检索结果-南通市图书馆

Emerging prospects of protein/peptide-based nanoassemblies for drug delivery and vaccine development

在线全文

学校读者我要写书评

暂无评论

Nano Research 2022年第8期15卷 7267-7285页

作者： Taiyu Liu lu Li cheng cheng Bingfang He Tianyue Jiang School of Pharmaceutical Sciences Nanjing Tech UniversityNanjing 211816China

Proteins have been widely used in the biomedical field because of their well-defined architecture,accurate molecular weight,excellent biocompatibility and biodegradability,and *** by the wisdom of nature,increasing proteins/peptides that possess self-assembling capabilities have been explored and designed to generate nanoassemblies with unique structure and function,including spatially organized conformation,passive and active targeting,stimuli-responsiveness,and high *** characteristics make protein/peptide-based nanoassembly an ideal platform for drug delivery and vaccine *** this review,we focus on recent advances in subsistent protein/peptide-based nanoassemblies,including protein nanocages,virus-like particles,self-assemblable natural proteins,and self-assemblable artificial *** origin and characteristics of various protein/peptide-based assemblies and their applications in drug delivery and vaccine development are *** the end,the prospects and challenges are discussed for the further development of protein/peptide-based nanoassemblies.

关键词： drug delivery vaccine protein/peptide self-assembly targeting controlled release

A contingency-aware method for N-2 security-constrained transmission expansion planning

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Modern Power Systems and Clean Energy 2019年第5期7卷 1008-1019页

作者： Dundun LIU lu LIU Haozhong cheng Key Laboratory of Control of Power Transmission and Conversion Ministry of EducationShanghai Jiao Tong UniversityShanghai 200240China

In this paper,a novel contingency-aware method for N-2 security-constrained transmission expansion planning is *** ensure that the transmission construction plan satisfies the N-2 security criterion,the proposed method takes advantage of the adjustable robust optimization(ARO)framework and upgrades *** construct a discrete uncertainty set in which component failures are treated as uncertain events that are handled as binary *** addition to the failure of existing lines and generators,we explicitly model the failure of candidate *** proposed model comprises a master problem that makes the transmission construction decision,and a series of subproblems that can detect not only the worst contingency,but also the potential *** studies on the IEEE RTS 24-bus and IEEE 118-bus test systems are carried out to validate the effectiveness of the proposed *** with the deterministic method and ARO method in the literature,the proposed method has higher computational efficiency.

关键词： Contingency N-2 security Robust optimization Transmission expansion planning

Microstructure and secondary phases in epitaxial LaBaCo_2O_(5.5 + δ) thin films

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2018年第2期34卷 398-402页

作者： Jiangbo lu lu lu Sheng cheng Ming Liu Chunlin Jia School of Electronic and Information Engineering & State Key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong University Ernst Ruska-Centre for Microscopy and Spectroscopy with Electrons Forschungszentrum Jülich GmbH

Aberration-corrected scanning transmission electron microscopy was employed to investigate the microstructures and secondary phases in LaBaCo2O5.5＋δ（LBCO） thin films grown on SrTiO3 （STO） substrates. The as-grown films showed an epitaxial growth on the substrates with atomically sharp interfaces and orientation relationships of [100]LBCO//[100]STO and （001）LBCO//（001）STO. Secondary phases were observed in the films, which strongly depended on the sample fabrication conditions. In the film prepared at a temperature of 900 ℃, nano-scale CoO pillars nucleated on the substrate, and grew along the [001] direction of the film. In the film grown at a temperature of 1000 ℃, isolated nano-scale C0304 particles appeared, which promoted the growth of {111 } twinning structures in the film. The orientation relationships and the interfaces between the secondary phases and the films were illustrated, and the growth mechanism of the film was discussed.

关键词： Nano-structure Faceted interfaces Secondary phase growth Epitaxial thin film Microstructure Aberration-corrected scanning transmission electron microscopy

Cloud Platform Based Automated Security Testing System for Mobile Internet

在线全文

学校读者我要写书评

暂无评论

Tsinghua Science and Technology 2015年第6期20卷 537-544页

作者： Dan Tao Zhaowen Lin cheng lu the School of Electronic and Information Engineering Beijing Jiaotong University Jiangsu High Technology Research Key Laboratory for Wireless Sensor Networks Network and Information Center Institute of Network TechnologyScience and Technology on Information Transmission and Dissemination in Communication Networks LaboratoryNational Engineering Laboratory for Mobile Network SecurityBeijing University of Posts and Telecommunications

