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Taxoids from the Needles of Taxus×media Hicksii

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Chinese Chemical Letters 1998年第12期9卷 0-0,0-0页

作者： Yong Li GAO Jin Yun zhou Di An SUN Qi cheng FANG Nan WU Yang LU Qi Tai ZHENG(Institute of Materia Medica, Chinese Academy of Medical Sciences andPeking Union Medical College, Beding 100050) Institute of Materia Medica Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100050 China

A new taxane diterpenoid, named 7-deacetoxy taxinine J, together with ten knowncompounds were isolated from the needles of Taxus × media Hickiii. The structures of allcompounds were elucidated and identified by spectroscopic methods. T'he structure of 7-deacetoxytaxinine J was further confirmed by X-ray crystallographic analysis. The structure of the knowncompound, taxinine E, was also revised.

关键词： Taxus×media, Taxaceae taxoids diterpenoids, 7-Deacetoxy taxinine J

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宜昌市致洪中尺度极端降水成因分析

人民长江 2024年第7期55卷 88-97页

作者：成勤王清龙孟芳李芳彭福强雷东洋三峡国家气候观象台湖北宜昌443000 湖北省宜昌市气象局湖北宜昌443000 中国地质大学海洋学院湖北武汉430074

极端降水对河流防洪调控、水库蓄水泄洪等具有重要的影响,研究极端降水成因成为强化区域洪水资源管理的必要环节。基于多源观测资料和ERA5再分析资料,利用HYSPLIT后向轨迹模式和锋生强度诊断等方法,对2023年8月26日夜间宜昌市致洪中尺... 详细信息

极端降水对河流防洪调控、水库蓄水泄洪等具有重要的影响,研究极端降水成因成为强化区域洪水资源管理的必要环节。基于多源观测资料和ERA5再分析资料,利用HYSPLIT后向轨迹模式和锋生强度诊断等方法,对2023年8月26日夜间宜昌市致洪中尺度极端降水成因进行分析。结果表明:①此次极端降水过程关键影响系统为低空急流、超低空急流、边界层冷空气和中尺度低涡。强降水可以分为中尺度低涡新生、低空急流发展,冷暖对峙、冷锋南下,低涡中心东移3个阶段。②此次过程中低层主要有4条暖湿输送通道,强降水区水汽通量超800 kg/(m·s),可降水量超70mm。③强降水时段低层相对涡度正值中心与垂直速度负值中心基本重合,加之锋生作用增强,强降水中心低层垂直速度达-7.1 pa/s。④强降水时段,地形过渡带附近形成θ_(se)(假相当位温)能量锋区,垂直方向上出现高能舌,800 hpa附近中心强度达360 K以上。⑤中尺度地形形成了“西北冷干、东南暖湿”中尺度温湿锋区,并起到了阻挡抬升和触发作用,使强降水出现在山前喇叭口内。研究成果可为汛期区域洪水资源管理策略制定提供依据。

关键词：极端降水超低空急流边界层冷空气中尺度锋区地形作用 HYSPLIT后向轨迹模式宜昌市

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Effect of calcium citrate on bone integration in a rabbit femur defect model

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Asian pacific Journal of Tropical Medicine 2012年第4期5卷 310-314页

作者： Wei Zhang Wei Wang Qing-Yu Chen Zhong-Qin Lin Shao-Wen cheng Dong-Quan Kou Xiao-zhou Ying Yue Shen Xiao-Jie cheng Peng-Fei Nie Xiu-Cui Li Ferdinand An Rompis Hang Huang Hua Zhang Zhong-Lin Mu Lei Peng Department of Orthopaedic Surgery the Second Affiliated Hospital of Wenzhou Medical College Department of Orthopaedic Surgery Hospital of Integrated Traditional Chinese and Western Medicine of Wenzhou Department of Respiratory Medicine Yuying Children's Hospital Affiliated to Wenzhou Medical College Trauma Center of the Affiliated Hospital of Hainan Medical College Haikou 120 Emergency Center International Nursing School of Hainan Medical College Graduate Department of Hainan Medical College The Second Affiliated Hospital of Wenzhou Medical College Trauma Center of the Affiliated Hospital of Hainan Medical College

