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Brain-derived neurotrophic factor plays with TRiC:focus on synaptic dysfunction in Huntington’s disease

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Neural Regeneration Research 2025年第10期20卷 2919-2920页

作者： Yingli Gu Kijung Sung chengbiao Wu Department of Neurosciences University of California San DiegoLa JollaCAUSA

Brain-derived neurotrophic factor(BDNF)exerts pleiotropic effects on brain processes including psychiatric disorders,aging,neurodegeneration,and metabolic homeostasis.A simple PubMed search using the key word“BDNF,”to date,yields over 33,000 *** fundamental biology to potential therapeutic applications,BDNF has clearly garnered extensive and significant attention in the field of neurobiology research.

关键词： Huntington homeostasis therapeutic

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擦亮楚雄尘封的瑰宝

楚雄师范学院学报 2006年第1期21卷 85-89页

作者：杨成彪楚雄州政协云南楚雄675000

中国是世界四大文明古国之一，除了许多珍贵的文化遗产展示着中华民族悠久的文明，还有大量的史书诠释了这个举世公认的界定。世界上每个国家都有记载自己国家产生、发展、演变的史书，但是没有哪个国家像中国这样有着一套完整的而且记... 详细信息

中国是世界四大文明古国之一，除了许多珍贵的文化遗产展示着中华民族悠久的文明，还有大量的史书诠释了这个举世公认的界定。世界上每个国家都有记载自己国家产生、发展、演变的史书，但是没有哪个国家像中国这样有着一套完整的而且记事时间与编纂年代跨度最长的史书，这就是我们常说的廿四史。这部近4000万字的史书，记录了从黄帝到明代长达4000年的历史演进过程。这部书是中华民族悠久历史的真实记录，是中华民族的基本史典，各地还有大量的史书，

关键词：楚雄中华民族文化遗产演进过程史书文明世界中国历史

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降低浮选精煤水份方法的探讨

江西煤炭科技 2008年第4期 88-89页

作者：杨诚彪丰城矿务局坪湖煤业

0引言坪湖矿洗煤厂近几年入洗原煤的性质发生了较大的变化,-0·5mm的粉煤大量增加,使得浮选精煤量增加。由于浮选精煤水份偏高(约30%左右)和浮选精煤量增加,造成总精煤水份超标,导致精煤质量等级下降。因此,降低浮煤水份已成为当务之急... 详细信息

0引言坪湖矿洗煤厂近几年入洗原煤的性质发生了较大的变化,-0·5mm的粉煤大量增加,使得浮选精煤量增加。由于浮选精煤水份偏高(约30%左右)和浮选精煤量增加,造成总精煤水份超标,导致精煤质量等级下降。因此,降低浮煤水份已成为当务之急。而降低浮选精煤水份,就洗煤厂现有的过滤机脱水效果而言,除完善设备性能外,应当更加注重浮选药剂制度的选择及入料浓度和粒度的控制。本文主要从浮选入料浓度和粒度的控制方面作一些探讨。1现有工艺流程及原理坪湖矿洗出的精煤经脱水筛和离心机脱水后直接作为精煤产品运往铁路煤仓外销,筛下水则进入主厂房一楼水池,经泵打入旋流器进行分级。之后,溢流进入沉淀塔作为浮选入料,底流则经高频筛、末煤跳汰机及末精筛再次分选脱水,筛下水又进入一楼水池。在这里,高频筛的脱水是为了对末煤跳汰机入料性质进行控制,而末精筛才图1工艺流程原理是对细粒精煤第二次脱水。由此可看出,进入浮选的洗选浓度和粒度完全由旋流器“把关”,也就是说,对浮选浓度和粒度的控制实质上是对旋流器的入料性质及分级效果的控制。其局部的工艺流程原理见图1。脱水筛筛板孔径为0·5 mm。从图1可看出,假如碰到筛板破损等问题时,就会有一部分+0·5mm的粗...

