检索结果-南通市图书馆

Fundamental Research 2024年第2期4卷 353-361页

作者： lu Yang Yao Ni chengpeng Jiang lu Liu Song Zhang Jiaqi Liu Lin Sun Wentao Xu Institute of Photoelectronic Thin Film Devices and Technology Key Laboratory of Optoelectronic Thin Film Devices and Technology of TianjinEngineering Research Center of Thin Film Photoelectronic TechnologyMinistry of EducationNankai UniversityTianjin 300350China Shenzhen Research Institute of Nankai University Shenzhen 518000China

The ionic environment of body fluids influences nervous functions for maintaining homeostasis in organisms and ensures normal perceptual abilities and reflex activities.Neural reflex activities,such as limb movements,are closely associated with potassium ions(K+).In this study,we developed artificial synaptic devices based on ion concentration-adjustable gels for emulating various synaptic plasticities under different K+concentrations in body fluids.In addition to performing essential synaptic functions,potential applications in information processing and associative learning using short-and long-term plasticity realized using ion concentration-adjustable gels are presented.Artificial synaptic devices can be used for constructing an artificial neural pathway that controls artificial muscle reflex activities and can be used for image pattern recognition.All tests show a strong relationship with ion homeostasis.These devices could be applied to neuromorphic robots and human-machine interfaces.

关键词： Nervous regulation Artificial synaptic device Ion gel Ion homeostasis Artificial reflex pathway

Overview of epigenetic degraders based on PROTAC, molecular glue, and hydrophobic tagging technologies

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第2期14卷 533-578页

作者： Xiaopeng Peng Zhihao Hu Limei Zeng Meizhu Zhang Congcong Xu Benyan lu chengpeng Tao Weiming Chen Wen Hou Kui Cheng Huichang Bi Wanyi Pan Jianjun Chen College of Pharmacy Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of EducationGannan Medical UniversityGanzhou 314000China College of Basic Medicine Gannan Medical UniversityGanzhou 314000China Guangdong Provincial Key Laboratory of New Drug Screening NMPA Key Laboratory for Research and Evaluation of Drug MetabolismSchool of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China

Epigenetic pathways play a critical role in the initiation, progression, and metastasis of cancer. Over the past few decades, significant progress has been made in the development of targeted epigenetic modulators(e.g., inhibitors). However, epigenetic inhibitors have faced multiple challenges,including limited clinical efficacy, toxicities, lack of subtype selectivity, and drug resistance. As a result,the design of new epigenetic modulators(e.g., degraders) such as PROTACs, molecular glue, and hydrophobic tagging(Hy T) degraders has garnered significant attention from both academia and pharmaceutical industry, and numerous epigenetic degraders have been discovered in the past decade. In this review,we aim to provide an in-depth illustration of new degrading strategies(2017-2023) targeting epigenetic proteins for cancer therapy, focusing on the rational design, pharmacodynamics, pharmacokinetics, clinical status, and crystal structure information of these degraders. Importantly, we also provide deep insights into the potential challenges and corresponding remedies of this approach to drug design and development. Overall, we hope this review will offer a better mechanistic understanding and serve as a useful guide for the development of emerging epigenetic-targeting degraders.

关键词： Epigenetic Degrader PROTAC Molecularglue Hydrophobic tagging

Application of Hausdorff fractal derivative to the determination of the vertical sediment concentration distribution

在线全文

学校读者我要写书评

暂无评论

International Journal of Sediment Research 2023年第1期38卷 12-23页

作者： Hongguang Sun Shiqian Nie Aaron I.Packman Yong Zhang Dong Chen chengpeng lu Chunmiao Zheng State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai University College of Mechanics and Materials Hohai University College of Mathematics and Systems Science Shandong University of Science and Technology Department of Civil and Environmental Engineering Northwestern University Department of Geological Sciences University of Alabama Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences College of Hydrology and Water Resources Hohai University School of Environmental Science and Engineering Southern University of Science and Technology

