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原发性腹膜后平滑肌肉瘤初次术后影响生存期的因素分析

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中国研究型医院 2024年第1期11卷 40-44页

作者：邹博远高海成李文杰陈小兵黄梅苗成利北京大学国际医院腹膜后肿瘤外科北京102206

目的分析初次手术后对原发性腹膜后平滑肌肉瘤患者生存期的影响因素,并了解其临床特征。方法搜集2018年1月—2023年1月67例原发性腹膜后平滑肌肉瘤患者的临床资料进行回顾性分析。根据患者的手术情况、年龄、性别、病理类型及其他相关因... 详细信息

目的分析初次手术后对原发性腹膜后平滑肌肉瘤患者生存期的影响因素,并了解其临床特征。方法搜集2018年1月—2023年1月67例原发性腹膜后平滑肌肉瘤患者的临床资料进行回顾性分析。根据患者的手术情况、年龄、性别、病理类型及其他相关因素,对其生存期进行统计和分析。符合正态分布的计量资料以xˉ±s表示、采用t检验;计数资料以%表示、采用χ2检验。对影响患者预后因素的分析采用单因素分析,其中差异有统计学意义的因素采用多因素Logistic回归分析。结果67例患者的平均生存期为(18.25±2.41)个月,病理证实肿瘤类型均为平滑肌肉瘤。生存分析显示,年龄>60岁、肿瘤最大径>10 cm、肿瘤分期Ⅲ~Ⅳ期、肿瘤分化程度低~差、肿瘤累及其他脏器均是影响患者术后生存期的危险因素(P均0.05)。经多因素Logistic回归分析,表明年龄≥60岁、显微镜下切缘看到肿瘤细胞(R1切除)、肿瘤最大径≥10 cm、肿瘤分期Ⅲ~Ⅳ期、肿瘤低~差分化、肿瘤累及其他脏器均是影响原发性腹膜后平滑肌肉瘤初次手术后生存率的独立危险因素。结论患者年龄、肿瘤最大径、肿瘤分期等是影响患者预后的主要因素,准确评估这些影响因素有助于指导临床决策,进一步改善患者的预后结果。

关键词：腹膜后肿瘤平滑肌肉瘤外科手术预后影响因素

Adjuvant radiotherapy in central hepatocellular carcinoma after narrow-margin hepatectomy:A 10-year real-world evidence

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Chinese Journal of Cancer Research 2020年第5期32卷 645-653页

作者： Weiqi Rong Weibo Yu Liming Wang Fan Wu Kai Zhang Bo Chen chengli miao Liguo Liu Songlin An Changcheng Tao Weihu Wang Jianxiong Wu Department of Hepatobiliary Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Pathology and Laboratory Medicine David Geffen School of MedicineUniversity of California Los AngelesLos AngelesCA 90095USA Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Retroperitoneal Tumor Surgery Peking University International HospitalBeijing 102206China Department of General Surgery China-Japan Friendship HospitalBeijing 100029China Department of Peritoneal Cancer Surgery Beijing Shijitan HospitalCapital Medical University BeijingBeijing 100038China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Radiation OncologyPeking University Cancer Hospital&InstituteBeijing 100142China

