检索结果-南通市图书馆

Dual-directional regulation of spinal cord injury and the gut microbiota

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第3期19卷 548-556页

作者： Yinjie Cui Jingyi Liu Xiao Lei Shuwen Liu Haixia Chen Zhijian Wei Hongru Li Yuan Yang chenguang zheng Zhongzheng Li Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina School of Medical Technology Tianjin University of Traditional Chinese MedicineTianjinChina Research Center of Experimental Acupuncture Science Tianjin University of Traditional Chinese MedicineTianjinChina International Cooperation and Exchange Office Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina International Cooperation Base of Spinal Cord Injury Tianjin Key Laboratory of Spine and Spinal Cord InjuryDepartment of OrthopedicsTianjin Medical University General HospitalTianjinChina Department of Orthopedics Qilu Hospital of Shandong UniversityJinanShandong ProvinceChina

There is increasing evidence that the gut microbiota affects the incidence and progression of central nervous system diseases via the brain-gut *** spinal cord is a vital important part of the central nervous system;however,the underlying association between spinal cord injury and gut interactions remains *** studies suggest that patients with spinal cord injury frequently experience intestinal dysfunction and gut *** in the gut microbiota can cause disruption in the intestinal barrier and trigger neurogenic inflammatory responses which may impede recovery after spinal cord *** review summarizes existing clinical and basic research on the relationship between the gut microbiota and spinal cord *** research identified three key ***,the gut microbiota in patients with spinal cord injury presents a key characteristic and gut dysbiosis may profoundly influence multiple organs and systems in patients with spinal cord ***,following spinal cord injury,weakened intestinal peristalsis,prolonged intestinal transport time,and immune dysfunction of the intestine caused by abnormal autonomic nerve function,as well as frequent antibiotic treatment,may induce gut ***,the gut microbiota and associated metabolites may act on central neurons and affect recovery after spinal cord injury;cytokines and the Toll-like receptor ligand pathways have been identified as crucial mechanisms in the communication between the gut microbiota and central nervous *** microbiota transplantation,probiotics,dietary interventions,and other therapies have been shown to serve a neuroprotective role in spinal cord injury by modulating the gut *** targeting the gut microbiota or associated metabolites are a promising approach to promote functional recovery and improve the complications of spinal cord injury.

关键词： chemokines cytokines gut microbiota NLRP3 spinal cord injury Toll-like receptor ligand tryptophan

β-Thalassemia mutations among children with anemia in Nanning city,China

在线全文

学校读者我要写书评

暂无评论

β-Thalassemia mutations among children with anemia in Nanni...

第十二次全国医学遗传学学术会议

作者： Sheng He Xuan Shang Dongming Li Qiang Zhang Yanqing Tang Yunli Lai Qiuli Chen chenguang zheng Prenatal Diagnostic Center GuangxiGuangxi Zhuang Automonous Region Women and Children Care Hospital Department of Medical Genetics School of Basical SciencesSouthern Medical University

Introduction:β-Thalassemia is a common genetic disorder in Southern of China. The aim of this retrospective study is to analyze the frequency ofβ-thalassemia among Children in Nanning City,which is one of the biggest cities located in southern of *** and methods:Data from 2685 children with symptoms of anemia were *** blood samples were collected into EDTA-containing tubes and hematological parameters were analyzed using an automatic cell *** performance liquid chromatography technique was used to determine the type of *** screening of theβ-globin gene was performed withβ-Globin Strip ***:Of 2685 cases,929 were diagnosed asβ-*** rates of occurrence reached to 34.60%.A total of 13 kinds of genotype were *** genotypes of CD41-42(-TCTT)/N and CD17(A→T))/N CD41-42(-TCTT)/N and CD17(A→T))/N were most common,with the frequencies of 37.46%) and 25.19%respectively. 10 differentβ-thalassemia mutations were *** mutations in order of frequency were CD41-42(-CTTT)(46.59%),CD17(A→T)(28.03%),IVS-Ⅱ-654(C→T)(8.28%),CD71-72(+A) (6.10%),-28(A→G)(4.82%),CD26(G→A)(3.37%),and IVS-I-1(G→T)(2.27%).Anther three mutations were less frequent or sporadic including CD43(G→T)(0.36%),CD27-28(+C) and -29(A→G).Conclusions:The incidence of mutations of P-thalassemia among children was *** still seem to be a public health issue in Guangxi,China,indicating the government should pay more attention to this disease,and the necessity of a screening thalassemia program is urgent and more important.

