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Metachronous isolated penile metastasis from sigmoid colon adenocarcinoma:A case report

World Journal of Clinical Cases 2022年第31期10卷 11658-11664页

作者： Guo-lin Yin Jiang-Bo Zhu cheng-lin fu Ru-Liang Ding Jun-Miao Zhang Qian lin Department of Urology Taizhou First People's HospitalTaizhou 318020Zhejiang ProvinceChina Department of Pathology Taizhou First People's HospitalTaizhou 318020Zhejiang ProvinceChina Department of Anorectology Taizhou First People's HospitalTaizhou 318020Zhejiang ProvinceChina

BACKGROUND Sigmoid colon adenocarcinoma has a high incidence among gastrointestinal tumors,and it very rarely metastasizes to the *** literature reports that the prognosis after penile metastasis is generally poor,with a median survival of about 9 *** isolated metastasis to the penis originating from sigmoid colon adenocarcinoma has not been reported so ***,we report a case of sigmoid colon adenocarcinoma with isolated penile metastasis occurring 2 years after *** mass was pathologically confirmed as metastatic adenocarcinoma,and oral chemotherapy with capecitabine was given after *** tumor did not recur during the 2-year follow-up *** SUMMARY A 79-year-old man presented to the urology department with"a mass located at the root of the penis since 1 mo".Enhanced computed tomography(CT)examination suggested a 12 mm×10 mm×9 mm nodule at the root of the right penile corpus ***,pulmonary,and abdominal CT;and bone scan did not show any tumorigenic *** carcinoembryonic antigen(CEA)level was slightly elevated(6.01 ng/mL,reference value 0-5 ng/mL).The patient had undergone laparoscopic radical sigmoidectomy for sigmoid colon cancer 2 years *** postoperative pathology showed moderately differentiated adenocarcinoma of the sigmoid colon,and the stage was *** penile mass was removed under general *** postoperative pathology showed adenocarcinoma,and immunohistochemistry showed CDX2(+),CK20(+),and Villin(+).Based on the medical history,he was diagnosed with penile metastasis from sigmoid colon *** CEA level returned to normal(3.34 ng/mL)4 d after *** chemotherapy with capecitabine was given subsequently,and tumor recurrence was not found during the 2-year follow-up *** To our knowledge,this is a rare case of metachronous isolated penile metastasis from sigmoid colon *** penis is a potential site of metastasis of colon adenocarcinoma,an

关键词： Colon adenocarcinoma Penis Metastases Metachronous Adenocarcinoma Case report

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Advancements and Challenges in Organic–Inorganic Composite Solid Electrolytes for All‑Solid‑State Lithium Batteries

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Nano-Micro Letters 2025年第1期17卷 46-97页

作者： Xueyan Zhang Shichao cheng Chuankai fu Geping Yin Liguang Wang Yongmin Wu Hua Huo State Key Laboratory of Space Power‑Sources School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001People’s Republic of China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310058People’s Republic of China State Key Laboratory of Space Power-Sources 2965 Dongchuan RoadMinhang DistrictShanghai 200240People’s Republic of China

To address the limitations of contemporary lithium-ion batteries,particularly their low energy density and safety concerns,all-solid-state lithium batteries equipped with solid-state electrolytes have been identified as an up-and-coming *** the various SEs,organic–inorganic composite solid electrolytes(OICSEs)that combine the advantages of both polymer and inorganic materials demonstrate promising potential for large-scale ***,OICSEs still face many challenges in practical applications,such as low ionic conductivity and poor interfacial stability,which severely limit their *** review provides a comprehensive overview of recent research advancements in ***,the influence of inorganic fillers on the main functional parameters of OICSEs,including ionic conductivity,Li+transfer number,mechanical strength,electrochemical stability,electronic conductivity,and thermal stability are systematically *** lithium-ion conduction mechanism of OICSE is thoroughly analyzed and concluded from the microscopic ***,the classic inorganic filler types,including both inert and active fillers,are categorized with special emphasis on the relationship between inorganic filler structure design and the electrochemical performance of ***,the advanced characterization techniques relevant to OICSEs are summarized,and the challenges and perspectives on the future development of OICSEs are also highlighted for constructing superior ASSLBs.

