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Artemisinin ameliorated proteinuria in rats with adriamycin-induced nephropathy through regulating nephrin and podocin expressions

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Journal of Traditional Chinese Medicine 2014年第1期34卷 63-68页

作者： Xili Wu Peng An Bingyu Ye Xingmin Shi Huimin Dang Rongguo Fu chenglin qiao Department of Integrated Chinese Traditional and Western Medicine Second Affiliated Hospital of Xi'an Jiaotong University School of Public Health of Xi'an Jiaotong University Department of Nephrology Second Affiliated Hospital of Xi'an Jiaotong University

OBJECTIVE:To investigate the effects of artemisinin against proteinuria and glomerular filtration barrier damage in rats with adriamycin-induced nephropathy,and the potential mechanism underpinned the ***:Forty adriamycin rats were randomly divided into two groups with the ratio of 1︰3;the small-number group served as control group(n=10),and the rats in the large-number group were treated with adriamycin to induce nephropathy;then they were further randomly assigned into 3subgroups:benazepril group(n=10),artemisiningroup(n=10),and adriamycin group(n=10).The benazepril group and artemisinin group were treated with benazepril suspl(5.0 mg/kg daily)and artemisinin suspl(150 mg/kg daily)respectively after being modeled;those in the control group and adriamycin group were intragastrically administered an equivalent volume of distilled water every *** treatment after model establishment lasted for a total of 4 *** 24 h uric protein,blood biochemicals,renal pathological changes,renal ultrastrutural changes,Nephrin and Podocin proteins and gene expressions were measured by Coomassie brilliant blue assay,completely automatic biochemical analyzer,light microscope,electron microscopy,Western blot and reverse transcription polymerase chain reaction,***:The rats in adriamycin group showed a significant increase in 24 h uric protein excretion,serum total cholesterol(TC),triglyceride(TG),blood urea nitrogen(BUN),serum creatinine(Scr)and decrease in albumin(Alb)(P0.05).The renal pathological and ultrastrutural observation indicate that artemisinin could attenuate the severity of foot process effacement and fusion in the nephropathic

关键词： Artemisinin Proteinuria Doxorubicin Kidney diseases Nephrin NPHS2 protein

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多传感器协同跟踪与辐射控制的调度算法

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北京航空航天大学学报 2018年第7期44卷 1472-1480页

作者：乔成林段修生单甘霖陆军工程大学石家庄校区电子与光学工程系石家庄050003 石家庄铁道大学机械工程学院石家庄050043

为了降低有源传感器在获得目标持续量测时被敌方截获的风险,提出一种多传感器协同跟踪与辐射控制的调度算法。该算法首先采用辐射度影响(ELI)衡量传感器辐射,将目标跟踪与辐射控制过程建立为部分可观马尔可夫决策(POMDP)过程。然后以隐... 详细信息

为了降低有源传感器在获得目标持续量测时被敌方截获的风险,提出一种多传感器协同跟踪与辐射控制的调度算法。该算法首先采用辐射度影响(ELI)衡量传感器辐射,将目标跟踪与辐射控制过程建立为部分可观马尔可夫决策(POMDP)过程。然后以隐马尔可夫模型(HMM)滤波器更新传感器辐射状态、推导长时辐射风险,以无迹卡尔曼滤波(UKF)更新目标状态、估计跟踪精度。最后考虑跟踪任务需求,构建精度约束下辐射控制的长时调度模型,并将该长时调度问题转化为决策树寻优问题,给出决策树节点次优下界值,采用改进分支定界技术(IB&B)快速求解最优调度序列。仿真结果验证了本文算法的有效性。

关键词：传感器调度协同跟踪辐射控制决策树任务需求部分可观马尔可夫决策过程(POMDP)