The Rouse formula and its variants have been widely used to calculate the steady-state vertical concentration distribution for suspended sediment in steady sediment-laden flows, where the diffusive flux is assumed to be Fickian. Turbulent flow, however, exhibits fractal properties, leading to non-Fickian diffusive flux for sediment particles. To characterize non-Fickian dynamics of suspended sediment, the current study proposes a Hausdorff fractal derivative based advection-dispersion equation(HADE)model, where the Fickian diffusive flux in the Rouse model is replaced by a fractal derivative re-scaled using a constant diffusivity. The order of the Hausdorff fractal derivative is designed to characterize the influence of the multi-fractal turbulence structure on sediment diffusion. Applications show that the HADE model, with the analytical solution expressed using a stretched exponential function, can accurately describe the observed vertical concentration profiles for suspended sediment with different sizes.This improvement well captures the non-exponential decay of the vertical sediment concentration in turbulent flow. Further analyses of measured sediment concentration profiles reveal that the Hausdorff fractal order decreases with the Rouse parameter, which describes the stronger impact of turbulent flow and a more uniform sediment concentration profile for smaller particles. Model comparisons also show that the HADE model provides better performance in describing the sediment concentration profiles than the improved Rouse formula and the standard fractional derivative advection-dispersion equation(FADE), which either under-or over-estimates vertical displacement of sediment particles, likely due to coherent turbulent structures.

关键词： Anomalous diffusion Hausdorff fractal derivative Vertical concentration distribution Suspended sediment Metric transform

Spatial-temporal Evolution and Its Influencing Factors of Tourism Eco-efficiency in China

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Geographical Research 2022年第3期5卷 1-12页

作者： chengpeng lu Tianyang Ma Zhiliang Liu Institute of County Economic Development&Rural Revitalization Strategy Lanzhou UniversityLanzhou730000China School of Economics Lanzhou UniversityLanzhou730000China

Eco-efficiency is an invaluable indicator for the measurement of the relationship between production activities and environmental depletion.This study measures the tourism eco-efficiency of 30 provinces in China from 2005 to 2020 based on the super-efficiency SBM model,and explores its spatial-temporal evolution characteristics using the kernel density function,standard deviation ellipse,and center of gravity model.Then,the influencing factors of the tourism eco-efficiency in China are analyzed by Tobit regression model.The results show that the tourism eco-efficiency of China is generally fluctuating upwards,but has not yet reached the maximum production possibility frontier.The kernel density curve shows a unimodal-bimodal-unimodal pattern,while the inter-provincial differences have been decreasing and becoming more balanced.The center of gravity of tourism eco-efficiency is located at the junction of Henan and Hubei province and generally moves to the south(slightly to the southwest).Meanwhile,it is revealed that the level of economic development and the tourism eco-efficiency has a significant inverted U-shaped relationship.The level of economic openness,traffic conditions,and tourism eco-efficiency is positively correlated.The environmental regulations and industrial structure have a negative but limited impact on tourism eco-efficiency.Finally,recommendations and suggestions for policy formulation to promote quality and sustainable development of the tourism industry are put forward,such as increasing investment in ecological protection and governance in tourism development,improving capacity-building in allocating green and low-carbon technologies and resources,strengthening tourism infrastructure construction,and enhancing environmental governance systems and mechanisms.

关键词： Tourism eco-efficiency Spatial pattern Influencing factors Spatial analysis China

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

淀粉基气凝胶的制备、改性与应用

中国食品学报 2024年第1期24卷 455-465页

作者：卢慧馨钟成鹏罗舜菁叶江平刘成梅南昌大学食品学院南昌330047

淀粉基气凝胶是一种密度低、比表面积大、孔隙率高的三维多孔网络新型轻质材料。淀粉基气凝胶的制备过程简单、清洁,是将淀粉糊化和回生制备水凝胶后脱水干燥而得。本文探讨影响气凝胶性能的主要因素,如淀粉来源、淀粉浓度、糊化温度、... 详细信息

淀粉基气凝胶是一种密度低、比表面积大、孔隙率高的三维多孔网络新型轻质材料。淀粉基气凝胶的制备过程简单、清洁,是将淀粉糊化和回生制备水凝胶后脱水干燥而得。本文探讨影响气凝胶性能的主要因素,如淀粉来源、淀粉浓度、糊化温度、回生条件和干燥方式。阐述淀粉基气凝胶的改性方法,如交联处理、复合改性、表面涂层等,以及改性后淀粉基气凝胶的应用。目前有关淀粉基气凝胶的应用研究主要围绕食品营养和生物医药方面,其在隔热材料、环境污染处理等领域存在应用潜力。本文对构建高品质的淀粉基气凝胶,拓展其应用具有重要意义。