关键词： β-thalassemia mutations Children anemia

Diagnosis,Etiology and outcome of Non-Immune Hydrops fetalis in Southern China

在线全文

cnki会议

学校读者我要写书评

暂无评论

Diagnosis,Etiology and outcome of Non-Immune Hydrops fetalis...

第十四次全国医学遗传学学术会议

作者： Sheng He Dahua Meng Qiang zhang Xiaoxian Tian Yunli Lai Yuan Wei Shaoke Chen chenguang zheng Prenatal Diagnostic Center Guangxi Zhuang Automonous Region Women and Children Care Hospital Guangxi Zhuang Automonous Region Women and Children Care Hospital

Objective:To analyze the etiology and outcome of non-immune hydrops fetalis(NIHF)in Southern ***:Data were reviewed for pregnancies diagnosed with NIHF at different gestational ages from 1 January 2007 to 31 December *** data,prenatal interventions,clinical and laboratory findings,outcomes,and the results of post mortem examinations were ***:During the period of study,a total of 482 cases were *** causes of fetal hydrops were identified in 86.9%.Hb Bart’s disease dominated as the main cause of NIHF(61.8%),followed by abnormal chromosomes(13.5%)and cardiovascular defects(8.1%).The underlying etiology remained unknown in 63 cases(12.5%).Four hundred and four cases with hydrops presented after 20 weeks’gestation,including 279 cases of Hb Bart’s disease,35 cases of cardiovascular defect,and 7 cases of *** chromosomes with hydrops mainly presented between 15-19 weeks’*** of pregnancy was performed in 461 ***:The causes of hydrops are in relation to gestational *** Bart’s disease is the most common cause of NIHF in Southern *** effective prenatal screening program for thalassemia should be established in this region.

关键词： Non-immune hydrops fetalis causes Hb Bart’·s disease thalassemia

Prevalence and Genetic analysis of α-and β-thalassemia in the Baise region of southern China

在线全文

cnki会议

学校读者我要写书评

暂无评论

Prevalence and Genetic analysis of α-and β-thalassemia in ...

第十四次全国医学遗传学学术会议

作者： Sheng He Qian Qin Shang Yi Peng Huang Jianping Deng Yuan Wei chenguang zheng Biyan Chen Prenatal diagnostic center Guangxi Zhuang Autonomous Region Women and Children Care Hospital Prenatal diagnostic center Baise Women and Children Care Hospital Guangxi Zhuang Autonomous Region Women and Children Care Hospital

Objective:Thalassemia is one of the most common hereditary blood *** data regarding the occurrence and distribution of thalassemia is important for designing appropriate prevention *** aim of this study is to reveal the prevalence of thalassemia and mutation spectrum in the Baise region of southern *** and methods:A total of 47500 individuals from Baise region were *** parameters were examined and globin genes were ***:Totally,11432(24.07%)subjects were diagnosed as being carriers of thalassemia,including 7290(15.35%)carriers ofα-thalassemia,3152(6.64%)carriers ofβ-thalassemia and 990(2.08%)carriers of bothα-thalassemia andβ-***α-thalassemia mutations with 31 genotypes and 13β-thalassemia mutations with 26 genotypes were identified in theα-andβ-thalassemia carriers,***,the true prevalence of nondeletional mutations and Thailand type(--Thai)deletion mutation were first reported in this *** addition,three cases ofαα/ααα3.7,five cases of HKαα/ααand two rareβ-globin mutations,-86 and Gγ(Aγδβ)0 were first identified in the Baise ***:Our data indicate that there was a high prevalence and extensive spectrum of thalassemias in the *** findings will be useful for genetic counselling and prevention of severe thalassemia in this region.

关键词： Thalassemia Prevalence Molecular spectrum Globin mutation

Heterozygosity for the Southeast Asian a0 -thalassemia deletion(hemoglobin Barts hydrops fetalis)

在线全文

cnki会议

学校读者我要写书评

暂无评论

Heterozygosity for the Southeast Asian a0 -thalassemia delet...

