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Functional dissection of parabrachial substrates in processing nociceptive information

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Zoological Research 2024年第3期45卷 633-647页

作者： jin Ke Wei-cheng Lu Hai-Yang jing Shen Qian Sun-Wook Moon Guang-Fu Cui Wei-Xin Qian Xiao-jing Che Qian Zhang Shi-Shi Lai Ling Zhang Ying-Jie Zhu jing-Dun Xie Tian-Wen Huang Shenzhen Key Laboratory of Drug Addiction Shenzhen-Hong Kong Institute of Brain ScienceBrain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China CAS Key Laboratory of Brain Connectome and Manipulation Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China University of Chinese Academy of Sciences Beijing 100049China Department of Anesthesiology State Key Laboratory of Oncology in South ChinaGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhouGuangdong 510060China University of Science and Technology of China HefeiAnhui 230027China Department of Anesthesiology Shenzhen University General Hospital and Shenzhen University Academy of Clinical Medical SciencesShenzhen UniversityShenzhenGuangdong 518055China School of Medicine Yunnan UniversityKunmingYunnan 650091China

Painful stimuli elicit first-line reflexive defensive reactions and,in many cases,also evoke second-line recuperative behaviors,the latter of which reflects the sensing of tissue damage and the alleviation of *** lateral parabrachial nucleus(lPBN),composed of external-(elPBN),dorsal-(dlPBN),and central/superior-subnuclei(jointly referred to as slPBN),receives sensory inputs from spinal projection neurons and plays important roles in processing affective information from external threats and body integrity ***,the organizational rules of lPBN neurons that provoke diverse behaviors in response to different painful stimuli from cutaneous and deep tissues remain *** this study,we used region-specific neuronal depletion or silencing approaches combined with a battery of behavioral assays to show that slPBN neurons expressing substance P receptor(NK1R)(lPBNNK1R)are crucial for driving pain-associated self-care behaviors evoked by sustained noxious thermal and mechanical stimuli applied to skin or bone/muscle,while elPBN neurons are dispensable for driving such ***,lPBNNK1R neurons are specifically required for forming sustained somatic pain-induced negative teaching signals and aversive memory but are not necessary for fear-learning or escape behaviors elicited by external ***,both lPBNNK1R and elPBN neurons contribute to chemical irritant-induced nocifensive *** results reveal the functional organization of parabrachial substrates that drive distinct behavioral outcomes in response to sustained pain versus external danger under physiological conditions.

关键词： Lateral parabrachial nucleus Substance P receptor Pain affect Defensive reaction Somatosensory

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海上浮式风机多体系统耦合动力模型研究

振动工程学报 2024年第1期37卷 20-30页

作者：李书进郑达成孔凡武汉理工大学土木工程与建筑学院湖北武汉430070 合肥工业大学土木与水利工程学院安徽合肥230009

海上浮式风机是近年来随着海上风电的快速发展,为了捕获深海更丰富、更持久的风能而提出的一种风力发电装置,已成为当今风能开发的主要方向。作为一种多体系统,由于海上浮式风机结构特殊,加上环境复杂,对其进行准确的计算和分析尤为重... 详细信息

海上浮式风机是近年来随着海上风电的快速发展,为了捕获深海更丰富、更持久的风能而提出的一种风力发电装置,已成为当今风能开发的主要方向。作为一种多体系统,由于海上浮式风机结构特殊,加上环境复杂,对其进行准确的计算和分析尤为重要。本文对海上浮式风机的耦合动力模型进行了研究,建立了复杂工况下Spar型海上浮式风机改进的14-DOF耦合动力模型,包括气动力模块、水动力模块和结构分析模块等,用于扩展其适用范围和准确计算风机的动力响应,并通过数值仿真对所建模型进行了分析和验证。主要的改进有:不对平台和塔架的转动角度作小量近似,扩展其适用范围;考虑角速度和欧拉角速度的换算关系,不作等化处理。此外,所建模型考虑风机叶片扭转角对叶片变形的影响,得到了较为准确的叶片面内外响应。同时采用线性势流理论对水动力进行计算,较之Morison方程适用性更广。仿真分析表明,本文所建模型可以更准确地计算海上浮式风机系统的动力响应,且具有更广的适用范围。

关键词：海上浮式风机多体系统气动力分析水动力分析耦合模型

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基于JADE-斜投影的鲁棒波束形成算法

系统工程与电子技术 2024年第2期46卷 401-406页

作者：程永杰李纯刘帅金铭哈尔滨工业大学(威海)信息科学与工程学院山东威海264209

针对矩阵重构类波束形成算法对阵列幅相误差敏感的问题,提出一种基于盲源信号分离和斜投影的矩阵重构鲁棒波束形成算法。首先,依靠盲源分离技术得到接收信号和混合矩阵,结合期望信号先验信息完成混合矩阵中信号导向矢量的搜索。然后,利... 详细信息

