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Role of MicroRNAs in malignant Glioma

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Chinese Medical Journal 2015年第9期128卷 1238-1244页

作者： Bao-cheng Wang jie ma Department of Pediatric Neurosurgery Xinhua Hospital Shanghai JiaoTong University Shanghai 200092 China

Objective：This overview seeked to bring together the microRNA （miRNA） researches on biogenesis and bio-function in these areas of clinical diagnosis and therapy for malignant *** Sources：Using the keyword terms ＂glioma＂ and ＂miRNA,＂ we performed the literature search in PubMed,Ovid,and *** databases from their inception to October *** Selection：In screening out the quality of the articles,factors such as clinical setting of the study,the size of clinical samples were taken into *** studied for verification and reviews article were also included in our data ***：Despite many advance in miRNA for malignant glioma,further studies were still required to focus on the following aspects：（i） Improving the understanding about biogenesis of miRNA and up-down regulation;（ii） utilizing high-throughput miRNA expression analysis to screen out the core miRNA for glioma;（iii） Focusing related miRNAs on the signal transduction pathways that regulate the proliferation and growth of ***：We discussed the most promising miRNA,correlative signaling pathway and their relation with gliomas in the way of prompting miRNA target into being a clinical therapeutic strategy.

关键词： Glioma malignant MicroRNA Pathway Target Treatment

Modificaomics:deciphering the functions of biomolecule modifications

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Science China Chemistry 2018年第5期61卷 381-392页

作者： Ting Liu cheng-jie ma Bi-Feng Yuan Yu-Qi Feng Key Laboratory of Analytical Chemistry for Biology and Medicine(Ministry of Education) Department of ChemistryWuhan University

The spatiotemporal expression of genes is sophisticatedly controlled through three main layers: transcriptional, translational and post-translational. Now increasing chemical modifications are discovered on genomic DNA, RNA and proteins. These modifications are recognized as additional layer of regulatory mechanisms in controlling gene expression that defines cell status. So far,more than 150 chemical modifications are identified in nucleic acids,and more than 400 discrete types of modifications are identified in proteins. How these modifications are interpreted are fundamental questions to our understanding of living organisms. The omics sciences of systems biology, including genomics, transcriptomics, proteomics, and metabolomics, have been in existence for decades. Due to the large numbers of modifications occurring in DNA, RNA and proteins with regulatory roles, we propose the modificaomics from the words of modification and omics. Modificaomics mainly refers to the comprehensive study of the modifications on DNA, RNA and proteins. In this review, we conceive modificaomics by introducing the discovered modifications in DNA, RNA and proteins as well as summarizing their biological functions. We hope the proposed modificaomics can provide a whole picture of modifications of these biopolymers and simulate the study of the functions of the modifications on DNA, RNA and proteins.

关键词： modificaomies DNA modifications RNA modifications protein modifications functions

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Hydration, Microstructure, and Properties of Sulphoaluminate Cement in Pure Water and Simulated Seawater

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Journal of Wuhan University of Technology(materials Science) 2025年第1期40卷 187-193页

作者： ma jie China Railway Design Corporation Tianjin 300250China

Paste and mortar specimens were prepared with sulfoaluminate cement(SAC),P⋅O 42.5 ordinary Portland cement(OPC),and standard sand,and mixed and cured with pure water and artificial seawater,*** mechanical properties of mortar specimens were *** and microstructure of paste specimens were also investigated using X-ray diffraction(XRD),scanning electron microscope(SEM),and 27Al nuclear magnetic resonance(NMR),*** results indicate that SAC mortar samples mixed and cured by seawater have faster strength growth before 28 d and higher compressive strength than OPC mortar *** to curing in deionized water,the hydration products of SAC are somewhat coarser when cured in simulated *** evolution of aluminum phase hydration products during the hydration process of SAC mixed and cured in simulated seawater is quite different from that of *** 3 to 28 d,the content of each aluminum phase hydration product in SAC paste cured in simulated seawater changed little,while that in OPC paste changed significantly;for example,from 7 to 28 d,the content of ettringite(AFt)in OPC paste increased *** type of AFt formed loosely,harming the mortar's microstructure.

