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Fundamental Research 2024年第2期4卷 353-361页

作者： Lu Yang Yao Ni chengpeng Jiang Lu Liu Song Zhang Jiaqi Liu Lin Sun Wentao Xu Institute of Photoelectronic Thin Film Devices and Technology Key Laboratory of Optoelectronic Thin Film Devices and Technology of TianjinEngineering Research Center of Thin Film Photoelectronic TechnologyMinistry of EducationNankai UniversityTianjin 300350China Shenzhen Research Institute of Nankai University Shenzhen 518000China

The ionic environment of body fluids influences nervous functions for maintaining homeostasis in organisms and ensures normal perceptual abilities and reflex activities.Neural reflex activities,such as limb movements,are closely associated with potassium ions(K+).In this study,we developed artificial synaptic devices based on ion concentration-adjustable gels for emulating various synaptic plasticities under different K+concentrations in body fluids.In addition to performing essential synaptic functions,potential applications in information processing and associative learning using short-and long-term plasticity realized using ion concentration-adjustable gels are presented.Artificial synaptic devices can be used for constructing an artificial neural pathway that controls artificial muscle reflex activities and can be used for image pattern recognition.All tests show a strong relationship with ion homeostasis.These devices could be applied to neuromorphic robots and human-machine interfaces.

关键词： Nervous regulation Artificial synaptic device Ion gel Ion homeostasis Artificial reflex pathway

Quasi-4-dimension ionospheric modeling and its application in PPP

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Satellite Navigation 2022年第3期3卷 207-220,I0005页

作者： Shengfeng Gu Chengkun Gan chengpeng he Haixia Lyu Manuel hernandez-Pajares Yidong Lou Jianghui Geng Qile Zhao GNSS Research Center Wuhan University129 Luoyu RoadWuhan430079China Hubei Luojia Laboratory Wuhan University129 Luoyu RoadWuhan430079China UPC-IonSAT/IEEC-UPC UPC Mod.C3 Campus Nord UPCc/Jordi Girona 1-3BarcelonaSpain

Ionospheric delay modeling is not only important for Global Navigation Satellite System(GNSS)based space weather study and monitoring,but also an efficient tool to speed up the convergence time of Precise Point Positioning(PPP).In this study,a novel model,denoted as Quasi-4-Dimension Ionospheric Modeling(Q4DIM)is proposed for wide-area high precision ionospheric delay correction.In Q4DIM,the Line Of Sight(LOS)ionospheric delays from a GNSS station network are divided into different clusters according to not only the location of latitude and longitude,but also satellite elevation and azimuth.Both Global Ionosphere Map(GIM)and Slant Ionospheric Delay(SID)models that are traditionally used for wide-area and regional ionospheric delay modeling,respectively,can be regarded as the special cases of Q4DIM by defining proper grids in latitude,longitude,elevation,and azimuth.Thus,Q4DIM presents a resilient model that is capable for both wide-area coverage and high precision.Four different sets of clusters are defined to illustrate the properties of Q4DIM based on 200 EUREF Permanent Network(EPN)stations.The results indicate that Q4DIM is compatible with the GIM products.Moreover,it is proved that by inducting the elevation and azimuth angle dependent residuals,the precision of the 2-dimensional GIM-like model,i.e.,Q4DIM 2-Dimensional(Q4DIM-2D),is improved from around 1.5 Total Electron Content Units(TECU)to better than 0.5 TECU.In addition,treating Q4DIM as a 4-dimensional matrix in latitude,longitude,elevation,and azimuth,whose sparsity is less than 5%,can result in its feasibility in a bandwidth-sensitive applications,e.g.,satellite-based Precising Point Positioning Real-Time Kinematic(PPP-RTK)service.Finally,the advantages of Q4DIM in PPP over the 2-dimensional models are demonstrated with the one month's data from 30 EPN stations in both high solar activity year 2014 and low solar activity year 2020.

