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Simulation of the Ecosystem Productivity Responses to Aerosol Diffuse Radiation Fertilization Effects over the Pan-Arctic during 2001–19

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Advances in Atmospheric Sciences 2024年第1期41卷 84-96页

作者： Zhiding ZHANG Xu YUE Hao ZHOU Jun ZHU Yadong LEI chenguang tian Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and EngineeringNanjing University of Information Science&Technology(NUIST)Nanjing 210044China Climate Change Research Center Institute of Atmospheric Physics(IAP)Chinese Academy of Sciences(CAS)Beijing 100029China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Severe Weather&Key Laboratory of Atmospheric Chemistry of CMA Chinese Academy of Meteorological SciencesBeijing 100081China

The pan-Arctic is confronted with air pollution transported from lower *** have shown that aerosols help increase plant photosynthesis through the diffuse radiation fertilization effects(DRFEs).While such DRFEs have been explored at low to middle latitudes,the aerosol impacts on pan-Arctic ecosystems and the contributions by anthropogenic and natural emission sources remain less ***,we perform regional simulations at 0.2o×0.2ousing a well-validated vegetation model(Yale Interactive terrestrial Biosphere,YIBs)in combination with multi-source of observations to quantify the impacts of aerosol DRFEs on the net primary productivity(NPP)in the pan-Arctic during *** show that aerosol DRFEs increase pan-Arctic NPP by 2.19 Pg C(12.8%)yr^(-1)under clear-sky conditions,in which natural and anthropogenic sources contribute to 8.9% and 3.9%,*** all-sky conditions,such DRFEs are largely dampened by cloud to only 0.26 Pg C(1.24%)yr^(-1),with contributions of 0.65% by natural and 0.59% by anthropogenic *** aerosols cause a positive NPP trend of 0.022% yr^(-1)following the increased fire activities in the *** contrast,anthropogenic aerosols induce a negative trend of-0.01% yr^(-1)due to reduced emissions from the middle *** trends in aerosol DRFEs show a turning point in the year of 2007 with more positive NPP trends by natural aerosols but negative NPP trends by anthropogenic aerosols *** affected by modeling uncertainties,this study suggests a likely increasing impact of aerosols on terrestrial ecosystems in the pan-Arctic under global warming.

关键词： diffuse radiation fertilization effects anthropogenic aerosols natural aerosols pan-Arctic net primary productivity

Increasing impacts of fire air pollution on public and ecosystem health

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The Innovation 2024年第3期5卷 11-12页

作者： Xu Yue Yihan Hu chenguang tian Rongbin Xu Wenhua Yu Yuming Guo Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologyNanjing 210044China School of Environmental Science and Engineering Nanjing University of Information Science&TechnologyNanjing 210044China Climate Air Quality Research UnitSchool of Public Health and Preventive MedicineMonash UniversityMelbourneVIC 3004Australia

Wildfire episodes have become more frequent and severe in recent years.1 Record-breaking fires devastated the Arctic,Amazon,and Australia in 2019–*** year,fires began in Canada in May and lasted for several months,resulting in an area burned of 16.5 million hectares by early *** size is 6–7 times the annual fire area for a normal year in *** favorable fire weather for burning and spread lasted for months(https://***/maps/fw).Furthermore,most Canadian fires occur in remote regions far from firefighting facilities,causing fire extinction to be ***,such“unprecedented”fire events occurred routinely in boreal regions between 2020 and 2023,although the locations varied from year to year(Figure 1).

关键词： Canada pollution Figure

Clinical Outcome of Internal Fixation and Fusion in the Treatment of Spinal Fractures by Paraspinal Muscular Space Approach

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Journal of Clinical and Nursing Research 2024年第7期8卷 10-15页

作者： Yafei Zhao Qiushuang Ma Meng Zhang Shengwang Li Yannan Li chenguang tian Baoding No.1 Hospital of TCM Baoding 071000Hebei ProvinceChina Baoding No.1 Central Hospital Baoding 071000Hebei ProvinceChina

