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Endoplasmic Reticulum Stress-induced Endothelial Dysfunction Promotes Neointima Formation after Arteriovenous Grafts in Mice on High-fat Diet

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Current Medical Science 2023年第1期43卷 115-122页

作者： Yan-xia ZHONG Chen-chen ZHOU Ying-fang ZHENG Hong-kai DAI Ren-yu CHEN Yu-rou WANG cheng-ye zhan Jin-long LUO Ai-ni XIE Emergency and Intensive Care Unit Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Divison of Cardiothoracic and Vascular Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective Endothelial dysfunction is one candidate for triggering neointima formation after arteriovenous grafts(AVGs),but the factors mediating this process are *** purpose of this study was to investigate the role of endoplasmic reticulum stress(ERS)-induced endothelial dysfunction in neointima formation following AVGs in high-fat diet(HFD)*** CCAAT-enhancer-binding protein-homologous protein(CHOP)knockout(KO)mice were *** were fed with HFD to produce HFD *** model were applied in the groups of WT ND,WT HFD,and CHOP KO *** umbilical vein endothelial cells(HUVECs)were cultured with oxidized low density lipoprotein(ox-LDL)(40 mg/L)for the indicated time lengths(0,6,12,24 h).ERS inhibitor tauroursodeoxycholic acid(TUDCA)was used to block *** staining was used to observe the changes of *** of ERS were detected by real-time *** expression levels and ERS activation were detected by Western *** cell function was determined by endothelial permeability assay and transendothelial migration *** HFD increased neointima formation in AVGs associated with endothelial *** the same time,ERS was increased in endothelial cells(ECs)after AVGs in mice consuming the *** vitro,ox-LDL was found to stimulate ERS,increase the permeability of the EC monolayer,and cause endothelial *** ERS with TUDCA or CHOP siRNA reversed the EC dysfunction caused by *** vivo,knockout of CHOP(CHOP KO)protected the function of ECs and decreased neointima formation after AVGs in HFD *** Inhibiting ERS in ECs could improve the function of AVGs.

关键词： endoplasmic reticulum stress endothelial dysfunction neointima formation arteriovenous grafts high-fat diet

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Three-dimensional fracture of UO2 ceramic pellets by phase field modeling

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 169-180页

作者： Wei Xiong Xuan ye Hongzhang cheng Xiaoming Liu Institute of Nuclear and New Energy Technology Collaborative Innovation Center of Advanced Nuclear Energy Technology Key Laboratory of Advanced Reactor Engineering and Safety of Ministry of Education Tsinghua University State Key Laboratory of Nonlinear Mechanics Institute of Mechanics Chinese Academy of Sciences School of Engineering Science University of Chinese Academy of Sciences

Fracture is the primary failure type for the UO2ceramic pellets,which are operated under irradiation and thermal processes,and physically confined by the *** this work,by combining closely coupled physical processes of heat conduction,heat transfer,and mechanical deformation with the cohesive phase field framework,we proposed a high-precision modeling of quasistatic cracking of three-dimensional （3D） UO2ceramic fuel pellets under high temperature and *** simulation results agree well with the experimental results,indicating that the proposed method has the potential to capture 3D crack modes in the interested time ***,we studied the relation of the 3D fracture patterns of fuel pellets with the peak power *** was found that the power level plays a critical role in determining the competition between radial and circumferential cracks,as well as transverse penetrating cracks.

关键词： phase field method nuclear fuel pellet coupled thermo-mechanical model thermal fracture

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An Unprecedented Efficiency with Approaching 21%Enabled by Additive‑Assisted Layer‑by‑Layer Processing in Organic Solar Cells

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Nano-Micro Letters 2025年第2期17卷 372-375页

