检索结果-南通市图书馆

Brain Pathology in COVID-19:Clinical Manifestations and Potential Mechanisms

Neuroscience Bulletin 2024年第3期40卷 383-400页

作者： Zhixing Xu Hui Wang Siya Jiang Jiao Teng Dongxu Zhou Zhong Chen chengping wen Zhenghao Xu First School of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhou 310053China School of Pharmaceutical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China Second School of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhou 310053China Afliated Lin’an People’s Hospital of Hangzhou Medical College First People’s Hospital of Hangzhou Lin’an DistrictLin’anHangzhou 311300China School of Life Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province College of Pharmaceutical ScienceZhejiang Chinese Medical UniversityHangzhou 310053China Laboratory of Rheumatology and Institute of TCM Clinical Basic Medicine College of Basic Medical ScienceZhejiang Chinese Medical UniversityHangzhou 310053China

Neurological manifestations of coronavirus disease 2019(COVID-19)are less noticeable than the respiratory symptoms,but they may be associated with disability and mortality in *** though Omicron caused less severe disease than Delta,the incidence of neurological manifestations is *** than 30%of patients experienced“brain fog”,delirium,stroke,and cognitive impairment,and over half of these patients presented abnormal neuroimaging *** this review,we summarize current advances in the clinical findings of neurological manifestations in COVID-19 patients and compare them with those in patients with influenza *** also illustrate the structure and cellular invasion mechanisms of SARS-CoV-2 and describe the pathway for central SARS-CoV-2 *** addition,we discuss direct damage and other pathological conditions caused by SARS-CoV-2,such as an aberrant interferon response,cytokine storm,lymphopenia,and hypercoagulation,to provide treatment *** review may offer new insights into preventing or treating brain damage in COVID-19.

关键词： COVID-19 SARS-CoV-2 Brain Neurological pathology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neddylation is a novel therapeutic target for lupus by regulating double negative T cell homeostasis

引用

Signal Transduction and Targeted Therapy 2024年第2期9卷 738-750页

作者： Yun Zhang Lijun Du Chenxi Wang Zhangsheng Jiang Qingchi Duan Yiping Li Zhijun Xie Zhixing He Yi Sun Lin Huang Liwei Lu chengping wen Key Laboratory of Chinese medicine rheumatology of Zhejiang Province Research Institute of Chinese Medical Clinical Foundation and ImmunologyCollege of Basic Medical ScienceZhejiang Chinese Medical UniversityHangzhou 310053China Department of General Surgery Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)of the Second Affiliated Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Cancer Center of Zhejiang University Hangzhou 310029China Department of Pathology and Shenzhen Institute of Research and Innovation The University of Hong KongHong KongChina Chongqing International Institute for Immunology Chongqing 400038China

Systemic lupus erythematosus(SLE),a severe autoimmune disorder,is characterized by systemic inflammatory response,autoantibody accumulation and damage to *** dysregulation of double-negative(DN)T cells is considered as a crucial commander during ***,a significant type of protein post-translational modification(PTM),has been well-proved to regulate T cell-mediated immune ***,the function of neddylation in SLE is still ***,we reported that neddylation inactivation with MLN4924,a specific inhibitor of NEDD8-activating enzyme E1(NAE1),or genetic abrogation of Ube2m in T cells decreased DN T cell accumulation and attenuated murine lupus *** investigations revealed that inactivation of neddylation blocked Bim ubiquitination degradation and maintained Bim level in DN T cells,contributing to the apoptosis of the accumulated DN T cells in lupus *** double knockout(KO)lupus-prone mice(Ube2m-/-Bim-/-lpr)were generated and results showed that loss of Bim reduced Ube2m deficiency-induced apoptosis in DN T cells and reversed the alleviated lupus *** findings identified that neddylation inactivation promoted Bim-mediated DN T cell apoptosis and attenuated lupus ***,we also found that in SLE patients,the proportion of DN T cells was raised and their apoptosis was ***,compared to healthy groups,SLE patients exhibited decreased Bim levels and elevated Cullin1 neddylation ***,the inhibition of neddylation induced Bim-dependent apoptosis of DN T cells isolated from SLE ***,our findings provide the direct evidence about the function of neddylation during lupus,suggesting a promising therapeutic approach for this disease.