Objective:To explore the clinical effect of internal fixation and fusion with the paraspinal muscle gap approach in the treatment of spinal fracture ***:104 spinal fracture patients admitted to Central Hospital of TCM from October 2022 to April 2024 were selected as the study subjects and were randomly divided into the control group(n=52)and the observation group(n=52)according to the random number table *** control group was treated with the conventional approach of internal fixation surgery,and the observation group was treated with the paraspinal muscular interspace approach of internal fixation *** two groups’general data,surgical indexes,pain,lumbar spine function,and postoperative complications were ***:The baseline data of the two groups of patients were not statistically significant(all P>0.05)while the intraoperative bleeding,the first postoperative time getting up from bed,and the length of hospital stay of the patients in the observation group were shorter than that of the control group(all P=0.000<0.001),and the duration of the operation was longer than that of the control group(t=2.644,P=0.010<0.05);at 3 months postoperatively,the VAS scores of the patients in the observation group were significantly lower than those in the control group(t=10.768,P=0.000<0.001),and the JOA score was higher than that of the control group(t=6.498,P=0.000<0.001);the total complication rate of patients in the observation group(3/5.77%)was significantly lower than that of the control group(12/23.08%)(χ^(2)=6.310,P=0.012<0.05).Conclusion:In the treatment of spinal fracture patients,compared with the conventional approach to internal fixation surgery,the paraspinal muscular gap approach to internal fixation and fusion treatment is less traumatic,postoperative lumbar spine function recovery is faster,and can reduce the incidence of postoperative complications.

关键词： Paraspinal muscular interspace approach Fixation and fusion Spinal fracture

硝苯地平联合盐酸利托君治疗早产胎膜早破患者的疗效及其对外周血炎症细胞因子的影响

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广西医学 2024年第4期46卷 519-523页

作者：高静张家宽邢书琴田晨光衡水市第四人民医院病区药房河北省衡水市053000 衡水市第四人民医院妇产科河北省衡水市053000

目的探讨硝苯地平联合盐酸利托君治疗早产胎膜早破(PROM)患者的疗效及其对外周血炎症细胞因子的影响。方法选取146例早产PROM患者作为研究对象,采用随机数字表法将患者分为研究组与常规组,各73例。给予常规组硫酸镁注射液及盐酸利托君... 详细信息

目的探讨硝苯地平联合盐酸利托君治疗早产胎膜早破(PROM)患者的疗效及其对外周血炎症细胞因子的影响。方法选取146例早产PROM患者作为研究对象,采用随机数字表法将患者分为研究组与常规组,各73例。给予常规组硫酸镁注射液及盐酸利托君片治疗,在常规组基础上,给予研究组硝苯地平治疗。比较两组疗效、母婴相关指标(宫缩抑制时间、孕龄延长时间、新生儿Apgar评分、新生儿出生体重)、治疗前后炎症细胞因子[高迁移率族蛋白B1(HMGB1)、可溶性Toll样受体4(sTLR4)、氧化型α1⁃抗胰蛋白酶(ox⁃AAT)]水平,以及新生儿并发症发生率、治疗期间患者不良反应发生情况。结果研究组的总有效率高于常规组,宫缩抑制时间短于常规组,孕龄延长时间长于常规组,新生儿Apgar评分、出生体重高于或大于常规组(P0.05)。结论硝苯地平联合盐酸利托君治疗早产PROM患者,可延长孕龄时间,缓解炎症反应,改善妊娠结局,且未明显增加不良反应。

关键词：胎膜早破早产硝苯地平盐酸利托君硫酸镁炎症因子妊娠结局

椎间孔镜靶向单通道髓核摘除术对腰椎融合术后相邻节段椎间盘突出症的临床运用分析

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西部医学 2024年第4期36卷 534-538页

作者：赵亚飞田斌武马秋双张猛田晨光李亚楠李生旺保定市第一中医院骨科河北保定071000 保定市第一中心医院病理科河北保定071000

目的探讨椎间孔镜靶向单通道髓核摘除术(TO-PTED)对腰椎融合术后相邻节段椎间盘突出症(LDH)的临床运用。方法选取2018年1月—2021年3月在我院行TO-PTED的45例腰椎融合术后相邻节段LDH患者为观察组,另随机选取同期在我院行椎板间开窗髓... 详细信息

目的探讨椎间孔镜靶向单通道髓核摘除术(TO-PTED)对腰椎融合术后相邻节段椎间盘突出症(LDH)的临床运用。方法选取2018年1月—2021年3月在我院行TO-PTED的45例腰椎融合术后相邻节段LDH患者为观察组,另随机选取同期在我院行椎板间开窗髓核摘除术的45例腰椎融合术后相邻节段LDH患者为对照组。比较两组患者的围手术期临床资料、手术前后的视觉模拟评分(VAS)、日本骨科协会评分(JOA)、影像学资料,采用改良MacNab标准来进行疗效的评价。结果观察组患者的手术时长、术中失血量、住院天数均显著低于对照组,术中X线透视次数、临床优良率显著高于对照组(P0.05)。结论TO-PTED能明显缓解腰椎融合术后相邻节段LDH患者的疼痛状况,促进腰椎功能的恢复,具有创伤小、术中失血量少、术后恢复快等优点,疗效优于传统的椎板间开窗髓核摘除术,可在临床推广应用。

