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An Efficient Threshold Blind Signature from Weil Pairing

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Wuhan University Journal of Natural Sciences 2005年第1期10卷 255-258页

作者： chengxiang-guo XUWei-dong WANGXin-mei NationalKeyLaboratoryofIntegratedServicesNetwork XidianUniversityXi＇an710071ShaanxiChina

Threshold blind signature is playing an important role in cryptography as well as in practical applications such as e-cash and e-voting systems, etc. In this paper, we present an efficient and practical threshold bind signature from Weil pairing on super-singular elliptic curves or hyper-elliptic curves over finite field and prove that our scheme is provably secure in the random oracle model.

关键词： signature scheme threshold blind signature Weil pairing GDH group

Computed tomography-based delta radiomics of tumor core_edge combination for systemic treatment response evaluation in pancreatic cancer

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Journal of Pancreatology 2024年第3期7卷 181-190页

作者： Xiang Li Na Lu Peijun Hu Yiwen Chen Liying Liu Xinyuan Liu chengxiang guo Wenbo Xiao Ke Sun Jingsong Li Xueli Bai Tingbo Liang Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhouChina Zhejiang Provincial Key Laboratory of Pancreatic Disease HangzhouChina Research Center for Healthcare Data Science Zhejiang LabHangzhou China Department of Radiology The First Affiliated HospitalZhejiang University School of MedicineHangzhouChina Department of Pathology The First Affiliated HospitalZhejiang University School of MedicineHangzhouChina Key Laboratory for Biomedical Engineering of Ministry of Education College of Biomedical Engineering and Instrument ScienceZhejiang UniversityHangzhouChina Zhejiang University Cancer Center HangzhouChina

Background:As a systemic disease,pancreatic cancer(PC)can be treated systemically to raise the R0 resection rate and enhance patient *** best ways to assess the treatment response to systemic treatment of patients with PC are still ***:A total of 122 PC patients were enrolled;25 of these patients were used as an independent testing *** to the pathologic response,PC patients were classified into the responder and nonresponder *** whole tumor,core,edge,and peritumoral were segmented from the enhanced computed tomography(CT)***-learning models were created by extracting the variations in radionics features before and after therapy(delta radiomics features).Finally,we compared the performance of models based on radiomics features,changes in tumor markers,and radiologic ***:The model based on the core(area under curve[AUC]=0.864)and edge features(AUC=0.853)showed better performance than that based on the whole tumor(AUC=0.847)or peritumoral area(AUC=0.846).Moreover,the tumor core_edge combination model(AUC=0.899)could better increase confidence in treatment response than using either of them *** accuracies of models based on changes in tumor markers and radiologic evaluation were relatively poorer than of the radiomics ***,Patients predicted to respond to therapy using the radiomics model showed a relatively longer overall survival(43 vs 27 months),although there were no significant differences(P=.063).Conclusions:The tumor core_edge combination delta radiomics model is an effective approach to evaluate pathologic response in PC patients with systemic treatment.

关键词： Computed tomography Delta radiomics Pancreatic cancer Pathologic response Systemic treatment

Micro-nanoarchitectonic of aluminum-hydrogel propellant with static stability and dynamic rheology

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Frontiers of Chemical Science and Engineering 2024年第4期18卷 87-96页

作者： Huiyan guo Huaiyu Li Hongzhi Zhang Lun Pan chengxiang Shi Kang Xue Xiangwen Zhang Ji-Jun Zou Key Laboratory for Advanced Fuel and Propellant of Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China

The aluminum-water system is a promising propellant due to high energy and low signal characteristics,and the gel form is easier to store and *** this work,hydrogels of water and aluminum particles were prepared using the low-molecular-weight gellant *** various physical properties of gel systems,including the water loss rate,phase transition temperature,and centrifugal stability at different gellant and aluminum contents,were *** properties were assessed through shear thinning tests,thixotropy tests,strain sweep analysis,and frequency sweep *** microstructure of the gel was obtained through scanning electron microscopy *** results show that the aluminum-hydrogel network structure is composed of micron-scale aluminum and agarose nanosheets,and the unique micro-nanostructure endows the gel with excellent mechanical strength and thermal stability,which improve with increasing gellant and aluminum ***,the gel with 2% agarose and 20% aluminum had the best performance;the storage modulus reached 90647 Pa,which was within the linear viscoelastic region,and the maximum withstand pressure was 111.2 kPa,which was 118.8% greater than that of the pure ***,the gel demonstrates remarkable shear thinning behavior and can undergo gel-sol transformation upon shearing or heating to exceeding 114℃.