关键词：淀粉气凝胶生物基制备改性应用

Dynamic analysis of agricultural green development efficiency in China: Spatiotemporal evolution and influencing factors

在线全文

学校读者我要写书评

暂无评论

Journal of Arid Land 2023年第2期15卷 127-144页

作者： LIU Yiping lu chengpeng CHEN Xingpeng Institute of County Economic Development&Rural Revitalization Strategy Lanzhou UniversityLanzhou 730000China College of Earth and Environmental Science Lanzhou UniversityLanzhou 730000China

Green development of agriculture is important for achieving coordinated and high-quality regional development for China. Using provincial data from 1990 to 2020, this work explored the dynamics of agricultural green development efficiency of 31 provinces in China, its spatiotemporal characteristics, and its driving factors using a super-efficiency slacks-based measure(Super-SBM), the Malmquist productivity index(MPI), spatial autocorrelation, and a geographic detector. Results showed that the overall agricultural green development efficiency showed a U-shaped trend, suggesting a low level of efficiency. Although a gradient difference was visible among eastern, central, and western regions, the efficiency gap narrowed each year. Technological progress and efficiency both promoted agricultural green development efficiency, especially technological progress. Agricultural green development efficiency had significant spatial aggregation characteristics, but Moran’s Ⅰ result showed a downward trend from 2015 to 2020, indicating a risk of spatial dispersion in the later stage. The provinces with high agricultural green development efficiency were mainly concentrated in the eastern region, while those with low efficiency were concentrated in the central and western regions. Agricultural green development efficiency was influenced by various factors, which showed differences according to time and region. The impact of the labor force’s education level and technological progress increased during the study period, and significantly facilitated agricultural green development efficiency in the eastern region, while the central and western regions were still affected by the scale level and environmental regulation, reflecting the advantages of the eastern region in terms of economy and technology. In the future, strengthening agricultural scientific and technological innovation and deepening interprovincial cooperation can help further improve the level of green agricultural development. In addition, local governments should f

关键词： regional development economy technology spatial evolution influencing factors super-efficiency slacks-based measure

基于知识图谱的“水文预报”课程教学改革实践

在线全文

学校读者我要写书评

暂无评论

科教导刊 2024年第8期 75-78页

作者：张小琴齐晓静瞿思敏鲁程鹏河海大学水文水资源学院江苏南京210098

知识图谱以图形化、结构化的方式呈现复杂的学科知识体系,帮助学生更好地理解和掌握知识,提高学习效率和质量。文章主要介绍了水文预报课程知识图谱建设,阐述了知识图谱在水文预报课程中的应用优势,包括构建完整的知识体系、提供个性化... 详细信息

知识图谱以图形化、结构化的方式呈现复杂的学科知识体系,帮助学生更好地理解和掌握知识,提高学习效率和质量。文章主要介绍了水文预报课程知识图谱建设,阐述了知识图谱在水文预报课程中的应用优势,包括构建完整的知识体系、提供个性化的学习支持等,探讨了知识图谱建设在水文预报课程教学实践改革中的成效。实践表明,水文预报课程知识图谱建设是提高课程教学质量的有效途径之一。

关键词：水文预报知识图谱课程质量改革实践

在线全文

学校读者我要写书评

暂无评论

油莎豆种子籽粒离散元仿真参数标定与试验

农机化研究 2024年第2期46卷 172-178页

作者：郑效帅何晓宁尚书旗王东伟李成鹏时延鑫赵壮卢玉伦青岛农业大学机电工程学院山东青岛266109

为了解决新型油料作物油莎豆排种器设计过程中种子物理参数不清及仿真参数与实际差异较大,造成模拟试验不准确,制约油莎豆排种器的发展的问题,测定了油莎豆种子的几何参数、弹性模量、泊松比、摩擦因数、碰撞恢复系数和休止角。以截面... 详细信息

为了解决新型油料作物油莎豆排种器设计过程中种子物理参数不清及仿真参数与实际差异较大,造成模拟试验不准确,制约油莎豆排种器的发展的问题,测定了油莎豆种子的几何参数、弹性模量、泊松比、摩擦因数、碰撞恢复系数和休止角。以截面圆跳动法测出油莎豆种子精确外形轮廓并建立仿真颗粒模型,通过离散元仿真参数标定得出油莎豆种间静摩擦系数为0.662,油莎豆种间滚动摩擦因数为0.024。通过休止角试验验证,得到误差为1.61%,较标定前降低92.9%。通过排种仿真试验、排种器试验台试验和播种田间试验验证,得到仿真重播指数相对误差为3.79%、4.64%,漏播指数相对误差为6.81%、8.64%。由此表明,油莎豆仿真参数标定值可靠,可为油莎豆单粒精播排种器设计优化提供参考。

