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Nitrous oxide reductase gene (nosZ) and N_2O reduction along the littoral gradient of a eutrophic freshwater lake

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Journal of Environmental Sciences 2013年第1期25卷 44-52页

作者： Chaoxu Wang Guibing Zhu Yu Wang Shanyun Wang chengqing Yin State Key Laboratory of Environmental Aquatic Quality Research Center for Eco-Environmental SciencesChinese Academy of Sciences University of Chinese Academy of Sciences State Key Laboratory of Urban Water Resource and Environment Harbin Institute of Technology

Lake littoral zones are characterized by heterogeneity in the biogeochemistry of nutrient elements. This study aimed to explore the relationship between the nitrous oxide reductase gene （nosZ）-encoding denitrifier community composition/abundance and N2O reduction. Five samples （deep sediment, near-transition sediment, transition site, near-transition land and land soil） were collected along a littoral gradient of eutrophic Baiyangdian Lake, North China. To investigate the relationship between the nosZ-encoding denitrifier community structure and N20 reduction, the nosZ-encoding denitrifier community composition/abundance, potential denitrification rate （DNR） and potential N20 production rate （pN20） were investigated using molecular biological technologies and laboratory incubation experiments. The results showed that the average DNR of sediments was about 25 times higher than that of land soils, reaching 282.5 nmol N/（g dry weight （dw）.hr） and that the average pN20 of sediments was about 3.5 times higher than that of land soils, reaching 15.7 nmol N/（g dw-hr）. In the land area, the nosZ gene abundance showed a negative correlation with the N20/（N20＋N2） ratio, indicating that nosZ gene abundance dominated N20 reduction both in the surface soils of the land area and in the soil core of the transition site. Phylogenetic analysis showed that all the nosZ sequences recovered from sediment clustered closely with the isolates Azospirillum largimobile and Azospirillum irakense affiliated to Rhodospirillaceae in alpha-Proteobacteria, while about 92.3% （12/13） of the nosZ sequences recovered from land soil affiliated to Rhizobiaceae and Bradyrhizobiaceae in a-Proteobacteria. The community composition of nosZ gene-encoding denitrifiers appeared to be coupled with N20 reduction along the littoral gradient.

关键词： littoral gradient N2O reduction nosZ gene abundance community composition

Assessment model for tribological property of ceramic/stainless steel rubbing pairs in H_2O_2 solution

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Science China(Technological Sciences) 2013年第12期56卷 3017-3023页

作者： DONG CongLin YUAN chengqing LI Jian YAN XinPing School of Energy and Power Engineering Wuhan University of Technology Key Laboratory of Marine Power Engineering & Technology of Ministry of Communications Wuhan University of Technology Wuhan Research Institute of Materials Protection

The tribological properties of ZrO2 ceramic and 1Cr18Ni9Ti stainless steel rubbing pairs were investigated using a special tribo-tester under different concentrations of hydrogen peroxide (H2O2) *** comparison analyses of the friction coefficients,worn volume rates,worn particles and surface roughness were conducted under the tested *** were significant differences of the tribological properties of the rubbing pairs in the different concentrations H2O2 solution because of oxidation and *** research has revealed that the main wear mechanisms between the rubbing pairs are severe adhesive wear,abrasive wear and corrosive wear in the H2O2 solution with different concentrations.A model has been established to assess the most suitable concentration of the H2O2 solution for the tribological properties of the rubbing *** result shows that 50% concentration of the H2O2 solution is the most *** assessment result is consistent with the experimental *** is believed that the knowledge gained in this study is useful for the optimization of the friction pairs in the extreme condition.

关键词： ZrO2 ceramic 1Cr18Ni9Ti stainless steel hydrogen peroxide

Interaction of major facilitator superfamily domain containing 2A with the blood-brain barrier

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Neural Regeneration Research 2025年第8期20卷 2133-2152页

作者： Yilun Ma Taiwei Dong Fei Luan Juanjuan yang Feng Miao Peifeng Wei College of Pharmacy and First Clinical Medical College Shaanxi University of Chinese MedicineXianyangShaanxi ProvinceChina National Drug Clinical Trial Agency The Second Affiliated Hospital of Shaanxi University of Chinese Medicine/Xixian New District Central HospitalXi′anShaanxi ProvinceChina

The functional and structural integrity of the blood-brain barrier is crucial in maintaining homeostasis in the brain microenvironment;however,the molecular mechanisms underlying the formation and function of the blood-brain barrier remain poorly *** major facilitator superfamily domain containing 2A has been identified as a key regulator of blood-brain barrier *** plays a critical role in promoting and maintaining the formation and functional stability of the blood-brain barrier,in addition to the transport of lipids,such as docosahexaenoic acid,across the blood-brain ***,an increasing number of studies have suggested that major facilitator superfamily domain containing 2A is involved in the molecular mechanisms of blood-brain barrier dysfunction in a variety of neurological diseases;however,little is known regarding the mechanisms by which major facilitator superfamily domain containing 2A affects the blood-brain *** paper provides a comprehensive and systematic review of the close relationship between major facilitator superfamily domain containing 2A proteins and the blood-brain barrier,including their basic structures and functions,cross-linking between major facilitator superfamily domain containing 2A and the blood-brain barrier,and the in-depth studies on lipid transport and the regulation of blood-brain barrier *** comprehensive systematic review contributes to an in-depth understanding of the important role of major facilitator superfamily domain containing 2A proteins in maintaining the structure and function of the blood-brain barrier and the research progress to *** will not only help to elucidate the pathogenesis of neurological diseases,improve the accuracy of laboratory diagnosis,and optimize clinical treatment strategies,but it may also play an important role in prognostic *** addition,the effects of major facilitator superfamily domain containing 2A on blood-brain barrier lea