关键词： aluminum-water propellant gelled propellant rheological property mechanical strength

The AKT-independent MET–V-ATPase–MTOR axis suppresses liver cancer vaccination

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1189-1198页

作者： Xing Huang Xingyuan Xu Xun Wang Tianyu Tang Enliang Li Xiaozhen Zhang Jian Xu Hang Shen chengxiang guo Tao Xu Jianhong Ren Xueli Bai Tingbo Liang Zhejiang Provincial Key Laboratory of Pancreatic Disease The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003 ZhejiangChina Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003 ZhejiangChina Innovation Center for the Study of Pancreatic Diseases of Zhejiang Province Hangzhou 310003 ZhejiangChina The Key Laboratory of Developmental Genes and Human Disease Institute of Life SciencesSoutheast UniversityNanjing 210096 JiangsuChina Suzhou BioNovoGene Metabolomics Platform Suzhou 215000 JiangsuChin

Despite recent progress in hepatitis treatment,there have been no significant advances in the development of liver cancer vaccines in recent *** this study,we investigated the regulatory effect and potential mechanism of hepatocyte growth factor receptor(MET,also known as HGFR)on tumor vaccinations for liver cancer in ***,we demonstrate that MET expression is significantly associated with the immunogenicity of liver cancer in mice and humans,and that MET depletion dramatically enhances the protective efficacy of chemotherapy-based anti-liver cancer ***,MET repressed liver cancer immunogenicity independent of the traditional PI3K–AKT cascade,and MET interacted with vacuolar ATP synthase(V-ATPase)and mediated the activation of mammalian target of rapamycin(MTOR),thus suppressing liver cancer *** efficacy of chemotherapy-based liver cancer vaccination was markedly enhanced by targeting the MET–V-ATPase–MTOR axis,highlighting a translational strategy for identifying MET-associated drug candidates for cancer prevention.

关键词： vaccination cancer protective

Resonant four-photon photoemission from SnSe_(2)(001)

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Frontiers of physics 2024年第3期19卷 83-92页

作者： chengxiang Jiao Kai Huang Hongli guo Xingxia Cui Qing Yuan Cancan Lou Guangqiang Mei Chunlong Wu Nan Xu Limin Cao Min Feng School of Physics and Technology and Key Laboratory of Artificial Micro-and Nano-Structures of Ministry of Education Wuhan UniversityWuhan 430072China Department of Physics and Astronomy California State University NorthridgeNorthridgeCA 91330-8268USA Institute for Advanced Study Wuhan UniversityWuhan 430072China

High-order nonlinear multiphoton absorption is usually inefficient,but can be enhanced by designing resonant excitations between occupied and unoccupied energy *** conducted angle-resolved multi-photon photoemission(mPPE)studies on the SnSe_(2)(001)surfaces excited by ultrashort laser *** tuning photon energy and light polarization,we demonstrate the presence of a resonant four-photon photoemission(4PPE)process involving the occupied valence band(VB),the unoccupied second conduction band(CB2)and the unoccupied image-potential state(IPs)of SnSe_(2).In this 4PPE process,VB electrons of SnSe_(2) are resonantly excited into CB2 by adsorbing two photons,followed by the adsorption of another photon to populate the n=1 IPs before being emitted out to the vacuum by adsorbing one more *** results in a double-resonant 4PPE process,which exhibits approximately a 40 times enhancement in photoemission yields compared to cases where one of the resonant pathways,CB2→IPs,is inhibited by involving a virtual state instead of the IPs in the *** double-resonant 4PPE process efficiently excite the bulk VB electrons outside the vacuum,like taking advantage of resonant“ladders”through two real empty electronic states of SnSe_(2).Our results highlight the important applications of mPPE in probing the band-structure,particularly the unoccupied states,of recently emerging main group dichalcogenide ***,the discovered resonant mPPE process contributes to the exploration of their promising optoelectronic applications.

