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C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury

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Neural Regeneration Research 2025年第8期20卷 2231-2244页

作者： Xiangzi Wang Xiaofei Niu Yingkai Wang Yang Liu cheng Yang Xuyi Chen Zhongquan Qi School of Medicine Guangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Graduate School of Tianjin University of Traditional Chinese Medicine TianjinChina Characteristic Medical Center of People’s Armed Police Forces TianjinChina Fujian Maternity and Child Health Hospital FuzhouFujian ProvinceChina

Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory *** expression of the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis exhibits significant differences before and after *** studies have revealed that the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis is closely associated with secondary inflammatory responses and the recruitment of immune cells following spinal cord injury,suggesting that this axis is a novel target and regulatory control point for *** review comprehensively examines the therapeutic strategies targeting the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis,along with the regenerative and repair mechanisms linking the axis to spinal cord ***,we summarize the upstream and downstream inflammatory signaling pathways associated with spinal cord injury and the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review primarily elaborates on therapeutic strategies that target the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the latest progress of research on antagonistic drugs,along with the approaches used to exploit new therapeutic targets within the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the development of targeted ***,there are presently no clinical studies relating to spinal cord injury that are focusing on the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review aims to provide new ideas and therapeutic strategies for the future treatment of spinal cord injury.

关键词： apoptosis C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway C-C motif chemokine receptor 2 antagonists chemokine ligand 2 chemokine receptor 2 inflammation macrophage microglia spinal cord injury therapeutic method

NUMERICAL SI MULATION OF MOVING SCOUR BOUNDARY AND TURBULENCE FLOWAROUND SUBMARINE PIPELINES

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Journal of Hydrodynamics 2005年第4期17卷 404-411页

作者： LI Yu-cheng lu Lin State Key Laboratory of Coastal and Offshore Engineering Dalian University of Technology Dalian 116024 China

A two dimensional vertical mathematical model is proposed in this paper for simulating the equilibrium profile of local scour around submarine pipelines. The current model is composed of a new k-ε turbulence model, fitting moving boundary with pre-meshed grid lines and incipient criterion of shear stress for sediments. Employing the proposed model, an instance is carried out numerically and compared with experiments. The calculation results agree well with the experiments. It shows that the improved two equation turbulence model, adopted in this paper is appropriate to simulating the turbulent flow ficld around submarine pipelines, fitting moving boundary with pre-mcshed grid lines method is efficient for moving boundary problems in a multiply connected domain and the stability evaluation method for seabed with critical shear stress based on log-wall law is a reliable choice.

关键词： numerical simulation submarine pipeline local scour moving boundary turbulence model

Friction and wear behaviors of Al_2O_3-13 wt% TiO_2 coatings

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Rare Metals 2013年第1期32卷 87-92页

作者： Lin lu zhuang Ma Fu-Chi Wang Yan-Bo Liu National Key Laboratory of Science and Technology on Materials under Shock and Impact School of Materials Science and Engineering Beijing Institute of Technology

Abstract Nanostructured and conventional AlzO3- 13 wt%TiO2 coatings were manufactured by air plasma spray. Friction and wear behaviors of coatings were investigated at room and elevated temperatures using an SRV wear test machine. The nanostructured coating has ＂two regions＂ microstructure, while the conventional coating has typical layered microstructure with obvious interfaces among splats. The coefficient of friction decreases with rising of temperature because of the for- mation of tribo-layer at elevated temperatures. The wear resistance of the nanostructured coatings is higher than that of the conventional coating, and the wear threshold of applied load is 30 N for conventional coating and 40 N for nanostructure coating. The wear resistance difference is related to the ＂two regions＂ microstructure of nanostruc- ture coating, which could blunt or branch the cracks propagation. In our test ranges, the wear rates rising are more sensitive with the applied wear load rising than with the temperature rising.