关键词： sulfoaluminate cement seawater mixing and curing 27Al NMR AFt

A Multi-Objective Particle Swarm Optimization Algorithm Based on Decomposition and Multi-Selection Strategy

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Computers, materials & Continua 2025年第1期82卷 997-1026页

作者： Li ma Cai Dai Xingsi Xue cheng Peng School of Computer Science Shaanxi Normal UniversityXi’an710119China Fujian Provincial Key Laboratory of Big Data Mining and Applications Fujian University of TechnologyFuzhou350118China Information Construction and management Center and Institute of Artificial Intelligence and Educational New Productivity Ningxia Normal UniversityGuyuan756099China

The multi-objective particle swarm optimization algorithm(MOPSO)is widely used to solve multi-objective optimization *** the article,amulti-objective particle swarm optimization algorithmbased on decomposition and multi-selection strategy is proposed to improve the search ***,two update strategies based on decomposition are used to update the evolving population and external archive,***,a multiselection strategy is *** first strategy is for the subspace without a non-dominated *** the neighbor particles,the particle with the smallest penalty-based boundary intersection value is selected as the global optimal solution and the particle far away fromthe search particle and the global optimal solution is selected as the personal optimal solution to enhance global *** second strategy is for the subspace with a non-dominated *** the neighbor particles,two particles are randomly selected,one as the global optimal solution and the other as the personal optimal solution,to enhance local *** third strategy is for Pareto optimal front(PF)discontinuity,which is identified by the cumulative number of iterations of the subspace without non-dominated *** the subsequent iteration,a new probability distribution is used to select from the remaining subspaces to ***,an adaptive inertia weight update strategy based on the dominated degree is designed to further improve the search ***,the proposed algorithmis compared with fivemulti-objective particle swarm optimization algorithms and five multi-objective evolutionary algorithms on 22 test *** results show that the proposed algorithm has better performance.

关键词： Multi-objective optimization multi-objective particle swarm optimization decomposition multi-selection strategy

Optimal investment, retirement, and life insurance with consumption ratcheting and time-inhomogeneous utility

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Science China mathematics 2025年

作者： jie Xing Jingtang ma School of Big Data Application and Economics Guizhou University of Finance and Economics School of mathematics Southwestern University of Finance and Economics

In this paper, we study a portfolio selection problem of an investor with a retirement option, who has possibility to buy life insurance and does not tolerate any decline in consumption. The agent's optimization problem can be viewed as a mixed singular control and optimal stopping problem with time-inhomogeneous utility functions. The closed-form optimal solution is not available in general. We use the dual control method to convert the original problem into two classes of optimal stopping problems in finite and infinite *** show that the optimal consumption strategy and the best retirement time depend on the free-boundary functions which satisfy Fredholm and Volterra integral equations. We derive the closed-form formulas for these two free boundaries for some special cases and develop numerical methods to solve the integral equations of the free boundaries for general cases.

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Ideal Bi‑Based Hybrid Anode material for Ultrafast Charging of Sodium‑Ion Batteries at Extremely Low Temperatures

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Nano-Micro Letters 2025年第3期17卷 152-167页

作者： jie Bai Jian Hui Jia Yu Wang Chun cheng Yang Qing Jiang Key Laboratory of Automobile materials(Jilin University) Ministry of EducationSchool of Materials Science and EngineeringJilin UniversityChangchun 130022People’s Republic of China

Sodium-ion batteries have emerged as competitive substitutes for low-temperature applications due to severe capacity loss and safety concerns of lithium-ion batteries at−20°C or ***,the key capability of ultrafast charging at ultralow temperature for SIBs is rarely ***,a hybrid of Bi nanoparticles embedded in carbon nanorods is demonstrated as an ideal material to address this issue,which is synthesized via a high temperature shock *** a hybrid shows an unprecedented rate performance(237.9 mah g^(−1)at 2 A g^(−1))at−60℃,outperforming all reported SIB anode *** with a Na_(3)V_(2)(PO_(4))_(3)cathode,the energy density of the full cell can reach to 181.9 Wh kg^(−1)at−40°*** on this work,a novel strategy of high-rate activation is proposed to enhance performances of Bi-based materials in cryogenic conditions by creating new active sites for interfacial reaction under large current.