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多平台主动与被动传感器协同跟踪的长时调度方法

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兵工学报 2019年第1期40卷 115-123页

作者：乔成林单甘霖段修生郭峰陆军工程大学石家庄校区电子与光学工程系河北石家庄050003 石家庄铁道大学机械工程学院河北石家庄050043 北京航天飞行控制中心北京100094

为了有效跟踪杂波环境下机动目标、降低系统辐射风险,提出一种多平台主动与被动传感器协同跟踪的长时调度方法。将长时调度问题构建为部分可观马尔可夫决策过程,采用交互式多模型概率数据关联算法更新目标信念状态,利用后验克拉美-罗下... 详细信息

为了有效跟踪杂波环境下机动目标、降低系统辐射风险,提出一种多平台主动与被动传感器协同跟踪的长时调度方法。将长时调度问题构建为部分可观马尔可夫决策过程,采用交互式多模型概率数据关联算法更新目标信念状态,利用后验克拉美-罗下界预测机动目标长时跟踪精度,提出改进的维特比算法以求解最优调度序列。仿真实验结果表明,所提搜索算法能够显著降低搜索空间和存储空间,所提长时调度方法能够有效控制系统辐射代价、克服传感器频繁切换。

关键词：传感器长时调度部分可观马尔可夫决策过程交互式多模型概率数据关联后验克拉美-罗下界维特比算法

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面向机动目标跟踪的多传感器长时调度策略

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哈尔滨工业大学学报 2019年第4期51卷 123-130页

作者：乔成林段修生单甘霖徐公国陆军工程大学(石家庄校区)电子与光学工程系石家庄050003

为解决杂波环境下机动目标跟踪以及系统辐射风险控制的问题,提出了一种面向机动目标跟踪的多传感器长时调度策略.该方法首先以交互式多模型和概率数据关联算法为基础,估计杂波环境下机动目标跟踪精度.然后以辐射度影响量化辐射代价、推... 详细信息

为解决杂波环境下机动目标跟踪以及系统辐射风险控制的问题,提出了一种面向机动目标跟踪的多传感器长时调度策略.该方法首先以交互式多模型和概率数据关联算法为基础,估计杂波环境下机动目标跟踪精度.然后以辐射度影响量化辐射代价、推导有限时域内辐射代价,以后验克拉美-罗下界衡量目标跟踪性能、预测机动目标有限时域内后验克拉美-罗下界.最后,引入传感器切换代价,考虑跟踪精度约束,建立基于代价函数和后验克拉美-罗下界的多传感器长时调度策略,并将该约束调度问题转化为决策树优化问题,采用阈值剪枝搜索技术求解最优策略.仿真结果表明:该方法验证了所提策略的有效性,与标准代价搜索相比,所提搜索算法能够以辐射风险略上升为代价,显著降低节点打开数、加快搜索空间;与随机调度、最近调度和贪婪调度相比,所提调度策略能够在满足跟踪任务需求下获得更低的辐射代价;与随机调度和贪婪调度相比,所提调度策略切换代价更低,有效克服了传感器频繁调度问题,更利于实际实现.

关键词：传感器调度辐射控制切换代价交互式多模型概率数据关联后验克拉美-罗下界决策树

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A Sensor Selection Algorithm with Improved Accuracy Constraint for Maneuvering Target Tracking

A Sensor Selection Algorithm with Improved Accuracy Constrai...

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第37届中国控制会议

作者： chenglin qiao Yuantao Yu Ganlin Shan Xiusheng Duan Binbin Fan Yi Miao Ce Pang Shijiazhuang Campus Army Engineering University School of Automation Beijing Institute of Technology Institute of Information and Communication National University of Defense technology 73903 Army of PLA

To control the sensor system radiation risk and satisfy the maneuvering target tracking requirement, a sensor selection algorithm with improved accuracy constraint for maneuvering target tracking is proposed. Firstly, the posterior Cramr-Rao lower bound（PCRLB） is utilized to assess the tracking performance. Then multiple model PCRLB is presented to calculate the PCRLB of maneuvering target. Secondly, tracking accuracy is treated in a probabilistic manner in the improved accuracy constraint. Then the improved accuracy constraint can be converted to a deterministic constraint by the given desired tracking accuracy and probability. Finally, as the active sensor obtain the target measurement by emitting energy that can betray their existence and location, radiation control policy is presented to minimize the times of active sensor selection. Simulation results prove the effectiveness of the proposed algorithm.

