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ANALYSIS OF HYDRODYNAMICS FOR TWO-DIMENSIONAL FLOW AROUND WAVING PLATES

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Journal of Hydrodynamics 2007年第1期19卷 18-22页

作者： ZHANG cheng zhuang Li-Xian lu Xi-Yun Department of Mechanics and Mechanical Engineering University of Science and Technology of China Hefei 230026 China

Hydrodynamic characteristics for two-dimensional flow around a waving plate are investigated. Under large Reynolds number approximation, the flow is assumed to be a combination of the outer potential flow and a thin vortex layer, which consists of a boundary layer and a shed free shear layer. A nonlinear mathematical formulation for describing the outer unsteady potential flow coupled with an unsteady boundary layer equation for the inner viscous flow adjacent to the waving plate is developed. A semi-analytical method with a nonlinear Kutta condition imposed at the trailing edge is used to solve the velocity field of the outer flow and the evolution of wake vortex induced by a large-amplitude waving plate. The unsteady boundary layer equation is solved by extending Pohlhausen＇s method to its unsteady counterpart. The thrust and viscous drag coefficients, propulsive efficiency, and the pattern of wake vortex sheet are discussed.

关键词： waving plate fish swimming unsteadyboundary layer vortex shedding

Lipid droplets in the nervous system:involvement in cell metabolic homeostasis

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Neural Regeneration Research 2025年第3期20卷 740-750页

作者： Yuchen Zhang Yiqing Chen cheng zhuang Jingxuan Qi Robert Chunhua Zhao Jiao Wang School of Life Sciences Shanghai UniversityShanghaiChina School of Medicine Shanghai UniversityShanghaiChina Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic MedicinePeking Union Medical CollegeBeijingChina Center of Excellence in Tissue Engineering Chinese Academy of Medical SciencesBeijingChina Beijing Key Laboratory of New Drug Development and Clinical Trial of Stem Cell Therapy BeijingChina

Lipid droplets serve as primary storage organelles for neutral lipids in neurons,glial cells,and other cells in the nervous *** droplet formation begins with the synthesis of neutral lipids in the endoplasmic ***,lipid droplets were recognized for their role in maintaining lipid metabolism and energy homeostasis;however,recent research has shown that lipid droplets are highly adaptive organelles with diverse functions in the nervous *** addition to their role in regulating cell metabolism,lipid droplets play a protective role in various cellular stress ***,lipid droplets exhibit specific functions in neurons and glial *** of lipid droplet formation leads to cellular dysfunction,metabolic abnormalities,and nervous system *** review aims to provide an overview of the role of lipid droplets in the nervous system,covering topics such as biogenesis,cellular specificity,and ***,it will explore the association between lipid droplets and neurodegenerative *** the involvement of lipid droplets in cell metabolic homeostasis related to the nervous system is crucial to determine the underlying causes and in exploring potential therapeutic approaches for these diseases.

关键词： Alzheimer's disease lipid droplet biogenesis lipid droplets lipid metabolism nervous system neurodegenerative disorders oxidative stress Parkinson's disease

Identifying the dynamic behaviors in complete reconstruction of Co-based complex precatalysts during electrocatalytic oxygen evolution

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Journal of Energy Chemistry 2025年第1期100卷 226-233页

作者： Jingfang Zhang Danyang Wu Linke Cai Youluan lu Fanpeng cheng Lijuan Shi Qun Yi Yao Liu Yi Huang Key Laboratory of Green Chemical Engineering Process of Ministry of Education Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of Education Hubei Key Laboratory of Novel Reactor and Green Chemical Technology School of Chemical Engineering & Pharmacy Wuhan Institute of Technology Key Laboratory of Pesticide & Chemical Biology of Ministry of Education Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction of Ministry of Education College of Chemistry Central China Normal University College of Materials Science and Engineering Fuzhou University

