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电解生产中降低氟化铝单耗实践

山西冶金 2024年第5期47卷 137-139页

作者：李成元李文超苏宝峰李源程鸿鹏山东南山铝业股份有限公司山东龙口265700

电解铝生产过程中,氟化铝作为重要的添加剂,主要起到调整电解质分子比,改善电解质性质的作用。重点介绍了氟化铝中杂质、电解生产工艺的搭配以及烟气净化系统对氟化铝单耗的影响,并通过应用实践,找到合理的电解工艺和最优烟气净化参数,... 详细信息

电解铝生产过程中,氟化铝作为重要的添加剂,主要起到调整电解质分子比,改善电解质性质的作用。重点介绍了氟化铝中杂质、电解生产工艺的搭配以及烟气净化系统对氟化铝单耗的影响,并通过应用实践,找到合理的电解工艺和最优烟气净化参数,将调整前后氟化铝单耗数据进行对比,证明调整的有效性,为行业降低氟化铝单耗提供依据。

关键词：氟化铝单耗降低生产

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铜冶炼厂阳极板转运及存储生产技术

有色设备 2024年第1期38卷 68-74,93页

作者：黄治亮杨国年邓冰陈宏鹏曹志杰刘续善广西金川有色金属有限公司广西防城港538000 中国恩菲工程技术有限公司北京100038

铜冶炼厂阳极板出炉转运作业,普遍采用的叉车叉运与车辆输送相结合的方式,进行阳极板转运,阳极板质量把控采用人工挑选的方式进行检测,人员劳动强度大,运行费用高,不利于企业生产成本控制。本文介绍一种阳极板自动转运存储生产模式,通... 详细信息

铜冶炼厂阳极板出炉转运作业,普遍采用的叉车叉运与车辆输送相结合的方式,进行阳极板转运,阳极板质量把控采用人工挑选的方式进行检测,人员劳动强度大,运行费用高,不利于企业生产成本控制。本文介绍一种阳极板自动转运存储生产模式,通过对阳极板自动提取、清洗、检测、分挑、存储及转运作业,实现阳极板自动转运替代人工转运作业模式,有效降低人员劳动强度,减少生产运行成本。

关键词：阳极板自动转运存储 RGV 铜冶炼 5G通讯

Personal experience with the procurement of 32 liver allografts

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World Journal of Gastroenterology 2005年第25期11卷 3939-3943页

作者： Guang-WenZhou cheng-hongpeng Hong-WeiLi DepartmentofSurgery RuijinHospitalShanghaiSecondMedicalUniversityShanghai200025China

AIM: To introduce the American Pittsburgh's method of rapid liver procurement under the condition of brain death and factors influencing the quality of donor ***: To analyze 32 cases of allograft liver procurement retrospectively and observe the clinical outcome of orthotopic liver ***: Average age of donors was 38.24±12.78 years,with a male:female ratio of 23:9. The causes of brain death included 21 cases of trauma (65.63%) and nine cases of cerebrovascular accident (28.13%). Fourteen grafts (43.75%) had hepatic arterial anomalies, seven cases only right hepatic arterial anomalies (21.88%), five cases only left hepatic arterial anomalies (15.63%) and two cases of both right and left hepatic arterial anomalies (6.25%) among them. Eight cases (57.14%) of hepatic arterial anomalies required arterial reconstruction prior to transplantation. Of the 32 grafts evaluated for early function, 27 (84.38%) functioned well, whereas three (9.38%) functioned poorly and two (6.25%) failed to function at all. Only one recipient died after transplantation and thirty-one recipients recovered. Four recipients needed retransplantation. The variables associated with less than optimal function of the graft consisted of donor age (35.6±12.9 years vs 54.1±4.3 years, P＜0.05), duration of donor's stay in the intensive care unit (ICU) (3.5±2.4 d vs 7.4±2.1 d, P＜0.005), abnormal graft appearance (19.0% vs 100%, P＜0.05), and such recipient problems as vascular thromboses during or immediately following transplantation (89.3% vs 50.0%, P＜0.005).CONCLUSION: During liver procurement, complete heparization, perfusion in situ with localized low temperature and standard technique procedures are the basis ensuring the quality of the graft. The hepatic arterial anomalies should be taken care of to avoid injury. The donor age,duration of donor's staying in ICU, abnormal graft appearance and recipient problem are important factors influencing the quality of the liver graft.

