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Zinc-based metal-organic frameworks as efficient carriers for anticancer drug to reduce toxicity and increase efficacy

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Rare metals 2024年第10期43卷 5152-5163页

作者： Dong-Wei ma Jing-Sheng Lu Xiang-Xin Cao Yan-Wei cheng Gang Wang Zi-Qian Zhang Bo-cheng chen Ning Lin Qing chen College of Pharmacy Guangxi Scientific Research Center of Traditional Chinese MedicineGuangxi University of Chinese Medicine Guangxi Zhuang Yao medicine Center of Engineering and Technology

The rational design of a specific co-drug delivery platform that can address the unavoidable resistance, toxic side effects and low targeting efficiency of traditional cancer treatments is of great ***, Zn-based mOF-zeolitic imidazole framework-90(ZIF-90) was selected as the drug delivery carrier, with the cancer therapeutic drug mercaptopurine(6-mP) and glucose oxidase(GOD) as the drug models, hyaluronic acid(HA) was used for protection and targeted delivery, which designed and fabricated an intelligent drug delivery platform(6-mP@ZIF-90@GOD@HA). This platform aims to reduce the toxic side effects of 6-mP and enhance its efficacy while improving the targeting ability of GOD,thereby further enhancing the treatment outcome. Notably,results from both in vitro and in vivo experiments demonstrate that the targeted synergistic chemo/reactive oxygen species(ROS)-mediated/starvation therapy inhibited the cancer cell growth while reducing the chemotherapy toxicity, which provides new possibilities for the development of more precise and effective treatment strategies.

关键词： Cancer treatment Combination therapy Drug delivery metal-organic framework Reduced toxicity

One-year observation of the mixing states of oxygenated organics-containing single particles in Guangzhou,China

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Frontiers of Environmental Science & Engineering 2024年第5期18卷 155-169页

作者： Liyuan mao Suxia Yang Xiaoya cheng Sulin Liu Duanying chen Zhen Zhou mei Li chenglei Pei Chunlei cheng Institute of mass Spectrometry and Atmospheric Environment Guangdong Provincial Engineering Research Center for the On-line Source Apportionment System of Air PollutionJinan UniversityGuangzhou510632China Guangdong-Hongkong-macao Joint Laboratory of Collaborative Innovation for Environmental Quality Guangzhou510632China Guangzhou Research Institute of Environment Protection Co. Ltd.Guangzhou510620China Guangzhou Ecological and Environmental monitoring Center of Guangdong Province Guangzhou510030China State Key Laboratory of marine Resource Utilization in South China Sea Hainan UniversityHaikou570228China State Key Laboratory of Loess and Quaternary Geology Institute of Earth EnvironmentChinese Academy SciencesXi’an710061China

Oxygenated organic molecules(OOms)play an important role in the formation of secondary organic aerosols(SOAs),but the mixing states of OOms are still *** study investigates the mixing states of OOm-containing single particles from the measurements taken using a single particle aerosol mass spectrometer in Guangzhou,China in ***,the particle counts of OOm particles and the mass concentration of secondary organic carbon(SOC)exhibited similar temporal trends throughout the entire *** OOm particles were consistently enriched in secondary ions,including ^(16)O^(−),^(26)CN^(−),^(46)NO_(2)^(−),^(62)NO_(3)^(−),and ^(97)HSO_(4)^(−).In contrast,the number fractions and diurnal patterns of OOm particles among the total detected particles showed similar distributions in August and October;however,the SOC ratios in fine particulate matter were quite different,suggesting that there were different mixing states of single-particle oxygenated *** addition,further classification results indicated that the OOm particles were more aged in October than August,even though the SOC ratios were higher in ***,the distribution of hydrocarbon fragments exhibited a notable decrease from January to October,emphasizing the more aged state of the organics in *** addition,the sharp increase in elemental carbon(EC)-OOm particles in the afternoon in October suggests the potential role of EC in the aging process of ***,in contrast to the bulk analysis of SOC mass concentration,the mixing states of the OOm particles provide insights into the formation process of SOAs in field studies.

