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Strategies for Inhibition and Disaggregation of Amyloid-β Fibrillation

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Chinese Journal of Chemistry 2022年第4期40卷 524-538页

作者： Hao Geng Dong Gao Zijuan Wang Xiaoning Liu Zhanshuo Cao chengfen xing School of Materials Science and Engineering Hebei University of TechnologyTianjin 300130China Key Laboratory of Hebei Province for Molecular Biophysics Institute of BiophysicsSchool of ScienceHebei University of TechnologyTianjin 300130China College of Chemical Engineering Hebei University of TechnologyTianjin 300130China

Comprehensive Summary Amyloid-β protein(Aβ)is a fatal cause of Alzheimer's disease,which can trigger a series of cytotoxicity by the abnormal aggregation of Aβ in human brain.The strategies for inhibition and disag... 详细信息

关键词： Amyloid beta-peptides Inhibition and disaggregation Materials science Photooxidation Photothermal effect

CO2/NIR light dual-controlled nanoparticles for dsDNA unzipping

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Chinese Chemical Letters 2020年第1期31卷 281-284页

作者： Yanjing Wang Hongbo Yuan Dawei Li chengfen xing Key Laboratory of Hebei Province for Molecular Biophysics Institute of BiophysicsHebei University of TechnologyTianjin 300401China Institute of Polymer Science and Engineering College of Chemical Engineering Hebei University of TechnologyTianjin 300130China

Both of carbon dioxide(CO2)and near-infrared(NIR)light as triggers for non-invasive remotely control are attracting wide attentions due to their good biocompatibility and easy operation.Here,CO2/NIR light dual controlled nanoparticles are proposed to remotely regulate the unzipping of dsDNA by using imidazole functionalized conjugated polymer nanoparticles(imidazole-CPNs).The dsDNA successfully coats on the shell of imidazole-CPNs to form imidazole-CPNs/dsDNA assembly due to intensively electrostatic interaction triggered by CO2.Furthermore,the unzipping process of dsDNA is remotely controlled by NIR light based on the photothermal effect,and it can be readily monitored by the fluorescence intensity of ethidium bromide(EB)and CD spectra of dsDNA.Thus,dual stimulation responsive imidazole-CPNs effectively control dsDNA unzipping under CO2 stimulus and NIR light,promising a new direction in the biological applications of DNA,such as the treatments of diseases caused by gene duplication abnormality.

关键词： Carbon dioxide Conjugated polymers nanoparticles Photothermal effect dsDNA Near-infrared light

Redox-responsive polymer prodrug/AgNPs hybrid nanoparticles for drug delivery

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Chinese Chemical Letters 2018年第2期29卷 301-304页

作者： Liang Qiu Linfei Zhao chengfen xing Yong Zhan Institute of Biophysics Hebei University of Technology

A drug carrier system of the hybrid nanoparticles based on the redox-responsive P[（2-（（2-（（camptothecin）-oxy）ethyl）disulfanyl）ethylmethacrylate）-co-（2-（D-galactose）methylmethacryl-ate）]（P（MACPTS-co-MAGP）） and AgNPs is developed to deliver the anti-cancer drug camptothecin（CPT） and monitor the drug release by the recovery of the fluorescence of CPT. CPT is linked to the polymer sidechains via a redox-responsive disulfide bond, attaching on the surface of AgNPs and leading to the quenching of CPT fluorescence（＂off＂ state） due to the nanoparticle surface energy transfer（NSET） effect.Upon the exposure to glutathione（GSH）, the disulfide bond is cleaved to release CPT, resulting in the recovery of the fluorescence of CPT（＂on＂ state）. The system offers a platform to track the CPT delivery and releasing in real time

关键词： Redox-responsive Drug delivery system Hybrid nanoparticles NSET effect

Functional molecular materials

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Chinese Chemical Letters 2018年第2期29卷 217-218页

作者： Jialiang Xu chengfen xing Xian-He Bu Tianjin University Tianjin 300350 China Hebei University of Technology Tianjin 300401 China Nankai University Tianjin 300071 China

Molecular materials, together with metals, ceramics, and polymer materials, are among the most important materials. The research efforts on molecular materials are targeting three main aspects, namely the assembly technique, multi-functionality, and their diverse application. In this regard, the main attention from the community is focused on the identification and construction of novel molecular materials with high performance for applications in the fields such as the optoelectronic devices and biological or medicine-related materials. This is a truly multi- disciplinary research field driven by the joint efforts of researchers from all different backgrounds including （but not limited to） Organic and Inorganic Chemistry, Supramolecular Chemistry, Semiconductor Molecules and Devices, Materials Science, as well as the Biological Chemistry. This special issue, themed on ＂Functional Molecular Materials＂, consists of 5 review articles and 19 original research papers, and covers a broad spectrum of important aspects in the research of functional molecular materials, ranging from the approaches for self-assembly and characterization of functional molecular systems, to their diverse applications in biological systems and optoelectronic materials and devices.