关键词：浮选精煤水份入料浓度质量等级脱水效果药剂制度洗煤厂洗原煤

奥美拉唑与泮托拉唑治疗消化道溃疡出血的效果研究

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中外医疗 2024年第12期43卷 109-112页

作者：杨承彪黎利平雷山县人民医院消化内科贵州雷山557199

目的探讨奥美拉唑与泮托拉唑治疗消化道溃疡出血(Peptic Ulcer Bleeding,PUB)的临床价值。方法随机选取2021年10月—2023年10月雷山县人民医院收治的90例PUB患者作为研究对象,采用随机数表法分为两组,各45例。对照组行奥美拉唑治疗,观... 详细信息

目的探讨奥美拉唑与泮托拉唑治疗消化道溃疡出血(Peptic Ulcer Bleeding,PUB)的临床价值。方法随机选取2021年10月—2023年10月雷山县人民医院收治的90例PUB患者作为研究对象,采用随机数表法分为两组,各45例。对照组行奥美拉唑治疗,观察组行泮托拉唑治疗。比较两组临床疗效、止血情况与恢复速度、空腹胃液pH值、幽门螺杆菌(Helicobacter Pylori,Hp)根治率、不良反应发生情况。结果观察组治疗总有效率为97.78%,高于对照组的84.44%,差异有统计学意义(χ^(2)=4.939,P=0.026)。观察组止血前出血量、止血前出血次数均优于对照组,止血用时、住院时间均短于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组的空腹胃液pH值、Hp根治率均高于对照组,不良反应总发生率低于对照组,差异有统计学意义(P均<0.05)。结论泮托拉唑治疗PUB的效果优于奥美拉唑,能够缩短止血时间与住院时间,减少出血次数及出血量,且在调节胃液pH值以及用药安全性等方面也有优势。

关键词：消化道溃疡溃疡出血泮托拉唑奥美拉唑止血免疫功能

海南福山油田流一段石英砂替代陶粒适应性评价及意义

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热带海洋学报 2024年第2期43卷 184-189页

作者：魏凯邓校国付杰刘植羊成彪张智勇李凯北京斯迪莱铂油气技术有限公司北京100176 中国石油南方石油勘探开发有限责任公司海南海口570216 中石化胜利石油工程有限公司井下作业公司山东东营257077

页岩气、致密油气等非常规油气资源开发,关键在于提质增效降低成本。文章阐明了海南近海福山油田流一段薄互层致密砂岩采用本地石英砂替代陶粒作为主流支撑剂的低成本和优化裂缝导流能力的适应性特征;提供了海南本地20/40目石英砂和20/4... 详细信息

页岩气、致密油气等非常规油气资源开发,关键在于提质增效降低成本。文章阐明了海南近海福山油田流一段薄互层致密砂岩采用本地石英砂替代陶粒作为主流支撑剂的低成本和优化裂缝导流能力的适应性特征;提供了海南本地20/40目石英砂和20/40目陶粒室内试验评价结果,在不同应力不同铺置浓度条件下, 20/40目石英砂和20/40目陶粒具有不同的导流能力;进一步揭示了地质参数相近两口开发井,在数值模拟优化试验基础上实施现场试验的结果:裂缝导流能力达到21D·cm,可满足流一段致密砂岩储层的导流需求;在35Mpa应力条件下, 10kg·m-2铺置浓度的20/40目石英砂可获得21D·cm以上的导流能力。现场试验表明,石英砂试验井压裂后前期基本可与陶粒试验井效果相同,随着开采时间延长,使用陶粒井的累计产油量和稳产有效期均超过使用本地石英砂开发井。因此,陶粒支撑剂经济效益更高,陶粒支撑剂值得继续长期和规模化使用。

关键词：薄互层砂岩石英砂替代陶粒导流能力支撑剂

Uncoupling neurotrophic function from nociception of nerve growth factor: what can be learned from a rare human disease?