关键词： Liver transplantation Liver procurement Donor Arterial anomalies

Different approaches to caudate Iobectomy with"curettage and aspiration"technique using a special instrument PMOD:A Report of 76 cases

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World Journal of Gastroenterology 2003年第10期9卷 2169-2173页

作者： Shu—YouPeng Jiang—TaoLi Yi-PingMou Ying-BinLiu Yu-LianWu He-QingFang Li-PingCao LiChen Xiu-JunCai cheng-hongpeng DepartmentofSurgery 2^ndAffiliatedHospitalSchoolofMedicineZhejiangUniversityHangzhou310009ZhejiangProvinceChina DepartmentofSurgery SirRunRunShawHospitalSchoolofMedicineZhejiangUniversityHangzhou310009ZhejiangProvinceChina

AIM:To study different approaches to caudate Iobectomy with'curettage and aspiration'technique using Peng's multifunctional operative dissector(PMOD).The surgical procedure of isolated complete caudate Iobectomy was specially discussed. METHODS:In 76 cases of various types of caudate Iobectomy,three approaches were used including left side approach,right side approach,and anterior approach. Among the 76 cases,isolated complete caudate Iobectomy was carried out in 6 cases with transhepatic anterior *** surgical procedure consisted of mobilization of the total liver,ligation and separation of the short hepatic veins,splitting the liver parenchyma through the Cantlie's plane,ligation and division of the caudate portal triads from the hilum,dissection of the root of major hepatic veins, detachment of the caudate lobe from liver parenchyma. RESULTS:The mean operative time was 285±51 min, the mean blood loss was 1 600 *** severe complications were *** the 6 cases receiving isolated complete caudate lobectomy with transhepatic anterior approach,one case died 17 months after operation due to disease recurrence and liver failure,the other 5 cases have been alive without recurrence,with one longest survival of 49 months. CONCLUSION:The choice of approach is essential to the success of caudate *** PMOD and'curettage and aspiration'technique can delineate intrahepatic or extrahepatic vessels clearly,caudate lobe resection has become safer,easier and faster.

关键词：肝尾叶切除术刮除术吸引术多功能外科解剖器临床应用

Effect of ischemic preconditioning on P-selectin expression in hepatocytes of rats with cirrhotic ischemia-reperfusion injury

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World Journal of Gastroenterology 2003年第10期9卷 2289-2292页

作者： Xiang-Dongcheng Xian-ChuanJiang Yin-BingLiu cheng-hongpeng BinXu Shu-YouPeng DepartmentofHepatobiliarySurgery ZhejiangCancerHospitalHangzhou310022ZhejiangProvinceChina DepartmentofSurgery SecondAffiliatedHospitalofZhcjiangUniversityHangzhou310006ZhejiangProvinceChina

AIM: To investigate the effects and mechanisms of ischemic preconditioning (IPC) on the ischemia/reperfusion (I/R) injury of liver cirrhosis in rats and the effect of IPC on P-selectin expression in ***: Forty male SD rats with liver cirrhosis were randomly divided into sham operation group (SO group),ischemia/reperfusion group (I/R group), ischemic preconditioning group (IPC group), L-Arginine preconditioning group (APC group), L-NAME preconditioning group (NPC group), eight rats in each group. Hepatocellular viability was assessed by hepatic adenine nucleotide level and energy charge (EC) determined by HPLC, ALT, AST and LDH in serum measured by auto- biochemical analyzer and bile *** expression of P-selectin in the liver tissue was analyzed by immunohistochemical technique. Leukocyte count in ischemic hepatic lobe was ***: At 120 min after reperfusion, the level of ATP and EC in IPC and APC groups was higher than that in I/R group significantly. The increases in AST, ALT and LDH were prevented in IPC and APC groups. The livers produced more bile in IPC group than in I/R group during 120 min after reperfusion (0.101±0.027 versus 0.066±0.027 ml/g liver,P=0.002). There was a significant difference between APC and I/R groups, (P=0.001). The leukocyte count in liver tissues significantly increased in I/R group as compared with SO group (P＜0.05). The increase in the leukocyte count was prevented in IPC group. Administration of L-arginine resulted in the same effects as in IPC group. However,inhibition of NO synthesis (NPC group) held back the beneficial effects of preconditioning. Significant promotion of P-selectin expression in hepatocytes in the I/R group was observed compared with the SO group (P＜0.01). IPC or L-arginine attenuated P-selectin expression remarkably (P＜0.01). However, inhibition of NO synthesis enhanced Pselectin expression (P＜0.01). The degree of P-selectin expression was positively correlated with the leukocyte