关键词： inactivation double finding

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International clinical practice guideline of Chinese medicine - Gout (SCM73–2024)

引用

Clinical Traditional Medicine and Pharmacology 2024年第4期5卷 1-8页

作者： Xuanlin Li Lin Huang Zhijun Xie Yaolong Chen chengping wen School of Basic Medical Science Zhejiang Chinese Medical UniversityHangzhou 31006ZhejiangChina Key Laboratory of Chinese Medicine Rheumatology of Zhejiang Province Zhejiang Chinese Medical UniversityHangzhou 31006ZhejiangChina School of Basic Medical Sciences Lanzhou UniversityLanzhou 730030GansuChina World Health Organization Collaborating Center for Guideline Implementation and Knowledge Translation Lanzhou UniversityLanzhou 730030GansuChina

Background:Gout is a metabolic rheumatic disease that seriously endangers human health,with a relatively high prevalence and disability rate *** international clinical practice guidelines provide recommendations from the diagnosis,treatment,and management of *** increasing influence of Chinese medicine globally raises the attention of adopting Chinese medicine prevention and treatment *** Chinese medicine or integrated traditional Chinese and Western medicine guidelines for gout have provide recommendations from the view of disease combined with syndrome,however,recommendations on the specific Chinese medicine prevention and treatment regimens at different stages are ***:To this end,this document summarized Chinese medicine regimens and recommendation opinions for diagnosing and treating gout of different stages after thoroughly considering the clinical practice of Chinese medicine in diagnosing and treating gout,collecting and evaluating evidence on Chinese medicine’s efficacy on gout,and consulting experts at home and abroad,hoping to provide reference for Chinese medicine and integrated Chinese and Western medicine clinicians worldwide in gout diagnosis and ***:This document specifies the terms and definitions of gout,diagnosis of syndromes,Chinese medicine treatment regimens,***:This document is a declarative document based on existing research evidence and specific methods,instead of a standard or norm for medical *** clinical practice,physicians can refer to this document to formulate personalized treatment plans based on the specific conditions of patients.

关键词： Gout Recommendations Chinese medicine Guideline

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

运脾解毒通络祛湿方靶向IRE1α/XBP1/PDK1抑制CD4^(+)T细胞中枢迁移改善CIA小鼠中枢敏化的机制研究

引用

中华中医药杂志 2024年第5期39卷 2166-2173页

作者：姜月蓬马晓郑孟佳赵小萱于捷金艳温成平浙江中医药大学基础医学院中医临床基础研究所杭州310053 浙江中医药大学附属杭州市中医院杭州310007 浙江中医药大学附属第二医院杭州310005

目的:探究运脾解毒通络祛湿方通过靶向肌醇需要酶1α(IRE1α)/X-box结合蛋白1(XBP1)/丙酮酸脱氢酶激酶1(PDK1)抑制CD4^(+)T细胞中枢迁移改善胶原诱导关节炎(CIA)小鼠中枢敏化的疗效机制。方法:32只雄性DBA/1小鼠经适应性喂养后随机分为4... 详细信息

目的:探究运脾解毒通络祛湿方通过靶向肌醇需要酶1α(IRE1α)/X-box结合蛋白1(XBP1)/丙酮酸脱氢酶激酶1(PDK1)抑制CD4^(+)T细胞中枢迁移改善胶原诱导关节炎(CIA)小鼠中枢敏化的疗效机制。方法:32只雄性DBA/1小鼠经适应性喂养后随机分为4组:空白组、CIA组、中药组、西药组,每组8只。向小鼠尾部2次注射胶原佐剂以构建CIA模型。初次免疫后,各药物组连续42 d接受相应药物治疗。自初次免疫后28 d起每周观察并记录各组小鼠痛阈及关节炎症评分情况。干预结束后分离与收集外周血、脊髓组织。此外,利用磁珠分选术收集空白组、CIA组及中药组脾脏CD4^(+)T细胞,并且将空白组随机分为:空白组与IRE1α激动剂组,其中IRE1α激动剂组予以毒胡萝卜素(Thapsigargin)1μmol/L处理24 h。采用ELISA法检测各组小鼠血清白细胞介素(IL)1β、IL-6的含量;免疫荧光检测各组小鼠脊髓背角CD4、cFos、IBA1及IRE1α/XBP1/PDK1通路相关蛋白荧光强度;乳酸试剂盒检测各组脊髓背角组织乳酸含量;此外,应用免疫荧光检测各组CD4^(+)T细胞IRE1α/XBP1/PDK1通路相关蛋白荧光强度,乳酸试剂盒检测各组CD4^(+)T细胞乳酸含量,Transwell实验观察各组CD4^(+)T细胞迁移能力。结果:与CIA组比较,中药组小鼠机械痛阈与热痛阈均显著升高(P<0.05),关节炎症评分显著减低(P<0.01),血清IL-1β、IL-6水平显著减低(P<0.05),中药组脊髓背角CD4、cFos及IBA1的荧光强度显著减低(P<0.05),IRE1α、XBP1、PDK1荧光强度显著减低(P<0.05),乳酸浓度显著减少(P<0.05)。体外实验表明:与空白组比较,CIA组、IRE1α激动剂组CD4^(+)T细胞IRE1α、XBP1、PDK1表达水平显著增加(P<0.01,P<0.05),乳酸浓度显著升高(P<0.01,P<0.05),CD4^(+)T细胞迁移能力显著增强(P<0.05)。与CIA组比较,中药组IRE1α、XBP1、PDK1表达水平显著下降(P<0.01,P<0.05),细胞乳酸浓度显著下降(P<0.05),CD4^(+)T细胞迁移能力显著减弱(P<0.05)。结论:运脾解毒通络祛湿方可通过靶向IRE1α/XBP1/PDK1,抑制CD4^(+)T细胞向糖酵解重编程,减少CD4^(+)T细胞中枢迁移,从而改善CIA小鼠中枢敏化。

