检索结果-南通市图书馆

Advances in the differentiation of pluripotent stem cells into vascular cells

World Journal of Stem Cells 2024年第2期16卷 137-150页

作者： Yi-Chang Jiao Ying-Xin Wang Wen-Zhu Liu Jing-Wen Xu Yu-Ying Zhao Chuan-Zhu Yan Fu-chen Liu Department of Neurology Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina Research Institute of Neuromuscular and Neurodegenerative Diseases Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina Mitochondrial Medicine Laboratory Qilu Hospital(Qingdao)of Shandong UniversityQingdao 266103Shandong ProvinceChina Brain Science Research Institute Shandong UniversityJinan 250012Shandong ProvinceChina

Blood vessels constitute a closed pipe system distributed throughout the body,transporting blood from the heart to other organs and delivering metabolic waste products back to the lungs and *** in blood vessels are related to many disorders like stroke,myocardial infarction,aneurysm,and diabetes,which are important causes of death *** research for new appro-aches to disease modeling and effective treatment is needed due to the huge socio-economic burden on healthcare *** mice or rats have been widely used,applying data from animal studies to human-specific vascular physiology and pathology is *** rise of induced pluripotent stem cells(iPSCs)provides a reliable in vitro resource for disease modeling,regenerative medicine,and drug discovery because they carry all human genetic information and have the ability to directionally differentiate into any type of human *** review summarizes the latest progress from the establishment of iPSCs,the strategies for differentiating iPSCs into vascular cells,and the in vivo trans-plantation of these vascular *** also introduces the application of these technologies in disease modeling,drug screening,and regenerative ***,the application of high-tech tools,such as omics analysis and high-throughput sequencing,in this field is reviewed.

关键词： Induced pluripotent stem cell Blood vessels Vascular organoids Endothelial cells Smooth muscle cells Pericytes Tissue engineering vascular graft

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于SMCS模型的高强螺栓及节点火灾全过程断裂性能模拟

引用

工程力学 2024年第2期41卷 56-70,159页

作者：陈桥姜健蔡文玉陈伟叶继红中国矿业大学力学与土木工程学院江苏徐州221116 海南大学土木建筑工程学院海南海口570228

高强螺栓广泛应用于钢结构节点连接,火灾高温会影响其基本材性和断裂行为,从而影响螺栓节点抗火性能甚至整体结构抗倒塌性能。基于10.9级高强螺栓火灾全过程(升温段、降温段、火灾后)单轴拉伸试验结果,结合有限元模拟,对不同温度历程和... 详细信息

高强螺栓广泛应用于钢结构节点连接,火灾高温会影响其基本材性和断裂行为,从而影响螺栓节点抗火性能甚至整体结构抗倒塌性能。基于10.9级高强螺栓火灾全过程(升温段、降温段、火灾后)单轴拉伸试验结果,结合有限元模拟,对不同温度历程和应力三轴度对应的螺栓SMCS断裂模型进行校准,并与螺栓材性试验和T-stub节点试验结果对比验证;对T-stub节点火灾全过程断裂行为进行参数分析,研究损伤准则和温度历程对节点失效模式和变形特征的影响。结果表明:校准的SMCS模型能够有效、准确地预测螺栓和节点在火灾全过程和高应力三轴度(0.3~1.2)下的受拉断裂行为,适用预测误差在12%以内;拉伸温度和峰值温度是影响高强螺栓抗断能力的主要因素,螺栓抗断能力随温度升高而提高;不同温度历程下T-stub节点可能发生翼缘板屈服断裂、翼缘板和螺栓同时屈服断裂、螺栓屈服断裂三种失效模式,且节点的变形能力(延性系数)与失效模式有关,确定钢板母材和螺栓的断裂模型是准确预测节点失效模式的关键。

关键词：火灾全过程高强螺栓 SMCS模型断裂性能 T-stub节点

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Androgen signaling inhibits de novo lipogenesis to alleviate lipid deposition in zebrafish

