检索结果-南通市图书馆

World Journal of Stem Cells 2023年第5期15卷 385-399页

作者： Li-Yi Huang Xin Sun Hong-Xia Pan Lu Wang cheng-qi he Quan Wei Rehabilitation Medicine Center and Institute of Rehabilitation Medicine West China Hospital/West China School of MedicineSichuan UniversityChengdu 610044Sichuan ProvinceChina

Spinal cord injury(SCI)is a devastating condition with complex pathological mechanisms that lead to sensory,motor,and autonomic dysfunction below the site of *** date,no effective therapy is available for the treatment of ***,bone marrow-derived mesenchymal stem cells(BMMSCs)have been considered to be the most promising source for cellular therapies following *** objective of the present review is to summarize the most recent insights into the cellular and molecular mechanism using BMMSC therapy to treat *** this work,we review the specific mechanism of BMMSCs in SCI repair mainly from the following aspects:Neuroprotection,axon sprouting and/or regeneration,myelin regeneration,inhibitory microenvironments,glial scar formation,immunomodulation,and ***,we summarize the latest evidence on the application of BMMSCs in clinical trials and further discuss the challenges and future directions for stem cell therapy in SCI models.

关键词： Spinal cord injury Bone marrow derived mesenchymal stem cells Neuroprotection Axon Myelin Inhibitory microenvironment

Extremely low frequency electromagnetic fields promote cognitive function and hippocampal neurogenesis of rats with cerebral ischemia

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2021年第7期16卷 1252-1257页

作者： qiang Gao Aaron Leung Yong-Hong Yang Benson Wui-Man Lau qian Wang Ling-Yi Liao Yun-Juan Xie cheng-qi he Department of Rehabilitation Medicine West China Hospital of Sichuan UniversityChengduSichuan ProvinceChina Institute of Disaster Management and Reconstruction Sichuan University–The Hong Kong Polytechnic UniversityChengduSichuan ProvinceChina Department of Biomedical Engineering The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina

Extremely low frequency electromagnetic fields(ELF-EMF) can improve the learning and memory impairment of rats with Alzheimer's disease, however, its effect on cerebral ischemia remains poorly *** this study, we established rat models of middle cerebral artery occlusion/*** day after modeling, a group of rats were treated with ELF-EMF(50 Hz, 1 mT) for 2 hours daily on 28 successive *** results showed that rats treated with ELF-EMF required shorter swimming distances and latencies in the Morris water maze test than those of untreated *** number of times the platform was crossed and the time spent in the target quadrant were greater than those of untreated *** number of BrdU~+/NeuN~+ cells, representing newly born neurons, in the hippocampal subgranular zone increased more in the treated than in untreated ***-regulation in the expressions of Notch1, hes1, and hes5 proteins, which are the key factors of the Notch signaling pathway, was greatest in the treated *** findings suggest that ELF-EMF can enhance hippocampal neurogenesis of rats with cerebral ischemia, possibly by affecting the Notch signaling *** study was approved by the Institutional Ethics Committee of Sichuan University, China(approval No.2019255A) on March 5, 2019.

关键词： cerebral ischemia cognitive function electromagnetic fields hippocampus neurogenesis plasticity repair signaling pathway stroke rat

Bone marrow mesenchymal stem cells and exercise restore motor function following spinal cord injury by activating PI3K/AKT/mTOR pathway

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第5期18卷 1067-1075页

作者： Xin Sun Li-Yi Huang Hong-Xia Pan Li-Juan Li Lu Wang Gai-qin Pei Yang Wang qing Zhang Hong-Xin cheng cheng-qi he Quan Wei Rehabilitation Medical Center and Institute of Rehabilitation Medicine West China HospitalSichuan UniversityChengduSichuan ProvinceChina Key Laboratory of Rehabilitation Medicine in Sichuan Province ChengduSichuan ProvinceChina

Although many therapeutic interventions have shown promise in treating spinal cord injury, focusing on a single aspect of repair cannot achieve successful and functional regeneration in patients following spinal cord injury. In this study, we applied a combinatorial approach for treating spinal cord injury involving neuroprotection and rehabilitation, exploiting cell transplantation and functional sensorimotor training to promote nerve regeneration and functional recovery. here, we used a mouse model of thoracic contusive spinal cord injury to investigate whether the combination of bone marrow mesenchymal stem cell transplantation and exercise training has a synergistic effect on functional restoration. Locomotor function was evaluated by the Basso Mouse Scale, horizontal ladder test, and footprint analysis. Magnetic resonance imaging, histological examination, transmission electron microscopy observation, immunofluorescence staining, and western blotting were performed 8 weeks after spinal cord injury to further explore the potential mechanism behind the synergistic repair effect. In vivo, the combination of bone marrow mesenchymal stem cell transplantation and exercise showed a better therapeutic effect on motor function than the single treatments. Further investigations revealed that the combination of bone marrow mesenchymal stem cell transplantation and exercise markedly reduced fibrotic scar tissue, protected neurons, and promoted axon and myelin protection. Additionally, the synergistic effects of bone marrow mesenchymal stem cell transplantation and exercise on spinal cord injury recovery occurred via the PI3 K/AKT/mTOR pathway. In vitro, experimental evidence from the PC12 cell line and primary cortical neuron culture also demonstrated that blocking of the PI3 K/AKT/mTOR pathway would aggravate neuronal damage. Thus, bone marrow mesenchymal stem cell transplantation combined with exercise training can effectively restore motor function after spinal cord inj