关键词：类风湿关节炎中枢敏化 CD4^(+)T细胞中枢迁移内质网应激运脾解毒通络祛湿方

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

系统性红斑狼疮的伏毒病机演变及辨治

引用

中医杂志 2024年第16期65卷 1721-1724页

作者：张祎谢志军黄琳王俏李海昌温成平浙江中医药大学浙江省杭州市310053

提出系统性红斑狼疮(SLE)的病机演变可以概括为四个阶段:邪伏初期,病机潜伏;伏毒积聚,病情渐显;邪毒致损,病势凶猛;因损致虚,病程迁延。根据伏毒病机演变过程对SLE进行辨治:邪伏阶段表现为伏湿郁热,方用三仁汤加减;毒发阶段表现为热毒炽... 详细信息

提出系统性红斑狼疮(SLE)的病机演变可以概括为四个阶段:邪伏初期,病机潜伏;伏毒积聚,病情渐显;邪毒致损,病势凶猛;因损致虚,病程迁延。根据伏毒病机演变过程对SLE进行辨治:邪伏阶段表现为伏湿郁热,方用三仁汤加减;毒发阶段表现为热毒炽盛,方用犀角地黄汤合清瘟败毒饮加减;毒损阶段表现为毒损脏腑,方用青蒿鳖甲汤加减;正虚阶段表现为气血阴阳俱虚,方用燮理十全膏加减。

关键词：系统性红斑狼疮阴阳毒伏毒病机演变

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multicomponent Reactions for Diverse Synthesis of N-Substituted and NH 1,4-Dihydropyridines

引用

Chinese Journal of Chemistry 2014年第3期32卷 219-226页

作者： Jieping Wan Youyi Zhou Yunyun Liu Zheng Fang chengping wen Key Laboratory of Functional Small Organic Molecule Ministry of Educationand College of Chemistry and Chemical EngineeringJiangxi Normal UniversityNanchangJiangxi 330022China College of Basic Medical Sciences Zhejiang Chinese Medical UniversityHangzhouZhejiang 310053China

The multicomponent reactions of aldehydes,electron deficient alkynes and amines have been successfully per-formed to yield a number of symmetrical 2,6-unsubstituted 1,4-dihydropyridines(1,4-DHPs).This method has been found generally applicable for the synthesis of both N-substituted and N-unsubstituted 1,4-DHPs by employing secondary amine to activate the alkyne component via enaminoester *** present method runs through an enamine type activation,which is different from the known approach employing AcOH as solvent.

