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The chemical characteristics of different sodium iron ethylenediaminetetraacetate sources and their relative bioavailabilities for broilers fed with a conventional corn‑soybean meal diet

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Journal of Animal Science and Biotechnology 2024年第2期15卷 826-843页

作者： Shengchen Wang Bingxin Wu Ling Zhu Weiyun Zhang Liyang Zhang We Wu Jiaqi Wu yun hu Tingting Li Xiaoyan Cui Xugang Luo College of Animal Science and Technology Yangzhou UniversityYangzhou 225000People’s Republic of China Mineral Nutrition Research Division State Key Laboratory of Animal NutritionInstitute of Animal ScienceChinese Academy of Agricultural SciencesBeijing 100193China

Background Our previous studies demonstrated that divalent organic iron(Fe)proteinate sources with higher complexation or chelation strengths as expressed by the greater quotient of formation(Qf)values displayed higher Fe bioavailabilities for *** iron ethylenediaminetetraacetate(NaFeEDTA)is a trivalent organic Fe source with the strongest chelating ligand ***,the bioavailability of Fe when administered as NaFeEDTA in broilers and other agricultural animals remains ***,the chemical characteristics of 12 NaFeEDTA products were *** these,one feed grade NaFeEDTA(Qf=2.07×10^(8)),one food grade NaFeEDTA(Qf=3.31×10^(8)),and one Fe proteinate with an extremely strong chelation strength(Fe-Prot ES,Qf value=8,590)were *** bioavailabilities relative to Fe sulfate(FeSO_(4)·7H_(2)O)for broilers fed with a conventional corn-soybean meal diet were evaluated during d 1 to 21 by investigating the effects of the above Fe sources and added Fe levels on the growth performance,hematological indices,Fe contents,activities and gene expressions of Fe-containing enzymes in various tissues of *** NaFeEDTA sources varied greatly in their chemical *** Fe concentration(PI),transferrin saturation(TS),liver Fe content,succinate dehydrogenase(SDH)activities in liver,heart,and kidney,catalase(CAT)activity in liver,and SDH mRNA expressions in liver and kidney increased linearly(P<0.05)with increasing levels of Fe ***,differences among Fe sources were detected(P<0.05)only for PI,liver Fe content,CAT activity in liver,SDH activities in heart and kidney,and SDH mRNA expressions in liver and *** on slope ratios from multiple linear regressions of the above indices on daily dietary analyzed Fe intake,the average bioavailabilities of Fe-Prot ES,feed grade NaFeEDTA,and food grade NaFeEDTA relative to the inorganic FeSO_(4)·7H_(2)O(100%)for broilers were 139%,155%,and 166%,***

关键词： Broilers Chelation strengths Fe-containing enzymes NaFeEDTA Relative bioavailabilities

Exploration of the mechanism of cavitation vortex rope and vortex development in the draft tube of tubular turbine units

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International Journal of Agricultural and Biological Engineering 2024年第1期17卷 163-171,F0002页

作者： Chuang cheng Zhenggui Li Changrong Shen Shenglong Gu Chuchu Zeng Chuanzheng Bai Meng Liu Junfeng hu Qinghai University of Science and Technology Xining 810000China Key Laboratory of Fluid and Power Machinery Ministry of Education(Xihua University)Chengdu 610039China South-to-North Water Diversion East Jiangsu Water Source Co. Ltd.Nanjing 210029China School of civil engineering and water resources Qinghai UniversityXining 810016China Dongyuan Branch of Shenzhen Water Planning and Design Institute Co. Ltd.Changsha 410000China

Draft tube vortex rope is considered a special cavitation flow phenomenon in tubular turbine *** vortex rope is one of the most detrimental factors affecting the safety of hydraulic *** this study,ANSYS CFX software was utilized to numerically simulate the internal cavitation flow of a hydraulic turbine draft *** evolution of the cavitation vortex core was characterized by vortex line distribution and vorticity transport *** shape and number of blades influenced the revolving direction and distribution characteristics of the vortex close to the runner cone,which formed a counterclockwise-clockwise-counterclockwise distribution ***,there were many secondary flows in the draft *** cancellation and dissipation between the flows was one of the reasons for reduction in *** the cross-sectional shape of the draft tube was changed,the vorticity was distributed from the center of the vortex rope to all parts of the cross-sectional draft tube,with extreme values at the center and at the *** vortex stretching and dilatation terms played a major role in the change in vorticity,with the baroclinic torque having an effect at the center of the vortex rope,this study is helpful to understand the flow of water in the draft tube and guide the design and optimization of the draft tube in engineering application.

