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体外药物肝代谢研究进展

第四军医大学学报 2008年第9期29卷 861-863页

作者：陈万平孙翔程鹏远第四军医大学门诊部陕西西安710033 第四军医大学口腔医院修复科陕西西安710033

目的:介绍药物体外肝代谢方法的最新进展.方法:根据近几年的文献资料进行分析、综合、归纳.分别按肝微粒体体外温孵法、肝细胞体外温孵法、肝匀浆体外孵育法进行介绍.结果:体外肝代谢研究方法发展迅速.结论:目前主要的药物体外肝代谢方... 详细信息

目的:介绍药物体外肝代谢方法的最新进展.方法:根据近几年的文献资料进行分析、综合、归纳.分别按肝微粒体体外温孵法、肝细胞体外温孵法、肝匀浆体外孵育法进行介绍.结果:体外肝代谢研究方法发展迅速.结论:目前主要的药物体外肝代谢方法各有利弊,但对于新药开发来都是必不可少的研究手段.

关键词：肝/代谢微粒体肝肝细胞药代动力学

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埋地输油管道腐蚀剩余寿命预测

压力容器 2009年第2期26卷 30-34页

作者：程远鹏白羽李小艳范桓长江大学石油工程学院湖北荆州434023 中国石油管道学院管道运输系河北廊坊065000

针对埋地输油管道的工作特点,研究了长输管道沿线的内压分布,在此基础上建立了基于ASME-B31G标准的腐蚀缺陷极限尺寸模型;根据埋地管道腐蚀失效的特点,以电化学理论为基础,建立了腐蚀缺陷的腐蚀速率模型;将腐蚀缺陷极限尺寸模型与腐蚀... 详细信息

针对埋地输油管道的工作特点,研究了长输管道沿线的内压分布,在此基础上建立了基于ASME-B31G标准的腐蚀缺陷极限尺寸模型;根据埋地管道腐蚀失效的特点,以电化学理论为基础,建立了腐蚀缺陷的腐蚀速率模型;将腐蚀缺陷极限尺寸模型与腐蚀速率模型相结合,提出了一种输油管道腐蚀剩余寿命预测模型。

关键词：埋地管道腐蚀剩余寿命腐蚀速率电化学模型

Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3

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Oncology Research 2025年第1期33卷 103-121页

作者： YAN LU KANG WANG yuanHONG peng MENG CHEN LIN ZHONG LUJI HUANG FU cheng XINDAN SHENG XIN YANG MANZHAO OUYANG GEORGE A.CALIN ZHIWEI HE China-America Cancer Research Institute Guangdong Medical UniversityDongguan523808China GCP Center Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China Department of Gastrointestinal Surgery Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou510080China Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Oncology Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China

Background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors,but the currently used immune checkpoint inhibitors targeting programmed cell death-1(PD-1),programmed cell death ligand-1(PD-L1),and cytotoxic T-lymphocyte antigen-4(CTLA-4)show limited clinical efficacy in many breast cancers.B7H3 has been widely reported as an immunosuppressive molecule,but its immunological function in breast cancer patients remains ***:We analyzed the expression of B7H3 in breast cancer samples using data from the Cancer Genome Atlas Program(TCGA)and the Gene Expression Omnibus(GEO)*** were selected using the TarBase,miRTarBase,and miRBase *** regulatory role of the microRNA hsa-miR-214-3p on B7H3 was investigated through dual-luciferase reporter assays,which identified the specific action sites of *** expression levels of B7H3 and hsa-miR-214-3p in human breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCR(qPCR).In vitro experiments were performed to observe the effects of modulating the expression of B7H3 or hsa-miR-214-3p on breast cancer cell proliferation and ***,the regulatory impact of hsa-miR-214-3p on B7H3 was ***-linked immunosorbent assays(ELISA)and flow cytometry were employed to assess the effects of co-cultured breast cancer cells and normal human peripheral blood mononuclear cells(PBMCs)on immune cells and associated ***:In breast cancer tissues,the expression level of B7H3 is inversely correlated with that of hsa-miR-214-3p,as well as with the regulatory effects on breast cancercell ***-miR-214-3p was found to inhibit breast cancer cell growth by downregulating ***,our research identified,for the first time,two binding sites for hsa-miR-214-3p on the 3’UTR of B7H3,both of which exert similar effects ***-culture experiments revealed that hsamiR-214-3p