With respect to security, the use of various terminals in the mobile Internet environment is *** terminal testing methods cannot simulate actual testing environments; thus, the test results do not accurately reflect the security of terminals. To address this problem, we designed and developed a cloud platform based automated testing system for the mobile Internet. In this system, virtualization and automation technology are utilized to integrate mobile terminals into the cloud platform as a resource, to achieve a novel cloud service called Testing as a Service(Taa S). The system consists of three functional modules: web front-end module, testing environment module, and automated testing module. We adopted the permeable automated testing tool Metasploit to perform security testing. In our test experiments, we selected 100 apps with diverse vulnerability levels, ranging from secure to vulnerable, to perform a series of functional tests. The experimental results show that this system can correctly test both the number of vulnerable apps and their corresponding vulnerability levels. As such, the designed system can flexibly configure various testing environments for different testing cases or projects, and thereby perform security testing automatically.

关键词： automated security testing cloud platform virtuali

Revised regional importance measures in the presence of epistemic and aleatory uncertainties

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2015年第1期58卷 84-94页

作者： cheng Lei lu ZhenZhou WU DanQing School of Aeronautics Northwestern Polytechnical University

Two revised regional importance measures(RIMs),that is,revised contribution to variance of sample mean(RCVSM)and revised contribution to variance of sample variance(RCVSV),are defined herein by using the revised means of sample mean and sample variance,which vary with the reduced range of the epistemic *** RCVSM and RCVSV can be computed by the same set of samples,thus no extra computational cost is introduced with respect to the computations of CVSM and *** the plots of RCVSM and RCVSV,accurate quantitative information on variance reductions of sample mean and sample variance can be read because of reduced upper bound of the range of the epistemic *** general form of quadratic polynomial output,the analytical solutions of the original and the revised RIMs are *** example is employed and results demonstrate that the analytical results are consistent and *** engineering example is applied to testify the validity and rationality of the revised RIMs,which can give instructions to the engineers about how to reduce variance of sample mean and sample variance by reducing the range of epistemic parameters.

关键词： revised rims sample mean sample variance variance reduction analytical solution

A comprehensive review of miniatured wind energy harvesters

在线全文

学校读者我要写书评

暂无评论

Nano Materials Science 2021年第2期3卷 170-185页

作者： Quan Wen Xianming He zhuang lu Reinhard Streiter Thomas Otto Key Laboratory of Fundamental Science of Micro/Nano-Device and System Technology Chongqing UniversityChongqing400044People's Republic of China Microsystem Research Center Chongqing UniversityChongqing400044People's Republic of China Fraunhofer Institute for Electronic Nano Systems(ENAS) Chemnitz09131Germany

Following the current rapid development of the Internet of Things(IoT)and wireless condition monitoring systems,energy harvesters which use ambient energy have become a key part of achieving an energy-autonomous *** wind energy harvesters have attracted widespread attention because of their great potential of power density as well as the rich availability of wind energy in many possible areas of *** article provides readers with a glimpse into the state-of-the-art of miniature wind energy *** crucial factors for them to achieve high working efficiency under lower operational wind speed excitation are *** potential energy coupling mechanisms are discussed in *** approaches for broadening operational wind-speed-range given a variety of energy coupling mechanisms are also presented,as observed in the *** enhancement mechanisms including hydrodynamic configuration optimization,and non-linear vibration pick-up structure are *** are drawn and the outlook for each coupling mechanisms is presented.

关键词： Energy harvester Wind energy Miniature wind-induced vibration energy harvester Energy coupling mechanism Performance enhancement mechanisms

Spatial distribution and dynamics of carbon storage in natural Larix gmelinii forest in Daxing'anling mountains of Inner Mongolia,northeastern China

在线全文

学校读者我要写书评

暂无评论

Journal of Mountain Science 2017年第8期14卷 1633-1641页

作者： MENG Sheng-wang LIU Qi-jing JIA Quan-quan zhuang Hui-xia QI Ying lu cheng-xue DENG Liu-bao College of Forestry Beijing Forestry University Forestry Industry Bureau of Inner Mongolia