关键词：椎间盘突出症椎间孔镜靶向单通道髓核摘除术临床疗效

Comparison of Ozone and PM2.5 Concentrations over Urban,Suburban,and Background Sites in China

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Advances in Atmospheric Sciences 2020年第12期37卷 1297-1309,I0001-I0004页

作者： Lan GAO Xu YUE Xiaoyan MENG Li DU Yadong LEI chenguang tian Liang QIU Climate Change Research Center Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environment Science and EngineeringNanjing University of Information Science&TechnologyNanjing 210044China China National Environmental Monitoring Center Beijing 100012China School of Atmospheric Sciences Chengdu University of Information and TechnologyChengdu 610225China

Surface ozone(O3)and fine particulate matter(PM2.5)are dominant air pollutants in *** of these pollutants can show significant differences between urban and nonurban ***,such contrast has never been explored on the country *** study investigates the spatiotemporal characteristics of urban-to-suburban and urban-tobackground difference for O3(Δ[O3])and PM2.5(Δ[PM2.5])concentrations in China using monitoring data from 1171 urban,110 suburban,and 15 background sites built by the China National Environmental Monitoring Center(CNEMC).On the annual mean basis,the urban-to-suburbanΔ[O3]is−3.7 ppbv in Beijing-tianjin-Hebei,1.0 ppbv in the Yangtze River Delta,−3.5 ppbv in the Pearl River Delta,and−3.8 ppbv in the Sichuan *** the contrary,the urban-to-suburbanΔ[PM2.5]is 15.8,−0.3,3.5 and 2.4μg m^−3 in those areas,*** urban-to-suburban contrast is more significant in winter for bothΔ[O3]andΔ[PM2.5].In eastern China,urban-to-background differences are also moderate during summer,with−5.1 to 6.8 ppbv forΔ[O3]and−0.1 to 22.5μg m^−3 forΔ[PM2.5].However,such contrasts are much larger in winter,with−22.2 to 5.5 ppbv forΔ[O3]and 3.1 to 82.3μg m^−3 forΔ[PM2.5].Since the urban region accounts for only 2%of the whole country’s area,the urban-dominant air quality data from the CNEMC network may overestimate winter[PM2.5]but underestimate winter[O3]over the vast domain of *** study suggests that the CNEMC monitoring data should be used with caution for evaluating chemical models and assessing ecosystem health,which require more data outside urban areas.

关键词： ozone PM2.5 urban suburban background

An MPXV mRNA-LNP vaccine candidate elicits protective immune responses against monkeypox virus

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Chinese Chemical Letters 2024年第8期35卷 466-470页

作者： Yuxin tian Mengjun Li Yang Yang Chunhui Li Yun Peng Haiyin Yang Mengyuan Zhao Pengfei Wu Shaobo Ruan Yuanyu Huang chenguang Shen Minghui Yang Advanced Research Institute of Multidisciplinary Science School of Life ScienceKey Laboratory of Molecular Medicine and BiotherapyBeijing Institute of TechnologyBeijing 100081China BSL-3 Laboratory(Guangdong) Guangdong Provincial Key Laboratory of Tropical Disease ResearchSchool of Public HealthDepartment of Laboratory MedicineZhujiang HospitalSouthern Medical UniversityGuangzhou 510280China National Clinical Research Center for infectious disease Shenzhen Third People’s HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518112China

The monkeypox virus(MPXV)outbreak,declared a Public Health Emergency of International Concern(PHEIC)by the World Health Organization(WHO)in 2022,continues to pose a significant threat due to the absence of vaccines or drugs for MPXV *** this study,we developed an mRNA vaccine that expressing the A29L antigen,a specific protein of the intracellular mature *** vaccine utilizes a thermostable ionizable lipid nanoparticle(iLNP)platform and has been administered to *** find-ings demonstrate that the MPXV A29L mRNA vaccine candidate induces robust cross-neutralizing immune responses against both vaccinia virus(VACV)and MPXV live ***,immunization with the vaccine candidate provided protection against the VACV challenge in *** findings underscore the potential of mRNA-LNP vaccines as safe and effective candidates against monkeypox *** the current absence of specific interventions for MPXV infection,our study represents a significant step forward in developing a viable solution to combat this ongoing public health threat.

