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Non-apoptotic cell death-based cancer therapy:Molecular mechanism,pharmacological modulators,and nanomedicine

Acta Pharmaceutica Sinica B 2022年第9期12卷 3567-3593页

作者： Xuan Wang Peng Hua chengwei he Meiwan Chen State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacaoSAR 999078China

As an emerging cancer therapeutic target,non-apoptotic cell death such as ferroptosis,necroptosis and pyroptosis,etc.,has revealed significant potential in cancer treatment for bypassing apoptosis to enhance the undermined therapeutic efficacy triggered by apoptosis resistance.A variety of anticancer drugs,synthesized compounds and natural products have been proven recently to induce non-apoptotic cell death and exhibit excellent anti-tumor effects.Moreover,the convergence of nanotechnology with functional materials and biomedicine science has provided tremendous opportunities to construct non-apoptotic cell death-based nanomedicine for innovative cancer therapy.Nanocarriers are not only employed in targeted delivery of non-apoptotic inducers,but also used as therapeutic components to induce non-apoptotic cell death to achieve efficient tumor treatment.This review first introduces the main characteristics,the mechanism and various pharmacological modulators of different non-apoptotic cell death forms,including ferroptosis,necroptosis,pyroptosis,autophagy,paraptosis,lysosomal-dependent cell death,and oncosis.Second,we comprehensively review the latest progresses of nanomedicine that induces various forms of non-apoptotic cell death and focus on the nanomedicine targeting different pathways and components.Furthermore,the combination therapies of non-apoptotic cell death with photothermal therapy,photodynamic therapy,immunotherapy and other modalities are summarized.Finally,the challenges and future perspectives in this regard are also discussed.

关键词： Non-apoptotic cell death Ferroptosis Necroptosis Pyroptosis Autophagy Nanomedicine Combination therapies Anticancer

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Development of nanoscale drug delivery systems of dihydroartemisinin for cancer therapy: A review

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Asian Journal of Pharmaceutical Sciences 2022年第4期17卷 475-490页

作者： Ka Hong Wong Donglin Yang Shanshan Chen chengwei he Meiwan Chen State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 999078China

Dihydroartemisinin(DHA),a first-line antimalarial drug,has demonstrated great anticancer effects in many types of tumors,including liver cancer,glioblastoma,and pancreatic cancer.Due to its abilities to induce programmed cell death(PCD;apoptosis,autophagy and ferroptosis),inhibit tumor metastasis and angiogenesis,and modulate the tumor microenvironment,DHA could become an antineoplastic agent in the foreseeable future.However,the therapeutic efficacy of DHA is compromised owing to its inherent disadvantages,including poor stability,low aqueous solubility,and short plasma halflife.To overcome these drawbacks,nanoscale drug delivery systems(NDDSs),such as polymeric nanoparticles(NPs),liposomes,and metal-organic frameworks(MOFs),have been introduced to maximize the therapeutic efficacy of DHA in either single-drug or multidrug therapy.Based on the beneficial properties of NDDSs,including enhanced stability and solubility of the drug,prolonged circulation time and selective accumulation in tumors,the outcomes of DHA-loaded NDDSs for cancer therapy are significantly improved compared to those of free DHA.This reviewfirst summarizes the current understanding of the anticancer mechanisms of DHA and then provides an overview of DHA-including nanomedicines,aiming to provide inspiration for further application of DHA as an anticancer drug.

关键词： Dihydroartemisinin Ferroptosis Nano-drug delivery Chemodynamic therapy Photodynamic therapy Photothermal therapy

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基于API的BIM模型属性自定义二次开发研究

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水利技术监督 2024年第3期 22-27,44页

作者：梁建波何成威朱乔利湖北省水利水电规划勘测设计院有限公司湖北武汉430072

为解决导入Navisworks软件中的Revit模型属性丢失或者属性类型及数量不满足Navisworks应用需求的问题,文章基于API,针对Navisworks和Revit软件进行二次开发研究,利用研究成果,即开发完成的相关工具软件,能够方便高效的对导入Navisworks... 详细信息