引用

Zoological Research 2024年第2期45卷 355-366页

作者： Jing-Yi Jia Guang-Hui chen Ting-Ting Shu Qi-Yong Lou Xia Jin Jiang-Yan He Wu-Han Xiao Gang Zhai Zhan Yin College of Fisheries Huazhong Agriculture UniversityWuhanHubei 430070China State Key Laboratory of Freshwater Ecology and Biotechnology Institute of HydrobiologyChinese Academy of SciencesWuhanHubei 430072China College of Advanced Agricultural Sciences University of Chinese Academy of SciencesBeijing 100049China Hubei Key Laboratory of Three Gorges Project for Conservation of Fishes Chinese Sturgeon Research InstituteChina Three Gorges CorporationYichangHubei 443100China Hubei Hongshan Laboratory Huazhong Agriculture UniversityWuhanHubei 430070China Innovative Academy of Seed Design Chinese Academy of SciencesBeijing 100049China

Testosterone is closely associated with lipid metabolism and known to affect body fat composition and muscle mass in ***,the mechanisms by which testosterone acts on lipid metabolism are not yet fully understood,especially in *** this study,cyp17a1-/-zebrafish(Danio rerio)exhibited excessive visceral adipose tissue(VAT),lipid content,and up-regulated expression and activity of hepatic de novo lipogenesis(DNL)*** assay for transposase accessible chromatinwithsequencing(ATAC-seq)results demonstrated that chromatin accessibility of DNL genes was increased in cyp17a1-/-fish compared to cyp17a1+/+male fish,including stearoyl-CoA desaturase(scd)and fatty acid synthase(fasn).Androgen response element(ARE)motifs in the androgen signaling pathway were significantly enriched in cyp17a1+/+male fish but not in cyp17a1-/-*** androgen receptor(ar)-/-and wildtype(WT)zebrafish administered with Ar antagonist flutamide displayed excessive visceral adipose tissue,lipid content,and up-regulated expression and activity of hepatic de novo lipogenesis *** Ar agonist BMS-564929 reduced the content of VAT and lipid content,and down-regulated acetyl-CoA carboxylase a(acaca),fasn,and scd ***,the rescue effect of testosterone on cyp17a1-/-fish in terms of phenotypes was abolished when ar was additionally ***,these findings reveal that testosterone inhibits lipid deposition by down-regulating DNL genes via Ar in zebrafish,thus expanding our understanding of the relationship between testosterone and lipid metabolism in teleosts.

关键词： Cyp17a1 Testosterone Androgen receptor De novo lipogenesis Fatty acid synthesis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mn掺杂Zigzag(8,0)型单壁碳纳米管吸附甲醛分子的密度泛函理论研究

引用

材料导报 2024年第4期38卷 58-63页

作者：程婷陈晨张晓温明月王磊江苏城市职业学院环境生态学院南京210017 江苏科技大学环境与化学工程学院江苏镇江212100 南京大学盐城环保技术与工程研究院江苏盐城224005

甲醛是一种对人体健康造成巨大威胁的污染物。气态甲醛浓度的准确检测对大气空气治理评估和室内环境安全均有重要意义,而高效传感器的研发则是甲醛分子检测技术优化的关键。本研究通过基于第一性原理的DFT计算软件VASP,对甲醛分子在Mn掺... 详细信息

甲醛是一种对人体健康造成巨大威胁的污染物。气态甲醛浓度的准确检测对大气空气治理评估和室内环境安全均有重要意义,而高效传感器的研发则是甲醛分子检测技术优化的关键。本研究通过基于第一性原理的DFT计算软件VASP,对甲醛分子在Mn掺杂Zigzag(8,0)型单臂碳纳米管上的吸附特性进行研究。结果表明:Mn掺杂Zigzag(8,0)型单臂碳纳米管是一种稳定的分子构型。区别于在原始CNT上的物理吸附过程,甲醛分子在Mn掺杂CNT上的吸附键长更短,吸附能更大,属于化学吸附过程。同时,甲醛分子在Mn掺杂CNT上的吸附过程还伴随着明显的电荷转移。吸附过程发生后,吸附样品的光吸收曲线在580~705 nm以及365~447 nm的范围内出现明显的蓝移,在307~360 nm的范围内出现了明显的红移。

关键词： Mn掺杂碳纳米管甲醛吸附

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Musielak–Orlicz–Lorentz Hardy Spaces: Maximal Function, Finite Atomic, and Littlewood–Paley Characterizations with Applications to Dual Spaces and Summability of Fourier Transforms