关键词： Breast cancer B7H3 Hsa-miR-214-3p Immunotherapy

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水环境中口罩源“塑料际”微生物生态

环境科学 2025年第2期46卷 1193-1202页

作者：彭思伟张广毅焦园园郑州大学水利与交通学院郑州450001 郑州大学地下工程研究院郑州450001

因疫情及其它呼吸道疾病影响,医用口罩常态化使用增加,其废弃物进入环境中风险增大且产生的微塑料可能会对水生态系统产生影响.通过对口罩进入水环境的模拟实验,探究口罩不同层微生物群落多样性、功能、组装机制和相互作用.结果表明,各... 详细信息

因疫情及其它呼吸道疾病影响,医用口罩常态化使用增加,其废弃物进入环境中风险增大且产生的微塑料可能会对水生态系统产生影响.通过对口罩进入水环境的模拟实验,探究口罩不同层微生物群落多样性、功能、组装机制和相互作用.结果表明,各层口罩源“塑料际”有独特的微生物群落,且随时间增加,丰富度逐渐提高.口罩源“塑料际”微生物功能也随时间显著变化,且与致病微生物、光营养、有机物降解和C、N、S元素循环有关.口罩源“塑料际”微生物群落组装机制研究结果表明,随机性过程更为重要(NST>0.5),但随时间增加,确定性过程的作用逐渐提高.共生网络结果表明,不同层口罩源“塑料际”微生物都有较高的模块数和模块化程度,且随着定植时间增加,微生物群落复杂性逐渐降低.口罩源“塑料际”有着独特的生态过程,该研究有助于对口罩源“塑料际”生态效应和微生物定植过程的理解.

关键词：口罩塑料际微生物组装机制生态学

基于神经网络模型的宽带非高斯随机过程疲劳损伤分析

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船舶力学 2025年第1期29卷 85-97页

作者：袁奎霖彭士凤大连理工大学工业装备结构分析国家重点实验室船舶工程学院辽宁大连116024

对于遭受各种随机环境载荷的海洋结构物而言,在设计阶段对其进行疲劳损伤评估尤为重要。海洋结构物的响应经常呈现出宽带特性和非高斯统计特征。因此,本文提出一种基于神经网络模型的宽带非高斯随机过程疲劳损伤评估方法。采用多种功率... 详细信息

对于遭受各种随机环境载荷的海洋结构物而言,在设计阶段对其进行疲劳损伤评估尤为重要。海洋结构物的响应经常呈现出宽带特性和非高斯统计特征。因此,本文提出一种基于神经网络模型的宽带非高斯随机过程疲劳损伤评估方法。采用多种功率谱与不同带宽参数、S-N曲线斜率参数以及非高斯过程偏度与峰度的组合对所提出的神经网络模型进行训练和测试。分析输入层神经元、隐藏层神经元个数以及隐藏层层数对模型预报精度的影响,确定最优的神经网络结构。以时域雨流计数法计算的疲劳损伤结果作为基准,采用真实双模态功率谱进行数值试验,并与多种频域疲劳损伤分析方法进行比较,证明本文所建立的神经网络模型具有更好的准确性和鲁棒性。

关键词：神经网络宽带非高斯过程疲劳损伤雨流计数法

“Zero‑Strain” NiNb_(2)O_(6) Fibers for All‑Climate Lithium Storage

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Nano-Micro Letters 2025年第1期17卷 348-360页

作者： Yan Zhao Qiang yuan Liting Yang Guisheng Liang Yifeng cheng Limin Wu Chunfu Lin Renchao Che College of Physics Donghua UniversityShanghai 201620People’s Republic of China School of Materials Science and Engineering Institute of Materials for Energy and EnvironmentQingdao UniversityQingdao 266071People’s Republic of China Laboratory of Advanced Materials Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsAcademy for Engineering&TechnologyFudan UniversityShanghai 200438People’s Republic of China Zhejiang Laboratory Hangzhou 311100People’s Republic of China Inner Mongolia University Hohhot 010021People’s Republic of China

