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Asian Pacific Journal of Tropical Medicine 2015年第3期8卷 249-252页

作者： cheng-de wang Xin-Rong wang Chao-Yang wang Yi-Jun Tang Ming-Wen Hao department of Thoracie Surgery Yantai Yuhuangding Hospital affiliated to Medical College of Qingdao University department of Reproductive Medicine.Yantai Yuhuangding Hospital affiliated to Medical College of Qingdao University

Objective:To study the relevance of EGFR gene mutation with pathological features and prognosis in patients with non-small-cell lung ***:A total of 297 patients from July 2009 to May 2013 were chosen as *** gene mutation were detected with fluorescence quantitative *** of EGFR gene mutation with clinical and pathological features was analyzed,and the prognosis of EGFR- mutant-patients and that of EGFR- wide type-patients was ***:In 297 patients.136(45.79%) showed EGFR gene *** gene mutation had no significant relevance with ***,smoking history,family history of cancer and clinical stage(P>0.05);there was significant relevance between EGFR gene mutation and blood type,pathologic types,differentiation and diameter of cancer(Pde type-patients was statistical significance(Pde type-patients.

关键词： Epidermal growth factor receptor Non-small-cell lung carcinoma Fluorescence quantitative PCR Pathological features Prognosis

Microstructure and microtexture evolution characteristics of a powder metallurgy Ni-based superalloy during static recrystallization

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Journal of Iron and Steel Research International 2024年第9期31卷 2308-2325页

作者： Zhi-qiang Li de-cheng wang Yue-wen Zhai Chao Jiang Le-yu Zhou Zhi-guang Zhou Hui-zhen wang Zi-bo Zhang Lin Yan Li-ping wang Guang Yu department of Mechanical Engineering Tsinghua UniversityBeijing100084China Beijing Research Institute of Mechanical and Electrical Technology Co. Ltd.CAMBeijing100083China China Academy of Machinery Science and Technology Group Beijing100044China Institute of Advanced Manufacturing and Intelligent Technology Beijing University of TechnologyBeijing100124China

Static recrystallization(SRX)characteristics of a powder metallurgy superalloy were investigated by isothermal compression at 1080–1170℃ under strain rates of 0.01–0.1 s^(−1),strains of 0.1,0.22,or 0.5,and holding time of 0–300 *** impacts of temperature,strain rate,holding time,and strain on the SRXed grain size,volume fraction,and microtexture were explored by electron backscatter diffraction *** was found that temperature played a key role in these *** SRX progressed,thefiber parallel to the axis compression direction gradually weakened and was replaced by thefiber becausewas the preferred recrystallization orientation and grain growth direction for the Ni-based ***,high temperatures and low strain rates promoted the formation of the*** nucleation mechanisms during SRX process were found:grain boundary bulging,primary twin assistance,and subgrain *** boundary bulging occurred under all process conditions;however,at low temperatures and high strain rates,the latter two mechanisms could provide additional nucleation *** addition,SRX size and volume fraction models were established.

关键词： Powder metallurgy Ni-based superalloy Static recrystallization Microtexture evolution Recrystallization mechanism Prediction model

Effect of PDGF-Rb antagonist imatinib on endometrial injury repairing in mouse model

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Asian Pacific Journal of Tropical Medicine 2015年第7期8卷 553-557页

作者： Xin-Rong wang cheng-de wang Xue-Mei Liu Hong-Chu Bao Qing-Lan Qu Cui-Fang Hao department of Reproductive Medicine Affiliated Yantai Yuhuangding Hospital of Qingdao University Medical College department of Thoracic Surgery Affiliated Yantai Yuhuangding Hospital of Qingdao University Medical College

Objective: To study the effects of PDGF-Rb antagonists imatinib on endometrial injury repairing in the mouse model. Methods: The cultured MSCs cells from male mice were marked with Brd U in vitro, and then transplanted to the female mice which suffered from radiation injury through tail vein, PDGF-Rb antagonists imatinib was injected through abdominal cavity. Four groups were arranged, which were radiation transplantation group, normal control group, imatinib intervention group and radiation control group. Brd U incorporation, SRY expression and MVD status were detected in uterus of mice. Results: SRY gene was negative expressed in normal control group and radiation control group. SRY gene presented positive in radiation transplantation group and imatinib intervention group; Brd U incorporation showed negative in radiation control group and normal control group which died in the early stage in mice; the incorporation of Brd U was higher in radiation transplantation group compared with imatinib intervention group; CD34 was positive on the uterus of all the four groups,which showed highest in radiation control group and lowest in radiation control group; The MVD in imatinib intervention group was lower than radiation control group; the difference of MVD was significantly compared with normal control group(P<0.05). Conclusions: PDGF-Rb antagonists imatinib could inhibit the repairing function of MSCs in the endometrial lesions in mice.

