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Hollow glass microspheres/silicone rubber composite materials toward materials for high performance deep in-situ temperaturepreserved coring

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Petroleum Science 2022年第1期19卷 309-320页

作者： Jian-Ping Yang Ling Chen Xiao-Bin Gu Zhi-Yu Zhao cheng-hang fu Dong-Sheng Yang Dong-Zhuang Tian Zhi-Sheng Chen He-Ping Xie College of Polymer Science and Engineering Sichuan UniversityChengdu610065China Guangdong Provincial Key Laboratory of Deep Earth Sciences and Geothermal Energy Exploitation and Utilization Institute of Deep Earth Sciences and Green EnergyCollege of Civil and Transportation EngineeringShenzhen UniversityShenzhen518060China School of Mechanical Engineering Sichuan UniversityChengdu610065China Jinshi Drilltech Company Limited Tangshan063004Hebei Institute of New Energy and Low-Carbon Technology Sichuan UniversityChengdu610065China College of Water Resource&Hydropower Sichuan UniversityChengdu610065China Xi'an Research Institute China Coal Technology&Engineering Group CorpXi'an710077China

Deep petroleum resources are stored under high temperature and pressure conditions,with the temperature having a significant influence on the properties of *** in-situ temperature-preserved coring(ITP-coring)devices were developed to assess deep petroleum reserves ***,hollow glass microspheres(HGMs)/silicone rubber(SR)composites that exhibit excellent thermal insulation properties were prepared as thermal insulation materials for deep ITP-coring *** mechanism and process of heat transfer in the composites were explored,as well as their other *** results show that the HGMs exhibit good compatibility with the SR *** the volume fraction of the HGMs is increased to 50%,the density of the HGMs/SR composites is reduced from 0.97 to 0.56 g/cm^(3).The HGMs filler introduces large voids into the composites,reducing their thermal conductivity to 0.11 W/m·*** addition of HGMs into the composites further enhances the thermal stability of the SR,wherein the higher the HGMs filler content,the better the thermal stability of the *** significantly enhance the mechanical strength of the *** increase the compressive strength of the composites by 828%and the tensile strength by 164%.Overall,HGMs improve the thermal insulation,pressure resistance,and thermal stability of HGMs/SR composites.

关键词： In-situ temperature-preserved coring(ITP-coring) Deep in-situ conditions Thermal insulation materials HGMs/SR composites

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Research and application of thermal insulation effect of natural gas hydrate freezing corer based on the wireline-coring principle

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Petroleum Science 2022年第3期19卷 1291-1304页

作者： Yun-Qi Hu Jing Xie Shou-Ning Xue Meng Xu cheng-hang fu Hui-Lan He Zhi-Qiang Liu Shao-Ming Ma Si-Qing Sun Chuan-Liu Wang School of Mechanical Engineering Sichuan UniversityChengdu610065China MOE Key Laboratory of Deep Underground Science and Engineering Sichuan UniversityCollege of Water Resource and HydropowerSichuan UniversityChengdu610065China Zhensha Hydropower Construction Management Branch of Guoneng Dadu River Basin Hydropower Development Co.Ltd Leshan614700SichuanChina Jin Shi Drill Tech Co. LtdTangshan063004HebeiChina Xi'an Research Institute China Coal Technology&Engineering Group CorpXi'an710077ShaanxiChina

Natural gas hydrate(NGH)holds great promise as a source of clean *** is critical for acquiring the largest possible in situ NGH core for NGH eigen features and resource ***,the existing NGH coring technology has limitations,such as temperature increments,limited coring diameters,low coring rates,and complex coring ***,this study designs and proposes an NGH freezing coring(NGHFC)method and verifies the freezing and coring capacities of the NGHFC method in laboratories and experimental *** suggest that NGHFC shows good freezing and heat-retention properties.A freezing core heat transfer model is *** to the actual air temperature and operating time,the optimum initial temperature of the cold source can be determined using this *** average coring rate of NGHFC can reach 77.86%.The research results will provide a new idea of coring gas hydrates.