关键词： cavitation vortex rope vorticity transport equation vortex line draft tube

Classification and treatment strategy for Moyamoya disease-related aneurysms

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Chinese Neurosurgical Journal 2024年第1期10卷 1-7页

作者： Yangchun hu Xiaojian Wang Chao Li Liang Zhao Jing Luo Lei Ye Baochun cheng Department of Neurosurgery The First Affiliated Hospital of Anhui Medical UniversityJixi 218Hefei 230022People’s Republic of China

Background Moyamoya disease(MMD)is a cerebrovascular disorder characterized by progressive unilateral or bilateral stenosis of the distal internal carotid *** hemodynamic features in MMD patients alter,the comorbidity of intracranial aneurysm(IA)is sometimes observed *** aim to investigate clinical characteristics and therapeutic strategies for the comorbidity of Moyamoya disease with intracranial aneurysms(MMD-IA).Methods A total of 13 MMD-IA patients were recruited in this study and were manifested to be intracranial *** reviewed the surgical technique notes for all *** According to the locations of an aneurysm,MMD-IA could be divided into several categories:(1)MMD-IA at a circle of Willis—aneurysms usually located at the trunk of Willis circle;(2)MMD-IA at collateral anastomosis—aneurysms located at the distal end of collateral anastomosis;and(3)MMA-IA at basal ganglia *** this report,aneurysms in 10 patients located at Willis circle,2 at the pericallosal artery,and 1 at the basal ganglia *** them,endovascular embolism was performed among 5 *** clipping was conducted among 7 patients.A patient with an aneurysm at the basal ganglia region just accepted revascularization *** the treatments were ***-up studies,ranging from 6 to 24 months,demonstrated all patients received satisfactory curative *** Diverse clinical presentations could be observed among MMD-IA *** neurosurgical treatments should be chosen according to the locations of the aneurysm.

关键词： Moyamoya disease Aneurysm Clipping Revascularization Endovascular embolism

Effect of viral hepatitis on type 2 diabetes:A Mendelian randomization study

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World Journal of Diabetes 2024年第2期15卷 220-231页

作者： yun-Feng Yu Gang hu Ke-Ke Tong Xin-Yu Yang Jing-Yi Wu Rong Yu The First Hospital of hunan University of Chinese Medicine Changsha 410007Hunan ProvinceChina The Hospital of hunan University of Traditional Chinese Medicine Changde 415213Hunan ProvinceChina College of Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina The Third Hospital of Zhejiang Chinese Medical University Hangzhou 310005Zhejiang ProvinceChina

BACKGROUND The effects of viral hepatitis(VH)on type 2 diabetes(T2D)remain *** To analyze the causal correlation between different types of VH and T2D using Mendelian randomization(MR).METHODS Single nucleotide polymorphisms of VH,chronic hepatitis B(CHB),chronic hepatitis C(CHC)and T2D were obtained from the BioBank Japan Project,European Bioinformatics Institute,and *** variance weighted,MREgger,and weighted median were used to test exposure-outcome *** MR-Egger intercept analysis and Cochran’s Q test were used to assess horizontal pleiotropy and heterogeneity,***-one-out sensitivity analysis was used to evaluate the robustness of the MR analysis *** The MR analysis showed no significant causal relationship between VH and T2D in Europeans[odds ratio(OR)=1.028;95%confidence interval(CI):0.995-1.062,P=0.101].There was a negative causal association between CHB and T2D among East Asians(OR=0.949;95%CI:0.931-0.968,P0.05).Sensitivity analysis showed that the results were *** Among East Asians,CHB is associated with a reduced T2D risk,but this association is limited by HBV load and *** VH among Europeans and CHC among East Asians are not associated with the risk of T2D,focusing on blood glucose in patients with CHC is still relevant for the early detection of T2D induced by CHCmediated pathways of hepatic steatosis,liver fibrosis,and cirrhosis.

关键词： Viral hepatitis Chronic hepatitis B Chronic hepatitis C Type 2 diabetes Mendelian randomization

MicroRNA-451a is a candidate biomarker and therapeutic target for major depressive disorder

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General Psychiatry 2024年第1期37卷 151-162页

作者： Panpan hu Qiuchen Cao hu Feng yun Liu Yan Chen Jingfan Xu Weixi Feng huaiqing Sun huachen Ding Chun Wang Junying Gao Ming Xiao Jiangsu Key Laboratory of Neurodegeneration Nanjing Medical UniversityNanjingJiangsuChina Department of Neurology The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsuChina Nanjing Brain Hospital Affliated to Nanjing Medical University NanjingJiangsuChina Functional Brain Imaging Institute of Nanjing Medical University NanjingJiangsuChina