关键词： multicomponent reactions enamine activation enaminoester 1,4-dihydropyridine diversity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Adding Fuel to the Fire by Increased GABAergic Inhibition:A Seizure-Amplifying Nigra-Parafascicular Pathway

引用

Neuroscience Bulletin 2021年第1期37卷 135-137页

作者： Yeping Ruan Rongrong Chen Jie Yu chengping wen Zhenghao Xu Zhejiang Chinese Medical University Hangzhou 310053China School of Basic Medical Science Zhejiang Chinese Medical UniversityHangzhou 310053China

Epilepsy is a common neurological disorder characterized by recurrent *** anti epileptic drugs (AEDs)work by regulating the balance of the excitatory glutamatergic and inhibitory GABAergic ***,the current AEDs cannot successfully control seizures in most (>70%) patients with temporal lobe epilepsy (TLE)[1],in whom seizures typically begin in the *** may be caused by changes in the synaptic efficacy and remodeling of neural circuits,such as alterations in the distribution/expression of GABA_A receptor subunits and mossy-fiber *** *** Gale and colleagues originally described the seizure-modulating effects of nigral GABAergic transmission in the early 1980s [2]。

关键词： epilepsy alterations AEDs

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于“五季应五脏”理论探讨类风湿关节炎的防治新思路

引用

中华中医药杂志 2024年第1期39卷 284-287页

作者：陈武温成平李殿明时玮蔓黄琳谢志军曹炜王俏浙江中医药大学杭州310053 中国中医科学院广安门医院北京100053

文章从“五季应五脏”理论的角度探讨五脏病理生理机能与自然时令之间的适应性规律,认为季节变化协同五脏变化的适应性规律在疾病发生发展过程中起到了至关重要的作用。文章结合现代医学对类风湿关节炎(RA)的研究进展发现,中医“五季应... 详细信息

文章从“五季应五脏”理论的角度探讨五脏病理生理机能与自然时令之间的适应性规律,认为季节变化协同五脏变化的适应性规律在疾病发生发展过程中起到了至关重要的作用。文章结合现代医学对类风湿关节炎(RA)的研究进展发现,中医“五季应五脏”思想在RA病理机制中的具体体现是通过“气候-气血-关节”轴实现的,并据此提出RA“本脏本季当疏散,所克之脏当调之”的调适原则。故文章在RA季节调适的基础上,提出有效的RA防治新思路,以期为中医药防治RA提供新的思路和指导。

关键词：类风湿关节炎五季五脏季节理论中医药

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

An Environmentally Benign Catalytic Method for Versatile Synthesis of 1,4-Dihydropyridines via Multicomponent Reactions

引用

中国化学:英文版 2015年第5期33卷 568-572页

作者： Shuo Cao Shanshan Zhong Changfeng Hu Jie-Ping Wan chengping wen Key Laboratory of Functional Small Organic Molecule Ministry of EducationCollege of Chemistry and Chemical EngineeringJiangxi Normal UniversityNanchangJiangxi 330022China College of Basic Medical Sciences Zhejiang Chinese Medical UniversityHangzhouZhejiang 310053China

The synthesis of diverse 1,4-dihydropyridines have been achieved via the multicomponent reactions of aldehydes,enaminones and *** reactions have been smoothly performed in water to provide all products with moderate t... 详细信息

关键词： lactic acid catalysis multicomponent reactions 1 4-dihydropyridines green catalysis heterocycle

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dissecting the Underlying Pharmaceutical Mechanism of Chinese Traditional Medicine Yun-Pi-Yi-Shen-Tong-Du-Tang Acting on Ankylosing Spondylitis through Systems Biology Approaches

Dissecting the Underlying Pharmaceutical Mechanism of Chines...

引用

“农业健康与环境”组学大数据整合生物信息学研讨会

作者： Duoli Xie Lin Huang Yiran Yua Jiawei Gao Haichang Li chengping wen TCM Clinical Basis Institute Zhejiang Chinese Medicine University

Traditional Chinese Medicine(TCM) has been served as complementary medicine for Ankylosing Spondylitis(AS) treatment for a long ***-Pi-Yi-Shen-Tong-Du-Tang(Y-Y-T)1 is one of the effective formulas and has been widely used in clinical for AS *** this study,a clinical practice proved the efficiency of Y-Y-T in AS treatment and then we tried to decipher the underlying molecular mechanism of Y-Y-T in the *** ingredients and targeting proteins were collected from available databases TCMID and *** networks were men constructed to further infer the relationship among Y-Y-T,drugs used for treating AS,differentially expressed genes of AS patients and AS disease *** found that TLR signaling pathway and T cell receptor signaling pathway may involve in the biological processes of AS progression and contribute to the curative effect,proteins such as JAK2,STAT3,HSP90 AA1,TNF and PTEN are the key targets in the *** systemic investigation to infer therapeutic mechanisms of Y-Y-T for AS treatment provides a new insight in the understanding of TCM functions.

关键词： Ankylosing Spondylitis Traditional Chinese Medicine formula pharmacology network

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：