针对矩阵重构类波束形成算法对阵列幅相误差敏感的问题,提出一种基于盲源信号分离和斜投影的矩阵重构鲁棒波束形成算法。首先,依靠盲源分离技术得到接收信号和混合矩阵,结合期望信号先验信息完成混合矩阵中信号导向矢量的搜索。然后,利用盲源分离得到的信号协方差矩阵完成阵列幅相误差估计。最后,基于幅相误差校准的混合矩阵和斜投影思想,构建各干扰的斜投影算子,将接收数据分别向干扰斜投影空间进行投影,得到对应的干扰信号,完成干扰噪声协方差矩阵重构。仿真结果表明,所提方法对阵列幅相误差具有较好的鲁棒性,验证了算法的有效性。

关键词：鲁棒波束形成矩阵重构幅相误差盲源信号分离斜投影

博物馆教育项目的设计、执行和评估——国际博物馆协会教育与文化委员会年度“五佳项目”评选的启示

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东南文化 2024年第1期 146-154页

作者：程艳妮黄瑾汉景帝阳陵博物院陕西西安712038 西安青龙寺遗址保管所陕西西安710043

国际博物馆协会教育与文化委员会每年评选五佳项目,旨在指导和规范教育与文化项目的设计和实施。五佳项目在设计、执行、评估阶段各有其遵循的原则,即设计阶段的目的性、相关性和合理性原则,执行阶段的适宜性原则,评估阶段的科学性和客... 详细信息

国际博物馆协会教育与文化委员会每年评选五佳项目,旨在指导和规范教育与文化项目的设计和实施。五佳项目在设计、执行、评估阶段各有其遵循的原则,即设计阶段的目的性、相关性和合理性原则,执行阶段的适宜性原则,评估阶段的科学性和客观性原则,同时还要阐释在人力物力方面的具体要求。对比中国博物馆的特色项目,中国博物馆在设计阶段存在目的性欠开放、科学相关性考量不足,在执行阶段存在贯彻适宜性专业程度不够深入、博物馆教育方法欠灵活,在评估阶段存在问卷设计欠科学、调查方法较单一、问题分析不足等问题,对此,中国博物馆教育项目设计应合理调整三阶段权重分配比例,遵循可持续发展原则,从而促进博物馆更好发挥教育功能。

关键词：博物馆教育项目国际博协教育与文化委员会五佳项目设计执行评估

A monolithic integrated medium wave Mercury Cadmium Telluride polarimetric focal plane array

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红外与毫米波学报 2024年第4期43卷 479-489页

作者： CHEN Ze-Ji HUANG You-Wen PU En-Xiang XIAO Hui-Shan XU Shi-Chun QIN Qiang KONG jin-cheng Infrared Detector Center Kunming Institute of PhysicsKunming 650223China

A medium wave(MW)640×512(25μm)Mercury Cadmium Telluride(HgCdTe)polarimetric focal plane array(FPA)was *** micro-polarizer array(MPA)has been carefully designed in terms of line grating structure optimization and crosstalk suppression.A monolithic fabrication process with low damage was explored,which was verified to be compatible well with HgCdTe *** monolithic integration of MPA,NETD<9.5 mK was still ***,to figure out the underlying mechanism that dominat⁃ed the extinction ratio(ER),specialized MPA layouts were designed,and the crosstalk was experimentally vali⁃dated as the major source that impacted *** expanding opaque regions at pixel edges to 4μm,crosstalk rates from adjacent pixels could be effectively reduced to approximately 2%,and promising ERs ranging from 17.32 to 27.41 were implemented.

关键词： infrared physics infrared polarimetric focal plane array monolithic integration Mercury Cadmium Telluride extinction ratio

自适应精简经验Ramanujan分解及其在复合故障诊断中的应用

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电子学报 2024年第6期52卷 1989-1999页

作者：潘海洋章颖程健郑近德童靳于安徽工业大学机械工程学院安徽马鞍山243002

Ramanujan傅里叶模态分解采用低频向高频扫描的方式获取分量信号,易出现过量分解和信息分散的现象,致使分解分量不具有单一完整的状态信息.为了解决上述问题,论文提出了一种自适应精简经验Ramanujan分解(Adaptive Concise Empirical Ram... 详细信息

Ramanujan傅里叶模态分解采用低频向高频扫描的方式获取分量信号,易出现过量分解和信息分散的现象,致使分解分量不具有单一完整的状态信息.为了解决上述问题,论文提出了一种自适应精简经验Ramanujan分解(Adaptive Concise Empirical Ramanujan Decomposition,ACERD)方法.在ACERD方法中,采用功率谱密度获取分割频带,旨在进行准确的频带划分.同时,利用Ramanujan傅里叶变换提取每个分割频带所对应的模式分量,提高周期分量的识别能力,并获得具有单一周期特征信息的模式分量.通过复合故障仿真信号和实测信号分析,结果表明:ACERD方法具有优异的频带分割和周期脉冲特征提取能力,适用于复合故障诊断.