Transition metal-based nanomaterials have emerged as promising electrocatalysts for oxygen evolution reaction（OER）. Considerable research efforts have shown that self-reconstruction occurs on these nanomaterials under operating conditions of OER process. However, most of them undergo incomplete reconstruction with limited thickness of reconstruction layer, leading to low component utilization and arduous exploration of real catalytic mechanism. Herein, we identify the dynamic behaviors in complete reconstruction of Co-based complexes during OER. The hollow phytic acid（PA） cross-linked CoFe-based complex nanoboxes with porous nanowalls are designed because of their good electrolyte penetration and mass transport ability, in favor of the fast and complete reconstruction. A series of experiment characterizations demonstrate that the reconstruction process includes the fast substitution of PA by OH-to form Co（Fe）(OH)xand subsequent potential-driven oxidation to Co（Fe）OOH. The obtained CoFeOOH delivers a low overpotential of 290 mV at a current density of 10 mA cm-2and a long-term *** experiment results together with theory calculations reveal that the Fe incorporation can result in the electron rearrangement of reconstructed CoFeOOH and optimization of their electronic structure,accounting for the enhanced OER activity. The work provides new insights into complete reconstruction of metal-based complexes during OER and offers guidelines for rational design of high-performance electrocatalysts.

关键词： Complete reconstruction Co-based complex Precatalysts Oxygen evolution reaction

High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai Yuan zhuang Shenghua lu Qianqian Ge Hao Li Yu Deng Hongbin Wu Xiaojian Xu Fei Niu Xinlong Dong Bin Zhang Baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

Optimal Allocation of Fault Current Limiter in MMC-HVDC Grid Based on Transient Energy Flow

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CSEE Journal of Power and Energy Systems 2023年第5期9卷 1786-1796页

作者： Meiqin Mao Hui lu Dejian cheng zhuang He Research Centre for Photovoltaic System Engineering.MOE Hefei University of TechnologyHefei 230009China

Economical and reliable protection of DC-side shortcircuit faults has become a key technology for promoting the development of module multilevel converters based on the high voltage direct current grid(MMC-HVDC-Grid).The fault current limiter(FCL)can effectively suppress the rapid development of the fault current and reduce the current breaking capacity of the circuit *** this paper,a method based on transient energy flow(TEF)analysis is proposed to optimize the allocation of a resistive and inductive FCL in the *** the proposed method,the electromagnetic TEF is measured first,and then,the TEF suppression rate and suppression efficiency are defined as optimization objectives,and the installation location of the FCL and its impedance parameters as optimization *** test the proposed method,two-terminal and four-terminal bipolar MMC-HVDC-Grids with single-pole-to-ground DC faults are modeled in the PSCAD/EMTDC so that the TEF data can be *** optimal FCLs’location and parameter values are determined through investigating the evolution paradigm of TEF along with changes of the FCL position and *** results prove that the selected parameters can effectively slow down the DC fault current rising rate,thus reducing the requirements on tripping current of the DC breakers.

关键词： MMC-HVDC-Grid TEF FCL DC fault protection optimal allocation

A novel flexible nerve guidance conduit promotes nerve regeneration while providing excellent mechanical properties

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Neural Regeneration Research 2025年第7期20卷 2084-2094页

作者： Tong Li Quhan cheng Jingai Zhang Boxin Liu Yu Shi Haoxue Wang Lijie Huang Su Zhang Ruixin Zhang Song Wang Guangxu lu Peifu Tang Zhongyang Liu Kai Wang Department of Orthopedics the Fourth Medical Center of Chinese PLA General HospitalBeijingChina Department of Training and Sports Medicine Characteristic Medical Center of Chinese People’s Armed Police ForceTianjinChina Medical School of Chinese PLA BeijingChina Key Laboratory of Bioactive Materials for the Ministry of Education College of Life SciencesNankai UniversityTianjinChina Department of Orthopedics Tianjin HospitalTianjinChina Department of Rehabilitation Medicine Er Quan Hospital of PAPWuxiJiangsu ProvinceChina

Autografting is the gold standard for surgical repair of nerve defects>5 mm in length;however,autografting is associated with potential complications at the nerve donor *** an alternative,nerve guidance conduits may be *** ideal conduit should be flexible,resistant to kinks and lumen collapse,and provide physical cues to guide nerve *** designed a novel flexible conduit using electrospinning technology to create fibers on the innermost surface of the nerve guidance conduit and employed melt spinning to align ***,we prepared disordered electrospun fibers outside the aligned fibers and helical melt-spun fibers on the outer wall of the electrospun fiber *** presence of aligned fibers on the inner surface can promote the extension of nerve cells along the *** helical melt-spun fibers on the outer surface can enhance resistance to kinking and compression and provide *** novel conduit promoted nerve regeneration and functional recovery in a rat sciatic nerve defect model,suggesting that it has potential for clinical use in human nerve injuries.