关键词： PDGF-Rb Endometrium Imatinib mesylate BrdU MVD

Cyclic Reconfigurable Flow Shop under Different Configurations Modeling and Optimization Based on Timed Event Graph

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自动化学报 2006年第1期32卷 15-20页

作者： REN Si-cheng XU de wang Fang TAN Min Institute of Automation Chinese Academy of Sciences Beijing 100080

Based on the idea that modules are independent of machines, different combinations of modules and machines result in different configurations and the system performances differ under different configurations, a kind of cyclic reconfigurable flow shops are proposed for the new manufacturing paradigm-reconfigurable manufacturing system. The cyclic reconfigurable flow shop is modeled as a timed event graph. The optimal configuration is defined as the one under which the cyclic reconfigurable flow shop functions with the minimum cycle time and the minimum number of pallets. The optimal configuration, the minimum cycle time and the minimum number of pallets can be obtained in two steps.

关键词：循环流程制造业时间事件建模优化设计

Moment Redistribution Effect of the Continuous Glass Fiber Reinforced Polymer-Concrete Composite Slabs Based on Static Loading Experiment

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Structural Durability & Health Monitoring 2025年第1期19卷 105-123页

作者： Zhao-Jun Zhang Wen-Wei wang Jing-Shui Zhen Bo-cheng Li de-cheng Cai Yang-Yang Du Hui Huang Offshore Oil Engineering Co.Ltd. Tianjin300461China department of Bridge Engineering School of TransportationSoutheast UniversityNanjing211189China

This study aimed to investigate the moment redistribution in continuous glass fiber reinforced polymer(GFRP)-concrete composite slabs caused by concrete cracking and steel bar yielding in the negative bending moment *** experimental bending moment redistribution test was conducted on continuous GFRP-concrete composite slabs,and a calculation method based on the conjugate beam method was *** composite slabs were formed by combining GFRP profiles with a concrete layer and supported on steel beams to create two-span continuous composite slab *** methods,epoxy resin bonding,and stud connection,were used to connect the composite slabs with the steel *** experimental findings showed that the specimen connected with epoxy resin exhibited two moments redistribution phenomena during the loading process:concrete cracking and steel bar yielding at the internal *** contrast,the composite slab connected with steel beams by studs exhibited only one-moment redistribution phenomenon throughout the loading *** the concrete at the internal support cracked,the bending moment decreased in the internal support section and increased in the midspan *** the steel bars yielded,the bending moment further decreased in the internal support section and increased in the mid-span *** GFRP profiles do not experience cracking,there was no significant decrease in the bending moment of the mid-span *** test specimens experienced compressive failure of concrete at the mid-span *** results showed good agreement between the calculated and experimental values of bending moments in the mid-span section and internal support *** proposed model can effectively predict the moment redistribution behavior of continuous GFRP-concrete composite slabs.

关键词： Moment redistribution GFRP-concrete composite slabs bending moment experimental study analysis model

The effect of radiotherapy on bone formation in rabbit mandible distraction during consolidation phase

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中国口腔颌面外科杂志 2008年第B5期6卷 75-76页

作者： Lei Tian Xiao Bing cheng Lei wang de Lin Lei department of Oral and Maxillofacial Surgery College ofStomatology Fourth Military Medical University Xi'an 710032China

C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury

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Neural Regeneration Research 2025年第8期20卷 2231-2244页

作者： Xiangzi wang Xiaofei Niu Yingkai wang Yang Liu cheng Yang Xuyi Chen Zhongquan Qi School of Medicine Guangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Graduate School of Tianjin University of Traditional Chinese Medicine TianjinChina Characteristic Medical Center of People’s Armed Police Forces TianjinChina Fujian Maternity and Child Health Hospital FuzhouFujian ProvinceChina

Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory *** expression of the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis exhibits significant differences before and after *** studies have revealed that the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis is closely associated with secondary inflammatory responses and the recruitment of immune cells following spinal cord injury,suggesting that this axis is a novel target and regulatory control point for *** review comprehensively examines the therapeutic strategies targeting the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis,along with the regenerative and repair mechanisms linking the axis to spinal cord ***,we summarize the upstream and downstream inflammatory signaling pathways associated with spinal cord injury and the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review primarily elaborates on therapeutic strategies that target the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the latest progress of research on antagonistic drugs,along with the approaches used to exploit new therapeutic targets within the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the development of targeted ***,there are presently no clinical studies relating to spinal cord injury that are focusing on the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review aims to provide new ideas and therapeutic strategies for the future treatment of spinal cord injury.