引用

Acta Mathematica Sinica,English Series 2024年

作者： Hong Chao JIA Der-chen CHANG Ferenc WEISZ Da Chun YANG Wen YUAN Department of Numerical Analysis E?tv?s L.University Laboratory of Mathematics and Complex Systems (Ministry of Education of China) School of Mathematical Sciences Beijing Normal University Department of Mathematics and Statistics Georgetown University Washington Institute of Business Administration College of Management Fu Jen Catholic University

Let q ∈(0, ∞] and φ be a Musielak–Orlicz function with uniformly lower type pφ-∈(0, ∞) and uniformly upper type pφ+∈(0, ∞). In this article, the authors establish various realvariable characterizations of the Musielak–Orlicz–Lorentz Hardy space Hφ,q(Rn), respectively, in terms of various maximal functions, finite atoms, and various Littlewood–Paley functions. As applications, the authors obtain the dual space of Hφ,q(Rn) and the summability of Fourier transforms from Hφ,q(Rn)to the Musielak–Orlicz–Lorentz space Lφ,q(Rn) when q ∈(0, ∞) or from the Musielak–Orlicz Hardy space Hφ(Rn) to Lφ,∞(Rn) in the critical case. These results are new when q ∈(0, ∞) and also essentially improve the existing corresponding results(if any) in the case q = ∞ via removing the original assumption that φ is concave. To overcome the essential obstacles caused by both that φmay not be concave and that the boundedness of the powered Hardy–Littlewood maximal operator on associated spaces of Musielak–Orlicz spaces is still unknown, the authors make full use of the obtained atomic characterization of Hφ,q(Rn), the corresponding results related to weighted Lebesgue spaces,and the subtle relation between Musielak–Orlicz spaces and weighted Lebesgue spaces.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

High patatin like phospholipase domain containing 8 expression as a biomarker for poor prognosis of colorectal cancer

引用

World Journal of Gastrointestinal Oncology 2024年第3期16卷 787-797页

作者： Peng-Yang Zhou De-Xiang Zhu Yi-Jiao chen Qing-Yang Feng Yi-Hao Mao Ao-Bo Zhuang Jian-Min Xu Department of General Surgery Zhongshan Hospital Fudan UniversityShanghai 200032China

BACKGROUND Patatin like phospholipase domain containing 8(PNPLA8)has been shown to play a significant role in various cancer *** studies have focused on its roles as an antioxidant and in lipid ***,the role of PNPLA8 in colorectal cancer(CRC)progression is *** To explore the prognostic effects of PNPLA8 expression in *** A retrospective cohort containing 751 consecutive CRC patients was ***8 expression in tumor samples was evaluated by immunohistochemistry staining and semi-quantitated with immunoreactive *** patients were divided into high and low PNPLA8 expression groups based on the cut-off va-lues,which were calculated by X-tile *** prognostic value of PNPLA8 was identified using univariate and multivariate Cox regression *** over-all survival(OS)rates of CRC patients in the study cohort were compared with Kaplan-Meier analysis and Log-rank *** PNPLA8 expression was significantly associated with distant metastases in our cohort(P=0.048).CRC patients with high PNPLA8 expression indicated poor OS(median OS=35.3,P=0.005).CRC patients with a higher PNPLA8 expression at either stage I and II or stage III and IV had statistically significant shorter *** patients with left-sided colon and rectal cancer,the survival curves of two PN-PLA8-expression groups showed statistically significant *** analysis also confirmed that high PNPLA8 expression was an independent prog-nostic factor for overall survival(hazard ratio HR=1.328,95%CI:1.016-1.734,P=0.038).

关键词： Biomarker Colorectal cancer Expression level Overall survival Patatin like phospholipase domain containing 8 Prognosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

引用

Neural Regeneration Research 2025年第2期20卷 402-415页

作者： Xiaorong Zhang Zhiying chen Yinyi Xiong Qin Zhou Ling-Qiang Zhu Dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

From Chooz to the Ling'ao NPP:The Technology Transfer of Pressurized Water Reactor Technology from France to China

引用

Chinese Annals of History of Science and Technology 2024年第1期8卷 97-124页

作者： chen Yue LI Yunyi Institute for the History of Natural Sciences Chinese Academy of SciencesBeijing 100190China

The transfer of pressurized water reactor(PWR)technology from France to China is an important event in the history of Sino-French scientific and technological *** has gradually achieved self-reliance in the field of PWR technology through the introduction and subsequent absorption of France's 900 MW *** with the process of introducing and absorbing similar technology from the United States by France,China's experience has been more *** circumstance reflects the differences in the nuclear power technology systems between the two ***'s industrial strength and early acquisition of nuclear power technology laid a solid foundation for mastering PWR *** the other hand,although China established a weak foundation through the implementation of the"728 Project,"and tried hard to negotiate with France,the substantive content of the technology transfer was very *** way of the policy transition from"unhooking of technology and trade"to"integration of technology and trade,"China ultimately accomplished the absorption and innovation of PWR technology through the Ling'ao NPP.