关键词： axon growth bone marrow mesenchymal stem cell exercise training mTOR neuroprotection neurotrophin remyelination scar formation spinal cord injury synaptic plasticity

Establishment and Clinical Application of a Multiplex Reverse Transcription-PCR for Porcine Epidemic Diarrhea Virus, Porcine Transmissible Gastroenteritis Virus and Porcine Group A Rotavirus

在线全文

学校读者我要写书评

暂无评论

畜牧兽医学报 2011年第B12期42卷 47-50页

作者： ZHANG Kun LIU Xin-jun KU Xu-gang cheng Shuang he qi-gai （State Key Laboratory of Agricultural Microbiology College of Animal science and Veterinary Medicine Huazhong Agricultural University Wuhan 430070 China）

A multiplex reverse transcription polymerase chain reaction (multiplex RT-PCR) was developed for the detection of porcine epidemic diarrhea virus (PEDV), porcine transmissible gastroenteritis virus (TGEV) and porcine group A rotavirus (GAR). Three pairs of primers were designed to target the M gene, N gene, and VP7 gene of PEDV, TGEV, GAR, respectively, and the multiplex RT-PCR was developed and optimized. The results of the multiplex RT-PCR and routine single RT-PCRs were compared using samples collected in the field. In laboratory testing, the detection limit of the multiplex RT-PCR is ～35 pg RNA of combined TGEV-PEDV-GAR vaccine. In the field trial, 75 fecal specimens collected from pigs with diarrhea, in the central area of China, were simultaneously tested by the multiplex RT-PCR and by routine single RT-PCRs to evaluate the relative sensitivity and specificity of the multiplex RT-PCR. The results indicate that this new assay is equal in quality to the routine RT-PCR assays (sensitivities were 92%, 100%, 100% for PEDV, TGEV, GAR, respectively; specificity was 100% for all three viruses). The multiplex RT-PCR, with high sensitivity and specificity, provides a new and alternative tool for the detection of PEDV, TGEV and GAR.

关键词：猪传染性胃肠炎病毒猪流行性腹泻病毒多重RT-PCR RT-PCR检测轮状病毒临床应用 RT-PCR技术反转录

Lipid droplets in the nervous system:involvement in cell metabolic homeostasis

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 740-750页

作者： Yuchen Zhang Yiqing Chen cheng Zhuang Jingxuan qi Robert Chunhua Zhao Jiao Wang School of Life Sciences Shanghai UniversityShanghaiChina School of Medicine Shanghai UniversityShanghaiChina Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic MedicinePeking Union Medical CollegeBeijingChina Center of Excellence in Tissue Engineering Chinese Academy of Medical SciencesBeijingChina Beijing Key Laboratory of New Drug Development and Clinical Trial of Stem Cell Therapy BeijingChina

Lipid droplets serve as primary storage organelles for neutral lipids in neurons,glial cells,and other cells in the nervous *** droplet formation begins with the synthesis of neutral lipids in the endoplasmic ***,lipid droplets were recognized for their role in maintaining lipid metabolism and energy homeostasis;however,recent research has shown that lipid droplets are highly adaptive organelles with diverse functions in the nervous *** addition to their role in regulating cell metabolism,lipid droplets play a protective role in various cellular stress ***,lipid droplets exhibit specific functions in neurons and glial *** of lipid droplet formation leads to cellular dysfunction,metabolic abnormalities,and nervous system *** review aims to provide an overview of the role of lipid droplets in the nervous system,covering topics such as biogenesis,cellular specificity,and ***,it will explore the association between lipid droplets and neurodegenerative *** the involvement of lipid droplets in cell metabolic homeostasis related to the nervous system is crucial to determine the underlying causes and in exploring potential therapeutic approaches for these diseases.

关键词： Alzheimer's disease lipid droplet biogenesis lipid droplets lipid metabolism nervous system neurodegenerative disorders oxidative stress Parkinson's disease

在线全文

学校读者我要写书评

暂无评论

高压带电作业人员的安全保障

山西建筑 2007年第20期33卷 187-188页

作者：成启和山西电子高级技校

通过对静电屏蔽的阐述,说明了等电势服能高压带电作业的原理以及静电屏蔽在工业电器中的广泛应用,并对为什么火花放电时人没有危险进行了研究,以提高人们对等电势服的认识,从而推广等电势服的应用。