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Neural Regeneration Research 2019年第4期14卷 570-573页

作者： Kijung Sung Wanlin yang chengbiao Wu Department of Neurosciences University of California San Diego

Nerve growth factor(NGF) is a powerful trophic factor that provides essential support for the survival and differentiation of sympathetic and sensory neurons during development. However, NGF also activates nociceptors contributing significantly to inflammatory pain and neuropathic pain after tissue injury. As such anti-NGF based therapies represent a promising strategy for pain management. Because of dose-dependent serious side effects such as back pain, injection site hyperalgesia, clinical trials of using NGF to treat various disorders such as diabetic neuropathies, chemotherapy-induced and human immunodeficiency virus-associated peripheral neuropathies were all discontinued. Thus far, worldwide clinical applications of NGF in treating patients are very limited except in China. Hereditary sensory autonomic neuropathy type V(HSAN V) is an extremely rare disease. Genetic analyses have revealed that HSAN V is associated with autosomal recessive mutations in NGF. One of the mutations occurred at the 100^(th) position of mature NGF resulting in a change of residue from arginine to tryptophan(R100W). Although those HSAN V patients associated with the NGF^(R100W) mutation suffer from severe loss of deep pain, bone fractures and joint destruction, interestingly patients with the NGF^(R100W) mutation do not show apparent cognitive deficits, suggesting important trophic support function is preserved. We believe that NGF^(R100W) provides an ideal tool to uncouple the two important functions of NGF: trophic versus nociceptive. Studies from investigators including ourselves have indeed confirmed in animal testing that the NGF^(R100W) no longer induced pain. More importantly, the trophic function seemed to be largely preserved in NGF harboring the R100W mutation. On the mechanistic level, we found that the NGF^(R100W) mutation was capable of binding to and signaling through the tyrosine receptor kinase A receptor. But its ability to bind to and activate the 75 kDa neurotrophic

关键词： hereditary sensory and autonomic neuropathy V nerve growth factor NGFR100W mutation pain tyrosine receptor kinase A p75 neurotrophic factor receptor

利用AlGaN耦合作用调控WS_(2)层内和层间谷激子

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Science China Materials 2023年第1期66卷 202-210页

作者：曾鑫龙康闻宇周小文李玲龙夏源政刘海洋杨成彪吴雅苹吴志明李煦康俊勇 College of Physical Science and Technology Key Laboratory of Semiconductors and Applications of Fujian ProvinceCollege of Chemistry and Chemical EngineeringJiujiang Research InstituteXiamen UniversityXiamen 361005China School of Physics Southeast UniversityNanjing 211189China

二维材料中的激子跃迁和能谷极化过程具有丰富的能谷物理特性,因此具有极大的研究价值.本文发现,单层和双层WS_(2)中激子和能谷特性可以通过耦合不同掺杂浓度的AlGaN进行有效调控.当WS_(2)和n型AlGaN耦合时,会出现显著的激子能量红移.... 详细信息

二维材料中的激子跃迁和能谷极化过程具有丰富的能谷物理特性,因此具有极大的研究价值.本文发现,单层和双层WS_(2)中激子和能谷特性可以通过耦合不同掺杂浓度的AlGaN进行有效调控.当WS_(2)和n型AlGaN耦合时,会出现显著的激子能量红移.值得一提的是,来自AlGaN的层间电荷转移作用会促使双层WS_(2)形成II型能带,进而产生层间激子跃迁.层内激子峰和层间激子峰的能量和强度还可以通过双层WS_(2)中的转角进行调控.在13 K条件下,通过耦合n型AlGaN,单层WS_(2)的谷极化率高达82.2%.这是由于AlGaN的电子-声子相互作用会带来更高的激子衰减速率,且掺杂导致的载流子屏蔽效应会减少层间谷散射.层间激子的谷极化率明显高于层内激子,这是由于在层间激子中电子-空穴相互作用较弱,导致层间谷散射受到抑制.本文提出了一种简便有效的方法来调控二维材料的激子特性,在单层WS_(2)中实现了极高的谷极化,并在双层WS_(2)中诱导出层间激子.这些发现将激发谷激子物理学的创新探索,并推动新兴的谷电子器件的应用研究.