Background Increasing evidence supports the role of microRNAs(miRNAs)in major depressive disorder(MDD),but the pathophysiological mechanism remains *** To explore the mechanism of microRNA-451a(miR-451a)in the pathology and behaviours of *** Abnormal miRNAs such as miR-451a reported previously in the serum of patients with MDD were screened and then confirmed in a mouse model of depression induced by chronic restraint stress(CRS).Eight-week-old male C57BL/6 mice had miR-451a overexpression in the medial prefrontal cortex(mPFC)via adeno-associated virus serotype 9 vectors encoding a pri-mmu-miR-451a-GFP fusion protein followed by behavioural and pathological ***,molecular biological experiments were conducted to investigate the potential mechanism of miR-451a against *** The serum levels of miRNA-451awere significantly lower in patients with MDD,with a negative correlation with the Hamilton Depression Scale ***,a negative association between serum miR-451a and behavioural despair or anhedonia was observed in CRS ***,miR-451a expression was significantly downregulated in the mPFC of CRS-susceptible *** miR-451a in the mPFC reversed the loss of dendritic spines and the depression-like phenotype of CRS ***,miR-451a could inhibit CRS-induced corticotropin-releasing factor receptor 1 expression via targeting transcription factor 2,subsequently protecting dendritic spine *** Together,these results highlighted miR-451a as a candidate biomarker and therapeutic target for MDD.

关键词： therapeutic medial behaviour

Blockade of the deubiquitinating enzyme USP48 degrades oncogenic HMGA2 and inhibits colorectal cancer invasion and metastasis

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1624-1643页

作者： Can cheng Hanhui Yao Heng Li Jingwen Liu Zhengyi Liu Yang Wu Liang Zhu Hejie hu Zhengdong Fang Liang Wu Department of General Surgery the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of Comprehensive Surgery Anhui Provincial Cancer HospitalWest District of the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Anhui Provincial Hospital Health Management Center the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of Breast Surgery Henan Provincial People's HospitalPeople's Hospital of Zhengzhou UniversityPeople's Hospital of Henan UniversityZhengzhou 450003China

HMGA2,a pivotal transcription factor,functions as a versatile regulator implicated in the progression of diverse aggressive *** this study,mass spectrometry was employed to identify ubiquitin-specific proteases that potentially interact with HMGA2,and USP48 was identified as a deubiquitinating enzyme of *** enforced expression of USP48 significantly increased HMGA2 protein levels by inhibiting its degradation,while the deprivation of USP48 promoted HMGA2 degradation,thereby suppressing tumor invasion and *** discovered that USP48 undergoes SUMOylation at lysine 258,which enhances its binding affinity to *** subsequent phenotypic screening of small molecules,we identified DUB-IN-2 as a remarkably potent pharmacological inhibitor of ***,the small-molecule inhibitor targeting USP48 induces destabilization of ***,upregulation of USP48 or HMGA2 in cancerous tissues is indicative of poor prognosis for patients with colorectal cancer(CRC).Collectively,our study not only elucidates the regulatory mechanism of DUBs involved in HMGA2 stability and validates USP48 as a potential therapeutic target for CRC,but also identifies DUB-IN-2 as a potent inhibitor of USP48 and a promising candidate for CRC treatment.

关键词： Colorectal cancer Invasion and metastasis Post-translational modification Ubiquitination SUMOylation USP48 HMGA2 Specific inhibitors

Detection and analysis of landslide geomorphology based on UAV vertical photogrammetry

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Journal of Mountain Science 2024年第4期21卷 1190-1214页

作者： BI Rui GAN Shu YUAN Xiping LI Kun LI Raobo LUO Weidong CHEN cheng GAO Sha hu Lin Zhu Zhifu School of Land and Resources Engineering Kunming University of Science and TechnologyKunming 650093China Plication Engineering Research Center of Spatial Information Surveying and Mapping Technology in Plateau and Mountainous Areas Set by Universities in yunnan Province Kunming 650093China West yunnan University of Applied Sciences Key Laboratory of Mountain Real Scene Point Cloud Data Processing and Application for Universities in Yunnan ProvinceDali 671006China

High-resolution landslide images are required for detailed geomorphological analysis in complex topographic environment with steep and vertical landslide *** study proposed a vertical route planning method for unmanned aerial vehicles(UAVs),which could achieve rapid image collection based on strictly calculated route *** effectiveness of this method was verified using a DJI Mavic 2 Pro,obtaining high-resolution landslide images within the Dongchuan debris flow gully,in the Xiaojiang River Basin,Dongchuan District,yunnan,China.A three-dimensional(3D)model was constructed by the structure-from-motion and multi-view stereo(SfM-MVS).Micro-geomorphic features were analyzed through visual interpretation,geographic information system(GIS),spatial analysis,and mathematical statistics *** results demonstrated that the proposed method could obtain comprehensive vertical information on landslides while improving measurement *** 3D model was constructed using the vertically oriented flight route to achieve centimeter-level accuracy(horizontal accuracy better than 6 cm,elevation accuracy better than 3 cm,and relative accuracy better than 3.5 cm).The UAV technology could further help understand the micro internal spatial and structural characteristics of landslides,facilitating intuitive acquisition of surface *** slope of landslide clusters ranged from 36°to 72°,with the majority of the slope facing east and *** elevation levels were relatively consistent while middle to lower elevation levels gradually decreased from left to right with significant variations in lower elevation *** the rainy season,surface runoff was abundant,and steep topography exacerbated changes in surface *** route method is suitable for unmanned aerial vehicle(UAV)landslide surveys in complex mountainous *** geomorphological analysis methods used will provide references for identifying and describing topographic