关键词： Oxygenated organics Single particles mixing state Secondary formation Photochemistry

City Network Evolution Characteristics of Smart Industry: Evidence from Yangtze River Delta, China

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Chinese Geographical Science 2024年第5期34卷 829-848页

作者： SHEN Lizhen ZHOng Zhaocheng chen cheng ZHAng Shanqi ZHEN Feng School of Architecture and Urban Planning Nanjing UniversityNanjing 210093China Hefei Urban Planning&Design Institute Hefei 230041China

The dual-path model of industrial evolution and spatial progression has been widely acknowledged and incorporated into the strategic planning to promote the development of urban industries and regional ***,current research on inter-enter-prise city networks mainly focuses on the single sector of flows on all enterprise branches,such as product value chains and production factors,but neglects that of particular industry *** upon the new economic geography and city networks theory,this paper develops a methodological framework that focuses on the analysis of city network evolution characteristics of smart ***-larly,a conceptual model of smart industry enterprise-industry-city is proposed and then applied to a case study of smart industry in the Yangtze River Delta Region,*** enterprise supplier-customer data,a city network of smart industry is constructed and sub-sequently analyzed with the proposed *** indicate that the smart industry network in Yangtze River Delta Region exhibits a hierarchical structure and the expansion of the network presents a small-world network *** study not only makes a meth-odological contribution for revealing the industrial and spatial evolution path of the current smart industry,but also provides empirical support for the formulation of new economic development policies focused on smart industries,demonstrating the role of city clusters as carriers of regional synergistic development.

关键词： smart industry city networks social network analysis methodological framework Yangtze River Delta,China

Flame-retardant ammonium polyphosphate/mXene decorated carbon foam materials as polysulfide traps for fire-safe and stable lithium-sulfur batteries

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Journal of Energy Chemistry 2024年第2期89卷 313-323,I0008页

作者： Yang Li Yong-cheng Zhu Sowjanya Vallem man Li Seunghyun Song Tao chen Long-cheng Tang Joonho Bae Department of Physics Gachon UniversitySeongnam-siGyeonggi-do 13120South Korea Key Laboratory of Organosilicon Chemistry and material Technology of ministry of Education College of MaterialChemistry and Chemical EngineeringHangzhou Normal UniversityHangzhou 311121ZhejiangChina Key laboratory of Advanced Energy materials Chemistry(ministry of Education) College of ChemistryNankai UniversityTianjin 300071China School of materials Engineering Changzhou Vocational Institute of Industry TechnologyChangzhou 213164JiangsuChina

Lithium-sulfur(Li-S)batteries are one of the most promising modern-day energy supply systems because of their high theoretical energy density and low ***,the development of high-energy density Li-S batteries with high loading of flammable sulfur faces the challenges of electrochemical performance degradation owing to the shuttle effect and safety issues related to fire or explosion *** this work,we report a three-dimensional(3D)conductive nitrogen-doped carbon foam supported electrostatic self-assembled mXene-ammonium polyphosphate(NCF-mXene-APP)layer as a heat-resistant,thermally-insulated,flame-retardant,and freestanding host for Li-S batteries with a facile and costeffective synthesis ***,through the use of NCF-mXene-APP hosts that strongly anchor polysulfides,the Li-S batteries demonstrate outstanding electrochemical properties,including a high initial discharge capacity of 1191.6 mA h g^(-1),excellent rate capacity of 755.0 mA h g^(-1)at 1 C,and long-term cycling stability with an extremely low-capacity decay rate of 0.12%per cycle at 2 *** importantly,these batteries can continue to operate reliably under high temperature or flame attack ***,this study provides valuable insights into the design of safe high-performance Li-S batteries.