关键词： blood-brain barrier(BBB) caveolin-1 central nervous system docosahexaenoic acid endothelial cells lysophosphatidylcholine major facilitator superfamily domain containing 2A(MFSD2A) transcytosis

Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 214-220页

作者： Chao Tan Junling Lü Chunchi Zhang Dong Liang Lei yang Zegao Wang College of Materials Science and Engineering Sichuan UniversityChengdu 610065China The 54th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2D-FET)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FET for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array

Insight into tribological problems of green ship and corresponding research progresses

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Friction 2018年第4期6卷 472-483页

作者： Yuwei SUN Xinping YAN chengqing YUAN Xiuqin BAI School of Energy and Power Engineering Wuhan University of Technology Reliability Engineering Institute National Engineering Research Center for Water Transport Safety(WTS Center) MoSTWuhan University of Technology Key Laboratory of Marine Power Engineering and Technology MoTWuhan University of Technology Reliability Engineering Institute National Engineering Research Center for Water Transport Safety (WTS Center)MoSTWuhan University of Technology

The so-called "green ship" is being regarded as a potential solution to the problems that the shipping industry faces, such as energy conservation and environmental protection. Some new features, such as integrated renewable energy application, biomimetic materials, and antifriction and wear resistant coating have been accepted as the typical characteristics of a green ship, but the tribology problems involved in these domains have not been precisely redefined yet. Further, the related research work is generally focused on the technology or material itself, but not on the integration of the applicable object or green ship, marine environment, and tribological systematical analysis from the viewpoint of the energy efficiency design index(EEDI) and ship energy efficiency management plan(SEEMP) improvements. Aiming at the tribology problems of the green ship, this paper reviews the research status of this issue from three specific domains, which are the tribology problems of the renewable energy system, tribological research for hull resistance reduction, and energy efficiency enhancement. Some typical tribological problems in the sail-auxiliary system are discussed, along with the solar photovoltaic system and hull drag reduction in traditional marine mechanical equipment. Correspondingly, four domains that should be further considered for the future development target of the green ship are prospected.

关键词： green ship tribology renewable energy biomimetic material ship drag reduction

Defect Engineering:Can it Mitigate Strong Coulomb Effect of Mg^(2+)in Cathode Materials for Rechargeable Magnesium Batteries?

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Nano-Micro Letters 2025年第1期17卷 135-159页

作者： Zhengqing Fan Ruimin Li Xin Zhang Wanyu Zhao Zhenghui Pan Xiaowei yang School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China School of Chemistry and Chemical Engineering Taiyuan University of TechnologyTaiyuan 030024People’s Republic of China School of Materials Science and Engineering Tongji UniversityShanghai 201804People’s Republic of China

Rechargeable magnesium batteries(RMBs)have been considered a promising“post lithium-ion battery”system to meet the rapidly increasing demand of the emerging electric vehicle and grid energy storage ***,the sluggish diffusion kinetics of bivalent Mg^(2+)in the host material,related to the strong Coulomb effect between Mg^(2+)and host anion lattices,hinders their further development toward practical *** engineering,regarded as an effective strategy to break through the slow migration puzzle,has been validated in various cathode materials for *** this review,we first thoroughly understand the intrinsic mechanism of Mg^(2+)diffusion in cathode materials,from which the key factors affecting ion diffusion are further ***,the positive effects of purposely introduced defects,including vacancy and doping,and the corresponding strategies for introducing various defects are *** applications of defect engineering in cathode materials for RMBs with advanced electrochemical properties are also ***,the existing challenges and future perspectives of defect engineering in cathode materials for the overall high-performance RMBs are described.