第十二次全国医学遗传学学术会议

作者： Sheng He Dongming Li Qiang Zhang Yanqing Tang Yunli Lai Qiuli Chen Xuan Shang chenguang zheng Prenatal Diagnostic Center GuangxiGuangxi Zhuang Automonous Region Women and Children Care Hospital Department of Medical Genetics School of Basical SciencesSouthern Medical University

Hemoglobin Barts hydrops fetalis syndrome is the most severe and generally fatal clinical phenotype ofα-*** diagnosed a fetus at 12-weeks gestation with having hydrops fetalis by *** studies revealed that the fetus had the hemoglobin Barts hydrops fetalis syndrome due to heterozygote for the Thaiα-thalassemia and SEAα-thalassemia *** gene types of Barts hydrops fetalis are complex in this ***,the detection of further cases might be more careful and should use ultrasound combined with molecular methods. Thaiα-thalassemia should be as a normal test in Guangxi *** Barts hydrops fetalis syndrome is the most severe and generally fatal clinical phenotype ofα-thalassemia,which is due to the deletion of all four functionalα-globin genes of the hemoglobin,resulting in noα-globin chain production(1).This clinical phenotype is most common in Guangxi zhuang automonous region which lies in the south of China,where it is mainly due to homozygosity to an Southeast Asian(SEA) deletion(--EA/--SEA)(2).In this study,we report a case caused by co-inheritance of two differentα-thalassemia defects in this region. Case A couple from Guangxi province of Southern China presented at our center for the first prenatal visit at 12 weeks of *** mother was 23-year-old and her spouse was *** was her second *** years previously,she had the pregnancy,and ended with the delivery of a stillborn hydropic child during the third *** her current pregnancy,sonographic imaging showed the cardiothoracic ration of the fetus was more than 0.5 and the placental thickness was 0.3 cm,mild pericardiac effusion,ascites,placentomegaly (placental depth 40 mm) and middle cerebral artery peak systolic velocity 45.6 cm/*** the fetus had a mild hydrop at 12-weeks *** diagnose the fetus was hydrops *** further study,chorionic villus sampling(CVS) of the fetus were cultured in the first ***

关键词：

Strategy of combining QF-PCR and MLPA for rapid diagnostic Fetal chromosome abnormalities

在线全文

cnki会议

学校读者我要写书评

暂无评论

Strategy of combining QF-PCR and MLPA for rapid diagnostic F...

第十四次全国医学遗传学学术会议

作者： Peng Huang Zefeng Sun Dahua Meng Dongmei Fei Yun Chen Tiansheng Liu chenguang zheng Shaoke Chen Central Laboratory of Genetic and Metabolism MCH Hospital(The Children’ s HospitalObstetrics & Gynecology Hospital)of Guangxi Autonomous Region

Objectives:So far,QF-PCR or MLPA can’t detect all common type of chromosomal abnormalities,to overcome their limitations,it is necessary to establish a novel diagnostic strategy which combines QF-PCR and MLPA for rapid detecting chromosomal *** to polymorphisms and variations of STRs that were observed in different populations,we chose to focus on the investigation of heterozygosities for selected STR ***:84 cases of chromosomal abnormalities were analyzed by QF-PCR and MLPA,respectively.A molecular based strategy for rapid fetal chromosomal abnormalities diagnosis was introduced.2880 prenatal samples were processed by the approach;all these samples were analyzed by conventional karyotyping in *** selected STR markers were calculated from 500 ***:Of all the84 samples,chromosome trisomy were detected by QF-PCR and MLPA,respectively;but polyploidy and mosaic could be detected by QF-PCR only,and monosomy were detected by *** the 2880 samples was successfully tested by new strategy;and the results were confirmed by conventional *** heterozygosities of most STR markers in south Chinese population are lower than those in Western populations,but higher than north Chinese ***:With the rapid diagnostic strategy,fetus chromosomal aneuploidies,polyploidy and mosaic could be diagnosed efficiently and *** strategy results in less labor-intensive,and cost-effective than regular karyotype analysis and other molecular methods.

