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Epigenetic regulation of the inflammatory response in stroke

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Neural Regeneration Research 2025年第11期20卷 3045-3062页

作者： Jingyi Liang Fei yang Zixiao Li Qian Li School of Basic Medical Sciences Capital Medical UniversityBeijingChina Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Laboratory for Clinical Medicine Beijing Key Laboratory of Neural Regeneration and RepairCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina Department of Biochemistry and Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Beijing Key Laboratory of Cancer Invasion and Metastasis Research Capital Medical UniversityBeijingChina

Stroke is classified as ischemic or hemorrhagic,and there are few effective treatments for either *** mechanisms play a critical role in secondary brain injury following a stroke,which manifests as cytokine release,blood–brain barrier disruption,neuronal cell death,and ultimately behavioral *** the inflammatory response has been shown to mitigate this cascade of events in experimental stroke ***,in clinical trials of anti-inflammatory agents,longterm immunosuppression has not demonstrated significant clinical benefits for *** may be attributable to the dichotomous roles of inflammation in both tissue injury and repair,as well as the complex pathophysiologic inflammatory processes in *** acute harmful inflammatory responses or inducing a phenotypic shift from a pro-inflammatory to an anti-inflammatory state at specific time points after a stroke are alternative and promising therapeutic *** agents that can modulate inflammation requires a detailed understanding of the inflammatory processes of ***,epigenetic reprogramming plays a crucial role in modulating post-stroke inflammation and can potentially be exploited for stroke *** this review,we summarize current findings on the epigenetic regulation of the inflammatory response in stroke,focusing on key signaling pathways including nuclear factor-kappa B,Janus kinase/signal transducer and activator of transcription,and mitogen-activated protein kinase as well as inflammasome *** also discuss promising molecular targets for stroke *** evidence to date indicates that therapeutic targeting of the epigenetic regulation of inflammation can shift the balance from inflammation-induced tissue injury to repair following stroke,leading to improved post-stroke outcomes.

关键词： DNA methylation histone modification intracerebral hemorrhage ischemic stroke neuroinflammation neuroprotection non-coding RNA RNA methylation subarachnoid hemorrhage treatment

Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin yang Yu-Wen Alvin Huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

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某低品位高铁铝土矿焙烧-碱浸预脱硅试验

有色金属（冶炼部分） 2025年第1期 77-83,118页

作者：张笑天徐璐李超李昃霖杨耀辉徐莺冀成庆中国地质科学院矿产综合利用研究所成都610041 自然资源部战略性矿产综合利用工程技术创新中心成都610041

针对云南某地铝土矿低铝、高硅和高铁的特点,采用焙烧—碱浸预脱硅工艺,获得高铝硅比铝精矿。考察焙烧温度、焙烧时间、碱液Na_(2)O浓度、碱浸时间、液固比对预脱硅效果的影响。在焙烧温度1050℃,焙烧时间30 min,浸出剂Na_(2)O浓度80 g... 详细信息

针对云南某地铝土矿低铝、高硅和高铁的特点,采用焙烧—碱浸预脱硅工艺,获得高铝硅比铝精矿。考察焙烧温度、焙烧时间、碱液Na_(2)O浓度、碱浸时间、液固比对预脱硅效果的影响。在焙烧温度1050℃,焙烧时间30 min,浸出剂Na_(2)O浓度80 g/L,碱浸时间90 min,液固比L/S=8 mL/g的最佳预脱硅条件下,可将低品位铝土矿的铝硅比由4.08提升至17.98,脱硅率高达77.31%,同时预脱硅精矿氧化铝相对溶出率可达94.56%,溶出效果理想。结合热重-示差扫描量热、X射线衍射分析、红外光谱等多种表征手段,分析了焙烧—碱浸预脱硅机理,该铝土矿铝硅比的提高得益于原矿中高岭土类硅酸盐矿物通过焙烧可转化为碱溶性的无定型SiO_(2),采用常压碱浸即可实现铝硅高效分离,获得高铝硅比的铝精矿。

关键词：铝土矿焙烧碱浸预脱硅

乡村振兴背景下涉农专业人才培养目标构建及实践探索

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西南林业大学学报（社会科学） 2019年第2期3卷 89-92页

作者：戴庆敏吕耀平徐传保李柱李季衡杨承清丽水学院浙江丽水323000 山东农业大学山东泰安271000

乡村振兴战略对高校涉农专业人才的培养提出了新的要求,结合当下地方高校涉农专业人才培养的现状,提出构建"一懂两爱三有四得"人才培养目标,通过涉农专业大学生四年的培养过程中构建"认知(C)-深化(D)-提升(P)-升华(S)"模式"培养模式,在... 详细信息