关键词： Composite solid electrolytes Inorganic filler Interfacial stability Li-ion conduction mechanism Characterization techniques

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Bidirectional regulation of the brain-gut-microbiota axis following traumatic brain injury

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Neural Regeneration Research 2025年第8期20卷 2153-2168页

作者： Xinyu You lin Niu Jiafeng fu Shining Ge Jiangwei Shi Yanjun Zhang Pengwei Zhuang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjinChina Haihe Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina First Teaching Hospital of Tianjin University of Traditional Chinese Medicine TianjinChina National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion TianjinChina

Traumatic brain injury is a prevalent disorder of the central nervous *** addition to primary brain parenchymal damage,the enduring biological consequences of traumatic brain injury pose long-term risks for patients with traumatic brain injury;however,the underlying pathogenesis remains unclear,and effective intervention methods are *** dysfunction is a significant consequence of traumatic brain *** the most densely innervated peripheral tissue in the body,the gut possesses multiple pathways for the establishment of a bidirectional“brain-gut axis”with the central nervous *** gut harbors a vast microbial community,and alterations of the gut niche contribute to the progression of traumatic brain injury and its unfavorable prognosis through neuronal,hormonal,and immune pathways.A comprehensive understanding of microbiota-mediated peripheral neuroimmunomodulation mechanisms is needed to enhance treatment strategies for traumatic brain injury and its associated *** comprehensively reviewed alterations in the gut microecological environment following traumatic brain injury,with a specific focus on the complex biological processes of peripheral nerves,immunity,and microbes triggered by traumatic brain injury,encompassing autonomic dysfunction,neuroendocrine disturbances,peripheral immunosuppression,increased intestinal barrier permeability,compromised responses of sensory nerves to microorganisms,and potential effector nuclei in the central nervous system influenced by gut ***,we reviewed the mechanisms underlying secondary biological injury and the dynamic pathological responses that occur following injury to enhance our current understanding of how peripheral pathways impact the outcome of patients with traumatic brain *** review aimed to propose a conceptual model for future risk assessment of central nervous system-related diseases while elucidating novel insights into the bidirectional effec

关键词： traumatic brain injury brain-gut-microbiome axis gut microbiota neuroimmune immunosuppression host defense vagal afferents bacterial infection dorsal root ganglia nociception neural circuitry

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Gradient‑Layered MXene/Hollow Lignin Nanospheres Architecture Design for Flexible and Stretchable Supercapacitors

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Nano-Micro Letters 2025年第2期17卷 447-462页

作者： Haonan Zhang cheng Hao Tongtong fu Dian Yu Jane Howe Kaiwen Chen Ning Yan Hao Ren Huamin Zhai Jiangsu Provincial Key Lab of Sustainable Pulp and Paper Technology and Biomass Materials NanJing Forestry UniversityNanjing 210037People’s Republic of China Department of Chemical Engineering and Applied Chemistry University of Toronto200 College StreetTorontoON M5S 3E5Canada Department of Materials Science and Engineering University of Toronto184 College StreetTorontoON M5S 3E4Canada College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037People’s Republic of China

With the rapid development of flexible wearable electronics,the demand for stretchable energy storage devices has *** this work,a novel gradient-layered architecture was design based on single-pore hollow lignin nanospheres(HLNPs)-intercalated two-dimensional transition metal carbide(Ti_(3)C_(2)T_(x) MXene)for fabricating highly stretchable and durable *** depositing and inserting HLNPs in the MXene layers with a bottom-up decreasing gradient,a multilayered porous MXene structure with smooth ion channels was constructed by reducing the overstacking of MXene ***,the micro-chamber architecture of thin-walled lignin nanospheres effectively extended the contact area between lignin and MXene to improve ion and electron accessibility,thus better utilizing the pseudocapacitive property of *** these strategies effectively enhanced the capacitive performance of the *** addition,HLNPs,which acted as a protective phase for MXene layer,enhanced mechanical properties of the wrinkled stretchable electrodes by releasing stress through slip and deformation during the stretch-release cycling and greatly improved the structural integrity and capacitive stability of the *** electrodes and symmetric flexible all-solid-state supercapacitors capable of enduring 600%uniaxial tensile strain were developed with high specific capacitances of 1273 mF cm^(−2)(241 F g^(−1))and 514 mF cm^(−2)(95 F g^(−1)),***,their capacitances were well preserved after 1000 times of 600%stretch-release *** study showcased new possibilities of incorporating biobased lignin nanospheres in energy storage devices to fabricate stretchable devices leveraging synergies among various two-dimensional nanomaterials.