Objective:To explore effect of calcium citrate on bone integration in a rabbit femur defect model, and to compare the bone formation with different sizes by radiological and histological study. Methods:Twenty-four male Japanese white rabbits were randomly divided into three groups (Group A.B.C)in this *** anesthesia,defects of four sizes(1.2,1.5,2.0 and 2.5 mm) were created in each of the *** pure calcium citrate powder was placed inside the medullary compartment of the femur(Experimental),while in the contralateral femur(Control) nothing was *** defects were analyzed using radiography and histological analysis by using Imagepro-Plus 6.0 software after animal was sacrificed at 4th(Group A),6th(Group B) and 8th(Group C) weeks *** samples were analyzed for each size of defect and each healing ***:The histological and the radiologic evaluation were performed after sacrification of all rabbits on postoperative 4th and 6th weeks,It showed significant difference between the experimental group and the control group when these defects were less than or equal to 2.0 *** statistical difference was observed when these defects were larger than 2.0 mm at all healing periods except at the 4th ***:Calcium citrate affects the early periods of hone defects healing mechanism in Japanese white rabbits positively,especially when the defect is not too large,We suggest further studies on calcium citrate to determine the effects of various dosages,administration ways and the experimental time on the bone defects.

关键词： Experiment Bone Fracture healing Calcium citrate

Protective humoral immunity in SARS-CoV-2 infected pediatric patients

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Cellular & Molecular Immunology 2020年第7期17卷 768-770页

作者： Yaguang Zhang Jin Xu Ran Jia Chunyan Yi Wangpeng Gu Pengcheng Liu Xinran Dong Hao zhou Bo Shang Shipeng cheng Xiaoyu Sun Jing Ye Xuezhen Li Jia Zhang Zhiyang Ling Liyan Ma Bingbing Wu Mei Zeng Wenhao zhou Bing Sun State Key Laboratory of Cell Biology CAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesUniversity of Chinese Academy of Sciences320 Yueyang RoadShanghai 200031China Children’s Hospital of Fudan University 399 Wanyuan RoadShanghai 201102China Shanghai Kehua Bio-Engineering Co. Ltd.1189 Qinzhou RoadShanghai 200233China

After the rapid spread of SARS-CoV-2 in Wuhan,China,at the beginning of 2020,about 1.5 million confirmed cases and over 80,000 deaths have been reported around 200 countries and territories all over the world and the number continues to ***,we still have limited knowledge of this new coronavirus,especially the interaction between SARS-CoV-2 and our immune system.

关键词： immunity pediatric infected

MIL-88B-Fe-based nanozymes withperoxidase-like activities for theoretical calculation of catalysis

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MIL-88B-Fe-based nanozymes withperoxidase-like activities fo...

Synthesis and Antibacterial Activity of Sulfur-linked Bis-benzothiazoles

中国化学会第二十届全国有机分析及生物分析学术研讨会

作者： LingliLong zhou Xu Maolong Chen Yunhui cheng College of Chemistry and Biological Engineering Changsha University of Science ＆ Technology

＜正＞Nanocatalytic mechanism is central to the exploitation and optimisation of nanomaterial catalysts in a variety of technologically important heterogeneous reactions, such as nanozyme immunoassay and automotive catalysis. Here, we present a catalytic mechanism for nanozyme, calculated as a function of exposure surface and architecture , using atom-level models.

关键词： MIL-88B-Fe biomimetic catalyst peroxidase-like enzyme Material studio

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Synthesis and Antibacterial Activity of Sulfur-linked Bis-be...

二维静态时空中Dirac场的重正化能动张量和Casimir效应

全国第十八届大环化学暨第十届超分子化学学术讨论会

作者： Gopala Lavanya Venkapuram padmavathi cheng-He zhou Sri Venkateswara University Laboratory of Bioorganic & Medicinal Chemistry School of Chemistry and Chemical Engineering Southwest University

＜正＞A series of benzothiazoles were synthesized through convenient and economic synthetic *** the target compounds were characterized by IR,1 H NMR,13 C NMR,and HRMS *** in vitro antibacterial and antifungal activities indicated that some of the synthesized compounds could effectively inhibit the growth of all the tested strains,and even

关键词： Benzothiazole 2.4-Dichloroquinazoline Antimicrobial activity

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物理学报 2007年第4期56卷 1928-1937页

作者：刘成周张昌平滨州学院物理与电子科学系

在一般渐近平直的二维静态黑洞时空中,利用重正化能动张量的一般性质,对位于两“平行板”间满足Dirichlet条件的无质量Dirac场的重正化能动张量的真空期待值进行了分析和计算,得到了一般表达式.利用该表达式可以给出各种具体渐近平直二... 详细信息

