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AS1411 aptamer-conjugated Gd2O3：Eu nanoparticles for target-specific computed tomography/magnetic resonance/fluorescence molecular imaging

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Nano Research 2014年第5期7卷 658-669页

作者： Tsungrong Kuo Weiyun Lai chenghung li Yanjhan Wun Huancheng Chang Jinnshiun Chen Panchyr Yang Chiachun Chen Department of Chemistry 'National Taiwan Normal University' Taipei 116 Taiwan China Institute of Atomic and Molecular Science 'Academia Sinica' Taipei 106 Taiwan China Molecular Medicine Program Taiwan International Graduate Program Institute of Biomedical Sciences 'Academia Sinica' Taipei 115 Taiwan China Institute of Biochemistry and Molecular Biology School of Life Sciences 'National Yang-Ming University' Taipei 112 Taiwan China Division of Colorectal Surgery Chang Gung Memorial Hospital Chang Gung University Taoyuan 333 Taiwan China College of Medicine 'National Taiwan University' Taipei 106 Taiwan China

Europium-doped gadolinium oxide （Gd2O3：Eu） nanoparticles have been synthesized, and then their surfaces have been conjugated with nucleolin- targeted AS1411 aptamer to form functionalized target-specific Gd2OB：EU nanoparticles （A-GdO：Eu nanoparticles）. The A-GdO：Eu nanoparticles present strong fluorescence in the visible range, high magnetic susceptibility, X-ray attenuation and good biocompatibility. The A-GdO：Eu nanoparticles have been applied to test molecular expression of nucleolin highly expressed CL1-5 lung cancer cells under a confocal microscope. Fluorescence imaging clearly reveals that the nanoparticles can be applied as fluorescent tags for cancer-targeting molecular imaging. Furthermore, taking together their excellent T1 contrast and strong computed tomography （CT） signal, the A-GdO：Eu nanoparticles demonstrate a great capability for use as a dual modality contrast agent for CT and magnetic resonance （MR） molecular imaging. Animal experiments also show that the A-GdO：Eu nanoparticles are able to contrast the tissues of BALB/c mice using CT modality. Moreover, the obvious red fluorescence of A-GdO：Eu nanoparticles can be visualized in a tumor by the naked eye. Overall, our results demonstrate that the A-GdO：Eu nanoparticles can not only serve as new medical contrast agents but also as intraoperative fluorescence imaging probes for guided surgery in the near future.

关键词： aptamer contrast agent Gd2O3 nanoparticles molecular imaging nanoparticles synthesis

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