关键词： Hollow lignin nanospheres MXene Gradient-layered architecture Wrinkled electrodes Stretchable supercapacitors

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103例胃肠道间质瘤的临床病理与预后分析

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肿瘤防治研究 2007年第11期34卷 864-867页

作者：程伏林魏正专武汉大学中南医院肿瘤研究所 430070

目的探讨胃肠道间质瘤(GISTs)的临床病理、免疫组化特征及预后相关因素。方法103例胃肠道间质瘤患者接受手术后分析其病理形态学,观察肿瘤大小、细胞核异性型和核分裂相,并根据这些指标进行分型。检测肿瘤组织CD117和CD34免疫学表型。... 详细信息

目的探讨胃肠道间质瘤(GISTs)的临床病理、免疫组化特征及预后相关因素。方法103例胃肠道间质瘤患者接受手术后分析其病理形态学,观察肿瘤大小、细胞核异性型和核分裂相,并根据这些指标进行分型。检测肿瘤组织CD117和CD34免疫学表型。结果本组103例胃肠道间质瘤中CD117阳性表达93例(90.3%),CD34阳性表达69例(70.0%),不同部位GISTs其CD117和CD34表达无显著差异(P>0.05)。良性肿瘤患者的三年无病生存率显著地高于恶性肿瘤(P<0.05)。结论CD34和CD117联合使用可协助鉴别诊断GISTs。基于肿瘤大小、细胞异型性以及核分裂相等的组织形态学分型可作为诊断恶性GISTs参考指标。

关键词：胃间质瘤临床病理免疫组化预后

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Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3

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Oncology Research 2025年第1期33卷 103-121页

作者： YAN LU KANG WANG YUANHONG PENG MENG CHEN lin ZHONG LUJI HUANG fu cheng XINDAN SHENG XIN YANG MANZHAO OUYANG GEORGE A.CAlin ZHIWEI HE China-America Cancer Research Institute Guangdong Medical UniversityDongguan523808China GCP Center Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China Department of Gastrointestinal Surgery Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou510080China Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Oncology Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China

Background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors,but the currently used immune checkpoint inhibitors targeting programmed cell death-1(PD-1),programmed cell death ligand-1(PD-L1),and cytotoxic T-lymphocyte antigen-4(CTLA-4)show limited clinical efficacy in many breast cancers.B7H3 has been widely reported as an immunosuppressive molecule,but its immunological function in breast cancer patients remains ***:We analyzed the expression of B7H3 in breast cancer samples using data from the Cancer Genome Atlas Program(TCGA)and the Gene Expression Omnibus(GEO)*** were selected using the TarBase,miRTarBase,and miRBase *** regulatory role of the microRNA hsa-miR-214-3p on B7H3 was investigated through dual-luciferase reporter assays,which identified the specific action sites of *** expression levels of B7H3 and hsa-miR-214-3p in human breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCR(qPCR).In vitro experiments were performed to observe the effects of modulating the expression of B7H3 or hsa-miR-214-3p on breast cancer cell proliferation and ***,the regulatory impact of hsa-miR-214-3p on B7H3 was ***-linked immunosorbent assays(ELISA)and flow cytometry were employed to assess the effects of co-cultured breast cancer cells and normal human peripheral blood mononuclear cells(PBMCs)on immune cells and associated ***:In breast cancer tissues,the expression level of B7H3 is inversely correlated with that of hsa-miR-214-3p,as well as with the regulatory effects on breast cancercell ***-miR-214-3p was found to inhibit breast cancer cell growth by downregulating ***,our research identified,for the first time,two binding sites for hsa-miR-214-3p on the 3’UTR of B7H3,both of which exert similar effects ***-culture experiments revealed that hsamiR-214-3p