乡村振兴战略对高校涉农专业人才的培养提出了新的要求,结合当下地方高校涉农专业人才培养的现状,提出构建"一懂两爱三有四得"人才培养目标,通过涉农专业大学生四年的培养过程中构建"认知(C)-深化(D)-提升(P)-升华(S)"模式"培养模式,在理论和实践教学中采用"I-V-S-S"教学实践,为进一步适应时代需要的人才培养提出相应对策。

关键词：乡村振兴涉农专业人才培养目标

Review of condition monitoring and fault diagnosis for marine power systems

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Transportation Safety and Environment 2021年第2期3卷 85-102页

作者： Xiaojian Xu Xinping Yan Kun yang Jiangbin Zhao Chenxing Sheng chengqing Yuan China Waterborne Transport Research Institute 100088 BeijingChina Reability Engineering Institute School of Energy and Power EngineeringWuhan University of TechnologyWuhan430063 HubeiChina National Engineering Research Center for Water Transport Safety Wuhan University of TechnologyWuhan430063 HubeiChina

The use of condition monitoring and fault diagnosis(CMFD)in marine power systems significantly influences ship *** study divides the development of CMFD for marine power systems into three periods and reviews the content,state and limitations of CMFD research for each *** to the research achievements and engineering experience of the authors’team,typical application cases are introduced for CMFD in ships,including CMFD platforms on engineering ships,salvage ships,container ships and ro-ro ships powered by solar photovoltaic ***,prospective research directions are proposed for CMFD in marine power systems,considering the research status of CMFD and the trend toward intelligent and eco-friendly ships.

关键词： marine power system condition monitoring fault diagnosis new energy ships

A Comparison of Co-temporal Vector Magnetograms Obtained with HMI/SDO and SP/Hinode

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Research in Astronomy and Astrophysics 2023年第12期23卷 175-183页

作者： Mei Zhang Haocheng Zhang chengqing Jiang National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Astronomy and Space Sciences University of Chinese Academy of SciencesBeijing 100049China High Altitude Observatory National Center for Atmospheric Research3080 Center Green DriveBoulderCO 80301USA Jericho High School 99 Cedar Swamp RoadJerichoNY 11753USA School of Space and Environment Beihang UniversityBeijing 100091China

Accurate measurement of magnetic fields is very important for understanding the formation and evolution of solar magnetic ***,there are two types of solar magnetic field measurement instruments:filter-based magnetographs and Stokes *** former gives high temporal resolution magnetograms and the latter provides more accurate measurements of magnetic *** the magnetograms obtained by filter-based magnetographs with those obtained by Stokes polarimeters is a good way to combine the advantages of the two *** previous studies have shown that,compared to the magnetograms obtained by the Spectro-Polarimeter(SP)on board Hinode,those magnetograms obtained by both the filter-based Solar Magnetic Field Telescope(SMFT)of the Huairou Solar Observing Station and by the filter-based Michelson Doppler Imager(MDI)aboard SOHO have underestimated the flux densities in their magnetograms and systematic center-to-limb variations present in the magnetograms of both ***,using a sample of 75 vector magnetograms of stable alpha sunspots,we compare the vector magnetograms obtained by the Helioseismic and Magnetic Imager(HMI)aboard Solar Dynamics Observatory(SDO)with co-temporal vector magnetograms acquired by SP/*** analysis shows that both the longitudinal and transverse flux densities in the HMI/SDO magnetograms are very close to those in the SP/Hinode magnetograms and the systematic center-to-limb variations in the HMI/SDO magnetograms are very *** study suggests that using a filter-based magnetograph to construct a low spectral resolution Stokes profile,as done by HMI/SDO,can largely remove the disadvantages of the filter-type measurements and yet still possess the advantage of high temporal resolution.