In order to clarify the geographic distribution and change of natural Larix gmelinii forest in carbon storage in Daxing'anling mountains(Great Khingan Range) in North China's Inner Mongolia, an area-irrelevant conversion equation of biomass from timber volume in the form of B = 0.6966 V was developed by using survey data. Based on the equation, the carbon storage was estimated at 190.172 Tg, and the average carbon density was 41.659 Mg/hm^2(area 4.565 × 10~6 hm^2). Carbon stored in standing trees was predominantly distributed in mid-age and mature forests and mainly stocked in the northern part of the study area. Assuming the carbon density of intact area as the maximum value, the potential carbon storage in the entire study area would be 263.674 Tg, approximately 1.4 times of the actual level. Over the period of 1995 to 2010, the carbon storage and carbon densityincreased by 3.260 Tg and 0.224 Mg/hm^2, respectively, indicating a weak carbon sink. Comparing with China's national average level, the carbon density in this area is not as high as expected. Forest quality in terms of carbon capacity is expected to be enhanced by appropriate management schemes under the in-implementation program of forest protection.

关键词： Biomass conversion equation Carbonstorage Great Khingan Range Distribution Larixgmelinii

Three-dimensional temperature prediction in cylindrical turning with large-chamfer insert based on a modified slip-line field approach

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2021年第10期34卷 265-281页

作者： cheng HU Kejia zhuang Yuanwei TANG Jian WENG Xiaoming ZHANG Han DING Hubei Digital Manufacturing Key Laboratory School of Mechanical and Electronic EngineeringWuhan University of TechnologyWuhan 430070China Institute of Advanced Materials and Manufacturing Technology Wuhan University of TechnologyWuhan 430070China AECC Guizhou Liyang Aviation Power CO.LTD Guiyang 550000China State Key Laboratory of Digital Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan 430074China

Chamfered inserts have found broader applications in metal cutting process especially in high-performance machining of hard-to-cut materials for their excellent edge resistance and cutting ***,excessive heat generation and resulting high cutting temperature eventually cause severe tool wear and poor surface integrity,which simultaneously limits the optimal selection of machining *** the present study,an analytical thermal–mechanical model is proposed for the prediction of the three-dimensional(3-D)temperature field in cylindrical turning with chamfered round insert based on a modified slip-line field ***,an innovative discretization method is introduced in a general 3-D coordinate system to provide a comprehensive demonstration of the irregular cutting geometry and heat generation ***,a plasticity-theory-based slip-line field model is developed and employed to determine the intensities and geometries of every elementary heat sources in Primary Deformation Zones(PDZ),Secondary Deformation Zones(SDZ)and Dead Metal Zones(DMZ).At last,a 3-D analytical model is suggested to calculate the temperature increases caused by the entire heat sources and associated *** maximum cutting temperature region predicted is found existing upon the chip-tool contact area rather than the tool ***,the rationalities of cutting parameters employed are analyzed along with theoretical material removal rates and ensuing maximum cutting *** results indicate that the cutting conditions with large depth of cut and high cutting speed are more desirable than those with high feed *** proposed models are respectively verified through a series of 3-D Finite Element(FE)simulations and dry cutting experiments of Inconel 718 with chamfered round *** agreement has been reached between the predictions and simulations as well as the measurements,which confirms the correctness and effectiveness of the presented analy

关键词： Analytical model Chamfered round insert Dead metal zone Prediction of temperature Slip-line field

Mesoporous silica decorated with platinum nanoparticles for drug delivery and synergistic electrodynamic-chemotherapy

在线全文

学校读者我要写书评

暂无评论

Nano Research 2020年第8期13卷 2209-2215页

作者： Tongxu Gu Tong Chen Liang cheng Xiang Li Gaorong Han zhuang Liu State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou310027China Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou215123China

Electrodynamic therapy(EDT)is a conceptually new cancer treatment approach recently proposed by our *** EDT,the electro-driven catalytic reaction would occur on the surface of platinum nanoparticles(PtNPs)to produce reactive oxygen species(ROS)under the direct current(DC)or square-wave alternating current(AC)electric *** further extend the potential of EDT,we hereby designed mesoporous silica-based nanocomposites decorated with PtNPs and loaded with anticancer drug doxorubicin(DOX)for synergistic *** silica-based nanocomposites could enable homogenous killing of large-sized tumors(over 500 mm^3)and realize remarkable tumor destruction efficacy at a relatively low quantity of *** our best knowledge,this is the first study to combine EDT and chemotherapy to develop a synergetic nanoplatform,openning a new dimension for the design of other EDT-based anticancer strategies.

关键词： mesoporous silica platinum nanoparticles electrodynamic therapy chemotherapy