关键词： Natural gas hydrate Coring Cold source freezing In situ temperature and pressure

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Advancements and Challenges in Organic–Inorganic Composite Solid Electrolytes for All‑Solid‑State Lithium Batteries

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Nano-Micro Letters 2025年第1期17卷 46-97页

作者： Xueyan Zhang Shichao cheng Chuankai fu Geping Yin Liguang Wang Yongmin Wu Hua Huo State Key Laboratory of Space Power‑Sources School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001People’s Republic of China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310058People’s Republic of China State Key Laboratory of Space Power-Sources 2965 Dongchuan RoadMinhang DistrictShanghai 200240People’s Republic of China

To address the limitations of contemporary lithium-ion batteries,particularly their low energy density and safety concerns,all-solid-state lithium batteries equipped with solid-state electrolytes have been identified as an up-and-coming *** the various SEs,organic–inorganic composite solid electrolytes(OICSEs)that combine the advantages of both polymer and inorganic materials demonstrate promising potential for large-scale ***,OICSEs still face many challenges in practical applications,such as low ionic conductivity and poor interfacial stability,which severely limit their *** review provides a comprehensive overview of recent research advancements in ***,the influence of inorganic fillers on the main functional parameters of OICSEs,including ionic conductivity,Li+transfer number,mechanical strength,electrochemical stability,electronic conductivity,and thermal stability are systematically *** lithium-ion conduction mechanism of OICSE is thoroughly analyzed and concluded from the microscopic ***,the classic inorganic filler types,including both inert and active fillers,are categorized with special emphasis on the relationship between inorganic filler structure design and the electrochemical performance of ***,the advanced characterization techniques relevant to OICSEs are summarized,and the challenges and perspectives on the future development of OICSEs are also highlighted for constructing superior ASSLBs.

关键词： Composite solid electrolytes Inorganic filler Interfacial stability Li-ion conduction mechanism Characterization techniques

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4种野菜种子的发芽特性及无菌播种培养研究

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广东农业科学 2008年第3期35卷 15-17页

作者：梁称福湖南环境生物职业技术学院湖南衡阳421005

对人参菜、益母草、菊花脑、荠菜等4种野菜种子的发芽特性及无菌播种培养技术进行了研究,结果表明:菊花脑种子发芽最快、荠菜次之、益母草再次、人参菜种子发芽速度最慢;发芽前的浸种时间,前3种野菜以6 h为宜,而人参菜以浸种9 h的效果... 详细信息

对人参菜、益母草、菊花脑、荠菜等4种野菜种子的发芽特性及无菌播种培养技术进行了研究,结果表明:菊花脑种子发芽最快、荠菜次之、益母草再次、人参菜种子发芽速度最慢;发芽前的浸种时间,前3种野菜以6 h为宜,而人参菜以浸种9 h的效果较好。此外,4种野菜种子用75%乙醇浸泡40～60 s后,再用0.1%HgCl2浸泡12 min,消毒效果较好,基本无污染现象发生;最适合益母草、菊花脑、荠菜无菌播种的培养基分别为1/2MS、MS、1/4MS,播种后11 d的发芽率分别达到37.50%、68.75%、62.50%,而人参菜种子播种后20 d仍不能发芽。

关键词：野菜发芽无菌播种

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Gradient‑Layered MXene/Hollow Lignin Nanospheres Architecture Design for Flexible and Stretchable Supercapacitors

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Nano-Micro Letters 2025年第2期17卷 447-462页

作者： Haonan Zhang cheng Hao Tongtong fu Dian Yu Jane Howe Kaiwen Chen Ning Yan Hao Ren Huamin Zhai Jiangsu Provincial Key Lab of Sustainable Pulp and Paper Technology and Biomass Materials NanJing Forestry UniversityNanjing 210037People’s Republic of China Department of Chemical Engineering and Applied Chemistry University of Toronto200 College StreetTorontoON M5S 3E5Canada Department of Materials Science and Engineering University of Toronto184 College StreetTorontoON M5S 3E4Canada College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037People’s Republic of China