关键词：

在线全文

cnki会议

学校读者我要写书评

暂无评论

新型凝胶泡沫材料阻化性能实验研究

矿业安全与环保 2021年第6期48卷 30-33,39页

作者：王建国刘鑫郑晨光西安科技大学安全科学与工程学院陕西西安710054

为研究新型凝胶泡沫对煤体阻化作用的效能与影响,基于程序升温实验,对凝胶泡沫处理前后的不同粒径煤样组进行实验,分析煤样升温过程中的耗氧速率、CO与CH_(4)气体体积分数及其产生率,以及凝胶泡沫对煤样的阻化率。研究结果表明:煤的粒... 详细信息

为研究新型凝胶泡沫对煤体阻化作用的效能与影响,基于程序升温实验,对凝胶泡沫处理前后的不同粒径煤样组进行实验,分析煤样升温过程中的耗氧速率、CO与CH_(4)气体体积分数及其产生率,以及凝胶泡沫对煤样的阻化率。研究结果表明:煤的粒径不同,其耗氧速率也不同,经新型凝胶泡沫处理煤样的CO、CH_(4)气体的体积分数及其产生率均明显低于未经处理的煤样;在100℃时,粒径小于0.9 mm煤样的阻化率为59.23%,粒径3~5 mm煤样的阻化率为61.69%,粒径6~10 mm煤样的阻化率为65.63%,各粒径煤样受凝胶泡沫的阻化影响顺序为大粒径>中粒径>小粒径;新型凝胶泡沫材料能有效延缓煤的氧化过程、抑制煤氧复合反应、延迟煤体蓄热进程,对防治煤自燃具有十分积极的作用。

关键词：凝胶泡沫煤自燃阻燃性能标志气体阻化率

同方期刊数据库

在线全文

学校读者我要写书评

暂无评论

热管充液率对高温煤堆内部温度场的影响分析

矿业安全与环保 2021年第3期48卷 39-42页

作者：王建国周侗柱郑晨光西安科技大学安全科学与工程学院陕西西安710054

为了研究热管充液率对热管散热性能及高温煤堆内部温度场的影响,采用实验的方法研究热管插入高温煤堆后煤堆内部的温度场变化,在75~25℃内分析了热管不同充液率条件下煤堆内部高温点的降温速率,研究了热管对煤堆内部温度场的影响。研究... 详细信息

为了研究热管充液率对热管散热性能及高温煤堆内部温度场的影响,采用实验的方法研究热管插入高温煤堆后煤堆内部的温度场变化,在75~25℃内分析了热管不同充液率条件下煤堆内部高温点的降温速率,研究了热管对煤堆内部温度场的影响。研究结果表明:热管可以有效地破坏煤堆内部蓄热环境,其作用效果可分为3个阶段,分别为大幅降温阶段、过渡阶段、稳定阶段;充液率对热管的传热性能有明显影响,热管充液率为40%时,煤堆内部高温点的降温速率最大为9.92℃/h,充液率为10%、30%时热管传热能力次之,充液率为20%时热管传热能力最差;热管对煤堆内部3个水平面温度场的影响有显著差异,在上水平面和中水平面主要依靠热管管壁传热,在下水平面主要依靠热管工质相变传热。

关键词：热管充液率煤堆煤自燃氧化蓄热温度场

冷凝段翅片类型对热管抑制煤自燃的降温效应影响研究

在线全文

学校读者我要写书评

暂无评论

矿业安全与环保 2020年第5期47卷 13-17页

作者：王建国郑晨光王延秋西安科技大学安全科学与工程学院陕西西安710054

为了研究热管冷凝段翅片类型对抑制煤自燃的降温效应的影响,实验研究了将热管插入加热煤堆后的降温效应。采用碳钢-水重力热管,在温度为75~20℃内,研究了不同冷凝段结构的热管对煤堆内部温度的影响,探讨了热管对煤堆内部温度场的影响规... 详细信息

为了研究热管冷凝段翅片类型对抑制煤自燃的降温效应的影响,实验研究了将热管插入加热煤堆后的降温效应。采用碳钢-水重力热管,在温度为75~20℃内,研究了不同冷凝段结构的热管对煤堆内部温度的影响,探讨了热管对煤堆内部温度场的影响规律。研究结果表明:相同时间段内弯曲垂直翅片热管作用下高温煤体在50℃前后降温速率衰减幅度为64.98%,大于无翅片、垂直翅片和圆形翅片3种热管作用下的煤体降温速率衰减幅度,即弯曲垂直翅片热管移热降温效果最好;弯曲垂直翅片热管对煤堆内部3个水平面温度场的影响有明显差异,在下水平面主要为热管工质相变移热,在中水平面及上水平面主要为热管管壁移热。

关键词：热管煤自燃翅片类型抑制移热降温效应