关键词： multi-photon photoemission four-photon photoemission SnSe_(2) unoccupied states resonant excitation

基于水平土拱效应的排桩支护结构合理桩间距的研究

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四川建筑科学研究 2008年第4期34卷 136-139页

作者：郭院成郭呈祥叶永峰郑州大学土木工程学院河南郑州450001 濮阳职业技术学院河南濮阳457000 同济大学地下建筑与工程系上海200092

在对排桩支护结构间水平土拱效应分析的基础上,给出了一种新的成拱桩间距计算模型,提出应在引入普氏理论的前提下,以桩间静力平衡条件、跨中截面强度条件以及拱脚处截面强度条件共同控制来确定桩间距。经过理论分析,推导出了桩间距、拱... 详细信息

在对排桩支护结构间水平土拱效应分析的基础上,给出了一种新的成拱桩间距计算模型,提出应在引入普氏理论的前提下,以桩间静力平衡条件、跨中截面强度条件以及拱脚处截面强度条件共同控制来确定桩间距。经过理论分析,推导出了桩间距、拱高和拱厚的计算公式,最后,通过工程算例证明本文算法的合理性。

关键词：排桩支护土拱效应桩间距

砂卵石地层地铁隧道下穿既有隧道影响分区与控制研究

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路基工程 2021年第2期 51-58页

作者：郭成祥中铁十四局集团隧道工程有限公司济南250000 中铁十四局集团有限公司济南250014

以成都地铁5号线下穿地铁3号线为工程背景,运用有限差分软件FLAC3D,研究合理的影响分区,并论证CRD工法在下穿既有隧道时的应用效果。研究结果表明:新建隧道对既有隧道的影响与埋深呈正相关,与净距呈负相关;影响分区揭示了大部分在成都... 详细信息

以成都地铁5号线下穿地铁3号线为工程背景,运用有限差分软件FLAC3D,研究合理的影响分区,并论证CRD工法在下穿既有隧道时的应用效果。研究结果表明:新建隧道对既有隧道的影响与埋深呈正相关,与净距呈负相关;影响分区揭示了大部分在成都砂卵石地层进行的既有隧道近接施工均需要采取相应的控制措施,以保证施工安全;CRD法可以有效地控制成都砂卵石地层强影响区近接施工对既有隧道的影响,弱影响区可采用注浆加固以及超前支护等方法进行控制。

关键词：砂卵石地层地铁隧道近接既有隧道施工影响分区 CRD工法控制措施

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核电厂不锈钢覆面焊接模拟件腐蚀行为研究

核动力工程 2022年第3期43卷 214-219页

作者：王宇欣胡月飞高宇郭城湘左景辉中国核电工程有限公司北京100840 中国科学院金属研究所沈阳110016

对3种核电厂乏燃料水池不锈钢覆面材料S32205、S32101和S30403的焊接模拟件,在H_(3)BO_(3)浓度2500 mg/L、SO_(4)^(2−)浓度1500 mg/L、Cl^(−)浓度5%、pH值5.0、温度80℃、饱和氧的条件下浸泡6个月,对比研究其腐蚀行为。结果发现:S30403... 详细信息

对3种核电厂乏燃料水池不锈钢覆面材料S32205、S32101和S30403的焊接模拟件,在H_(3)BO_(3)浓度2500 mg/L、SO_(4)^(2−)浓度1500 mg/L、Cl^(−)浓度5%、pH值5.0、温度80℃、饱和氧的条件下浸泡6个月,对比研究其腐蚀行为。结果发现:S30403焊接模拟件在焊接节点和缝隙附近出现了大量的氯致应力腐蚀裂纹;S32101焊接模拟件出现了腐蚀坑,在焊接节点和缝隙附近腐蚀尤其严重;S32205焊接模拟件腐蚀最轻,试件表面未发现腐蚀坑及裂纹。研究表明:3种材料模拟件的耐腐蚀性规律为:S32205>S32101>S30403。S32205具有良好的综合力学性能和耐腐蚀性能,是一种理想的改进型水池覆面材料。

关键词：不锈钢覆面焊接模拟件腐蚀行为 S32205

Diversity of organopollutant-degrading Bacteria isolated from Taklamakan desert: potential resources for bioremediation in radioactive mixed waste environments

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Diversity of organopollutant-degrading Bacteria isolated fro...