关键词： AlGaN 二维材料激子屏蔽效应衰减速率极化过程创新探索极化率

Cutting Performance of WC-Co Alloys Modified by Nano-Additives

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Journal of Materials Science & Technology 2012年第3期28卷 205-213页

作者： You Wang Zhaoyi Pan chengbiao Wang Xiaoguang Sun Zhijian Peng BaolinWang Laboratory of Nano Surface Engineering Department of Materials Science Harbin Institute of Technology Harbin 150001 China School ＇of Engineering and Technology China University of Geosciences Beijing 100083 China

In this paper,the microstructure of WC-Co alloys with and without nano-additives was characterized by scanning electron microscopy（SEM） and transmission electron microscopy（TEM）.The hardness and fracture toughness was tested by using a Vickers hardness tester and a universal testing *** cutting test was carried out at different feed velocities（250 r/min and 320 r/min）,and the contact pairs are cutting tools and 45# steel *** showed that the hardness and fracture toughness of WC-Co cemented carbides with nano-additives are higher than that of WC-Co cemented carbides without nano-additives,and they are increased 10.21% and 19.69%,*** flank worn width and crater width of cutting tools decrease greatly with the addition of *** the nano-modified specimen with WC grain size of 7 μm,both the flank worn width and crater width are the minimum after the cutting *** there are little built-up layers and some pile-up regions on the flank face leading to high cutting performance for the nano-modified cemented *** are some melted regions on the flank face of cutting tools without nano-additives,and the WC grains on the cross section of alloys without nano-additives show severe *** wear type of WC-Co is flank wear,and the wear mechanism is abrasive,adhesion and oxidation wear.

关键词： Cutting tools Hardness Fracture Surface analysis

Enhanced oxidation and graphitization resistance of polycrystalline diamond sintered with Ti-coated diamond powders

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Journal of Materials Science & Technology 2020年第8期36卷 64-73页

作者： Xiaohua Sha Wen Yue Haichao Zhang Wenbo Qin Dingshun She chengbiao Wang School of Engineering and Technology China University of Geosciences(Beijing)Beijing 100083China Zhengzhou Institute China University of Geosciences(Beijing)Zhengzhou 451283China Zhengzhou Institute of Multipurpose Utilization of Mineral Resources Chinese Academy of Geological SciencesZhengzhou 450006China Ningxia Vocational Technical College of Industry and Commerce Ningxia 750021China

To improve the oxidation and graphitization resistances of the polycrystalline diamond(PCD), Ti coating was deposited on the diamond powders via magnetic sputtering method, which achieved a uniform Ti C protection barrier in PCD during the sintering process. The phase compositions, microstructures and thermal stability of Ti-PCD were characterized by X-ray diffraction(XRD), Auger electron spectroscopy(AES),scanning electron microscopy(SEM) and thermal gravimetric-differential scanning calorimetry(TG-DSC).The results demonstrate that the oxidation and graphitization resistances of PCD are strengthened due to the existence of Ti C phase, which acts as an effective inhibitor. The as-received inhibitor delays the oxidation and graphitization of PCD, elevating their initial temperature by ~50°C and ~100°C, respectively. During the annealing treatment of Ti-PCD, the priory oxidation of Ti C, which produces Ti O2 as an oxygen barrier, postpones the diamond oxide. Moreover, the Ti C barrier also protects diamond grains from direct contact with cobalt, thus a lower cobalt-catalytic graphitization, and yields to an improved graphitization resistance of PCD. The enhanced oxidation and graphitization resistances of PCD are of significant importance for practical applications to elevated temperatures.

关键词： Polycrystalline diamond Ti-coated diamond powder TiC barrier Oxidation resistance Graphitization resistance