关键词：油莎豆排种器离散元法参数标定

Ultra-high strength yet superplasticity in a hetero-grain-sized nanocrystalline Au nanowire

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2022年第6期101卷 95-106页

作者： Libo Fu Deli Kong chengpeng Yang Jiao Teng Yan lu Yizhong Guo Guo Yang Xin Yan Pan Liu Mingwei Chen Ze Zhang Lihua Wang Xiaodong Han Beijing Key Lab of Microstructure and Properties of Advanced Materials Beijing University of TechnologyBeijing 100124China Department of Material Physics and Chemistry University of Science and Technology BeijingBeijing 100083China School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Materials Science and Engineering Johns Hopkins UniversityBaltimoreMD 21218United States School of Materials Science and Engineering Zhejiang UniversityHangzhou 310027China

Nanocrystalline metals often display a high strength up to the gigapascal level,yet they suffer from poor plasticity.Previous studies have shown that the development of hetero-sized grains can efficiently overcome the strength-ductility trade-off of nanocrystalline metals.However,whether this strategy can lead to the fabrication of nanocrystalline nanowires exhibiting both high strength and superplasticity is unclear,similar to the atomistic deformation mechanism.In this paper,we show that ultra-small nanocrystalline Au nanowires comprising grains in both the Hall–Petch and inverse Hall–Petch grain-size regions can exhibit extremely high uniform elongation(236%)and high strength(2.34 gigapascals)at room temperature.In situ atomic-scale observations revealed that the plastic deformation underwent two stages.In the first stage,the super-elongation ability originated from the intergrain plasticity of small grains via mechanisms such as grain boundary migration and grain rotation.This intergrain plasticity caused the grains in the heterogeneous-structured nanowires to grow very large.In the second stage,the superelongation ability originated from intragrain plasticity accompanied by the diffusion of surface atoms.Our results show that the hetero-grain-sized nanocrystalline nanowires,comprising grains with sizes both in the strongest Hall–Petch effect region and the inverse Hall–Petch effect region,were simultaneously ultrastrong and ductile.They displayed neither a strength-ductility trade-off nor plastic instability.

关键词： In situ Mechanical property Metallic nanowires Transmission electron microscopy Plastic deformation

Effects of the Northeast China Revitalization Strategy on Regional Economic Growth and Social Development

在线全文

学校读者我要写书评

暂无评论

Chinese Geographical Science 2020年第5期30卷 791-809页

作者： REN Wanxia XUE Bing YANG Jun lu chengpeng Key Laboratory of Pollution and Environment Engineering Institute of Applied EcologyChinese Academy of SciencesShenyang 110016China Key Lab for Environmental Computation and Sustainability of Liaoning Province Shenyang 110016China Ji-angho Architecture Northeastern UniversitShenyang 110016China Institute for County Economy Developments&Rural Revi-talization Strategy Lanzhou UniversityLanzhou 730000China

Measuring the economic and social effects of the Northeast China Revitalization Strategy is critical to addressing regional sustainable development in China. To shed light on this issue, an integrated perspective was adopted that is combined with the difference-in-differences method to measure the effects of the strategy on economic growth and social development in Northeast China. The findings suggest that the strategy has significantly improved regional economic growth and per-capita income by increasing its gross domestic product(GDP) and GDP per capita by 25.70% and 46.00%, respectively. However, the strategy has significantly worsened the regional employment in the secondary industry of the region. In addition, the strategy has not significantly improved regional infrastructural road, education investment or social security, and has had no significant effect on mitigating regional disparity. In addition, the policy effects are highly heterogeneous across cities based on city size and characteristics. Therefore, there is no simple answer regarding whether the Northeast China Revitalization Strategy has reached its original goals from an integrated perspective. The next phase of the strategy should emphasize improving research and development(R&D) and human capital investments based on urban heterogeneity to prevent conservative path-dependency and the lock-in of outdated technologies.

关键词： policy evaluation difference-in-differences(DID)method regional disparity urban heterogeneity regional revitalization old industrial base Northeast China