关键词： Rechargeable magnesium battery Sluggish diffusion kinetic Defect engineering Cathode materials Ion migration

Induced neural stem cells regulate microglial activation through Akt-mediated upregulation of CXCR4 and Crry in a mouse model of closed head injury

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Neural Regeneration Research 2025年第5期20卷 1416-1430页

作者： Mou Gao Qin Dong Dan Zou Zhijun yang Lili Guo Ruxiang Xu Department of Neurosurgery Sichuan Academy of Medical Sciences and Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Department of Neurosurgery Chinese PLA General HospitalBeijingChina Department of Neurology Fu Xing HospitalCapital Medical UniversityBeijingChina

Microglial activation that occurs rapidly after closed head injury may play important and complex roles in neuroinflammation-associated neuronal damage and *** previously reported that induced neural stem cells can modulate the behavior of activated microglia via CXCL12/CXCR4 signaling,influencing their activation such that they can promote neurological ***,the mechanism of CXCR4 upregulation in induced neural stem cells remains *** this study,we found that nuclear factor-κB activation induced by closed head injury mouse serum in microglia promoted CXCL12 and tumor necrosis factor-αexpression but suppressed insulin-like growth factor-1 ***,recombinant complement receptor 2-conjugated Crry(CR2-Crry)reduced the effects of closed head injury mouse serum-induced nuclear factor-κB activation in microglia and the levels of activated microglia,CXCL12,and tumor necrosis factor-α.Additionally,we observed that,in response to stimulation(including stimulation by CXCL12 secreted by activated microglia),CXCR4 and Crry levels can be upregulated in induced neural stem cells via the interplay among CXCL12/CXCR4,Crry,and Akt signaling to modulate microglial *** agreement with these in vitro experimental results,we found that Akt activation enhanced the immunoregulatory effects of induced neural stem cell grafts on microglial activation,leading to the promotion of neurological recovery via insulin-like growth factor-1 secretion and the neuroprotective effects of induced neural stem cell grafts through CXCR4 and Crry upregulation in the injured cortices of closed head injury ***,these beneficial effects of Akt activation in induced neural stem cells were positively correlated with the therapeutic effects of induced neural stem cells on neuronal injury,cerebral edema,and neurological disorders post–closed head *** conclusion,our findings reveal that Akt activation may enhance the immunoregulatory effects of induced neura

关键词： Akt signaling cerebral edema closed head injury Crry CXCR4 induced neural stem cell microglia neuroinflammation

DISC1基因rs821633位点多态性与中国汉族人群精神分裂症的相关性研究（英文）

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上海精神医学 2015年第6期27卷 348-355页

作者：胡国芹杨程青赵静朱明环郭向晴鲍晨曦贾思徐阿红介勇汪作为张晨何永光吕钦谕禹顺英易正辉 Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Mental Health Center of Hongkou District

背景:既往研究报告显示精神分裂症断裂基因1(Disrupted-in-Schizophrenia 1 gene,DISC1)中不同的单核苷酸多态性(single nucleotide polymorphisms,SNP)与精神分裂症密切相关,但目前尚无研究评估了SNP与精神分裂症发病年龄之间的关系。... 详细信息

背景:既往研究报告显示精神分裂症断裂基因1(Disrupted-in-Schizophrenia 1 gene,DISC1)中不同的单核苷酸多态性(single nucleotide polymorphisms,SNP)与精神分裂症密切相关,但目前尚无研究评估了SNP与精神分裂症发病年龄之间的关系。目的:探讨DISC1基因中rs821633位点的SNP和中国汉族精神分裂症患者的发病及首发年龄的相关性。方法:我们采用TaqM an基因分型技术对315例19岁之前发病的精神分裂症患者(即"早发性")、407例19岁后发病的精神分裂症患者(即"非早发性")和482名健康对照进行DISC1基因rs821633位点的SNP检测。我们使用生存分析研究rs821633(C)位点的危险等位基因与精神分裂症患者首发年龄之间的关系。结果:相比健康对照组,rs821633位点C/C基因型和C等位基因型频率分布在早发性(X^2=7.17,df=1,p=0.007;X^2=7.20,df=2,p=0.032)和晚发性(X^2=5.36,df=1,p=0.022;X^2=6.58,df=2,p=0.041)精神分裂症患者中显著较高。然而,C/C基因型或C等位基因型的携带率在早发和晚发性精神分裂症患者中没有显著差异。Kaplan-Meier生存分析发现rs821633(C)危险等位基因与精神分裂症首发年龄之间没有显著相关性。结论:我们证实了DISC1基因rs821633位点多态性的SNP与中国汉族人群精神分裂症之间存在相关性,但未发现rs821633(C)危险等位基因与精神分裂症首发年龄之间的相关性。

关键词：精神分裂症 DISC1基因传递不平衡检验单核苷酸多态性首发年龄中国

Risk identification,future value and credit capitalization:Research on the theory and policy of poverty alleviation by internet finance

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China Finance and Economic Review 2016年第3期5卷 38-50页

作者： Li Yongjian Wang chengqing National Academy of Economic Strategy of Chinese Academy of Social Sciences

Elimination of poverty is an important part to achieve a comprehensive well-off in China,and financial means and tools play an important role on *** paper tries to show the problems in current financial poverty alleviation practice,such as the lack of unified organization,high cost,poor sustainability,uncertain effects,etc.,and illustrates that internet finance,based on new information technologies which enable more comprehensive information collection of poverty population and employ future-oriented valuation method,can help the poor households accumulate credit capital and play a greater role in the process of poverty *** paper also puts forward some policy recommendations to support internet finance in poverty alleviation.

关键词： internet finance financial poverty alleviation poverty alleviation