关键词： Undifferenced and uncombined observation Ionosphere delay modeling PPP Design Wide-area

Material-SAM:Adapting SAM for Material XCT

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Computers, Materials & Continua 2024年第3期78卷 3703-3720页

作者： Xuelong Wu Junsheng Wang Zhongyao Li Yisheng Miao chengpeng Xue Yuling Lang Decai Kong Xiaoying Ma Haibao Qiao School of Materials Science and Engineering Beijing Institute of TechnologyBeijing100081China Senior Engineer at the Simulation Center Citic Dicastal Co.Ltd.Qinhuangdao066010China

X-ray Computed Tomography(XCT)enables non-destructive acquisition of the internal structure of materials,and image segmentation plays a crucial role in analyzing material XCT images.This paper proposes an image segmentation method based on the Segment Anything model(SAM).We constructed a dataset of carbide in nickel-based single crystal superalloys XCT images and preprocessed the images using median filtering,histogram equalization,and gamma correction.Subsequently,SAM was fine-tuned to adapt to the task of material XCT image segmentation,resulting in Material-SAM.We compared the performance of threshold segmentation,SAM,U-Net model,and Material-SAM.Our method achieved 88.45%Class Pixel Accuracy(CPA)and 88.77%Dice Similarity Coefficient(DSC)on the test set,outperforming SAM by 5.25%and 8.81%,respectively,and achieving the highest evaluation.Material-SAM demonstrated lower input requirements compared to SAM,as it only required three reference points for completing the segmentation task,which is one-fifth of the requirement of SAM.Material-SAM exhibited promising results,highlighting its potential as a novel method for material XCT image segmentation.

关键词： Segment Anything model X-ray computed tomography U-Net Ni-based superalloys foundation models

Overview of epigenetic degraders based on PROTAC, molecular glue, and hydrophobic tagging technologies

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Acta Pharmaceutica Sinica B 2024年第2期14卷 533-578页

作者： Xiaopeng Peng Zhihao Hu Limei Zeng Meizhu Zhang Congcong Xu Benyan Lu chengpeng Tao Weiming Chen Wen Hou Kui Cheng Huichang Bi Wanyi Pan Jianjun Chen College of Pharmacy Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of EducationGannan Medical UniversityGanzhou 314000China College of Basic Medicine Gannan Medical UniversityGanzhou 314000China Guangdong Provincial Key Laboratory of New Drug Screening NMPA Key Laboratory for Research and Evaluation of Drug MetabolismSchool of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China

Epigenetic pathways play a critical role in the initiation, progression, and metastasis of cancer. Over the past few decades, significant progress has been made in the development of targeted epigenetic modulators(e.g., inhibitors). However, epigenetic inhibitors have faced multiple challenges,including limited clinical efficacy, toxicities, lack of subtype selectivity, and drug resistance. As a result,the design of new epigenetic modulators(e.g., degraders) such as PROTACs, molecular glue, and hydrophobic tagging(Hy T) degraders has garnered significant attention from both academia and pharmaceutical industry, and numerous epigenetic degraders have been discovered in the past decade. In this review,we aim to provide an in-depth illustration of new degrading strategies(2017-2023) targeting epigenetic proteins for cancer therapy, focusing on the rational design, pharmacodynamics, pharmacokinetics, clinical status, and crystal structure information of these degraders. Importantly, we also provide deep insights into the potential challenges and corresponding remedies of this approach to drug design and development. Overall, we hope this review will offer a better mechanistic understanding and serve as a useful guide for the development of emerging epigenetic-targeting degraders.

关键词： Epigenetic Degrader PROTAC Molecularglue Hydrophobic tagging

Enhancing Capacitance Performance of Ti3C2Tx MXene as Electrode Materials of Supercapacitor: From Controlled Preparation to Composite Structure Construction

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Nano-Micro Letters 2020年第6期12卷 152-175页

作者： Xiaobei Zang Jiali Wang Yijiang Qin Teng Wang chengpeng he Qingguo Shao Hongwei Zhu Ning Cao School of Materials Science and Engineering China University of Petroleum(East China)Qingdao 266580People’s Republic of China School of Materials Science and Engineering Tsinghua UniversityBeijing 100084People’s Republic of China

Ti3C2Tx,a novel two-dimensional layer material,is widely used as electrode materials of supercapacitor due to its good metal conductivity,redox reaction active surface,and so on.However,there are many challenges to be addressed which impede Ti3C2Tx obtaining the ideal specific capacitance,such as restacking,re-crushing,and oxidation of titanium.Recently,many advances have been proposed to enhance capacitance performance of Ti3C2Tx.In this review,recent strategies for improving specific capacitance are summarized and compared,for example,film formation,surface modification,and composite method.Furthermore,in order to comprehend the mechanism of those efforts,this review analyzes the energy storage performance in different electrolytes and influencing factors.This review is expected to predict redouble research direction of Ti3C2Tx materials in supercapacitors.