关键词： A1203-TiO2 Tribo-layer Wear resistance

In situ fastening graphene sheets into a polyurethane sponge for the highly efficient continuous cleanup of oil spills

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Nano Research 2017年第5期10卷 1756-1766页

作者： zhuang Kong Jinrong Wang Xianyong lu Ying Zhu Lei Jiang Key Laboratory of Bio-inspired Smart Interfacial Science and Technology of Ministry of Education School of Chemistry and Environment Beihang University Beijing 100191 China Laboratory of Bio-inspired Smart Interfacial Science Technology Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190 China

Oil sorbents are an attractive option for oil-spill cleanup as they may be used for collection and complete removal of oil without adversely affecting the environment. However, traditional oil sorbents exhibit low oil/water separation efficiency and/or low oil-sorption capacity. In this study, an ultra-high performance graphene/polyurethane （PU） sponge has been successfully obtained by in situ polymerization in the presence of graphene dispersed in N-methylpyrrolidone （NMP）. During polymerization, the NMP/graphene dispersion not only serves as a weak amine catalyst for the formation of the sponge, but promotes fixation of the graphene sheets in the framework of the PU sponge owing to the strong dipole interaction between NMP and graphene. The as-prepared graphene/PU sponge was used as an absorbing material for the continuous removal of oil from oil-spill water. The graphene/PU sponge can continuously and rapidly remove oils from immiscible oil/water mixtures in corrosive solutions, including strong acids and bases, hot water, and ice water, with an excellent separation efficiency of above 99.99%. In addition, the as-prepared graphene/PU sponge was effective in separating surfactant-stabilized emulsions with a high separation efficiency of 〉99.91%.

关键词： graphene/polyurethane(PU) sponge in-situ polymerization continuous oil cleanup ultrahigh stability

Constructing multifunctional deep-blue emitters with weak charge transfer excited state for high-performance non-doped blue OLEDs and single-emissive-layer hybrid white OLEDs

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Chinese Chemical Letters 2024年第10期35卷 175-179页

作者： Hui Liu Xiangyang Tang zhuang cheng Yin Hu Yan Yan Yangze Xu Zihan Su Futong Liu Ping lu State Key Laboratory of Supramolecular Structure and Materials Department of Chemistry Jilin UniversityChangchun 130012China Sichuan Province Key Laboratory of Information Materials and Devices Application College of Optoelectronic EngineeringChengdu University of Information TechnologyChengdu 610225China

Deep-blue emitter with high photoluminescence efficiency(PLQY)is highly desirable in ultra-high definition displays and white solid-state *** this work,two deep-blue phenanthro[9,10]imidazole derivatives,PPIS and PPPIS,with hot exciton property are successfully *** to PPIS,the embedded phenyl bridge in PPPIS is able to effectively increase the overlap of frontier molecular *** consequence,PPPIS shows higher oscillator strength and significantly enhanced *** also achieves better electroluminescence performance in non-doped device,showing deep-blue emission with Commission International de l’Eclairage(CIE)coordinates of(0.153,0.087)and the maximum external quantum efficiency(EQEmax)of 8.5%with minuscule efficiency ***,when PPPIS serves as the host for phosphor PO-01,high-efficiency orange phosphorescent device is obtained with high EQEmax of 29.8%and negligible efficiency roll-off at 1000 cd/m^(2).Further,efficient single-emissive-layer white device is assembled via utilizing PPPIS as a blue emitter as well as the host for PO-01 simultaneously,providing warm-white emission with CIE coordinates of(0.429,0.433)at 1000 cd/m^(2),the forward-viewing EQEmaxof 27.2%and maximum power efficiency(PEmax)of 80.1 lm/W,*** studies can establish a viable design strategy for deep-blue emitters in high-performance non-doped blue OLEDs and hybrid WOLEDs.

关键词： Deep-blue emitters Phenanthroimidazole Hot exciton Host Single-emissive-layer white device

Metal–organic framework-derived Co_(3)O_(4)modified nickel foam-based dendrite-free anode for robust lithium metal batteries

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Chinese Chemical Letters 2023年第8期34卷 382-386页

作者： Tao Wei Jiahao lu Pan Zhang Guang Yang cheng Sun Yanyan Zhou Quanchao zhuang Yongfu Tang School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003China Hebei Key Laboratory of Applied Chemistry School of Environmental and Chemical EngineeringYanshan UniversityQinhuangdao 066004China Li-ion Batteries Lab School of Materials Science and EngineeringChina University of Mining and TechnologyXuzhou 221116China

For several decades,the promise of implementing of lithium(Li)metal anodes for Li batteries has been a"holy grail"for ***,we have proposed a facile design of a MOF-derived Co_(3)O_(4)nanoparticles modified nickel foam,i.e.,Co_(3)O_(4)-NF,as a 3D host to achieve a uniform infusion of the molten *** molten Li was uniformly absorbed on the Co_(3)O_(4)-NF host only in 10 s due to its high Li *** obtained Li-Co_(3)O_(4)-NF composite electrode shows high cycling stability in symmetric cells with low voltage hysteresis even at a high current density of 5 mA/*** full cells of Li-Co_(3)O_(4)-NF/LiFePO_(4)can cycle for more than 500 cycles at 2C without obvious capacity *** after cycling and in situ optical microscope results suggest that the unique 3D host structure of the Li-Co_(3)O_(4)-NF anode plays key roles on suppressing the dendrite growth and decreasing the local current *** believe this work might provide a new strategy for fabricating dendrite-free Li metal anodes and facilitate practical applications in Li batteries.