为解决导入Navisworks软件中的Revit模型属性丢失或者属性类型及数量不满足Navisworks应用需求的问题,文章基于API,针对Navisworks和Revit软件进行二次开发研究,利用研究成果,即开发完成的相关工具软件,能够方便高效的对导入Navisworks中的模型进行属性编辑,包括属性的输出、查找、添加、排序、搜索、定位、匹配、删除、导出等功能,有效助力BIM模型在不同软件中的流转,为BIM软件二次开发应用研究提供参考,对拓展BIM模型在不同软件中的应用具有重要意义。

关键词： BIM模型二次开发属性传递属性编辑

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基于Cesium的倾斜摄影加载优化策略研究

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水利规划与设计 2024年第6期 105-108页

作者：何成威吴鼎梁建波朱乔利刘浩杰湖北省水利水电规划勘测设计院有限公司湖北武汉430070 湖北省汉江兴隆水利枢纽管理局湖北武汉430070

水利行业对信息化的要求越来越高,水利数字孪生的建设正如火如荼,BIM模型和海量倾斜摄影广泛应用于水利三维场景中。由于受限于硬件和网络,海量三维数据的加载容易出现卡顿等情况。为提升水利数字孪生的效果,该问题亟需得到解决。结合... 详细信息

水利行业对信息化的要求越来越高,水利数字孪生的建设正如火如荼,BIM模型和海量倾斜摄影广泛应用于水利三维场景中。由于受限于硬件和网络,海量三维数据的加载容易出现卡顿等情况。为提升水利数字孪生的效果,该问题亟需得到解决。结合倾斜影像的数据格式和Cesium的加载机制,研究了合并根节点、压缩顶层、纹理压缩的数据优化措施和Cesium的参数加载优化措施等关键性技术,实现了海量倾斜摄影在三维场景中的加载优化,为水利数字孪生的可视化提供基础。

关键词： Cesium 倾斜摄影加载优化

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Strengthening Network Security: Deep Learning Models for Intrusion Detectionwith Optimized Feature Subset and Effective Imbalance Handling

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Computers, Materials & Continua 2024年第2期78卷 1995-2022页

作者： Bayi Xu Lei Sun Xiuqing Mao chengwei Liu Zhiyi Ding School of Cyber Science and Engineering Zhengzhou UniversityZhengzhou450000China Three Academy Information Engineering UniversityZhengzhou450001China The 3rd Research Department Nanjing Research Institute of Electronic EngineeringNanjing210007China

In recent years,frequent network attacks have highlighted the importance of efficient detection methods for ensuring cyberspace security.This paper presents a novel intrusion detection system consisting of a data prepro-cessing stage and a deep learning model for accurately identifying network attacks.We have proposed four deep neural network models,which are constructed using architectures such as Convolutional Neural Networks(CNN),Bi-directional Long Short-Term Memory(BiLSTM),Bidirectional Gate Recurrent Unit(BiGRU),and Attention mechanism.These models have been evaluated for their detection performance on the NSL-KDD dataset.To enhance the compatibility between the data and the models,we apply various preprocessing techniques and employ the particle swarm optimization algorithm to perform feature selection on the NSL-KDD dataset,resulting in an optimized feature subset.Moreover,we address class imbalance in the dataset using focal loss.Finally,we employ the BO-TPE algorithm to optimize the hyperparameters of the four models,maximizing their detection performance.The test results demonstrate that the proposed model is capable of extracting the spatiotemporal features of network traffic data effectively.In binary and multiclass experiments,it achieved accuracy rates of 0.999158 and 0.999091,respectively,surpassing other state-of-the-art methods.