关键词： Monkeypox virus mRNA vaccine Lipid-nano particle A29L VACV

Aptamers targeting SARS-CoV-2 nucleocapsid protein exhibit potential ant1ip1 an-coronavirus activity

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1186-1198页

作者： Minghui Yang Chunhui Li Guoguo Ye chenguang Shen Huiping Shi Liping Zhong Yuxin tian Mengyuan Zhao Pengfei Wu Abid Hussain tian Zhang Haiyin Yang Jun Yang Yuhua Weng Xinyue Liu Zhimin Wang Lu Gan Qianyu Zhang Yingxia Liu Ge Yang Yuanyu Huang Yongxiang Zhao School of Life Science Advanced Research Institute of Multidisciplinary ScienceKey Laboratory of Molecular Medicine and BiotherapyBeijing Institute of TechnologyBeijing 100081China National Clinical Research Center for infectious disease Shenzhen Third People’s HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518112China Guangdong Provincial Key Laboratory of Tropical Disease Research School of Public HealthSouthern Medical UniversityGuangzhou 510515China State Key Laboratory of Targeting Oncology National Center for International Research of Biotargeting TheranosticsGuangxi Key Laboratory of Biotargeting TheranosticsCollaborative Innovation Center for Targeting Tumor Diagnosis and TherapyGuangxi Medical UniversityNanning 530021China CAMS Key Laboratory of Antiviral Drug Research Beijing Key Laboratory of Antimicrobial AgentsInstitute of Medicinal BiotechnologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Emerging and recurrent infectious diseases caused by human coronaviruses(HCoVs)continue to pose a significant threat to global public health *** light of this ongoing threat,the development of a broad-spectrum drug to combat HCoVs is an urgently ***,we report a series of anti-pan-coronavirus ssDNA aptamers screened using Systematic Evolution of Ligands by Exponential Enrichment(SELEX).These aptamers have nanomolar affinity with the nucleocapsid protein(NP)of Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and also show excellent binding efficiency to the N proteins of both SARS,MERS,HCoV-OC43 and-NL63 with affinity KD values of 1.31 to 135.36 *** aptamer-based therapeutics exhibited potent antiviral activity against both the authentic SARS-CoV-2 prototype strain and the Omicron variant(BA.5)with EC50 values at 2.00 nM and 41.08 nM,*** protein docking analysis also evidenced that these aptamers exhibit strong affinities for N proteins of pan-coronavirus and other HCoVs(−229E and-HKU1).In conclusion,we have identified six aptamers with a high pan-coronavirus antiviral activity,which could potentially serve as an effective strategy for preventing infections by unknown coronaviruses and addressing the ongoing global health threat.

关键词： acute threat conclusion

Multimodel ensemble projection of photovoltaic power potential in China by the 2060s

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大气和海洋科学快报:英文版 2023年第5期16卷 102-107页

作者： Xu Zhao Xu Yue chenguang tian Hao Zhou Bin Wang Yuwen Chen Yuan Zhao Weijie Fu Yihan Hu Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Colaborative Innovation Center of Atmospheric Environment and Equipment Technology School of Environmental Science and EngineeringNanjing University of Information Science&Technology(NUIST)NanjingChina Climate Change Research Center Institute of Atmospheric Physics(IAP)Chinese Academy of Sciences(CAS)BeijingChina University of Chinese Academy of Sciences BejingChina

为了实现能源转型的目标,中国对太阳能的需求一直在极速增长.然而,太阳能发电潜力受到天气条件的影响并预期在气候变暖背景下发生改变.本文中,作者利用第六次国际耦合模式比较计划(CMIP6)24个气候模式的气象变量以及4个不同形式的光伏模... 详细信息

为了实现能源转型的目标,中国对太阳能的需求一直在极速增长.然而,太阳能发电潜力受到天气条件的影响并预期在气候变暖背景下发生改变.本文中,作者利用第六次国际耦合模式比较计划(CMIP6)24个气候模式的气象变量以及4个不同形式的光伏模型,预估了在2060年代低排放或高排放情况下中国的光伏发电潜力.多模式集合平均光伏功率在2004-2014年为277.2KWhm-2yr-1,并呈现出从西到东的下降趋势.到2054-2064年,在低排放情景下,全国平均光伏发电潜力将增加2.29%,而在高排放情景下则减少0.43%.低排放情景的排放控制大大增强了地表太阳辐射,促进了东部的光伏发电.相反,在高排放情景下,强烈的变暖对光伏发电产生了抑制作用.极端暖事件使光伏发电潜力在低排放情景下降低0.28%,而高排放情景下降低0.44%,分别相当于当代损失量的两倍和三倍.预估表明排放控制带来的清洁空气和适度变暖对中国未来的太阳能利用是有益的.

关键词：光伏发电气候变化极端暖事件第六次国际耦合模式比较计划集合预估