodelphinidins that improve postprandial hyperglycemia were first discovered in Chinese bayberry(Myrica rubra Sieb. et Zucc.) fruits

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Food Science and Human Wellness 2024年

作者： Yi Wang Laiming Zhang Jiaxiong Wu chengxiao yu Xingqian Ye Haibo Pan Shiguo Chen Ningbo Research Institute， Zhejiang University College of Biosystems Engineering and Food Science，Zhejiang Key Laboratory for Agro-Food Processing， Integrated Research Base of Southern Fruit and Vegetable Preservation Technology， Zhejiang International Scientific and Technological Cooperation Base of Health Food Manufacturing and Quality Control， Zhejiang University Zhejiang University Zhongyuan Institute Innovation Center of Yangtze River Delta， Zhejiang University

Plant polyphenols are potential substitutes for clinical α-glucosidase inhibitors. Our previous studies indicated that prodelphinidins from Chinese bayberry leaves (BLPs) have stronger α-glucosidase inhibitory activity than other common polyphenols， but they have no safe history of consumption. There is a reasonable prospect that prodelphinidins from Chinese bayberry fruits (BFPs) can improve postprandial hyperglycemia， though known active components are only myricetin and cyanidin-3-O-glucoside. Hence， the aim of this study was to analyze structure and hypoglycemic effect of BFPs of “Biqi” (BQPs) and “Dongkui” (DKPs) cultivars， and compare their difference with BLPs. The contents of BQPs and DKPs were (221.73±0.60) and (136.82±4.33) mg EC equivalents/g dry weight， respectively. The most subunits were EGCG along with a small amount of EGC， ECG and EC connected by B-type linkages and a small portion of A-type linkages with mean polymerization degree of 4.25 and 4.08， respectively. Importantly， BQPs and DKPs were α-glucosidase inhibitors with IC50of 11.91 and 9.47 μg/mL respectively， which were significantly stronger than BLPs. DKPs could also improve postprandial hyperglycemia of normal mice and high fat diet-induced type Ⅱ diabetic mice. Therefore， edible prodelphinidins， which have stronger hypoglycemic effect than BLPs， were first found in Chinese bayberry fruits.

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Smart Contract Based DDoS Attack Traceability Audit Mechanism in Intelligent IoT

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China Communications 2023年第8期20卷 54-64页

作者： Zhuohao Wang Weiting Zhang Runhu Wang Ying Liu Chenyang Xu chengxiao yu Institute of Scientific and Technical Information of China Beijing 100038China School of Electronic and Information Engineering Beijing Jiaotong UniversityBeijing 100044China

In this paper,we focus on providing data provenance auditing schemes for distributed denial of service(DDoS)defense in intelligent internet of things(IoT).To achieve effective DDoS defense,we introduce a two-layer collaborative blockchain framework to support data ***,using data scattered among intelligent IoT devices,switch gateways self-assemble a layer of blockchain in the local autonomous system(AS),and the main chain with controller participation can be aggregated by its associated layer of blocks once a cycle,to obtain a global security *** optimize the processing delay of the security model,we propose a process of data pre-validation with the goal of ensuring data consistency while satisfying overhead *** the flood of identity spoofing packets,it is difficult to solve the identity consistency of data with traditional detection methods,and accountability cannot be pursued ***,we proposed a Packet Traceback Telemetry(PTT)scheme,based on in-band telemetry,to solve the ***,the PTT scheme is executed on the distributed switch side,the controller to schedule and select routing ***,a tracing probabilistic optimization is embedded into the PTT scheme to accelerate path reconstruction and save device *** results show that the PTT scheme can reconstruct address spoofing packet forward path,reduce the resource consumption compared with existing tracing *** tracing audit method has fine-grained detection and feasible performance.

关键词： smart contract Internet of Things distributed denial of service telemetry audit

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A rapid method for extraction,purification and structure analysis of chondroitin sulfate from six marine tissues

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Food Quality and Safety 2023年第1期7卷 20-29页

作者： yuying Wang Shokouh Ahmadi chengxiao yu Laiming Zhang Xinxin Hu Xingqian Ye Shiguo Chen College of Biosystems Engineering and Food Science National-Local Joint Engineering Laboratory of Intelligent Food Technology and EquipmentZhejiang Key Laboratory for Agro-Food ProcessingZhejiang Engineering Laboratory of Food Technology and EquipmentZhejiang UniversityHangzhouChina Zhejiang University Zhongyuan Institute ZhengzhouChina Shandong(Linyi)Institute of Modern Agriculture Zhejiang UniversityLinliChina Fuli Institute of Food Science Zhejiang UniversityHangzhouChina Ningbo Research Institute Zhejiang UniversityHangzhouChina