关键词： Flame-retardant mXene Ammonium polyphosphate Safety Lithium-sulfur battery

Exercise-induced adaptation of neurons in the vertebrate locomotor system

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Journal of Sport and Health Science 2024年第2期13卷 160-171页

作者： Yue Dai Yi cheng Renkai Ge Ke chen Liming Yang Key Lab of Adolescent Health Assessment and Exercise Intervention of ministry of Education College of Physical Education and Health CareEast China Normal UniversityShanghai 200241China Shanghai Key Laboratory of multidimensional Information Processing School of Communication and Electronic EngineeringEast China Normal UniversityShanghai 200241China School of Physical Education and Health Care East China Jiaotong UniversityNanchang 330013China Key Laboratory of High Confidence Software Technologies of ministry of Education School of Computer SciencePeking UniversityBeijing 100871China

Vertebrate neurons are highly dynamic cells that undergo several alterations in their functioning and physiologies in adaptation to various external *** particular,how these neurons respond to physical exercise has long been an area of active *** of the vertebrate locomotor system’s adaptability suggest multiple mechanisms are involved in the regulation of neuronal activity and properties during *** this brief review,we highlight recent results and insights from the field with a focus on the following mechanisms:(a)alterations in neuronal excitability during acute exercise;(b)alterations in neuronal excitability after chronic exercise;(c)exercise-induced changes in neuronal membrane properties via modulation of ion channel activity;(d)exercise-enhanced dendritic plasticity;and(e)exercise-induced alterations in neuronal gene expression and protein *** hope is to update the community with a cellular and molecular understanding of the recent mechanisms underlying the adaptability of the vertebrate locomotor system in response to both acute and chronic physical exercise.

关键词： Dendritic plasticity Excitability Exercise Ion channel modulation Neuron adaptation

OSmR is a potential driver of inflammation in amyotrophic lateral sclerosis

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Neural Regeneration Research 2024年第11期19卷 2513-2521页

作者： Wenzhi chen Shishi Jiang Shu Li cheng Li Renshi Xu Department of Neurology Jiangxi Provincial People’s HospitalXiangya Hospital Jiangxi Hospital of Central South UniversityThe Clinical College of Nanchang Medical CollegeThe First Affiliated Hospital of Nanchang Medical CollegeNanchangJiangxi ProvinceChina

Amyotrophic lateral sclerosis is a neurodegenerative disease,and the molecular mechanism underlying its pathology remains poorly ***,inflammation is known to play an important role in the development of this *** identify driver genes that affect the inflammatory response in amyotrophic lateral sclerosis,as well as potential treatment targets,it is crucial to analyze brain tissue samples from patients with both sporadic amyotrophic lateral sclerosis and C9orf72-related amyotrophic lateral ***,in this study we used a network-driven gene analysis tool,NetBID2.0,which is based on SJARACNe,a scalable algorithm for the reconstruction of accurate cellular networks,to experimentally analyze sequencing data from patients with sporadic amyotrophic lateral *** results showed that the OSmR gene is pathogenic in amyotrophic lateral sclerosis and participates in the progression of amyotrophic lateral sclerosis by mediating the neuroinflammatory ***,there were differences in OSmR activity and expression between patients with sporadic amyotrophic lateral sclerosis and those with C9orf72-related amyotrophic lateral *** findings suggest that OSmR may be a diagnostic and prognostic marker for amyotrophic lateral sclerosis.

关键词： amyotrophic lateral sclerosis driver neuroinflammation OSmR C9ORF72 neurodegenerative disease pathogenesis oxidative stress protein misfolding mitochondrial dysfunction

miniature tunable Airy beam optical meta-device

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Opto-Electronic Advances 2024年第2期7卷 5-12页

作者： Jing cheng Zhang mu Ku chen Yubin Fan Qinmiao chen Shufan chen Jin Yao Xiaoyuan Liu Shumin Xiao Din Ping Tsai Department of Electrical Engineering City University of Hong KongKowloonHong Kong SAR 999077China State Key Laboratory of Terahertz and millimeter Waves City University of Hong KongKowloonHong Kong SAR 999077China Centre for Biosystems Neuroscienceand NanotechnologyCity University of Hong KongKowloonHong Kong SAR 999077China ministry of Industry and Information Technology Key Lab of micro-Nano Optoelectronic Information System Guangdong Provincial Key Laboratory of Semiconductor Optoelectronic Materials and Intelligent Photonic SystemsHarbin Institute of TechnologyShenzhen 518055China