关键词： All solid-state lithium-ion batteries Metal-organic frameworks(MOFs) Lithium metal anodes Dendrite-free anode Three-dimensional anode

Bus travel time reliability incorporating stop waiting time and in‑vehicle travel time with AVL data

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International Journal of Coal Science & Technology 2022年第5期9卷 187-202页

作者： Zixu zhuang Zhanhong cheng Jia Yao Jian Wang Shi An School of Transportation Science and Engineering Harbin Institute of TechnologyHarbin 150090HeilongjiangChina School of Economics and Management Dalian University of TechnologyDalian 116024LiaoningChina

Improving bus travel time reliability can attract more commuters to use bus transit,and therefore reduces the share of cars and alleviates trafc *** paper formulates a new bus travel time reliability metric that jointly considers two stochastic processes:the in-stop waiting process and in-vehicle travel time process,and the bus travel time reliability function is calculated by the convolution of independent events’*** new reliability metric is defned as the probability when bus travel time is less than a certain threshold and can be used in both conditions with and without bus ***,Automatic Vehicle Location(AVL)data of the city of Harbin is used to demonstrate the applicability of the proposed *** show that factors such as weather,day of the week,departure time,travel distance,and the distance from the boarding stop to the bus departure station can signifcantly afect the travel time ***,a case with low bus departure frequency is analyzed to show the impact of travelers’arrival distribution on their bus travel time ***,it is demonstrated that the travel time reliabilities of two bus transfer schemes of the same Origin–Destination(O–D)pair can have signifcantly diferent *** the bus travel time reliability pattern of the alternative bus routes can help passengers to choose a more reliable bus route under diferent *** proposed bus travel time reliability metric is tested to be sensitive to the efect of diferent factors and can be applied in bus route recommendation,bus service evaluation,and optimization.

关键词： Reliability Bus travel time Automatic vehicle location Bus departure frequency

Numerical analysis of the correlation between fluid dynamic modes and hydrodynamic noise in flows around a three-dimensional circular cylinder

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Journal of Hydrodynamics 2024年第1期36卷 119-129页

作者： Jia-jia Qin Ming-xin Zou Yuan zhuang De-cheng Wan Computational Marine Hydrodynamics Lab(CMHL) School of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai200240China Wuhan Second Ship Design and Research Institute Wuhan430205China

The flow around a circular cylinder for Re=1000 is characterized by flow separation and Karman vortex *** typical flow features can be captured to study the correlation between fluid fields and sound *** this paper,the three-dimensional circular cylinder is taken as the research object,and the probes of surface fluctuating pressure and far field sound pressure are arranged every 10°.The directional diagram and the coherence of fluctuating pressure and sound pressure are *** relationship between the flow mode and hydrodynamic noise is studied by using dynamic mode decomposition(DMD).The characteristics of the dipole and quadrupole sound source term of a long span cylinder are *** results show that at the angles between 30°–120°and 190°–350°,the fluctuating pressure contributes more to the generation of dipole *** quadrupole sound source shows three-dimensional effects,which is more obvious in a cylinder with large spanwise length.

关键词： Pressure coherence dynamic mode decomposition flow-sound correlation circular cylinder

Enhancement of Virus Replication in An Influenza A Virus NS1-Expresssing 293 Cell Line

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Biomedical and Environmental Sciences 2016年第3期29卷 224-228页

作者： ZHU Wu Yang TAO Xiao Yan LYU Xin Jun YU Peng cheng lu Zhuo zhuang National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention State Key Laboratory for Infectious Disease Prevention and Control Chinese Center for Disease Control and Prevention

The nonstructural protein 1 （NS1） of influenza A virus, which is absent from the viral particle, but highly expressed in infected cells, strongly antagonizes the interferon （IFN）-mediated antiviral response. We engineered an NS1-expressing 293 （293-NS1） cell line with no response to IFN stimulation. Compared with the parental 293 cells,

关键词： NS Enhancement of Virus Replication in An Influenza A Virus NS1-Expresssing 293 Cell Line IFN Figure