This study was designed to establish a strategy for the extraction,purification,and structure analysis of chondroitin sulfate(cs)in milligram *** acidic polysaccharides were extracted from six kinds of marine animals by enzymatic hydrolysis and hexadecylpyridinium chloride precipitation and purified by Q Sepharose Fast Flow strong anion exchange *** purification of each crude polysaccharide was completed within 1 *** structure of the polysaccharides,*** chemical characterization,functional group,molecular weight and monosaccharide composition,were analyzed by colorimetry,nuclear magnetic resonace and high-performance liquid chromatogrpahy,*** polysaccharides were identified as *** oligosaccharide profile produced by enzyme hydrolysis of polysaccharides was determined by strong anion-exchange high-performance liquid *** method can be widely applied to the extraction and characterization of chondroitin sulfate from unknown raw materials,screening high-quality sources of functional polysaccharides,and laying a good foundation for thefollowing studyof the structure-function relationshipof polysaccharides.

关键词： Chondroitin sulfate marinepolysaccharide disaccharide analysis

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Optimization of high-pressure processing-assisted extraction of pectic polysaccharides from three berries

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Food Quality and Safety 2023年第1期7卷 1-12页

作者： Xinxin Hu chengxiao yu Shokouh Ahmadi yuying Wang Xingqian Ye Zhiqiang Hou Shiguo Chen College of Biosystems Engineering and Food Science National-Local Joint Engineering Laboratory of Intelligent Food Technology and EquipmentZhejiang Key Laboratory for Agro-Food ProcessingZhejiang Engineering Laboratory of Food Technology and EquipmentZhejiang UniversityHangzhouChina Zhejiang University Zhongyuan Institute ZhengzhouChina Shandong(Linyi)Institute of Modern Agriculture Zhejiang UniversityLinyiChina Fuli Institute of Food Science Zhejiang UniversityHangzhouChina Ningbo Research Institute Zhejiang UniversityHangzhouChina

Background and objectives:High-pressure processing(HPP)is a promising assistive method to extract pectic polysaccharides with high rhamnogalacturonan I(RG-I)domain and berries are sources of such pectic *** study extracts pectic polysaccharides from goji berry,raspberry,and cranberry,examines how HPP influences the pectic polysaccharide structure of three berries,and provides a basis for the extraction and modification of pectic polysaccharides with specific structure and *** and methods:An orthogonal test was performed to optimize the HPP-assisted alkali method to extract the high yield and high RG-I content pectic polysaccharides from three *** information of pectic polysaccharides extracted by the HPP method and conventional methods were compared from the perspectives of monosaccharide composition,molecular weight,Fourier transform infrared spectroscopy,***:For raspberry,the optimal conditions consisted of a pressure of 50o MPa,a pH of 13,and a pressure-holding time of 12 min,while the optimal conditions for goji berry and cranberry were both 40o MPa,pH 13,and 15 *** the optimal conditions,the yields for goji berry,raspberry,and cranberry were 10.49%,16.63%,and 17.52%,respectively,and RG-l contents were 81.85%,83.30%,and 63.22%,*** showed an effect to degrade homogalacturonan backbones and side chains and increase the RG-I content to some ***:HPP-assisted alkali method was revealed to be an efficient method to extract high RG-I content pectic polysaccharides,especially for cranberry,and was a potential method to modify pectic polysaccharide structure in a certain way.

关键词： Pectic polysaccharide High-pressure processing Rhamnogalacturonan-I Structural characteristics

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ICN Based Vehicle-to-Cloud Delivery for Multimedia Streaming in Urban Vehicular Networks

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China Communications 2016年第9期13卷 103-112页

作者： Wei Quan Fei Song chengxiao yu Mingchuan Zhang National Engineering Laboratory for Next Generation Internet Technologies School of Electronic and Information EngineeringBeijing Jiaotong University College of Information Engineering Henan University of Science and Technology

Mobile multimedia streaming is an open topic in vehicular environment. Due to the high intermittent links, it has become a critical challenge to deliver high quality video streaming in vehicular networks. In this paper, we reform the Information Centric Networking （ICN） concept for multimedia delivery in urban vehicular networks. By leveraging the 1CN perspective, we highlight that vehicular peers can obtain multimedia chunks via the vehicle-to-cloud （V2C） approach to improve the delivery quality. Based on this, we propose a lightweight multipath selection strategy to guide the network system to adaptively adjust the forwarding means. Extensive simulations show that the proposed solution can optimize the utilization of network paths, lighten network loads as well as avoid wasting resources.