Tunable Airy beams with controllable propagation trajectories have sparked interest in various fields,such as optical manipulation and laser *** research approaches encounter challenges related to insufficient compactness and integration feasibility,or they require enhanced tunability to enable real-time dynamic manipulation of the propagation *** this work,we present a novel method that utilizes a dual metasurface system to surpass these limitations,significantly enhancing the practical potential of the Airy *** approach involves encoding a cubic phase profile and two off-axis Fresnel lens phase profiles across the two *** validity of the proposed strategy has been confirmed through simulation and experimental *** proposed meta-device addresses the existing limitations and lays the foundation for broadening the applicability of Airy beams across diverse domains,encompassing light-sheet microscopy,laser fabrication,optical tweezers,etc.

关键词： metasurface miniature device tunable Airy beam tunable meta-device

A Comprehensive Review of Thermal Performance Improvement of High-Temperature Heat Pipes

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Journal of Thermal Science 2024年第2期33卷 625-647页

作者： chen Qihan ZHOU Jingzhi ZHOU Guohui cheng Keyong HUAI Xiulan WEI Gaosheng School of Energy Power and Mechanical EngineeringNorth China Electric Power UniversityBeijing100096China Nanjing Institute of Future Energy System Nanjing211135China Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing100190China

Energy efficiency issues are being focused on the growing concern of global warming and environmental *** high-temperature heat pipe(HTHP) is an effective and environmental-friendly heat transfer device employed in many industries,including solar power generation,high-temperature flue gas waste heat recovery,industrial furnaces,nuclear industries,and *** a critical factor in HTHPs,thermal performance is mainly introduced in the entire *** date,most reviews have been published concerning one or several application ***,to the best of authors' knowledge,it is hard to find a review discussing how to improve the thermal performance of HTHPs ***,the impact on the performance of three main components of HTHPs over the past 30 years is introduced:the working fluid,the HTHP structure,and the wick ***,it is a considerable review of the optimal operating conditions for each direction,and we expect this paper contribute to improving the thermal performance of ***,current numerical simulations and theoretical research on the heat transfer limit of HTHPs are *** significant hypotheses used in numerical simulations and the present theoretical studies are compiled ***,some potential future directions and tentative suggestions for HTHP research are put forward.

关键词： high-temperature heat pipe review alkali metal heat pipe thermal performance

Amorphous electrocatalysts for urea oxidation reaction

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Progress in Natural Science:materials International 2024年第2期34卷 362-375页

作者： Fenghui Guo Dongle cheng Qian chen Hao Liu Zhiliang Wu Ning Han Bing-Jie Ni Zhijie chen School of materials Science and Technology China University of Geosciences Shenzhen Academy of metrology and Quality Inspection Centre for Technology in Water and Wastewater School of Civil and Environmental Engineering University of Technology Sydney College of Safety and Environmental Engineering Shandong University of Science and Technology Institute of Yellow River Delta Earth Surface Processes and Ecological Integrity Shandong University of Science and Technology Discipline of Chemical Engineering Western Australian School of Mines: Minerals Energy and Chemical Engineering Curtin University Department of materials Engineering School of Civil and Environmental Engineering The University of New South Wales

Electrochemical urea oxidation reaction(UOR) is a promising alternative to oxygen evolution reaction(OER) for realizing energy-saving hydrogen production. Developing efficient electrocatalysts for UOR becomes a central challenge. Recently, amorphous materials have been extensively used as UOR catalysts because of their numerous defective sites and flexible electronic properties. In this review, recent advancements in the development of amorphous UOR electrocatalysts are analyzed. The UOR mechanism is discussed, and the design of amorphous catalysts is then analyzed. The main catalyst design strategies are illustrated, including nanostructure control,heteroatom doping, composition regulation, and heterostructure construction. Also, electrocatalysts' structureperformance correlation is interpreted. Perspectives in this field are proposed for guiding future studies on the development of high-performance amorphous catalysts towards energy sustainability.

关键词： Catalyst design Component regulation Heteroatom doping Heterostructures Hydrogen energy