关键词：静电屏蔽电荷电场线等电势服

C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2231-2244页

作者： Xiangzi Wang Xiaofei Niu Yingkai Wang Yang Liu cheng Yang Xuyi Chen Zhongquan qi School of Medicine Guangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Graduate School of Tianjin University of Traditional Chinese Medicine TianjinChina Characteristic Medical Center of People’s Armed Police Forces TianjinChina Fujian Maternity and Child health Hospital FuzhouFujian ProvinceChina

Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory *** expression of the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis exhibits significant differences before and after *** studies have revealed that the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis is closely associated with secondary inflammatory responses and the recruitment of immune cells following spinal cord injury,suggesting that this axis is a novel target and regulatory control point for *** review comprehensively examines the therapeutic strategies targeting the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis,along with the regenerative and repair mechanisms linking the axis to spinal cord ***,we summarize the upstream and downstream inflammatory signaling pathways associated with spinal cord injury and the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review primarily elaborates on therapeutic strategies that target the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the latest progress of research on antagonistic drugs,along with the approaches used to exploit new therapeutic targets within the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the development of targeted ***,there are presently no clinical studies relating to spinal cord injury that are focusing on the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review aims to provide new ideas and therapeutic strategies for the future treatment of spinal cord injury.

关键词： apoptosis C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway C-C motif chemokine receptor 2 antagonists chemokine ligand 2 chemokine receptor 2 inflammation macrophage microglia spinal cord injury therapeutic method

Osteogenic Differentiation of Amniotic Epithelial Cells:Synergism of Pulsed Electromagnetic Field and Biochemical Stimuli

在线全文

学校读者我要写书评

暂无评论

Osteogenic Differentiation of Amniotic Epithelial Cells:Syne...

第十届全国生物力学学术会议暨第十二届全国生物流变学学术会议

作者： qian Wang Wen-chao Wu Xiao-yu Han Ai Zheng Song Lei Jiang Wu Huai-qing Chen cheng-qi he Feng-ming Luo Xiao-jing Liu Department of Rehabilitation Medicine Key Laboratory of Rehabilitation Medicine of Sichuan ProvinceWest China HospitalSichuan University Laboratory of Cardiovascular Diseases Regenerative Medicine Research Center West China HospitalSichuan University

Pulsed electromagnetic field(PEMF)is a non-invasive physical treatment used in the clinic rehabilitation,which facilitates the osteogenesis by direct actions on *** evidence suggests an important role of PEMF in the osteogenic differentiation of bone marrow mesenchymal stem cells(BM-MSCs) in *** epithelial cells(AECs) have been proposed as a potential source of stem cells for cell ***,whether PEMF could modulate the osteogenic differentiation of AECs is unknown. In the present study,the effects of PEMF on the osteogenic differentiation of AECs were in-

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

P2P网络借贷市场利率风险测度研究

兰州财经大学学报 2016年第6期32卷 62-69页

作者：彭承亮何启志巢湖学院应用数学学院安徽合肥238000 安徽财经大学金融学院安徽蚌埠233030

该文利用2013年7月1日至2015年12月31日每日P2P网贷市场利率数据,基于不同分布下的ARGARCH模型研究网贷市场利率波动,运用VaR及CVaR技术研究其利率风险。研究结果表明:(1)网贷市场利率波动具有丛集性、持久性,但其杠杆效应并不明显;(2)A... 详细信息

该文利用2013年7月1日至2015年12月31日每日P2P网贷市场利率数据,基于不同分布下的ARGARCH模型研究网贷市场利率波动,运用VaR及CVaR技术研究其利率风险。研究结果表明:(1)网贷市场利率波动具有丛集性、持久性,但其杠杆效应并不明显;(2)AR-GARCH-t模型能较为有效地测度利率风险衡量指标VaR和CVaR,并且CVaR比VaR更能有效地刻画极端风险;(3)从VaR和CVaR来看,呈现出数值和波动幅度逐渐衰减趋势,但利率风险仍然不容忽视。监测网贷市场利率及其波动、建立有效预警机制以及促进网贷市场形成合理利率定价机制是防范和控制网贷市场利率风险的较好思路。

关键词： P2P网络借贷市场利率波动风险测度

菲涅耳阵在固体中所产生的声束聚焦和扫描特性

在线全文

学校读者我要写书评

暂无评论

物理学报 1988年第10期 1575-1584页

作者：吴进远汪承灏何启光中国科学院声学研究所

用固体表面上的菲涅耳换能器阵实现固体中声束的聚焦和扫描,它具有实用意义。本文将分别运用标量和矢量理论,分析菲涅耳阵在固体中产生的声束特性。理论与实验结果进行了比较。最后,基于射频频谱分析的角度,对聚焦束的建立时间和加权... 详细信息

用固体表面上的菲涅耳换能器阵实现固体中声束的聚焦和扫描,它具有实用意义。本文将分别运用标量和矢量理论,分析菲涅耳阵在固体中产生的声束特性。理论与实验结果进行了比较。最后,基于射频频谱分析的角度,对聚焦束的建立时间和加权技术进行了研讨。

关键词：阵元数固体表面扫描特性换能器阵光谱分析器渡越时间表面相频谱分析器菲涅耳矢量理论声束