作者： Shuai Xu Youdi zhang Yanna Sun Pei cheng Zhaoyang Yao Ning Li Long ye Lijian Zuo Ke Gao Key Laboratory of Advanced Green Functional Materials College of ChemistryChangchun Normal UniversityChangchun 130032People’s Republic of China Shandong Provincial Key Laboratory for Science of Material Creation and Energy Conversion School of Chemistry and Chemical EngineeringShandong UniversityQingdao 266237People’s Republic of China College of Polymer Science and Engineering Sichuan UniversityChengdu 610065People’s Republic of China State Key Laboratory and Institute of Elemento‑Organic Chemistry Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer MaterialsRenewable Energy Conversion and Storage Center(RECAST)College of ChemistryNankai UniversityTianjin 300071People’s Republic of China Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and Devices South China University of TechnologyGuangzhou 510640People’s Republic of China Tianjin Key Laboratory of Molecular Optoelectronic Sciences School of Materials Science and EngineeringTianjin UniversityTianjin 300350People’s Republic of China State Key Laboratory of Silicon Materials MOE Key Laboratory of Macromolecular Synthesis and FunctionalizationDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China

Recently published in Joule,Feng Liu and colleagues from Shanghai Jiaotong University reported a record-breaking 20.8%power conversion efficiency in organic solar cells(OSCs)with an interpenetrating fibril network active layer morphology,featuring a bulk p-in structure and proper vertical segregation achieved through additive-assisted layer-by-layer *** optimized hierarchical gradient fibrillar morphology and optical management synergistically facilitates exciton diffusion,reduces recombination losses,and enhances light capture *** approach not only offers a solution to achieving high-efficiency devices but also demonstrates the potential for commercial applications of OSCs.

关键词： Organic solar cells Additive-assisted layer-by-layer processing Three-dimensional fibril morphology Bulk p-i-n structure Optical management

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The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan Liu Wei Wu Xuejuan Li chengyan Wang Ke Chai Fanru Yuan Huijuan Zheng Yuxing Yao Chenlu Li Zu-cheng ye Daijun Zha Department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of Laboratory Animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

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Carbon Dioxide Sequestration via Steelmaking Slag Carbonation in Alkali Solutions: Experimental Investigation and Process Evaluation

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Acta Metallurgica Sinica(English Letters) 2018年第7期31卷 771-784页

作者： Chen-ye Wang Wei-Jun Bao zhan-cheng Guo Hui-Quan Li State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing Key Laboratory of Green Process and Engineering National Engineering Laboratory for Hydrometallurgical Cleaner Production Technology Institute of Process EngineeringChinese Academy of Sciences

Carbon dioxide mineral sequestration with steelmaking slag is a promising method for reducing carbon dioxide in a large- scale setting. Existing calcium oxide or calcium hydroxide in steelmaking slag can be easily leached by water, and the formed calcium carbonate can be easily wrapped on the surface of unreacted steelmaking slag particles. Thus, further increase in the carbonation reaction rate can be prevented. Enhanced carbon dioxide mineral sequestration with steel- making slag in dilute alkali solution was analysed in this study through experiments and process evaluation. Operating conditions, namely alkali concentration, reaction temperature and time, and liquid-to-solid ratio, were initially investigated. Then, the material and energy balance of the entire process was calculated, and the net carbon dioxide sequestration efficiency at different reaction times was evaluated. Results showed that dilute alkali solution participated in slowing down the leaching of active calcium in the steelmaking slag and in significantly improving carbonation conversion rate. The highest carbonation conversion rate of approximately 50% can be obtained at the optimal conditions of 20 g/L alkali concentration, 2 mL/L liquid-to-solid ratio, and 70 ℃ reaction temperature. Carbonation reaction time significantly influences the net carbon dioxide sequestration efficiency. According to calculation, carbon dioxide emission of 52.6 kg/t- slag was avoided at a relatively long time of 120 min.