关键词： pressurized water reactor(PWR) technology transfer Sino-French relations Chooz NPP Daya Bay NPP Ling'ao NPP

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Qualitative exploration of home life experiences and care needs among elderly patients with temporary intestinal stomas

引用

World Journal of Gastroenterology 2024年第22期30卷 2893-2901页

作者： Si-Meng Wang Jian-Ling Jiang Rui Li Juan-Juan Wang Chun-Hong Gu Jia Zeng Xiao-Hui Wei Mei chen Wuxi Medical College of Jiangnan University Jiangnan UniversityWuxi 214122Jiangsu ProvinceChina Department of Gastrointestinal Surgery Tongren Hospital Shanghai Jiao Tong University School of MedicineShanghai 200335China Department of Nursing Tong Ren Hospital Shanghai Jiao Tong University School of MedicineShanghai 200335China

BACKGROUND This study employed a phenomenological research approach within qualitative research to explore the challenges encountered by elderly individuals with temporary colostomies in managing their daily lives and care *** the anus surgery combined with temporary colostomy has emerged as a prevalent treatment modality for low rectal ***,the ileostomy is susceptible to peri-stoma skin complications,as well as fluid,electrolyte,and nutritional imbalances,posing challenges to effective *** successful selfmanagement of patients is intricately linked to their adjustment to temporary colostomy;nonetheless,there remains a dearth of research examining the factors influencing self-care among temporary colostomy patients and the obstacles they *** To investigate the lived experiences,perceptions,and care requirements of temporary colostomy patients within their home environment,with the ultimate goal of formulating a standardized management *** Over the period of June to August 2023,a purposive sampling technique was utilized to select 12 patients with temporary intestinal stomas from a tertiary hospital in Shanghai,*** a phenomenological research approach,a semi-structured interview guide was developed,and qualitative interviews were conducted using in-depth interview *** acquired data underwent coding,analysis,organization,and summarization following Colaizzi’s seven-step *** The findings of this study revealed that the experiences and needs of patients with temporary intestinal stomas can be delineated into four principal themes:Firstly,Temporary colostomy patients bear various burdens and concerns about the uncertainty of disease progression;secondly,patients exhibit limited self-care capabilities and face information deficits,resulting in heightened reliance on healthcare professionals;thirdly,patients demonstrate the potential for internal motivation through proactive self-adj

关键词： Elderly Temporary intestinal stomas Life experiences Intestinal ostomy complications Qualitative study

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于视觉同时定位与地图构建的水下图像增强式视觉三维重建方法

引用

中国机械工程 2024年第2期35卷 268-279页

作者：梅杰覃嘉锐陈定方陈昆武汉理工大学交通与物流工程学院武汉430063 武汉理工大学智能制造与控制研究所武汉430063 武汉理工大学港口货物装卸技术交通部重点实验室武汉430063

针对仿生机器鱼水下作业时面临的水下图像质量偏低、水下自主定位难的问题,提出一种颜色均衡与G-B通道先验融合的水下图像增强式算法。将该算法和视觉同时定位与地图构建(SLAM)方法结合,实现了水下图像增强式的视觉三维重建。在不同水... 详细信息

针对仿生机器鱼水下作业时面临的水下图像质量偏低、水下自主定位难的问题,提出一种颜色均衡与G-B通道先验融合的水下图像增强式算法。将该算法和视觉同时定位与地图构建(SLAM)方法结合,实现了水下图像增强式的视觉三维重建。在不同水域环境下进行了水下图像处理实验、水下环境视觉三维重建实验和运动轨迹跟踪实验,结果表明该方法有效提高了水下图像综合质量,特征匹配效率提高了16.03%,真实轨迹与估计轨迹的误差平均约为7.99 mm。

关键词：水下图像增强三维重建运动轨迹跟踪视觉同时定位与地图构建(SLAM)

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：