关键词： The Sun-Sun magnetic fields-Sun photosphere-(Sun:)sunspots

Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions

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Neural Regeneration Research 2025年第7期20卷 2116-2128页

作者： Yuxue Mu Ning Zhang Dongyu Wei Guoqing yang Lilingxuan Yao Xinyue Xu yang Li Junhui Xue Zuoming Zhang Tao Chen Aerospace Clinical Medical Center School of Aerospace MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Aviation Medicine Xijing HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Emergency Medicine Wuhan No.1 HospitalWuhanHubei ProvinceChina Third Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Fourth Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina

A microgravity environment has been shown to cause ocular damage and affect visual acuity,but the underlying mechanisms remain ***,we established an animal model of weightlessness via tail suspension to examine the pathological changes and molecular mechanisms of retinal damage under *** 4 weeks of tail suspension,there were no notable alterations in retinal function and morphology,while after 8 weeks of tail suspension,significant reductions in retinal function were observed,and the outer nuclear layer was thinner,with abundant apoptotic *** investigate the mechanism underlying the degenerative changes that occurred in the outer nuclear layer of the retina,proteomics was used to analyze differentially expressed proteins in rat retinas after 8 weeks of tail *** results showed that the expression levels of fibroblast growth factor 2(also known as basic fibroblast growth factor)and glial fibrillary acidic protein,which are closely related to Müller cell activation,were significantly *** addition,Müller cell regeneration and Müller cell gliosis were observed after 4 and 8 weeks,respectively,of simulated *** findings indicate that Müller cells play an important regulatory role in retinal outer nuclear layer degeneration during weightlessness.

关键词： glial fibrous acidic protein gliosis Müller cells nerve growth factor neural differentiation neurodegeneration proteomic retinal degeneration retinal outer nuclear layer simulated weightlessness

Insight into the Lubrication Performance of Biomimetic Porous Structure Material for Water-lubricated Bearings

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Journal of Bionic Engineering 2023年第5期20卷 1905-1916页

作者： Xuefei Li Zhiwei Guo Qiren Huang chengqing Yuan School of Transportation and Logistics Engineering Wuhan University of TechnologyWuhan430063China National Engineering Research Center for Water Transport Safety Reliability Engineering InstituteWuhan430063China

Water-lubricated bearings have great advantages in the application of ship tail bearings due to the characteristics of green,pollution-free,and ***,the poor wettability of water-lubricated materials,as well as the low viscosity and poor load-carrying capacity of water,resulting in poor lubricating film integrity and short material service life under low-speed,heavy-load,start-stop conditions,which limits its *** study the relationship between wettability and lubrication state and improve the lubrication performance of Si_(3)N_(4) under water lubrication conditions,the characteristic parameters that determine the hydrophilicity of Sphagnum were detected and extracted,and the bionic Si_(3)N_(4) model was established using Material ***,the molecular dynamic behavior and tribological properties of different Si_(3)N_(4) models were simulated and *** structure affects the spreading and storage of water on the material surface and changes the wettability of the *** the condition of water lubrication,better wettability and water storage promote the formation of water film,effectively improve the lubrication state of the material,and improve its bearing performance.

关键词： Molecular dynamic Water-lubricated bearing Wettability Friction

Friction reduction behavior of oil-infused natural wood

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Friction 2022年第11期10卷 1824-1837页

作者： Shutian LIU Conglin DONG chengqing YUAN Xiuqin BAI School of Transportation and Logistics Engineering Wuhan University of TechnologyWuhan 430063China Key Laboratory of Marine Power Engineering&Technology(Ministry of Transport) Wuhan University of TechnologyWuhan 430063China Polymer Technology Department of Mechanical EngineeringEindhoven University of TechnologyEindhoven 5600 MBthe Netherlands

Natural materials tend to exhibit excellent performance in the engineering field because of their structure and special functions.A natural red willow,called natural porous wood material(NPWM),was found,and wear tests were conducted to determine its potential as an oil-impregnated material by utilizing its special porous *** treatment was adopted to improve the NPWM properties for absorbing and storing lubricating *** different contributions of soaking and fluorination-soaking treatments on the tribological properties of NPWMs and their respective mechanism of effect were *** results showed that the fluorination-soaking treatment helped absorb and store sufficient lubricating oil in the NPWM porous structure;therefore,more lubricating oil would be squeezed out and function as a tribol-film between contacting surfaces during the friction process,thus ultimately contributing to stable and smooth wear responses even under prolong ***,the formation of an oil-in-water emulsion,caused by the buoyancy effect,destroyed the oil films on the worn NPWM surface in a water environment,resulting in higher coefficients of friction(COFs)under water conditions than under dry friction,even after the fluorination-soaking *** knowledge gained herein could not only verify the potential of NPWM as an excellent oil-impregnated material in the engineering field but also provide a new methodology for the design of artificial porous materials with stable and smooth friction processes.

关键词： natural porous material oil infusion treatment fluorination frictional behaviors