Objective:A prospective randomized control study investigated the feasibility and efficacy of adjuvant radiotherapy on patients with central hepatocellular carcinoma(HCC)after narrow-margin hepatectomy(<1 cm).This study presents an updated 10-year real-world evidence to further characterize the role of adjuvant ***:Patients with central HCC after narrow-margin hepatectomy(<1 cm)were prospectively assigned to adjuvant radiotherapy group and control ***'outcome,adverse events,long-term recurrence and survival rates were ***:The 1-,5-,and 10-year recurrence-free survival(RFS)rates were 81.0%,43.9%,and 38.7%,respectively in adjuvant radiotherapy group and 71.7%,35.8%,and 24.2%,respectively in control group(log-rank test,P=0.09).The 1-,5-,and 10-year overall survival(OS)rates were 96.6%,54.7%,and 42.8%,respectively in adjuvant radiotherapy group and 90.2%,55.1%,and 30.0%,respectively in control group(log-rank test,P=0.20).The 1-,5-,and 10-year RFS rates for patients with small HCC(≤5 cm)were 91.1%,51.6%,and 48.4%,respectively in adjuvant radiotherapy group and 80.0%,36.6%,and 26.6%,respectively in control group(log-rank test,P=0.03).Landmark analysis demonstrated that patients with small HCC in adjuvant radiotherapy group had a significantly improved OS in second five years after treatment in comparison to patients in control group(log-rank test,P=0.05).Conclusions:Our updated results showed a sustained clinical benefit on reducing recurrence,improving longterm survival for small central HCC by adjuvant radiotherapy after narrow-margin ***-term survival data also indicated that hepatectomy is an optimal treatment for selected patients with central HCC.

关键词： Three-dimensional conformal radiotherapy recurrence long-term survival narrow-margin hepatectomy real-world evidence

Ferroptosis:a potential therapeutic target for stroke

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Neural Regeneration Research 2024年第5期19卷 988-997页

作者： chengli Liu Guijun Wang Wenrui Han Qi Tian Mingchang Li Department of Neurosurgery Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Ferroptosis is a form of regulated cell death characterized by massive iron accumulation and iron-dependent lipid peroxidation,differing from apoptosis,necroptosis,and autophagy in several *** is regarded as a critical mechanism of a series of pathophysiological reactions after stroke because of iron overload caused by hemoglobin degradation and iron metabolism *** this review,we discuss ferroptosis-related metabolisms,important molecules directly or indirectly targeting iron metabolism and lipid peroxidation,and transcriptional regulation of ferroptosis,revealing the role of ferroptosis in the progression of *** present updated progress in the intervention of ferroptosis as therapeutic strategies for stroke in vivo and in vitro and summarize the effects of ferroptosis inhibitors on *** review facilitates further understanding of ferroptosis pathogenesis in stroke,proposes new targets for the treatment of stroke,and suggests that more efforts should be made to investigate the mechanism of ferroptosis in stroke.

关键词： cell death ferroptosis oxidative stress stroke treatment

Tipping Point Detection Using Reservoir Computing

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Research 2024年第1期2023卷 779-790页

作者： Xin Li Qunxi Zhu chengli Zhao Xuzhe Qian Xue Zhang Xiaojun Duan Wei Lin College of Science National University of Defense TechnologyChangshaHunan 410073China Research Institute of Intelligent Complex Systems and MOE Frontiers Center for Brain Science Fudan UniversityShanghai 200433China Shanghai Artificial Intelligence Laboratory Shanghai 200232China School of Mathematical Sciences SCMSSCAMand CCSBFudan UniversityShanghai 200433China

Detection in high fidelity of tipping points,the emergence of which is often induced by invisible changes in internal structures or/and external interferences,is paramountly beneficial to understanding and predicting complex dynamical systems(CDSs).Detection approaches,which have been fruitfully developed from several perspectives(e.g.,statistics,dynamics,and machine learning),have their own advantages but still encounter difficulties in the face of high-dimensional,fluctuating ***,using the reservoir computing(RC),a recently notable,resource-conserving machine learning method for reconstructing and predicting CDSs,we articulate a model-free framework to accomplish the detection only using the time series observationally recorded from the underlying unknown CDSs.