关键词： aligned fibers anti-kinking helical fibers nerve guidance conduit nerve regeneration peripheral nerve injury topological guidance

Non-Hermitian polarization quantized by time-reversal symmetry

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Science China(Physics,Mechanics & Astronomy) 2024年第12期67卷 141-147页

作者： Jing cheng Jinbing Hu Zhigao Hu Lin Chen Minghui lu Songlin zhuang Technical Center for Multifunctional Magneto-Optical Spectroscopy(Shanghai) Engineering Research Center of Nanophotonics&Advanced Instrument(Ministry of Education)Department of Physics and Electronic ScienceEast of China Normal UniversityShanghai200241China College of Optical-Electrical Information and Computer Engineering University of Shanghai for Science and TechnologyShanghai200093China Wuhan National Laboratory for Optoelectronics and School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan430074China National Laboratory of Solid State Microstructures Science and Engineering Nanjing UniversityNanjing210093China

It is well known that in one-dimensional(1D) crystalline insulators,the electric polarization is a manifestation of Berry phase,which can not be quantized by time-reversal symmetry(TRS) as in Hermitian physics TRS does not induce any topological phase in one *** this paper we report that even though associated with complex eigenenergies a 1D non-Hermitian insulator obeying only TRS is capable of presenting quantized bulk *** underlying physical reason is unveiled:TRS guarantees the complex energies to come in pair(E,E*),and the corresponding decaying and amplifying wave functions also come in pair and have the same variation rate,hence,giving rise to a stable wannier *** electron transport is performed by means of charge pumping process,which verifies the physical mechanism *** last,we discuss the possible experimental implementation of the proposed model by means of twisted-π gauge flux.

关键词： non-Hermitian polarization time-reversal symmetry complex hopping

Parametric study of a new HOS-CFD coupling method

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Journal of Hydrodynamics 2021年第1期33卷 43-54页

作者： Yuan zhuang De-cheng Wan Computational Marine Hydrodynamics Lab(CMHL) School of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China

This paper presents a developed new coupled method which combined our in-house CFD solver naoe-FOAM-SJTU and naoe-FOAM-os with a potential theory High Order Spectral method(HOS).A parametric study of nonlinear wave propagation in computational fluid dynamics(CFD)zone is *** convergence,time step convergence,time discretization scheme and length of relaxation zone are all carried *** parametric studies verify the steady of this new combined method and give better choice for wave *** dissipation in propagation of nonlinear regular wave can be lower than 3%in static mesh,and less than 2%in overset grid ***,a LNG FPSO is put into the viscous wave tank to study the suitable size of CFD *** achieve a better solution with least calculating resources and best numerical results,the length of CFD zone is *** parametric studies can give reference upon employment of the potential-viscous coupled method and validation of the coupled method.

关键词： High Order Spectral method(HOS)parametric study naoe-FOAM-SJTU solver potential-viscous coupled method

An experimental investigation of one-and two-degree of freedom VIV of cylinders

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Acta Mechanica Sinica 2013年第2期29卷 284-293页

作者： zhuang Kang lu-Sheng Jia College of Shipbuilding Harbin Engineering University CNOOC Research Institute

In the paper,an experiment investigation was conducted for one-and two-degree of freedom vortex-induced vibration（VIV） of a horizontally-oriented cylinder with diameter of 11 cm and length of 120 *** the experiment,the spring constants in the cross-flow and in-line flow directions were regulated to change the natural vibration frequency of the model *** was found that,in the one-degree of freedom VIV experiment,a ＂double peak＂ phenomenon was observed in its amplitude within the range of the reduced velocities tested,moreover,a ＂2T＂ wake appeared in the vicinity of the second *** the two-degree of freedom VIV experiment,the trajectory of cylinder exhibited a reverse ＂C＂ shape,i.e.,a ＂new moon＂ *** analysis of these data,it appears that,besides the non-dimensional in-line and cross-flow natural vibration frequency ratios,the absolute value of the natural vibration frequency of cylinder is also one of the important parameters affecting its VIV behavior.

关键词： One- and two-degree of freedom VIV “2T” wake “New moon” trajectory Natural vibration frequency ratio