关键词： Bi nanoparticles High temperature shock High-rate activation Ultrafast charging Low-temperature sodium-ion batteries

Transformation of 5-Carboxylcytosine to Cytosine Through C-C Bond Cleavage in Human Cells Constitutes a Novel Pathway for DNA Demethylation

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CCS Chemistry 2021年第4期3卷 994-1008页

作者： Yang Feng Neng-Bin Xie Wan-Bing Tao Jiang-Hui Ding Xue-Jiao You cheng-jie ma Xiaoxue Zhang chengqi Yi Xiang Zhou Bi-Feng Yuan Yu-Qi Feng Key Laboratory of Analytical Chemistry for Biology and Medicine(Ministry of Education) Sauvage Center for Molecular SciencesDepartment of ChemistryWuhan UniversityWuhan 430072 State Key Laboratory of Protein and Plant Gene Research School of Life SciencesPeking UniversityBeijing 100871 Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871 Department of Chemical Biology and Synthetic and Functional Biomolecules Center College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871

Active demethylation of 5-methylcytosine(5mC)can be realized through ten-eleven translocation(TET)dioxygenase-mediated oxidation of 5mC to 5-hydroxymethylcytosine(5hmC),5-formylcytosine(5fC),and 5-carboxylcytosine(5caC),followed by thymine DNA glycosylase(TDG)-initiated base excision repair(BER).The TDG-BER pathwaymay lead to the generation of DNA strand breaks,potentially compromising genome ***,direct decarboxylation of TET-produced 5caC is highly attractive because this mechanism allows for conversion of 5mC to cytosine without the formation of DNA strand ***,cleavage of the C–C bond in 5caC in human cells remains an open *** examined this reaction in cell extract and live cells using 5caC-carrying hairpin DNA *** incubation with whole-cell protein extract or transfection into human cells,we monitored the transformation of 5caC to cytosine through direct decarboxylation or BER using liquid chromatography–tandem mass spectrometry(LCMS/MS)analyses at both the mononucleotide and oligodeoxynucleotide *** results clearly showed the direct conversion of 5caC to cytosine in human cells,providing evidence to support a novel pathway for active DNA demethylation.

关键词： epigenetics DNA demethylation 5-carboxylcytosine decarboxylation mass spectrometry stable isotope labeling

Quantification and single-base resolution analysis of N1-methyladenosine by ligation-assisted differentiation

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Quantification and single-base resolution analysis of N1-met...

N~6-Hydroxymethyladenine: A Hydroxylation Derivative of N~6-methyladenine in Genomic DNA of mammals

第十一届全国化学生物学学术会议

作者： Jiang-Hui Ding cheng-jie ma Bi-Feng Yuan Yu-Qi Feng Key Laboratory of Analytical Chemistry for Biology and Medicine(Ministry of Education) Department of ChemistryWuhan University

N1-methyladenosine(ma),first characterized more than 50 years ago, has recently been found as a reversible and dynamic modification in ***,ma-induced mispairing and stall during reverse transcription were developed for transcriptome-wide mapping of ma sites. Herein,we present a straightforward method for the site-specific detection of ma in mRNA by ligation-assisted *** method utilizes the fact that the methyl group in ma disrupts the Watson-Crick base pairing,which therefore compromises the nick ligation efficiency of *** decreased ligation efficiency will result in less ligated products,thus enabling the subsequent quantitative real-time PCR detection and evaluation of the site of *** proposed method was successfully employed to accurately determine ma in HEK293 T cells and lung carcinoma tissues.

关键词： N1-methyladenosine T3 DNA ligase quantitative real-time PCR

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N~6-Hydroxymethyladenine: A Hydroxylation Derivative of N~6-...