关键词： Steelmaking slag Dilute alkali solution COe mineral sequestration. Process evaluation

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In Silico Cloning and Sequence Analysis of Phospholipase Dα Gene from Peach Fruit

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Agricultural Sciences in China 2009年第11期8卷 1293-1300页

作者： WAN Si-bao zhanG Bin zhan Ji-cheng CHEN Jian-ye YIN Jing-yuan School of Life Science Shanghai University Shanghai 200444 P.R. China College of Food Science and Nutritional Engineering China Agricultural University Beijing 100083 P.R. China Guangdong Key Laboratory for Postharvest Science College of Horticultural Science South China Agricultural University Guangzhou 510642 P.R. China

Phospholipase D （PLD, EC 3.***.4.4） plays an important role in adaptive response of postharvest fruit to environment. In this study, a novel cDNA of PLDα was isolated with the strategy of in silico cloning in combination with RT-PCR from peach （Prunus persica L. cv. Jiubao）. The obtained PLDα gene contained a complete open reading frame encoding a 92- kDa protein of 810 amino acid residues, which possessed the characteristic C2 domain and two catalytic HKD motifs. The alignment analysis of the deduced peach PLDa protein with other known PLDα family proteins indicated that peach PLDα was conserved and highly homologous with strawberry PLDα. Semi-quantitative RT-PCR and Northern blot analysis indicated PLDα mRNA in peach fruits could be induced by low temperature. This work provided a scientific basis for further investigating the mechanism of postharvest fruit adaptation to low temperature.

关键词： peach phospholipase Dα in silico cloning RT-PCR Northern blot

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Truncation and aliasing errors for Whittaker-Kotelnikov-Shannon sampling expansion

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Applied Mathematics(A Journal of Chinese Universities) 2012年第4期27卷 412-418页

作者： ye Pei-xin SONG zhan-jie School of Mathematics and LPMC Nankai UniversityTianjin 300071China Department of Mathematics School of ScienceTianjin UniversityTianjin 300072China

Let B^pΩ, 1 ≤ p 〈 ∞, be the space of all bounded functions from Lp（R） which can be extended to entire functions of exponential type Ω. The uniform error bounds for truncated Whittaker-Kotelnikov-Shannon series based on local sampling are derived for functions f ∈ B^pΩ without decay assumption at infinity. Then the optimal bounds of the aliasing error and truncation error of Whittaker-Kotelnikov-Shannon expansion for non-bandlimited functions from Sobolev classes L/（Wp（R）） are determined up to a logarithmic factor.

关键词： Whittaker-Kotelnikov-Shannon theorem localized sampling truncation error aliasing error,Sobolev class.

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长江经济带新型城镇化与空气污染的脱钩分析

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生态经济 2025年第1期41卷 140-148,194页

作者：詹成郭明晶周文潇陈嘉浩中国地质大学(武汉)经济管理学院湖北武汉430074

城市的快速发展带来了污染物的集中。为了协调经济发展与环境污染之间的关系,中国制定并实施了新型城镇化战略。但是,对新型城镇化与空气污染的具体关系的研究尚不充足,仍不清楚空气污染是否与新型城镇化脱钩。因此,基于2009—2021年长... 详细信息

城市的快速发展带来了污染物的集中。为了协调经济发展与环境污染之间的关系,中国制定并实施了新型城镇化战略。但是,对新型城镇化与空气污染的具体关系的研究尚不充足,仍不清楚空气污染是否与新型城镇化脱钩。因此,基于2009—2021年长江经济带108个城市的面板数据,构建了人口、经济、空间、社会和生态五个维度的新型城镇化评价指标体系。利用Tapio脱钩模型和追赶脱钩模型探讨了新型城镇化与PM_(2.5)浓度之间的脱钩关系和区域异质性。结果表明:(1)长江经济带PM_(2.5)浓度在2013年后持续减少。(2)新型城镇化的驱动力主要来自经济城镇化和社会城镇化。(3)PM_(2.5)浓度与新型城镇化之间长期保持脱钩状态,但在短期尺度内存在脱钩和负脱钩的交替现象。(4)大部分追赶城市对模范城市的追赶并不理想,地区间的不平衡现象还将长期持续。

关键词：新型城镇化空气质量 PM2.5 Tapio模型

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SCHEDULING ALGORITHM BASED ON FOLLOW-UP SHARING CHARACTER FOR POST-EVENT RESPONSE RESOURCE DISTRIBUTION IN LARGE-SCAL DISASTERS

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Journal of Systems Science and Systems Engineering 2016年第1期25卷 77-101页