关键词： NLO Functional molecular materials

Carbon dioxide-controlled assembly based on conjugated polymer and boron nitride

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Chinese Chemical Letters 2020年第1期31卷 261-264页

作者： Bo Wang chengfen xing Dong Gao Hongbo Yuan Liang Qiu Xue Yang Yang Huang Yong Zhan Institute of Biophysics Hebei University of TechnologyTianjin 300401China Hebei Key Laboratory of Boron Nitride Micro and Nano Materials Hebei University of TechnologyTianjin 300130China

C02-controlled assembly of conjugated polymer and boron nitride(BN)was fabricated via electrostatic and hydrophobic interactions between the BN fiber and conjugated polymer of PFBT containing fluorene units and 2,1,3-benzothiadiazole units.C02,an effective and green stimulus for regulating the assembly of PFBT and BN fibers,leads to an obvious fluorescence variation.Moreover,PFBT enables the assembly with the signal amplification and light-harvesting properties.This work provides a new triggering method to construct intelligent conjugated polymer-based platform,and offers fluorescence monitoring strategy for carbon dioxide capture.

关键词： Conjugated polymers Energy transfer Boron nitride Electrostatic interactions Hydrophobic interactions CO2

Side Chain Functional Conjugated Porous Polymers for NIR Controlled Carbon Dioxide Adsorption and Release

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Chemical Research in Chinese Universities 2022年第6期38卷 1467-1474页

作者： CHEN Liquan LI Dawei REN Jinghan LI Yameng GAO Dong xing chengfen Institute of Biophysics Hebei University of TechnologyTianjin300401P.R.China College of Chemical Engineering Hebei University of TechnologyTianjin300401P.R.China

Conjugated porous polymers exhibit considerable advantage as attractive candidate for carbon dioxide(CO_(2)) capture. However, the regeneration of the CO_(2) still faces the problem of high energy cost. Here we synthesize a near-infrared region(NIR) light responsive conjugated porous polymer(PDPP-Gu) [DPP=3,6-di(thiophen-2-yl)pyrrolo[3,4-c]pyrrole-1,4(2H,5H)-dione] by constructing porous amorphous networks with a side chain engineering strategy to regulate CO_(2) adsorption and release through photothermal conversion. The PDPP-Gu is featured by a torsional conjugated backbone as well as a functional side chain of guanidino group. The donor-acceptor configuration of PDPP-Gu afforded strong absorption in the NIR and an excellent photothermal conversion capability of up to 48.8%, as well as a high surface energy. Moreover, guanidine modified side chain further enhanced the CO_(2)-polymers interactions, resulting in a high CO_(2) selective adsorption capacity(0.8 mmol/g) at 273 K, 1 bar(1 bar=105 Pa). The adsorbed CO_(2) can be released under NIR light irradiation. This strategy of molecule design combined the dual features of photothermal conversion and gas adsorption, which is beneficial for the development of materials to dynamically control the adsorption and release of CO_(2) through NIR light.

关键词： Conjugated porous polymer Carbon dioxide Controllable adsorption and release Near-infrared response Photothermal effect

Controlling the gelation temperature of biomimetic polyisocyanides

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Chinese Chemical Letters 2018年第2期29卷 281-284页

作者： Paul H.J. Kouwer Paula de Almeida Onno ven den Boomen Zaskia H. Eksteen-Akeroyd Roel Hammink Maarten Jaspers Stijn Kragt Mathijs F.J. Mabesoone RoelandJ.M. Nolte Alan E. Rowan Martin G.T.A. Rutten Vincent A.A. Le Sage Daniel C. Schoenmakers chengfen xing Jialiang xu Institute for Molecules and Materials Radboud University Nijmegen 6525 A J The Netherlands

Thermosensitive polymers show an entropy-driven transition from a well-solvated to a poorly solvated polymer chain, resulting in a more compact globular conformation. The transition at the lower critical solution temperature（LCST） is often sharp, which allows for a wide range of smart material applications.At the LCST, oligo（ethylene glycol）-substituted polyisocyanides（PICs） form soft hydrogels, composed of polymer bundles similar to biological gels, such as actin, fibrin and intermediate filaments. Here, we show that the LCST of PICs strongly depends linearly on the length of the ethylene glycol（EG） tails; every EG group increases the LCSTand thus the gelation temperature by nearly 30 ℃. Using a copolymerisation approach, we demonstrate that we can precisely tailor the gelation temperature between 10 ℃ and 60 ℃and, consequently, tune the mechanical properties of the PIC gels.

关键词： Smart materials Lower critical solution temperature Polyisocyanides Mechanical properties Biomimetic polymers

Redox-responsive polymer prodrug/AgNPs hybrid nanoparticles for drug delivery

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Redox-responsive polymer prodrug/AgNPs hybrid nanoparticles ...

Graphene Oxide-Conjugated Polymer Hybrid Materials for Protein Sensing

中国化学会第五届全国生物物理化学会议（NCBPC5）

作者：邱亮 Linfei Zhao chengfen xing Yong Zhan Institute of Biophysics Hebei University of Technology

＜正＞A drug carrier system of the hybrid nanoparticles based on the redox-responsive P[（2-（（2-（（camptothecin）-oxy） ethyl）disulfanyl）ethylmethacrylate）-co-（2-（D galactose）methylmethacryl-ate）]（P（MACPTS-co-MAGP）） and AgNPs is developed to deliver the anti-cancer drug camptothecin（CPT） and monitor the drug release by the recovery of the fluorescence of CPT.

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Graphene Oxide-Conjugated Polymer Hybrid Materials for Prote...