关键词： UAV Landslide Vertical route SfM-MVS Topographic features

Assessment of early factors for identification or prediction severe acute pancreatitis in pregnancy

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World Journal of Clinical Cases 2024年第24期12卷 5502-5512页

作者： Li-Fen Mei Quan Gan Jing hu yun-Xiang Li Rui Tian cheng-Jian Shi Department of Critical Care Medicine Maternal and Child Health Hospital of Hubei ProvinceWuhan 430000Hubei ProvinceChina Department of Biliary-Pancreatic Surgery Tongji Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina

BACKGROUND Acute pancreatitis in pregnancy(APIP)is a rare and serious condition,and severe APIP(SAPIP)can lead to pancreatic necrosis,abscess,multiple organ dysfunction,and other adverse maternal and infant ***,early identification or prediction of SAPIP is *** To assess factors for early identification or prediction of *** The clinical data of patients with APIP were retrospectively *** were classified with mild acute pancreatitis or severe acute pancreatitis,and the clinical characteristics and laboratory biochemical indexes were compared between the two *** regression and receiver operating characteristic curve analyses were performed to assess the efficacy of the factors for identification or prediction of *** A total of 45 APIP patients were *** with the mild acute pancreatitis group,the severe acute pancreatitis group had significantly increased(P<0.01)heart rate(HR),hemoglobin,neutrophil ratio(NEUT%),and neutrophil–lymphocyte ratio(NLR),while lymphocytes were significantly decreased(P<0.01).Logical regression analysis showed that HR,NEUT%,NLR,and lymphocyte count differed significantly(P<0.01)between the *** may be factors for early identification or prediction of *** area under the curve of HR,NEUT%,NLR,and lymphocyte count in the receiver operating characteristic curve analysis was 0.748,0.732,0.821,and 0.774,*** combined analysis showed that the area under the curve,sensitivity,and specificity were 0.869,90.5%,and 70.8%,*** HR,NEUT%,NLR,and lymphocyte count can be used for early identification or prediction of SAPIP,and the combination of the four factors is expected to improve identification or prediction of SAPIP.

关键词： Severe acute pancreatitis in pregnancy Early identification factors Early predictive factors Clinical features Laboratory biochemical index

Late Mesozoic Exhumation of the huangling Massif:Constraints on the Evolution of the Middle Yangtze River

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Acta Geologica Sinica(English Edition) 2024年第1期98卷 250-264页

作者： SU Jianchao LIN Xu LI Chang’an Jolivet MARC WU Lin cheng Feng DENG Bin WU Zhonghai CHEN Xiaokang hu chengwei School of Geography and Information Engineering China University of GeosciencesWuhan 430074China College of Civil Engineering and Architecture China Three Gorges UniversityYichangHubei 443002China Géosciences Rennes CNRS-UMR6118Univ RennesRennesFrance State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBejing 100029China Key Laboratory of Orogenic Belts and Crustal Evolution Ministry of EducationSchool of Earth and Space SciencesPeking UniversityBeijing 100871China State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation/chengdu University of Technology Chengdu 100871China Institute of Geological Mechanics Chinese Academy of Geological ScienceBeijing 100081China

Plate subduction leads to complex exhumation processes on *** huangling Massif lies at the northern margin of the South China *** the huangling Massif was exhumed as a watershed of the middle reaches of the Paleo-Yangtze River during the Mesozoic remains under *** examined the exhumation history of the huangling Massif based on six granite bedrock samples,using apatite fission track(AFT)and apatite and zircon(U-Th)/He(AHe and ZHe)*** samples yielded ages of 157–132 Ma(ZHe),119–106 Ma(AFT),and 114–72 Ma(AHe),*** modeling revealed that three phases of rapid cooling occurred during the Late Jurassic–Early Cretaceous,late Early Cretaceous,and Late *** exhumation processes led to the high topographic relief responsible for the emergence of the huangling *** integrated of our new data with published sedimentological records suggests that the huangling Massif might have been the watershed of the middle reaches of the Paleo-Yangtze River since the *** that time,the rivers flowed westward into the Sichuan Basin and eastward into the Jianghan *** subduction of the Pacific Plate beneath the Asian continent in the Mesozoic deeply influenced the geomorphic evolution of the South China Block.

关键词： apatite zircon (U-Th)/He fission track huangling Massif Yangtze River