关键词： Sensor Selection Radiation Risk Maneuvering Target Tracking PCRLB Improved Accuracy Constraint

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面向跟踪任务需求的主动传感器调度方法

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系统工程与电子技术 2017年第11期39卷 2515-2521页

作者：乔成林单甘霖段修生刘欣怡军械工程学院电子与光学工程系河北石家庄050003 中国白城兵器试验中心吉林白城137001

以多传感器多目标跟踪为背景,针对跟踪任务需求中辐射风险控制问题,提出一种面向跟踪任务需求的主动传感器调度方法。该方法首先结合不敏卡尔曼滤波,给出了仅考虑跟踪任务需求的传感器调度策略;然后建立基于部分可观马尔可夫决策过程的... 详细信息

以多传感器多目标跟踪为背景,针对跟踪任务需求中辐射风险控制问题,提出一种面向跟踪任务需求的主动传感器调度方法。该方法首先结合不敏卡尔曼滤波,给出了仅考虑跟踪任务需求的传感器调度策略;然后建立基于部分可观马尔可夫决策过程的辐射模型,并采用隐马尔可夫模型滤波器动态更新传感器辐射;最后考虑跟踪任务需求和传感器约束,将辐射风险控制下传感器调度问题转化为非线性约束下寻优问题。仿真实验结果验证了所提方法有效性。

关键词：传感器调度跟踪任务需求部分可观马尔可夫决策过程辐射风险

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PHASE DIAGRAM OF PrCl_3-SrCl_2-CaCl_2 SYSTEM

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Acta Metallurgica Sinica(English Letters) 1993年第7期6卷 46-51页

作者： ZHENG Chaogui BAO chenglin qiao Zhiyu YE Yupu Peking University,Beijing,China 1 University of Science and Technology Beijing,Beijing,China Associate Professor,Department of Chemistry,Peking University,Beijing 100871,China

Five fields corresponding to the primary crystallization of PrCl_3,Sr_3PrCl_9,α(SrCl_2, CaCl_2),α_1(CaCl_2,SrCl_2)and α_2(SrCl_2,CaCl_2)respectively,six univariant lines related to the secondary crystallization,one ternary eutectic(48.0 wt-％ PrCl_3,23.5 wt-％ SrCl_2; 590℃)and ternary peritectic point(45.5 wt-％ PrCl_3,24.5 wt-％ SrCl_2;614℃) were determined by *** were also made to explore the rule governing the alteration in the phase diagram containing rare earth chloride,formation of compound and its stability by means of polarization and counter-polarization.

关键词： PrCl_3 PrCl-3-SrC1_2-CaCl_2 phase diagram rule of pihase diagram

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Tetrahedron constellation of gravitational wave observatory

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Science China(Physics,Mechanics & Astronomy) 2025年第2期68卷 86-93页

作者： Hong-Bo Jin Cong-Feng qiao National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China International Centre for Theoretical Physics Asia-Pacific University of Chinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China