关键词： Intrusion detection CNN BiLSTM BiGRU attention

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Improving the mechanical properties and inhibiting strain softening behavior of the biodegradable Zn-0.06Mg alloy via ECAP plus rolling processing

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Progress in Natural Science:Materials International 2024年第1期34卷 45-55页

作者： chengwei Ji Aibin Ma Jinghua Jiang Dan Song Huan Liu Liwen Zhao Xuefei Fang College of Mechanics and Materials Hohai University Suqian Institute Hohai University

The practical application of micro-alloying Zn–Mg alloys is limited due to their poor mechanical properties and evident strain softening behavior. Therefore, this paper proposed the utilization of ECAP plus rolling processing as an innovative approach to potentially address these limitations. herein, effects of ECAP and rolling processing on the microstructures, mechanical properties and strain softening behavior were investigated. It was found that the grain refinement achieved through 1-pass ECAP and 8-pass ECAP processing differed significantly, and subsequent rolling processing can further regulate grain size and dislocation distribution. The 1-pass ECAP plus cold rolling(1p-CR), 1-pass ECAP plus hot-cold rolling(1p-HC), and 8-pass ECAP plus hot-cold rolling(8p-HC) processed alloys exhibited heterostructure characterized by fine grains encircling coarse grains. Additionally, regions with high density dislocations were uniformly distributed alongside regions with low density dislocations. This unique microstructure promoted the accumulation and interaction of dislocation during deformation, resulting in the inhibition of strain softening behavior while maintaining high strength and high elongation. Therefore, the 1p-CR, 1p-HC, and 8p-HC alloys demonstrated excellent formability and mechanical stability while meeting the required mechanical properties for implant materials, which highlight their significant potential for practical applications.

关键词： Zn-Mg alloys ECAP Rolling Mechanical properties Strain softening behavior

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Effects of surface morphology on tribological properties of Arapaima gigas scales

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Friction 2024年第7期12卷 1469-1482页

作者： Shuaijun ZHANG Pengpeng BAI Xiangli WEN chengwei WEN Hui CAO Wanyou YANG Yu TIAN State Key Laboratory of Tribology in Advanced Equipment Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China Key Laboratory of Bionic Engineering(Ministry of Education China)Jilin UniversityChangchun 130022China

The remarkable mechanical adaptability of arapaima(Arapaima gigas)scales has made them an important subject of study.However,no research has been conducted into their tribological properties,which are crucial for the protectability and flexibility of arapaimas.In this study,by combining morphological characterizations,friction experiments,and theoretical analyses,the relationship between the surface morphology and tribological properties of arapaima scales is determined.These results indicate that arapaima scales exhibit varying surface morphologies in different regions.More specifically,the exposed regions of scales feature grooves and a circulus,whereas the covered regions exhibit bumps.The specific surface morphology of arapaima scales produces varying tribological properties across different regions and sliding directions.The unique tribological properties of arapaima scales influence the forces received from predator attacks and neighboring scales,directly influencing the arapaima’s protective capabilities.This study provides new insights into the mechanisms of natural flexible dermal armors,and it has potential applications in personal protective systems.

关键词： arapaima scales surface morphology tribological properties protectability

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High-efficiency preparation of multifunctional conjugated electrospun graphene doped PVDF/CF yarns for energy harvesting and human movement monitoring in TENG textile

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Nano Research 2024年第5期17卷 4478-4488页

作者： Ting Yang chengwei Wan Xiaoyu Zhang Tong Liu Li Niu Jian Fang Yuqing Liu College of Textile and Clothing Engineering Soochow UniversitySuzhou 215123China

Portable power is an effective solution to realize self-powered sensors for wearable devices,promoting future sustainable development.Membrane-based triboelectric nanogenerators(M-TENGs)have emerged as a promising technology for harvesting biomechanical energy from human motion owing to their advantages,such as simple structure,lightweight design,and efficient energy conversion.However,the poor durability,low adaptability,and un-washability of two-dimensional membrane materials have largely hindered their application in wearable electronics.In this study,we propose a sheath-core polyvinylidene fluoride(PVDF)/graphene(G)-carbon fiber(CF)yarn fabricated via conjugate electrospinning,comprising a commercial CF core and an electrospun graphene-doped PVDF sheath,which improves the fatigue resistance of electrospun nanofiber films under prolonged friction and keeps a high degree of freedom.The resulting electronic textile,woven with the large-scale electrospun PVDF/G-CF yarn,demonstrates a remarkable power density of 25.5 mW·m^(-2).The tight distribution of PVDF/G nanofibers on the textile surface ensures excellent softness,washability,and durability.Furthermore,the electrospun PVDF/G-CF textile exhibits significant potential in pressure sensing,self-powered operation,and motion detection,making it highly suitable for wearable electronics applications.