关键词： information centric networking vehicle-to-cloud multimedia streaming VANET

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Comparison of Clinical Characteristics and Outcomes of MAFLD and NAFLD in Chinese Health Examination Populations

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Journal of Clinical and Translational Hepatology 2023年第4期11卷 777-786页

作者： Xin Xu Xiaohua Zhou Ting Tian yuqing Ding chengxiao yu Wei Zhao Xiao Wang Jing Lu Wen Guo Longfeng Jiang Quanrongzi Wang Qun Zhang Ci Song Department of Epidemiology Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsuChina The Affiliated Suzhou Hospital of Nanjing Medical University Suzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhouJiangsuChina Department of Infectious Disease the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsuChina Department of Health Promotion Center the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsuChina Department of Radiology the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsuChina

Background and Aims:The recently proposed concept of metabolic dysfunction-associated fatty liver disease(MAFLD)has remained *** aimed to describe the features and associated outcomes to examine the diagnostic ability of MAFLD for identifying high-risk ***:In this retrospective cohort study,we enrolled 72,392 Chinese participants between 2014 and *** were classified as MAFLD,nonalcoholic fatty liver disease(NAFLD),non-MAFLD-NAFLD,and a normal control *** primary outcomes were liver-related and cardiovascular disease(CVD)***-years of follow-up were calculated from enrolment to the diagnosis of the event,or the last date of data(June,2020).Results:Of the 72,392 participants,31.54%(22,835)and 28.33%(20,507)qualified the criteria for NAFLD or MAFLD,*** with NAFLD,MAFLD patients were more likely to be male,overweight,and have higher biochemical indices including liver enzyme *** MAFLD diagnosed with≥2 or≥3 metabolic abnormalities presented similar clinical *** the median follow-up of 5.22 years,919 incident cases of severe liver disease and 2,073 CVD cases were *** with the normal control group,the NAFLD and MAFLD groups had a higher cumulative risk of liver failure and cardiac-cerebral vascular *** were no significant differences in risk between the non-MAFLD-NAFLD and normal ***-MAFLD group had the highest incidence of liver-related and cardiac-cerebral vascular diseases,lean MAFLD came second,and obese-MAFLD had the lowest ***:This real-world study provided evidence for rationally assessing the benefit and practicability of the change in terminology from NAFLD to *** may be better than NAFLD in identifying fatty liver with worse clinical features and risk profile.

关键词： Metabolic-associated fatty liver disease Non-alcoholic fatty liver disease Liver-related disease Cardiac vascular disease Cerebral vascular disease

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Distributed Asynchronous Learning for Multipath Data Transmission Based on P-DDQN

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China Communications 2021年第8期18卷 62-74页

作者： Kang Liu Wei Quan Deyun Gao chengxiao yu Mingyuan Liu yuming Zhang School of Electronic and Information Engineering Beijing Jiaotong UniversityBeijing 100044China

Adaptive packet scheduling can efficiently enhance the performance of multipath Data ***,realizing precise packet scheduling is challenging due to the nature of high dynamics and unpredictability of network link *** this end,this paper proposes a distributed asynchronous deep reinforcement learning framework to intensify the dynamics and prediction of adaptive packet *** framework contains two parts:local asynchronous packet scheduling and distributed cooperative control *** local asynchronous packet scheduling,an asynchronous prioritized replay double deep Q-learning packets scheduling algorithm is proposed for dynamic adaptive packet scheduling learning,which makes a combination of prioritized replay double deep Q-learning network(P-DDQN)to make the fitting *** distributed cooperative control center,a distributed scheduling learning and neural fitting acceleration algorithm to adaptively update neural network parameters of P-DDQN for more precise packet *** results show that our solution has a better performance than Random weight algorithm and Round-Robin algorithm in throughput and loss ***,our solution has 1.32 times and 1.54 times better than Random weight algorithm and Round-Robin algorithm on the stability of multipath data transmission,respectively.

关键词： distributed asynchronous learning multipath data transmission deep reinforcement learning

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三峡水库场次洪水排沙规律及影响因素

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水科学进展 2024年第1期35卷 112-122页

作者：高宇任实王海吕超楠赵汗青张成潇中国长江三峡集团有限公司湖北宜昌443100

水库泥沙淤积导致库容损失,影响水库综合效益发挥,研究水库排沙规律及影响因素对于改善水库淤积状况具有重要意义。根据2003—2021年朱沱、北碚、武隆、寸滩等水文站实测数据,合理划分三峡水库场次洪水过程,分析其排沙规律,并重点研究... 详细信息

水库泥沙淤积导致库容损失,影响水库综合效益发挥,研究水库排沙规律及影响因素对于改善水库淤积状况具有重要意义。根据2003—2021年朱沱、北碚、武隆、寸滩等水文站实测数据,合理划分三峡水库场次洪水过程,分析其排沙规律,并重点研究坝前水位、入出库输沙率、洪水滞留时间等因素对排沙的影响。结果表明:三峡水库场次洪水过程的划分采用统一的定量标准并考虑洪峰沙峰异步传播的影响更加合理;水库排沙主要集中在汛期场次洪水,各年汛期场次洪水排沙总量平均占全年的67.0%;场次洪水排沙比与坝前水位成反比、与入出库输沙率成正比,但相关性均小于与其成反比的洪水滞留时间,且当入库平均流量大于30000 m^(3)/s或坝前平均水位低于150 m时,排沙比与各因素之间的相关性均有所提升。研究成果可为优化三峡水库运行方式、减少水库泥沙淤积等提供重要参考。