关键词： Ti3C2Tx MXene Capacitance performance Storage mechanism Electrode materials Supercapacitor

酶-碱联合嫩化过程中预制火锅肥肠品质特性的变化

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西南大学学报（自然科学版） 2024年第7期46卷 20-28页

作者：程成鹏贺稚非李洪军西南大学食品科学学院重庆400715 川渝共建特色食品重庆市重点实验室重庆400715

利用酶-碱联合嫩化工艺处理猪大肠平滑肌样品,通过测定水分、脂肪、氨基酸、蛋白质和灰分等指标分析评价其营养成分变化,测定pH值、色差和水分分布等指标分析评价其食用品质变化,以期为酶-碱联合嫩化工艺在实际生产中的合理应用提供一... 详细信息

利用酶-碱联合嫩化工艺处理猪大肠平滑肌样品,通过测定水分、脂肪、氨基酸、蛋白质和灰分等指标分析评价其营养成分变化,测定pH值、色差和水分分布等指标分析评价其食用品质变化,以期为酶-碱联合嫩化工艺在实际生产中的合理应用提供一定的理论依据.结果表明:猪大肠平滑肌的氨基酸评分较高,甜味氨基酸量最高,占总氨基酸量的31.00%.酶-碱联合嫩化工艺可以显著改善色泽、提高水分含量、改善猪大肠平滑肌嫩度和质构特性,引起猪大肠平滑肌营养成分发生变化,且不同嫩化工艺均会使猪大肠平滑肌中结合水和不易流动水增加,自由水减少,使得水分子与底物结合更紧密.

关键词：猪大肠平滑肌嫩化营养成分食用品质

基于单踏板驾驶模式的电能两轮车能源回收系统

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机械制造 2024年第2期62卷 48-52页

作者：贺呈鹏昆明理工大学城市学院昆明650504

由于蓄电池容量的限制,电能两轮车行驶里程相对较短,节省电能,延长里程成为电能两轮车发展的关键。设计了一种基于单踏板驾驶模式的电能两轮车能源回收系统。基于浏览器/服务器结构将系统划分为三层架构模式,分别为数据层、控制层、显... 详细信息

由于蓄电池容量的限制,电能两轮车行驶里程相对较短,节省电能,延长里程成为电能两轮车发展的关键。设计了一种基于单踏板驾驶模式的电能两轮车能源回收系统。基于浏览器/服务器结构将系统划分为三层架构模式,分别为数据层、控制层、显示层。利用角度传感器采集单踏板驾驶信号,并将其作为系统的触发依据。当电能两轮车处于制动状态时,在微控制器控制下配置永磁同步电机的制动转矩,永磁同步电机执行单踏板驾驶模式能量回收路径,将机械能转换为电能,并存储至蓄电池中,实现能源回收。测试结果表明,应用所设计的系统,电池荷电状态和能源回收效率相对更大,能够帮助电能两轮车回收更多的能量。

关键词：单踏板驾驶电动汽车能源回收

2D-C/SiC复合材料热膨胀系数演化模型

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复合材料学报 2024年第4期41卷 2083-2098页

作者：郑茹悦杨成鹏贾斐西北工业大学力学与土木建筑学院西安710072 西安电子科技大学机电工程学院西安710071

热膨胀系数是耐高温复合材料的重要热力学参数。针对复合材料在服役条件下存在基体开裂和界面脱粘而影响其热膨胀变形的现象,通过理论模拟和实验测试,研究了含损伤2D-C/SiC复合材料热膨胀系数随环境温度的演变行为。首先,基于Mini复合... 详细信息