关键词：缺血预处理缺血再灌注 P-选择素肝实质细胞肝硬化

Establishment of a new pig model for auxiliary partial orthotopic liver transplantation

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World Journal of Gastroenterology 2005年第6期11卷 917-921页

作者： cheng-hongpeng Liu-BinShi Hong-WeiZhang Shu-YouPeng Guang-WenZhou Hong-WeiLi TransplantationCenter RuijinHospitalShanghai200025China TransplantationCenter HuashanHospitalShanghai200040China DepartmentofGeneralSurgery theSecondAffiliatedHospitalMedicalCollegeZhejiangUniversityHangzhou310009ZhejiangProvinceChina

AIM: To establish a new pig model for auxiliary partial orthotopic liver transplantation (APOLT).METHODS: The liver of the donor was removed from its body. The left lobe of the liver was resected in vivo and the right lobe was used as a graft. After the left lateral lobe of the recipient was resected, end-to-side anastomoses of suprahepatic inferior vena cava and portal vein were performed between the donor and recipient livers,respectively. End-to-end anastomoses were made between hepatic artery of graft and splenic artery of the *** drainage was placed in donor common bile ***: Models of APOLT were established in 5 pigs with a success rate of 80%. Color ultrasound examination showed an increase of blood flow of graft on 5th d compared to the first day after operation. When animals were killed on the 5th d after operation, thrombosis of hepatic vein (HV) and portal vein (PV) were not found. Histopathological examination of liver samples revealed evidence of damage with mild steatosis and sporadic necrotic hepatocytes and focal hepatic lobules structure disorganized in graft. Infiltration of inflammatory cells was mild in portal or central vein area. Hematologic laboratory values and blood chemical findings revealed that compared with group A (before transplantation), mean arterial pressure (MAP), central venous pressure (CVP), buffer base (BB), standard bicarbonate (SB) and K+ in group B (after portal vein was clamped) decreased (P＜0.01). After reperfusion of the graft, MAP, CVP and K+ restored ***: Significant decrease of congestion in portal vein and shortened blocking time were obtained because of the application of in vitro veno-venous bypass during complete vascular clamping. This new procedure,with such advantages as simple vessel processing, quality anastomosis, less postoperative hemorrhage and higher success rate, effectively prevents ischemia reperfusion injury of the host liver and deserves to be spread.

关键词： Auxiliary partial orthotopic liver transplantation Model pig

Inhibitory effect of adeno-associated virus-mediated gene transfer of human endostatin on hepatocellular carcinoma

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World Journal of Gastroenterology 2005年第22期11卷 3331-3334页

作者： HongLiu Ying-BinLiu Yu-LianWu Zhi-MingZhao YongWang Bao-SanHan cheng-hongpeng DepartmentofSurgery SecondAffiliatedHospitalZhejiangUniversityCollegeofMedicine.Hangzhou310006ZhejiangProvinceChina DepartmentofSurgery RuijinHospitalShanghaiSecondMedicalUniversityShanghai200025China

AIM: To investigate the effect of adeno-associated virusmediated gene transfer of human endostatin on the growth of hepatocellular carcinoma (HCC).METHODS: HCC cell line Hep3B was infected with recombinantadeno-associated virus containing human endostatin gene (rAAV2-hEndo). The results of transfection were detected by RT-PCR and SDS-PAGE assay. MTT assay was used to observe the effects of supernatant of transfected cells on ECV304 cell proliferation. An animal model of HCC was established by injecting Hep3B cells subcutaneously into the back of nude mice. Intratumoral injection of rAAV2hEndo, empty virus and phosphate-buffered saline were given sequentially. Serum endostatin was determined byELISA, the inhibitory effect of endostatin on the growth of xenograft was assessed in 3 ***: The results of RT-PCR and SDS-PAGE assay confirmed that rAAV2-hEndo successfully transfected Hep3B cells, and endostatin was secreted from Hep3B cells to medium. The supernatant of transfected cells markedly inhibited the proliferation of ECV304 cells (P＜0.01). Intratumoral injection of rAAV2-hEndo (2×1010v.g.) led to a sustained serum endostatin level ofapproximately (86.71±5.19) ng/mL. The tumor volumeand microvessel density were less in rAAV2-hEndo group than in control groups (P＜0.01).CONCLUSION: Human endostatin can be stably expressed by adeno-associated virus-mediated gene transfer and effectively inhibit the growth of HCC.