关键词：排沙比场次洪水洪峰沙峰异步洪水滞留时间三峡水库

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鼠李半乳糖醛酸聚糖Ⅰ的结构特性及分离检测研究进展

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陕西师范大学学报（自然科学版） 2022年第5期50卷 51-63页

作者：虞诚潇陈健乐叶兴乾陈士国浙江大学生物系统工程与食品科学学院智能食品加工技术与装备国家地方联合工程实验室浙江大学馥莉食品研究院浙江杭州310058 浙江大学宁波研究院浙江宁波315100

鼠李半乳糖醛酸聚糖Ⅰ(rhamnogalacturonanⅠ,RG-Ⅰ)是植物果胶的主要结构域之一,其结构复杂、功能多样,受到广泛关注。当前,对RG-Ⅰ的界定及分离检测体系仍不完善,制约了RG-Ⅰ的活性研究和功能产品开发,限制了其产业化应用。基于此,通... 详细信息

鼠李半乳糖醛酸聚糖Ⅰ(rhamnogalacturonanⅠ,RG-Ⅰ)是植物果胶的主要结构域之一,其结构复杂、功能多样,受到广泛关注。当前,对RG-Ⅰ的界定及分离检测体系仍不完善,制约了RG-Ⅰ的活性研究和功能产品开发,限制了其产业化应用。基于此,通过系统归纳和总结RG-Ⅰ的定义、分子结构、生物活性、提取纯化方法及检测手段,明确了RG-Ⅰ是一类主链由鼠李糖和半乳糖醛酸以α-1,4糖苷键依次相连的酸性果胶样多糖,其鼠李糖残基可连接中性糖侧链;提出偏碱性条件的顺序提取是RG-Ⅰ较为理想的提取方法,而阴离子交换层析分级结合凝胶柱层析法是较为适宜的RG-Ⅰ分离纯化方式;指出以单糖组成为主要检测依据,结合核磁、质谱、抗体等手段进行验证,能够更全面地揭示RG-Ⅰ结构和特征。通过对RG-Ⅰ进行总结、归纳和展望,以期为RG-Ⅰ果胶多糖的后续研究提供参考。

关键词：鼠李半乳糖醛酸聚糖Ⅰ 结构特性提取纯化检测方法

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汛期洪水资源化利用对三峡水库淤积影响研究

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湖泊科学 2024年第2期36卷 634-644页

作者：赵汗青任实闫静张成潇刘志武高宇中国长江三峡集团有限公司武汉430010 水资源高效利用与工程安全国家工程研究中心南京210024 河海大学水利水电学院南京210098

作为三峡水库诸多优化调度方式中的一种,洪水资源化利用对水库淤积的影响受到持续关注,开展针对场次洪水的相关研究有助于进一步深化对水库淤积科学问题的认识,有望为调度工作提供一定的技术支撑。通过2013年以来的历史水文资料分析与... 详细信息

作为三峡水库诸多优化调度方式中的一种,洪水资源化利用对水库淤积的影响受到持续关注,开展针对场次洪水的相关研究有助于进一步深化对水库淤积科学问题的认识,有望为调度工作提供一定的技术支撑。通过2013年以来的历史水文资料分析与水沙运动数值模拟,探究了入库洪水的输沙过程以及洪水资源化利用对库区淤积与水库排沙的影响。结果表明:洪峰流量介于30000~55000 m 3/s的中小洪水是近年三峡入库洪水的主要形式,随着入库洪峰流量的增加,洪水的地区组成逐渐趋向于金沙江下游、嘉陵江共同主导;常年回水区淤积、水库排沙是“消化”入库泥沙的两种主要途径,且以前者的作用为主;针对Ⅰ-3类入库洪水,坝前起调水位Z 0的抬升或洪水资源化利用对水库淤积的影响主要在于造成了库区淤积的重分布,次要在于改变了水库的排沙作用,在Z 0≤150 m条件下,洪水资源化利用对水库淤积的影响相对较小;针对典型洪水,当武隆洪峰流量Q′WL与入库洪峰流量Q′RK的比值小于1/5(即Q′WL/Q′RK<1/5)且朱沱洪峰流量Q′ZT与北碚洪峰流量Q′BB的比值介于3/2和3之间(即3/2

关键词：三峡水库洪水资源化利用场次洪水坝前起调水位入库水沙体量地区组成

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