热膨胀系数是耐高温复合材料的重要热力学参数。针对复合材料在服役条件下存在基体开裂和界面脱粘而影响其热膨胀变形的现象,通过理论模拟和实验测试,研究了含损伤2D-C/SiC复合材料热膨胀系数随环境温度的演变行为。首先,基于Mini复合材料模型给出了组分材料的三维热失配应力计算模型;其次,引入基体开裂和界面脱粘损伤,并考虑组分材料热膨胀性能差异、纤维的横观各向同性以及泊松效应的影响,推导了Mini复合材料轴向和径向热膨胀系数的解析表达式;再次,基于[0/90]正交层压板模型和宏观应变的一致性假设,建立了2D-C/SiC复合材料含损伤表观热膨胀系数的分析预测模型;最后,将本模型与经典Schapery模型及实验值进行对比,分析了热膨胀系数的主要影响因素。参数分析表明:基体裂纹间距、界面脱粘率、孔隙率、组分材料的弹性模量及热膨胀系数等均会影响复合材料的表观热膨胀系数,其中基体膨胀系数的影响尤为显著;验证结果表明:本模型具有合理性与正确性,其预测值与经典模型及实验曲线均吻合良好。

关键词：热膨胀系数 Mini复合材料模型 2D-C/SiC 热失配应力 Schapery模型

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各向异性复合材料强度失效判据综述

力学学报 2024年第4期56卷 1006-1024页

作者：贾斐杨成鹏宋远翔西安电子科技大学机电工程学院西安710071 西北工业大学力学与土木建筑学院西安710072

失效判据在复合材料的渐进损伤模拟和极限强度预测中具有极其重要的意义.针对各向异性复合材料的损伤-破坏问题,根据理论架构与发展脉络,对现有失效判据进行了分类汇总和全面综述,重点总结了破坏模式无关判据和破坏模式相关判据,分析了... 详细信息

失效判据在复合材料的渐进损伤模拟和极限强度预测中具有极其重要的意义.针对各向异性复合材料的损伤-破坏问题,根据理论架构与发展脉络,对现有失效判据进行了分类汇总和全面综述,重点总结了破坏模式无关判据和破坏模式相关判据,分析了基于破坏面假设的相关理论成果,阐述了基于应力不变量进行判据构建的基本理论、方法和模型,并论述了基于应变能和基于损伤参量的两类失效判据.研究表明,各向异性复合材料强度理论发展的基础和主线仍然是二次应力判据,高阶唯象失效判据的合理性和适用性尚需验证;能量判据和损伤判据对于非线性-准脆性复合材料显示出了合理性和适用性,但表达式较为复杂.在深入分析研究的基础上,对复合材料强度理论的发展趋势进行了展望,提出了“损伤-断裂协同理论”这一重点与难点方向,以期对复合材料及其结构的设计、评估与应用提供更有价值的参考.

关键词：复合材料强度理论损伤演化失效判据断裂模式

中国预制菜加工及其包装技术现状分析与发展趋势

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西南大学学报（自然科学版） 2024年第7期46卷 1-10页

作者：李洪军兰子帆贺稚非程成鹏李洪列西南大学食品科学学院/川渝共建特色食品重庆市重点实验室重庆400700 重庆洪成食品有限公司重庆长寿401200

随着人们生活节奏的不断加快,许多人的消费和饮食习惯发生了较大变化,“懒人经济”开始蓬勃发展,而预制菜凭借其方便及快捷的特点受到人们的广泛关注.预制菜作为我国发展速度最快的食品种类之一,在受消费者喜爱的同时,也有效促进了地方... 详细信息

随着人们生活节奏的不断加快,许多人的消费和饮食习惯发生了较大变化,“懒人经济”开始蓬勃发展,而预制菜凭借其方便及快捷的特点受到人们的广泛关注.预制菜作为我国发展速度最快的食品种类之一,在受消费者喜爱的同时,也有效促进了地方经济的发展和乡村振兴.当前我国预制菜在食品加工领域,尤其是自动计量包装、食品加工生产装备等方面尚存在一些技术瓶颈问题,且现阶段对预制菜不同包装技术的研究还不完善.从预制菜产业发展现状出发,就其加工与包装中存在的问题进行分析,提出预制菜行业要高质量发展需要国家政策的支持和研发技术创新等有效措施,并对预制菜未来发展前景做出了展望.

关键词：预制菜加工技术包装技术发展趋势