关键词： yarn-based triboelectric nanogenerator(TENG) graphene polyvinylidene fluoride(PVDF) conjugated-electrospinning multifunctional

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The chemical environment and structural ordering in liquid Mg-Y-Zn system:An ab-initio molecular dynamics investigation of melt for the formation mechanism of LPSO structure

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Journal of Magnesium and Alloys 2024年第2期12卷 815-824页

作者： Tangpeng Ma Jin Wang Kaiming Cheng chengwei Zhan Jixue Zhou Jingyu Qin Guochen Zhao Xinfang Zhang Shandong Provincial Key Laboratory of High Strength Lightweight Metallic Materials Advanced Materials InstituteQilu University of Technology(Shandong Academy of Sciences)Jinan 250014China Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials Ministry of EducationShandong UniversityJinan 250061China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China

In an effort to clarify the formation mechanism of LPSO structure in Mg-Y-Zn alloy,the chemical environment and structural ordering in liquid Mg-rich Mg-Y-Zn system are investigated with the aid of ab-initio molecular dynamics simulation.In liquid Mg-rich Mg-Y alloys,the strong Mg-Y interaction is determined,which promotes the formation of fivefold symmetric local structure.For Mg-Zn alloys,the weak Mg-Zn interaction results in the fivefold symmetry weakening in the liquid structure.Due to the coexistence of Y and Zn,the strong attractive interaction is introduced in liquid Mg-Y-Zn ternary alloy,and contributes to the clustering of Mg,Y,Zn launched from Zn.What is more,the distribution of local structures becomes closer to that in pure Mg compared with that in binary Mg-Y and Mg-Zn alloys.These results should relate to the origins of the Y/Zn segregation zone and close-packed stacking mode in LPSO structure,which provides a new insight into the formation mechanism of LPSO structure at atomic level.

关键词： Mg-Y-Zn Chemical environment Structural ordering ab-initio molecular dynamics

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Failure mechanism and safety control technology of a composite strata roadway in deep and soft rock masses:a case study

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Journal of Mountain Science 2024年第7期21卷 2427-2444页

作者： ZHAO chengwei ZHOU Hui SUN Xiaoming ZHANG Yong MIAO Chengyu WANG Jian State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory for GeoMechanics and Deep Underground Engineering China University of Mining and Technology(Beijing)Beijing 100083China School of Mechanics and Civil Engineering China University of Mining and Technology(Beijing)Beijing 100083China

The construction of coal mines often encounters deep composite soft rock roadways,which is characterized by significant deformation and poor stability.To deeply study the failure mechanism and large deformation challenges of a composite strata roadway in deep and soft rock masses,a numerical model of 3DEC tetrahedral blocks was established based on the method of rock quality designation(RQD).The results showed that original support cannot prevent asymmetric failure and large deformation due to the adverse geological environment and unsuitable support design.According to the failure characteristics,a coupling support of“NPR bolt/cable+mesh+shotcrete+steel pipe”was proposed to control the stability of the surrounding rock.The excellent mechanical properties of large deformation(approximately 400 mm)and high constant resistance force(bolt with 180 k N;cable with 350 k N)were evaluated by the tensile tests.The numerical results showed that the maximum deformation was minimized to 243 mm,and the bearing capacity of the surrounding rock of the roadway was enhanced.The field test results showed that the maximum deformation of the surrounding rock was 210 mm,and the forces of the NPR bolt and cable were stable at approximately 180 k N and 350 k N,respectively.This demonstrated the effectiveness of the coupling support with the NPR bolt and cable,which could be a guiding significance for the safety control of large deformation and failure in deep composite soft rock roadways.

关键词： 3DEC Composite strata roadway Soft rock NPR bolt and cable Asymmetric large deformation

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