关键词：自适应精简经验Ramanujan分解功率谱密度 Ramanujan傅里叶变换复合故障

SRY-Box transcription factor 9 triggers YAP nuclear entry via direct interaction in tumors

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2285-2297页

作者： Hui Qian Chen-Hong Ding Fang Liu Shi-Jie Chen Chen-Kai Huang Meng-Chao Xiao Xia-Lu Hong Ming-Chen Wang Fang-Zhi Yan Kai Ding Ya-Lu Cui Bai-Nan Zheng jin Ding cheng Luo Xin Zhang Wei-Fen Xie Department of Gastroenterology Changzheng HospitalNaval Medical UniversityShanghaiChina Department of Gastroenterology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Drug Discovery and Design Center CAS Key Laboratory of Receptor ResearchState Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina Department of Gastroenterology First Affiliated Hospital of Nanchang UniversityNanchangChina Clinical Cancer Institute Center for Translational MedicineNaval Medical UniversityShanghaiChina

The translocation of YAP from the cytoplasm to the nucleus is critical for its activation and plays a key role in tumor ***,the precise molecular mechanisms governing the nuclear import of YAP are not fully *** this study,we have uncovered a crucial role of SOX9 in the activation of ***9 promotes the nuclear translocation of YAP by direct ***,we have identified that the binding between Asp-125 of SOX9 and Arg-124 of YAP is essential for SOX9-YAP interaction and subsequent nuclear entry of ***,we have discovered a novel asymmetrical dimethylation of YAP at Arg-124(YAP-R124me2a)catalyzed by ***-R124me2a enhances the interaction between YAP and SOX9 and is associated with poor prognosis in multiple ***,we disrupted the interaction between SOX9 and YAP using a competitive peptide,S-A1,which mimics anα-helix of SOX9 containing Asp-125.S-A1 significantly inhibits YAP nuclear translocation and effectively suppresses tumor *** study provides the first evidence of SOX9 as a pivotal regulator driving YAP nuclear translocation and presents a potential therapeutic strategy for YAP-driven human cancers by targeting SOX9-YAP interaction.

关键词： interaction interaction precise

糖尿病患者骨科手术后糖代谢异常与术后神经认知功能障碍相关性的研究进展

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临床麻醉学杂志 2024年第8期40卷 877-880页

作者：程琳高进重庆医科大学第一临床学院 400046 重庆医科大学附属第一医院麻醉科 400046

术后神经认知功能障碍(NCD)是指患者在术后出现认知、记忆、定向力等能力下降的神经系统退行性病变。随着社会老龄化发展,多数老年患者由于衰老、行动不便等因素往往会经历骨科手术,这类手术刺激强、时间长,患者术后NCD的发生率较高。... 详细信息

术后神经认知功能障碍(NCD)是指患者在术后出现认知、记忆、定向力等能力下降的神经系统退行性病变。随着社会老龄化发展,多数老年患者由于衰老、行动不便等因素往往会经历骨科手术,这类手术刺激强、时间长,患者术后NCD的发生率较高。糖尿病是老年群体中较常见的慢性疾病,并且大多数会出现认知功能下降等中枢神经系统损伤性反应。因此,老年糖尿病患者在手术后由于自身糖代谢异常、手术刺激及麻醉药物的影响,往往更容易出现术后谵妄或术后认知功能障碍等神经系统并发症,因退行性变是一个慢性病理过程,会导致患者预后不良、医疗成本增加、生活质量下降等不良后果。本文主要通过讨论糖尿病患者糖代谢异常与术后NCD发生发展的关系,进而探讨糖代谢异常在患者骨科术后NCD发生中的作用和影响。

关键词：糖尿病糖代谢骨科手术术后神经认知功能障碍

Volatile Solid and Bury Period Influence on Odorous Material Production in Simulating Landfill Treatment

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Journal of Geoscience and Environment Protection 2024年第1期12卷 120-129页

作者： Peng Lu Yuanyuan Zhang Linan Xing Ying Wang Hong Lu Dongbei Yue Wei cheng jin Liu Department of Environmental Engineering Technology Beijing Polytechnic Beijing China Beijing Municipal Institute of City Management Beijing China Department of Environmental Science and Engineering Tsinghua University Beijing China Chinese Academy of Meteorological Sciences Beijing China China Meteorological Administration Beijing China

Odor pollution in landfill area has attracted more social attention in China. It is very important to control the generation of odor pollutants in situ. Analyzing odorous materials production form buried waste, simulated columns of different volatile solid (VS) content and different buried period waste were designed. Gas compounds produced from the columns were collected and analyzed by comprehensive two-dimensional gas chromatography (GC × GC) method. It has remarkable relationship between VS content and concentrations of odorous material. When VS content more than 40%, the total amount of odorous compounds increases remarkably. It can be inferred that reduced VS content of original waste may effective decreasing odorous materials production in landfill area. The old rubbish produced more odorous compounds than that of fresh one in simulated columns.

关键词： Volatile Solid Odorous Material Bury Period