作者： Yong ye Nan Liu Guiping Hu Shalei zhan Department of Management College of Humanities and Management Wenzhou Medical University Wenzhou 325035 P.R. China Department of Management Sciences & Engineering School of Management Zhejiang University Hangzhou 310058 P.R. China Industrial and Manufacturing Systems Engineering 3014 Black Engineering Iowa State University Ames IA 50011 School of Computer Science and Information Engineering Zhejiang Gongshang University Hangzhou 310058 P.R. China

Post-event response planners must develop effective and efficient plans for the proper allocation and distribution of resources to impacted areas （IAs） within a critical time window. To determine the effectiveness and efficiency of distribution plans, this study addresses resource allocation effectiveness losses （RAEL, or losses caused by the mismatch between supply and demand in IAs） and emergency logistics time costs （ELTC, or transportation time of logistics processes under emergency conditions）. Moreover, this study examines a follow-up sharing character （FSC） that coordinates resources among different phases. This research proposes an integrated model （IM） based on this character. This model aims to minimize RAEL and ELTC. Furthermore, the IM combines the time dimension model （TDM）, which coordinates the demands and supplies of all phases in the planning horizon, and the space dimension model （SDM）, which generates a specific distribution plan for the first phase. An analytical solution is obtained for the TDM as per the definition of FSC, after which the SDM is solved through a single-objective linear programming model. After solving the IM effectively, we fred that the proposed methodology fits the emergency circumstance well. Insights derived from the model are also presented in the conclusion.）

关键词： Emergency management humanitarian logistics decision-making resource distribution

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AntarcticaLC2000：The new Antarctic land cover database for the year 2000

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Science China Earth Sciences 2017年第4期60卷 686-696页

作者： HUI FengMing KANG Jing LIU Yan cheng Xiao GONG Peng WANG Fang LI zhan ye YuFang GUO ZiQi State Key Laboratory of Remote Sensing Science College of Global Change and Earth System Science Beijing Normal University Beijing 100875 China Ministry of Education Key Laboratory for Earth System Modeling Centre for Earth System Science Tsinghua University Beijing 100084 China State Key Laboratory of Remote Sensing Science Institute of Remote Sensing and Digital Earth Chinese Academy of Sciences Beijing 100101 China School for the Environment University of Massachusetts Boston Boston MA 02125 USA Institute of Environmental Physics University of Bremen Bremen 28359 Germany Joint Center for Global Change Studies Beijing 100875 China

Antarctica plays a key role in global energy balance and sea level *** has been conventionally viewed as a whole ice body with high albedo in General Circulation Models or Regional Climate Models and the differences of land cover has usually been *** cover in Antarctica is one of the most important drivers of changes in the Earth *** land cover information over the Antarctic region is necessary as spatial resolution improves in land process ***,there is a lack of complete Antarctic land cover dataset derived from a consistent data *** fill this data gap,we have produced a database named Antarctic Land Cover Database for the year 2000(AntarcticaLC2000) using Landsat Enhanced Thematic Mapper Plus(ETM+) data acquired around 2000 and Moderate Resolution Imaging Spectrometer(MODIS) images acquired in the austral summer of 2003/2004 according to the criteria for the 1:*** land cover types were included in this map,separately,ice-free rocks,blue ice,and snow/*** classification legend was determined based on a review of the land cover systems in Antarctica(LCCSA) and an analysis of different land surface types and the potential of satellite *** classification was conducted through a combined usage of computer-aided and manual interpretation methods.A total of 4067 validation sample units were collected through visual interpretation in a stratified random sampling *** overall accuracy of 92.3%and the Kappa coefficient of 0.836 were *** show that the areas and percentages of ice-free rocks,blue ice,and snow/firn are 73268.81 km2(0.537%),225937.26 km2(1.656%),and 13345460.41 km2(97.807%),*** comparisons with other different data proved a higher accuracy of our product and a more advantageous data *** indicate that AntarcticaLC2000,the new land cover dataset for Antarctica entirely derived from satellite data,is a reliable product for a broad spectrum of applicat

关键词： Snowdrift process Air-snow interaction Ice core dating Ultrasonic sounder Post depositional process

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