在一般渐近平直的二维静态黑洞时空中,利用重正化能动张量的一般性质,对位于两“平行板”间满足Dirichlet条件的无质量Dirac场的重正化能动张量的真空期待值进行了分析和计算,得到了一般表达式.利用该表达式可以给出各种具体渐近平直二维静态黑洞时空中的相应Casimir力.对于重正化能动张量及Casimir力与真空态定义(包括Boulware真空态、Hartle-Hawking真空态和Unrum真空态三种情况)、Hawking辐射和反常迹的关系分别进行了讨论,给出了相应的表达式和计算结果.

关键词：能动张量 Casimir效应黑洞真空态

大庆油田三元复合驱结垢样品中碳酸钙的结晶特性及形貌特征

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高等学校化学学报 2012年第6期33卷 1138-1142页

作者：程杰成周万富王庆国程铁欣周广栋大庆油田有限责任公司大庆163453 吉林大学化学学院长春130021

采用EDAX,XRD和SEM等方法对大庆油田三元复合驱结垢样品中碳酸钙的结晶特性及形貌特征进行了研究.结果表明,结垢样品中的碳酸钙呈现出球形、棒状和花状等形貌特征和层状生长的结晶特征.部分水解聚丙烯酰胺(HpaM)降低了重烷基苯磺酸盐(HA... 详细信息

采用EDAX,XRD和SEM等方法对大庆油田三元复合驱结垢样品中碳酸钙的结晶特性及形貌特征进行了研究.结果表明,结垢样品中的碳酸钙呈现出球形、棒状和花状等形貌特征和层状生长的结晶特征.部分水解聚丙烯酰胺(HpaM)降低了重烷基苯磺酸盐(HABS)表面活性剂的临界胶束浓度(cmc),促进了其胶束化作用;HABS使溶液中HpaM链的刚性增强,负电吸引能力增强;二者均会形成模板,导致结垢样品中的碳酸钙具有不同的形貌特征.聚丙烯酰胺和表面活性剂的存在未改变结垢样品中碳酸钙的层状生长特征.

关键词：碱/表面活性剂/聚合物三元复合驱结垢碳酸钙形貌结晶

RNA interference by expression of short hairpin RNAs suppresses bcl-xL gene expression in nasopharyngeal carcinoma cells

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Acta Pharmacologica Sinica 2005年第2期26卷 228-234页

作者： Fang LIU~2,cheng-wei HE,Yue-fei ZHANG~4,Ke-yuan zhou~3~2Institute of Biochemistry and Molecular Biology ~4Department of Otorhinolaryngology,The First Affiliated Hospital,Guangdong MedicalCollege,Zhanjiang 524023,China Institute of Biochemistry and Molecular Biology Guangdong Medical College Zhanjiang China Department of Otorhinolaryngology The First Affiliated Hospital Guangdong Medical College Zhanjiang China

Aim:To evaluate a new plasmid mediated RNA interference(RNAi)system andinvestigate whether knock-down of bcl-xL by short hairpin RNA(shRNA)caninduce apoptosis of human nasopharyngeal carcinoma(NPC)cell line CNE-2Z ***:The plasmid containing mU6 promoter was subcloned to yield thepmU6 plasmid,recombinant plasmid expressing shRNA targeting bcl-xL gene wasdesigned and constructed,and were co-transfected cells with green fluorescenceprotein expressing *** cytometry was used to evaluate transfectionefficiency,and RT-PCR and Western blot were applied to analyze bcl-xL mRNAand protein levels,***:The shRNA expressed by the recombi-nant plasmid efficiently suppressed bcl-xL gene expression and induced apoptosisof NPC cells in ***:The recombinant plasmid can sufficientlymediate RNAi in CNE-2Z cells,and knock-down of the bcl-xL expression by shRNAsignificantly induced apoptosis in CNE-2Z *** results suggest this newsystem,mediated RNAi can be used as a tool for the study of gene function andgene therapy.

关键词： RNAi plasmid gene transfection short hairpin RNA bcl-xL apoptosis nasopharyngeal carcinoma cells