For the first time,we have introduced the tetrahedron constellation of gravitational wave observatory(TEGO)composed of four identical spacecrafts(S/Cs).The laser telescopes and their pointing structures are mounted on the S/C platform and are evenly distributed at three locations 120 degrees *** structures form automatically a stable mass center for the *** time delay interferometry(TDI)is used to suppress the frequency noise of gravitational wave(GW)*** unequal-arm Michelson TDI configuration and the Sagnac TDI configuration are equally effective at eliminating the laser frequency noise based on the TEGO ***,compared with the configurations of LISA,Taiji,and Tian Qin,the TEGO has more combinations of optical paths in its TDI system sensitive to GW *** six arms of TEGO are simultaneously sensitive to the six polarization modes of *** sensitivity implies that GW modes beyond the predictions of general relativity(GR)can be detected *** instance,a scalar longitudinal mode of GWs,which is not predicted by GR,has been identified as a dominant polarization *** mode is found to be evident in the response amplitudes of the TEGO arms,such as between S/C1 and S/C4,and S/C3 and S/C4,at certain orbital positions.

关键词： gravitational wave detectors and experiments gravitational waves experimental tests of gravitational theories experimental studies of gravity

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Effects of emodin on the proliferation of the glomerular mesangial cell and correlative cytokines in rats

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Journal of Nanjing Medical University 2007年第5期21卷 298-301页

作者： Xili Wu Wanggang Zhang Wansen Sun chenglin qiao Department of Integrated Chinese Traditional and Western Medicine the Second Affiliated Hospital of Xi＇ an Jiaotong University Xi＇ an 710004 Shanxi Province China Department of Hematology the Second Affiliated Hospital of Xi＇ an Jiaotong University Xi＇ an 710004 Shanxi Province China

Objective：To investigate the effects of emodin（EMD） on cell proliferation and correlative cytokines secretion of glomerular mesangial in rats. Methods：The effects of EMD on cell proliferation and IL-6, TGF-β1 secretion of glomerular mesangial in rats were observed. Cell proliferation was measured by MTT method. IL-6 and TGF-β1 secretion was detected with ELISA. Results：EMD was able to inhibit the cell proliferation and down-regulate the IL-6 and TGF-β 1 secretion of glomerular mesangial, as compared to the model group in rats （P 〈 0.05）. Conclusion：EMD could significantly inhibit the cell proliferation, and reduce the creation of extracellular matrix（ECM）, this indicated that it could play an important role in alleviation and prevention of glomerular sclerosis. The mechanism may be that EMD can reduce the IL-6 and TGF-β1 secretion ofglomerular mesangial cell in rats.

关键词： emodin glomerular mesangial cell mesangial cell proliferation correlative cytokines

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The profound review of Fenton process:What’s the next step?

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Journal of Environmental Sciences 2025年第1期147卷 114-130页

作者： Yimin Lin Junlian qiao Yuankui Sun Hongyu Dong State Key Laboratory of Pollution Control and Resources Reuse College of Environmental Science and EngineeringTongji UniversityShanghai 200092China Department of Environmental Science School of Ecological and Environmental SciencesEast China Normal UniversityShanghai 200241China

Fenton and Fenton-like processes,which could produce highly reactive species to degrade organic contaminants,have been widely used in the field of wastewater ***,the chemistry of Fenton process including the nature of active oxidants,the complicated reactions involved,and the behind reason for its strongly pH-dependent performance,is the basis for the application of Fenton and Fenton-like processes in wastewater ***,the conflicting views still exist about the mechanism of the Fenton *** instance,reaching a unanimous consensus on the nature of active oxidants(hydroxyl radical or tetravalent iron)in this process remains *** review comprehensively examined the mechanism of the Fenton process including the debate on the nature of active oxidants,reactions involved in the Fenton process,and the behind reason for the pH-dependent degradation of contaminants in the Fenton ***,we summarized several strategies that promote the Fe(Ⅱ)/Fe(Ⅲ)cycle,reduce the competitive consumption of active oxidants by side reactions,and replace the Fenton reagent,thus improving the performance of the Fenton ***,advances for the future were proposed including the demand for the high-accuracy identification of active oxidants and taking advantages of the characteristic of target contaminants during the degradation of contaminants by the Fenton process.

关键词： Advanced oxidation process Fenton Hydroxyl radical Fe(IV) Wastewater treatment

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