关键词： computing record ping

Personalized assessment and training of neurosurgical skills in virtual reality:An interpretable machine learning approach

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虚拟现实与智能硬件（中英文） 2024年第1期6卷 17-29页

作者： Fei LI Zhibao QIN Kai QIAN Shaojun LIANG chengli LI Yonghang TAI Yunnan Key Laboratory of Opto-electronic Information Technology Yunnan Normal UniversityKunming 650500China Department of Thoracic Surgery Institute of The First People’s Hospital of Yunnan ProvinceKunming 650500China Faculty of Life and Biotechnology Kunming University of Science and TechnologyKunming 650031China

Background Virtual reality technology has been widely used in surgical simulators,providing new opportunities for assessing and training surgical *** learning algorithms are commonly used to analyze and evaluate the performance of ***,their interpretability limits the personalization of the training for individual *** Seventy-nine participants were recruited and divided into three groups based on their skill level in intracranial tumor *** on the use of surgical tools were collected using a surgical *** selection was performed using the Minimum Redundancy Maximum Relevance and SVM-RFE algorithms to obtain the final metrics for training the machine learning *** machine learning algorithms were trained to predict the skill level,and the support vector machine performed the best,with an accuracy of 92.41%and Area Under Curve value of *** machine learning model was interpreted using Shapley values to identify the important factors contributing to the skill level of each *** This study demonstrates the effectiveness of machine learning in differentiating the evaluation and training of virtual reality neurosurgical *** use of Shapley values enables targeted training by identifying deficiencies in individual *** This study provides insights into the use of machine learning for personalized training in virtual reality *** interpretability of the machine learning models enables the development of individualized training *** addition,this study highlighted the potential of explanatory models in training external skills.

关键词： Machine learning Neurosurgery Shapley values Virtual reality Human-robot interaction

Brain-inspired dual-pathway neural network architecture and its generalization analysis

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Science China(Technological Sciences) 2024年第8期67卷 2319-2330页

作者： DONG SongLin TAN chengli ZUO ZhenTao HE YuHang GONG YiHong ZHOU TianGang LIU JunMin ZHANG JiangShe College of Artiﬁcial Intelligence Xi’an Jiaotong UniversityXi’an 710049China School of Mathematics and Statistics Xi’an Jiaotong UniversityXi’an 710049China State Key Laboratory of Brain and Cognitive Science Institute of BiophysicsChinese Academy of SciencesBeijing 100101China Institute of Artiﬁcial Intelligence Hefei Comprehensive National Science CenterHefei 230088China University of Chinese Academy of Sciences Beijing 100049China

In this study, we explored the neural mechanism of global topological perception in the human visual system. We showed strong evidence that the retinotectal pathway in the archicortex of the human brain is responsible for global topological perception, and for modulating the local feature processing in the classical ventral visual pathway. Inspired by this recent cognitive discovery,we developed a novel CogNet architecture to emulate the global-local dichotomy of human visual cognitive mechanisms. The thorough experimental results indicate that the proposed CogNet not only significantly improves image classification accuracies but also effectively addresses the texture bias problem observed in baseline CNN models. We have also conducted mathematical analysis for the generalization gap for general neural networks. Our theoretical derivations suggest that the Hurst parameter, a measure of the curvature of the loss landscape, can closely bind the generalization gap. A larger Hurst parameter corresponds to a better generalization ability. We found that our proposed CogNet achieves a lower test error and attains a larger Hurst parameter,strengthening its superiority over the baseline CNN models further.

关键词： global topological perception dual-pathway generalization gap analysis Hurst parameter

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肛门失禁的诊断及外科治疗研究进展

医学综述 2024年第6期30卷 719-723页

作者：刘文庆刘世博邹博远唐茂盛苗成利北京大学国际医院腹膜后肿瘤肛肠外科北京102206

肛门失禁可严重影响患者身心健康、日常生活及社会交往,还可能合并严重并发症,增加家庭和社会负担。目前,肛门失禁的诊断主要依赖于病史、体格检查、生理检查及影像学检查等综合方案,这为该疾病的诊断提供了有价值的参考信息,并有利于... 详细信息