With the rapid development of flexible wearable electronics,the demand for stretchable energy storage devices has *** this work,a novel gradient-layered architecture was design based on single-pore hollow lignin nanospheres(HLNPs)-intercalated two-dimensional transition metal carbide(Ti_(3)C_(2)T_(x) MXene)for fabricating highly stretchable and durable *** depositing and inserting HLNPs in the MXene layers with a bottom-up decreasing gradient,a multilayered porous MXene structure with smooth ion channels was constructed by reducing the overstacking of MXene ***,the micro-chamber architecture of thin-walled lignin nanospheres effectively extended the contact area between lignin and MXene to improve ion and electron accessibility,thus better utilizing the pseudocapacitive property of *** these strategies effectively enhanced the capacitive performance of the *** addition,HLNPs,which acted as a protective phase for MXene layer,enhanced mechanical properties of the wrinkled stretchable electrodes by releasing stress through slip and deformation during the stretch-release cycling and greatly improved the structural integrity and capacitive stability of the *** electrodes and symmetric flexible all-solid-state supercapacitors capable of enduring 600%uniaxial tensile strain were developed with high specific capacitances of 1273 mF cm^(−2)(241 F g^(−1))and 514 mF cm^(−2)(95 F g^(−1)),***,their capacitances were well preserved after 1000 times of 600%stretch-release *** study showcased new possibilities of incorporating biobased lignin nanospheres in energy storage devices to fabricate stretchable devices leveraging synergies among various two-dimensional nanomaterials.

关键词： Hollow lignin nanospheres MXene Gradient-layered architecture Wrinkled electrodes Stretchable supercapacitors

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Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3

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Oncology Research 2025年第1期33卷 103-121页

作者： YAN LU KANG WANG YUANHONG PENG MENG CHEN LIN ZHONG LUJI HUANG fu cheng XINDAN SHENG XIN YANG MANZHAO OUYANG GEORGE A.CALIN ZHIWEI HE China-America Cancer Research Institute Guangdong Medical UniversityDongguan523808China GCP Center Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China Department of Gastrointestinal Surgery Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou510080China Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Oncology Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China

Background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors,but the currently used immune checkpoint inhibitors targeting programmed cell death-1(PD-1),programmed cell death ligand-1(PD-L1),and cytotoxic T-lymphocyte antigen-4(CTLA-4)show limited clinical efficacy in many breast cancers.B7H3 has been widely reported as an immunosuppressive molecule,but its immunological function in breast cancer patients remains ***:We analyzed the expression of B7H3 in breast cancer samples using data from the Cancer Genome Atlas Program(TCGA)and the Gene Expression Omnibus(GEO)*** were selected using the TarBase,miRTarBase,and miRBase *** regulatory role of the microRNA hsa-miR-214-3p on B7H3 was investigated through dual-luciferase reporter assays,which identified the specific action sites of *** expression levels of B7H3 and hsa-miR-214-3p in human breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCR(qPCR).In vitro experiments were performed to observe the effects of modulating the expression of B7H3 or hsa-miR-214-3p on breast cancer cell proliferation and ***,the regulatory impact of hsa-miR-214-3p on B7H3 was ***-linked immunosorbent assays(ELISA)and flow cytometry were employed to assess the effects of co-cultured breast cancer cells and normal human peripheral blood mononuclear cells(PBMCs)on immune cells and associated ***:In breast cancer tissues,the expression level of B7H3 is inversely correlated with that of hsa-miR-214-3p,as well as with the regulatory effects on breast cancercell ***-miR-214-3p was found to inhibit breast cancer cell growth by downregulating ***,our research identified,for the first time,two binding sites for hsa-miR-214-3p on the 3’UTR of B7H3,both of which exert similar effects ***-culture experiments revealed that hsamiR-214-3p