关键词： Endostatin Gene Adeno-associated virus Hepatocellular carcinoma

Protective effect of doxorubicin induced heat shock protein 72 on cold preservation injury of rat livers

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World Journal of Gastroenterology 2004年第9期10卷 1375-1378页

作者： HaoChen Ying-YanYu Ming-JunZhang Xia-XingDeng Wei-PingYang JunJi cheng-hongpeng Hong-WeiLi DepartmentofSurgeryandCenterofOrganTransplantation RuijinHospitalShanghaiSecondMedicalUniversityShanghai200025China CenterofOrganTransplantation RuijinHospitalShanghaiSecondMedicalUniversityShanghai200025China AnimalLaboratory RuijinHospitalShanghaiSecondMedicalUniversityShanghai200025China

AIM: To observe the protective effect of heat shock protein 72 (HSP 72) induced by pretreatment of doxorubicin (DXR) on long-term cold preservation injury of rat ***: Sprague-Dawley rats were administered intravenously DXR at a dose of 1 mg/kg body mass in DXR group and saline in control group. After 48 h, the rat liver was perfused with cold Linger's and University of Wisconsin (UW) solutions and then was preserved in UW solution at 4℃ for 24, 36 and 48 h. AST, ALT, LDH and hyaluronic acid in preservative solution were determined. Routine HE,immunohistochemical staining for HSP 72 and electron microscopic examination of hepatic tissues were ***: After 24, 36 and 48 h, the levels of AST, ALT and hyaluronic acid in preservative solution were significantly higher in control group than in DXR group (P0.05). Hepatic tissues in DXR group were morphologically normal and significantly injured in control group. HSP 72 was expressed in hepatocytes and sinusoidal endothelial cells in DXR group but not in control ***: Pretreatment of DXR may extend the time of rat liver cold preservation and keep liver alive. The expression of HSP 72 in liver can prevent hepatocytes and sinusoidal endothelial cells from long-term cold preservation injury.

关键词：阿霉素肝损伤抗肿瘤药冷冻保存热休克蛋白-72 预处理缺血再灌注

Heparanase mRNA expression and point mutation in hepatocellular carcinoma

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World Journal of Gastroenterology 2004年第19期10卷 2795-2799页

作者： Xiao-PengChen Yin-BibLiu JingRui Shu-YouPeng cheng-hongpeng Zi-YanZhou Liang-HuiShi Hong-WeiShen BinXu DepartmentofSurgery AffiliatedYijishanHospitalWannanMedicalCollegeWuhu241001AnhuiProvinceChina DepartmentofSurgery SecondAffiliatedHospitalMedicalSchoolofZhejiangUniversityHangzhou310009ZhejiangProvinceChina

AIM: To explore the expression of heparanase mRNA and point mutation in hepatocellular carcinoma (HCC). METHODS: Reverse transcription polymerase chain reaction was used to measure the expression of heparanase mRNA in the primary tumor tissues and surrounding liver tissues of 33 HCC patients. T-A cloning and sequencing were used to detect whether there was any mutation in the amplified PCR products. RESULTS: The expression of heparanase mRNA waspositive in 16 primary tumor tissues of HCC, and the positive rate was 48.5%, which was significantly higher than that in the surrounding liver parenchyma (P<0.01). The positive rate for heparanase gene in high-tendency to metastatic recurrence group (71.4%, 10/14) was obviously higher than that in low-tendency to metastatic recurrence group (31.6%, 6/19) (P= 0.023). The positive rate for heparanase gene in paltients with metastatic recurrence during postoperative follow-up (78.6%, 11/14) was also significantly higher than that in those without metastatic recurrence (21.4%, 3/14) (P = 0.003). Sequence analysis of the HPA PCR products was made in 7 patients, and 2-point mutations were found in 4 patients, one of which was sense mutation, neither base insertion nor deletion was detected. The mutation rate was 57.1% (4/7). CONCLUSION- The expression rate of heparanase mRNA increases in HCC, and HPA mRNA may be one of the reliable markers for the metastatic activity gained by the liver tumor cells and could be used clinically in predicting metastatic recurrence of HCC. Point mutation may be one of the causes for enhanced heparanase mRNA expression.

关键词：肝素酶 mRNA 基因表达基因突变肝细胞癌肿瘤