关键词： Breast cancer B7H3 Hsa-miR-214-3p Immunotherapy

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Reducing the measurement errors in nonadiabatic holonomic quantum computers

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 64-70页

作者： Guo-fu Xu Department of Physics Shandong University

Nonadiabatic holonomic quantum computers serve as the physical platform for nonadiabatic holonomic quantum *** quantum computation has entered the noisy intermediate-scale era, building accurate intermediate-scale nonadiabatic holonomic quantum computers is clearly necessary. Given that measurements are the sole means of extracting information, they play an indispensable role in nonadiabatic holonomic quantum computers. Accordingly, developing methods to reduce measurement errors in nonadiabatic holonomic quantum computers is of great importance. However, while much attention has been given to the research on nonadiabatic holonomic gates, the research on reducing measurement errors in nonadiabatic holonomic quantum computers is severely lacking. In this study, we propose a measurement error reduction method tailored for intermediate-scale nonadiabatic holonomic quantum computers. The reason we say this is because our method can not only reduce the measurement errors in the computer but also be useful in mitigating errors originating from nonadiabatic holonomic gates. Given these features,our method significantly advances the construction of accurate intermediate-scale nonadiabatic holonomic quantum computers.

关键词： quantum holonomy quantum computation measurement errors

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基于VB/CAE/Access的桥式起重机可适应设计平台构建

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机械设计 2017年第9期34卷 54-58页

作者：程贤福林品斌华东交通大学机电工程学院江西南昌330013

针对桥式起重机设计特点,将可适应设计与平台技术结合起来,提出一种基于VB/CAE/Access接口的桥式起重机可适应平台设计方法。在整个平台开发过程中,以VB6.0为开发软件,根据设计要求,将接口技术、编码技术、数据库技术运用于平台开发,利... 详细信息

针对桥式起重机设计特点,将可适应设计与平台技术结合起来,提出一种基于VB/CAE/Access接口的桥式起重机可适应平台设计方法。在整个平台开发过程中,以VB6.0为开发软件,根据设计要求,将接口技术、编码技术、数据库技术运用于平台开发,利用平台实现桥式起重机模型的建立、装配、有限元分析及生成工程图。最后,基于参数化设计、模块化设计等技术,并结合Access,Solid Works,ANSYS通用软件,构建了桥式起重机的可适应设计平台,并给出了可适应设计平台的开发流程。

关键词：桥式起重机可适应设计产品平台 VB/CAE/Access

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基于频率敏感三维自组织映射的视差估计算法

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计算机科学 2017年第B11期44卷 225-227页

作者：任云程福林黎洪松桂林电子科技大学信息与通信学院桂林541004

提出基于频率敏感三维自组织映射的立体视频视差估计算法,视差预测采用基于亮度分类频率敏感三维自组织映射(Classified Frequency Sensitive Three-Dimensional Self-Organizing Map,CFS-3DSOM)的视差模式识别(Disparity pattern recognition,DPR)算法。其基本思想是对视差图像的低亮度区域和高亮度区域分别进行预测,在训练模式库时引入频率敏感方法。实验表明,与传统基于块的视差估计算法相比,CFS-3DSOM-DPR算法的视差预测图像的平均峰值信噪比提高了0.78~1.78dB,时间减少了70%。

关键词：视差估计自组织映射视差模式识别立体视频编码

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城镇化中农民迁移与制度创新的实证分析

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市场与人口分析 2004年第6期10卷 20-25页

作者：刘汉成梅福林黄冈师范学院贸经系湖北黄冈438000

相关的制度安排与创新是农村城镇化发展的推阻机制。众多学者已经证明 ,与二元户籍制度相关的系列制度安排是导致我国城镇化滞后和大量农村隐形失业人口存在的直接因素。结合新制度经济学理论 ,对城镇化中的制度创新绩效进行了实证研究... 详细信息

相关的制度安排与创新是农村城镇化发展的推阻机制。众多学者已经证明 ,与二元户籍制度相关的系列制度安排是导致我国城镇化滞后和大量农村隐形失业人口存在的直接因素。结合新制度经济学理论 ,对城镇化中的制度创新绩效进行了实证研究。结果发现。

关键词：城镇化农民迁移制度创新实证分析

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