关键词： Breast cancer B7H3 Hsa-miR-214-3p Immunotherapy

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基于OpenSim预测青少年跖屈肌无力的下肢生物力学行为

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中国组织工程研究 2025年第9期29卷 1789-1795页

作者：付恩洪杨行梁成张小刚张亚丽靳忠民西南交通大学机械工程学院四川省成都市610031

背景:跖屈肌无力是痉挛型脑瘫和腓骨肌萎缩症患者的常见肌肉缺陷,临床上会表现出异常步态,而跖屈肌无力与异常步态间的关系尚不明晰。目的:探讨跖屈肌无力单因素作用时对下肢生物力学行为的影响,以揭示跖屈肌无力诱发异常步态的机制,为... 详细信息

背景:跖屈肌无力是痉挛型脑瘫和腓骨肌萎缩症患者的常见肌肉缺陷,临床上会表现出异常步态,而跖屈肌无力与异常步态间的关系尚不明晰。目的:探讨跖屈肌无力单因素作用时对下肢生物力学行为的影响,以揭示跖屈肌无力诱发异常步态的机制,为跖屈肌无力患者康复训练提供指导。方法:基于OpenSim Moco建立矢状面内骨肌多体动力学预测框架,预测正常受试者下肢关节角和肌肉激活变化,结合实验数据逆运动学和肌电图激活时间,验证框架有效性。减小等距肌肉力进行跖屈肌无力建模并将预测得到的下肢关节角、关节力矩和肌肉能量消耗,与正常受试者对比,以分析跖屈肌无力对下肢生物力学的影响。结果与结论:①基于Moco的预测框架较真实地预测了正常受试者步行过程中的下肢生物力学变化(关节角归一化相关系数≥0.73,均方根误差≤7.10°);②跖屈肌无力时模型采用小步幅且支撑相上升的“脚跟行走”步态,当跖屈肌无力达到80%时,肌肉能量消耗为5.6914 J/(kg·m),腓肠肌和比目鱼肌激活度最大分别为0.72,0.53,可能致使跖屈肌无力患者步行时更易疲劳;③当跖屈肌无力超过40%时,肌肉能量消耗显著升高;跖屈肌无力超过60%时,下肢关节角和关节力矩出现较明显恶化,说明跖屈肌无力对步态的影响可能存在“阈值”,这或许对应于医护人员进行临床干预的时间点。

关键词：下肢跖屈肌无力生物力学步态预测肌肉能量消耗肌肉激活 OpenSimMoco

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Mechanical properties and failure behavior of 3D printed thermoplastic composites using continuous basalt fiber under high-volume fraction

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Defence Technology（防务技术） 2023年第9期27卷 237-250页

作者： hang Zhang Wei-fu Sun State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China Beijing Institute of Technology Chongqing Innovation Center Chongqing401120China Explosion Protection and Emergency Disposal Technology Engineering Research Center of the Ministry of Education Beijing10081China

Continuous basalt fiber(CBF)is an outstanding inorganic fiber produced from nature,which has a wide range of applications in the field of armor protection of national defense ***,the mechanical response and failure mechanism of 3D printed CBF reinforced components are still not well ***,the 3D printing thermoplastic composites with high volume fraction CBF have been successfully prepared by fused deposition modelling(FDM)*** effects of fiber printing direction and polymer matrix type on the tensile and flexural properties of the 3D printed composites have been explored,and the detailed failure morphology has been characterized using scanning electron microscopy and optical *** was found that under high fiber volume fraction,3D printed CBF reinforced polyamides(PA)composites have the best ability to maintain material integrity of the composites,followed by acrylonitrile butadiene styrene(ABS)and high impact polystyrene(HIPS).Besides,the results from rule of mixtures can accurately predict the longitudinal Young’s modulus of the 3D printed specimens,but there exists a large discrepancy for the prediction of the tensile *** microstructure analysis shows that the failure modes of 3D printed composites mainly include fiber debonding,fiber pull-out,stress whitening and matrix cracking.