肛门失禁可严重影响患者身心健康、日常生活及社会交往,还可能合并严重并发症,增加家庭和社会负担。目前,肛门失禁的诊断主要依赖于病史、体格检查、生理检查及影像学检查等综合方案,这为该疾病的诊断提供了有价值的参考信息,并有利于后续治疗方案的制订。当前,肛门失禁的治疗以手术为主,如肛门括约肌修补手术、股薄肌成形术,在临床中应用广泛且疗效显著,但各术式也有不足之处。相信未来随着临床科学技术的不断发展,神经电刺激、人工括约肌植入术、股薄肌成形术等可获得更好的效果,并提高患者生活质量。

关键词：肛门失禁诊断外科治疗

The First Global Map of Atmospheric Ammonia(NH_(3)) as Observed by the HIRAS/FY-3D Satellite

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Advances in Atmospheric Sciences 2024年第3期41卷 379-390页

作者： Minqiang ZHOU Zhili DENG Charles ROBERT Xingying ZHANG Lu ZHANG Yapeng WANG chengli QI Pucai WANG Martine De MAZIÈRE Institute of Atmospheric Physics Chinese Academy of SciencesBeijing 100029China Royal Belgian Institute for Space Aeronomy(BIRA-IASB) Brussels 1180Belgium National Satellite Meteorology Center China Meteorological AdministrationBeijing 100081China Department of Science&Technology and Climate Change China Meteorological AdministrationBeijing 100081China University of Chinese Academy of Sciences Beijing 100049China

Atmospheric ammonia(NH_(3)) is a chemically active trace gas that plays an important role in the atmospheric environment and climate change. Satellite remote sensing is a powerful technique to monitor NH_(3) concentration based on the absorption lines of NH_(3) in the thermal infrared region. In this study, we establish a retrieval algorithm to derive the NH_(3)column from the Hyperspectral Infrared Atmospheric Sounder(HIRAS) onboard the Chinese Feng Yun(FY)-3D satellite and present the first atmospheric NH_(3) column global map observed by the HIRAS instrument. The HIRAS observations can well capture NH_(3) hotspots around the world, e.g., India, West Africa, and East China, where large NH_(3) emissions exist. The HIRAS NH_(3) columns are also compared to the space-based Infrared Atmospheric Sounding Interferometer(IASI)measurements, and we find that the two instruments observe a consistent NH_(3) global distribution, with correlation coefficient(R) values of 0.28–0.73. Finally, some remaining issues about the HIRAS NH_(3) retrieval are discussed.

关键词： ammonia HIRAS/FY-3D satellite thermal-infrared observation remote sensing optimal estimation method

DIA-based quantitative proteomic analysis on porcine meat quality at different chilling rates

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Food Science and Human Wellness 2024年第5期13卷 2573-2583页

作者： Yuqiang Bai Tongjing Yan Fei Fang Xin Li Su Wang Juan Li chengli Hou Dequan Zhang Key Laboratory of Agro-Products Quality and Safety Control in Storage and Transport Process Ministry of Agriculture and Rural AffairsInstitute of Food Science and TechnologyChinese Academy of Agricultural SciencesBeijing 100193China

The objective of this study was to evaluate the effects of chilling rate on porcine meat quality from the perspective of proteome using data independent acquisition(DIA)-based quantitative proteomic strategy. M. longissimus thoracis et lumborum(n = 9) was assigned randomly to the control group(3.72 ℃/h), very fast chilling-Ⅰ group(VFC-Ⅰ, 9.31℃/h) and VFC-Ⅱ group(14.43 ℃/h). The DIA was used to analyze the difference in proteins under different chilling rates. Results showed that tenderness was improved significantly in meat at the chilling rate of 14.43 ℃/h. Seventy-nine differential abundant proteins(fold change > 1.5, P < 0.05), including 46 up-regulated and 33 down-regulated proteins, were identified and mainly involved in carbon metabolism, pyruvate metabolism and proteasome pathways. These pathways indicated that VFC delayed cell metabolism and glycolysis by down-regulating the expression of metabolic enzymes. The tenderness was improved by up-regulating the expression of proteasome and m-calpain.

关键词： Very fast chilling Tenderness Proteomic Glycolysis Proteasome

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