关键词： apoptosis C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway C-C motif chemokine receptor 2 antagonists chemokine ligand 2 chemokine receptor 2 inflammation macrophage microglia spinal cord injury therapeutic method

Ideal Bi‑Based Hybrid Anode Material for Ultrafast Charging of Sodium‑Ion Batteries at Extremely Low Temperatures

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Nano-Micro Letters 2025年第3期17卷 152-167页

作者： Jie Bai Jian Hui Jia Yu wang Chun cheng Yang Qing Jiang Key Laboratory of Automobile Materials(Jilin University) Ministry of EducationSchool of Materials Science and EngineeringJilin UniversityChangchun 130022People’s Republic of China

Sodium-ion batteries have emerged as competitive substitutes for low-temperature applications due to severe capacity loss and safety concerns of lithium-ion batteries at−20°C or ***,the key capability of ultrafast charging at ultralow temperature for SIBs is rarely ***,a hybrid of Bi nanoparticles embedded in carbon nanorods is demonstrated as an ideal material to address this issue,which is synthesized via a high temperature shock *** a hybrid shows an unprecedented rate performance(237.9 mAh g^(−1)at 2 A g^(−1))at−60℃,outperforming all reported SIB anode *** with a Na_(3)V_(2)(PO_(4))_(3)cathode,the energy density of the full cell can reach to 181.9 Wh kg^(−1)at−40°*** on this work,a novel strategy of high-rate activation is proposed to enhance performances of Bi-based materials in cryogenic conditions by creating new active sites for interfacial reaction under large current.

关键词： Bi nanoparticles High temperature shock High-rate activation Ultrafast charging Low-temperature sodium-ion batteries

Advancements and Challenges in Organic–Inorganic Composite Solid Electrolytes for All‑Solid‑State Lithium Batteries

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Nano-Micro Letters 2025年第1期17卷 46-97页

作者： Xueyan Zhang Shichao cheng Chuankai Fu Geping Yin Liguang wang Yongmin Wu Hua Huo State Key Laboratory of Space Power‑Sources School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001People’s Republic of China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310058People’s Republic of China State Key Laboratory of Space Power-Sources 2965 Dongchuan RoadMinhang DistrictShanghai 200240People’s Republic of China

To address the limitations of contemporary lithium-ion batteries,particularly their low energy density and safety concerns,all-solid-state lithium batteries equipped with solid-state electrolytes have been identified as an up-and-coming *** the various SEs,organic–inorganic composite solid electrolytes(OICSEs)that combine the advantages of both polymer and inorganic materials demonstrate promising potential for large-scale ***,OICSEs still face many challenges in practical applications,such as low ionic conductivity and poor interfacial stability,which severely limit their *** review provides a comprehensive overview of recent research advancements in ***,the influence of inorganic fillers on the main functional parameters of OICSEs,including ionic conductivity,Li+transfer number,mechanical strength,electrochemical stability,electronic conductivity,and thermal stability are systematically *** lithium-ion conduction mechanism of OICSE is thoroughly analyzed and concluded from the microscopic ***,the classic inorganic filler types,including both inert and active fillers,are categorized with special emphasis on the relationship between inorganic filler structure design and the electrochemical performance of ***,the advanced characterization techniques relevant to OICSEs are summarized,and the challenges and perspectives on the future development of OICSEs are also highlighted for constructing superior ASSLBs.

关键词： Composite solid electrolytes Inorganic filler Interfacial stability Li-ion conduction mechanism Characterization techniques

Lipid droplets in the nervous system:involvement in cell metabolic homeostasis

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Neural Regeneration Research 2025年第3期20卷 740-750页

作者： Yuchen Zhang Yiqing Chen cheng Zhuang Jingxuan Qi Robert Chunhua Zhao Jiao wang School of Life Sciences Shanghai UniversityShanghaiChina School of Medicine Shanghai UniversityShanghaiChina Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic MedicinePeking Union Medical CollegeBeijingChina Center of Excellence in Tissue Engineering Chinese Academy of Medical SciencesBeijingChina Beijing Key Laboratory of New Drug development and Clinical Trial of Stem Cell Therapy BeijingChina

Lipid droplets serve as primary storage organelles for neutral lipids in neurons,glial cells,and other cells in the nervous *** droplet formation begins with the synthesis of neutral lipids in the endoplasmic ***,lipid droplets were recognized for their role in maintaining lipid metabolism and energy homeostasis;however,recent research has shown that lipid droplets are highly adaptive organelles with diverse functions in the nervous *** addition to their role in regulating cell metabolism,lipid droplets play a protective role in various cellular stress ***,lipid droplets exhibit specific functions in neurons and glial *** of lipid droplet formation leads to cellular dysfunction,metabolic abnormalities,and nervous system *** review aims to provide an overview of the role of lipid droplets in the nervous system,covering topics such as biogenesis,cellular specificity,and ***,it will explore the association between lipid droplets and neurodegenerative *** the involvement of lipid droplets in cell metabolic homeostasis related to the nervous system is crucial to determine the underlying causes and in exploring potential therapeutic approaches for these diseases.

关键词： Alzheimer's disease lipid droplet biogenesis lipid droplets lipid metabolism nervous system neurodegenerative disorders oxidative stress Parkinson's disease