关键词： Additive manufacturing Continuous basalt fiber Failure behavior Mechanical properties Thermoplastic composites

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高技术产品出口、数字贸易壁垒与“双环流”价值链分工地位

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经济问题 2025年第1期 37-47页

作者：周国富湛婧宁熊宇航天津财经大学统计学院天津300222

随着《区域全面经济伙伴关系协定》(RCEP)的全面生效,中国将同时置身于全球价值链大环流和RCEP价值链小环流贸易网络中。在理论分析的基础上,采用社会网络分析与跨国面板数据模型相结合的方法,基于2007—2023年全球52个国家的高技术产... 详细信息

随着《区域全面经济伙伴关系协定》(RCEP)的全面生效,中国将同时置身于全球价值链大环流和RCEP价值链小环流贸易网络中。在理论分析的基础上,采用社会网络分析与跨国面板数据模型相结合的方法,基于2007—2023年全球52个国家的高技术产品出口数据测算了全球高技术产品贸易网络和RCEP高技术产品贸易网络的结构指标,并考察其对“双环流”价值链分工地位的影响及作用机制。结果显示:(1)在高技术产品贸易网络中,中国已成为链接全球大环流与RCEP小环流的枢纽国家;(2)相对于全球大环流,RCEP小环流的高技术产品贸易网络更有利于中国摆脱“被俘获”式发展和国际分工地位的跃升;(3)一国在高技术产品贸易网络中的广度和深度对其在全球大环流和RCEP小环流价值链中分工地位的提升具有显著促进作用;(4)相对于全球大环流,RCEP小环流高技术产品贸易网络对价值链分工地位的促进作用受到数字贸易壁垒的负面影响更显著。基于上述结论,从中国如何充分利用RCEP的全面生效和新的“双环流”带来的机遇与挑战,以及促进高技术产业发展和提升价值链分工地位等方面给出了对策建议。

关键词：高技术产品出口 “双环流”价值链分工地位数字贸易壁垒

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MoFLP1,encoding a novel fungal fasciclin-like protein,is involved in conidiation and pathogenicity in Magnaporthe oryzae

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第6期10卷 434-444页

作者： Tong-bao LIU Guo-qing CHEN hang MIN fu-cheng LIN State Key Laboratory for Rice Biology Biotechnology Institute Zhejiang University Hangzhou 310029 China College of Life Sciences Zhejiang University Hangzhou 310058 China

Fasciclin family proteins have been identified as cell adhesion molecules in various organisms. In this study, a novel Magnaporthe oryzae fasciclin-like protein encoding gene, named MoFLP1, was isolated from a subtractive suppressive cDNA library and functionally analyzed. Sequence analysis showed that the MoFLP1 gene contains an open reading frame (ORF) of 1050 nucleotides encoding 349 amino acids with a calculated molecular weight of 35.85 kDa and a pI of 7.76. The deduced MoFLP1 protein contains a 17-amino acid secretion signal sequence and an 18-amino acid sequence with the characteristics of a glycosylphosphotidylinositol (GPI) anchor additional signal at its N- and C-terminuses, respectively. Potential N-glycosylation sites and domains involving cell adhesion were also identified in MoFLP1. Sequence analysis and subcellular localization by the expression of MoFLP1-GFP fusion construct in M. oryzae indicated that the MoFLP1 protein is probably localized on the vacuole membrane. Two MoFLP1 null mutants generated by targeted gene disruption exhibited marked reduction of conidiation, conidial adhesion, appressorium turgor, and pathogenicity. Our results indicate that fasciclin proteins play important roles in fungal de-velopment and pathogenicity in M. oryzae.

关键词： Magnaporthe oryzae Fasciclin MoFLP1 Cellular localization Conidiation Pathogenicity

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