Niobates are promising all-climate Li^(+)-storage anode material due to their fast charge transport,large specific capacities,and resistance to electrolyte ***,their moderate unit-cellvolume expansion(generally 5%–10%)during Li^(+)storage causes unsatisfactory long-term ***,“zero-strain”NiNb_(2)O_(6) fibers are explored as a new anode material with comprehensively good electrochemical *** Li^(+)storage,the expansion of electrochemical inactive NiO_(6) octahedra almost fully offsets the shrinkage of active NbO_(6) octahedra through reversible O *** superior volume-accommodation capability of the NiO_(6) layers guarantees the“zero-strain”behavior of NiNb_(2)O_(6) in a broad temperature range(0.53%//0.51%//0.74%at 25//−10//60℃),leading to the excellent cyclability of the NiNb_(2)O_(6) fibers(92.8%//99.2%//91.1%capacity retention after 1000//2000//1000 cycles at 10C and 25//−10//60℃).This NiNb_(2)O_(6) material further exhibits a large reversible capacity(300//184//318 mAh g−1 at 0.1C and 25//−10//60℃)and outstanding rate performance(10 to 0.5C capacity percentage of 64.3%//50.0%//65.4%at 25//−10//60℃).Therefore,the NiNb_(2)O_(6) fibers are especially suitable for large-capacity,fast-charging,long-life,and all-climate lithium-ion batteries.

关键词： NiNb_(2)O_(6)porous fiber “Zero-strain”mechanism Electrochemical property Harsh-temperature operation Operando characterization

正交试验法研究X90管线钢在CO_2环境中的腐蚀行为

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腐蚀与防护 2016年第12期37卷 970-972,1002页

作者：刘倩倩李自力程远鹏中国石油大学(华东)储运与建筑工程学院山东省油气储运安全重点实验室青岛266580

通过正交试验法研究了CO_2环境中各因素对X90管线钢腐蚀行为的影响。结果表明:各因素对X90管线钢在CO_2环境中腐蚀速率的影响按大小顺序是原油含水率、温度、CO_2分压、流速;X90管线钢腐蚀产物膜表面布满网状裂纹,呈鳞片状,产物膜结构疏... 详细信息

通过正交试验法研究了CO_2环境中各因素对X90管线钢腐蚀行为的影响。结果表明:各因素对X90管线钢在CO_2环境中腐蚀速率的影响按大小顺序是原油含水率、温度、CO_2分压、流速;X90管线钢腐蚀产物膜表面布满网状裂纹,呈鳞片状,产物膜结构疏松,对基体保护作用较弱,表面点蚀坑较多,点蚀严重,X90管线钢抗CO_2腐蚀性能较差;产物膜成分随腐蚀环境变化而不相同,所有产物中都含有FeCO_3和Fe,部分试样产物膜中还有腐蚀介质析出的碳酸盐。

关键词：正交试验 X90管线钢 CO2腐蚀

The application of moxibustion in infectious skin diseases

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Infectious Diseases Research 2025年第1期6卷 35-42页

作者： Bai Tang Hui yuan Juan Ji peng Lin Lu Pei Institute of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjing 210042China

The skin,being the largest organ in the human body,is susceptible to a wide array of diseases,particularly infectious skin *** of these skin conditions are chronic and challenging to treat,markedly impacting the quality of life for those ***,some chronic skin diseases necessitate the prolonged use of antibiotics,rendering antibiotic resistance *** the problem of antibiotic resistance grows increasingly severe,finding alternative treatment options to antibiotics becomes ***,an integral component of traditional Chinese medicine,stands out as a distinctive external *** a storied history in the realm of dermatological treatment,moxibustion has amassed a wealth of clinical expertise and holds certain advantages,offering viable options for managing skin ***,given the diversity of skin diseases,the application of moxibustion in dermatology requires further exploration and comprehensive ***,the quality of current moxibustion research needs enhancement,necessitating the conduct of high-quality randomized controlled trials to facilitate the integration of moxibustion into dermatological *** mechanism of action for moxibustion is intricate,encompassing thermal effect,light effect,and the pharmacological effect resulting from the burning of *** article aims to encapsulate the mechanisms of moxibustion and its utilization in prevalent infectious skin conditions,while also outlining existing challenges and prospective avenues for development.

关键词： moxibustion infectious skin diseases clinical research mechanism traditional Chinese medicine

NIR-Ⅱfluorescence lateral flow immunosensor based on efficient energy transfer probe for point-of-care testing of tumor biomarkers

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Chinese Chemical Letters 2025年第1期36卷 469-473页

作者： Zhaorui Song Qiulian Hao Bing Li Yuwei yuan Shanshan Zhang Yongkuan Suo Hai-Hao Han Zhen cheng Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug DiscoveryYantai 264117China State Key Laboratory of Drug Research Molecular Imaging CenterShanghai Institute of Materia MedicaShanghai 201203China Institute of Molecular Medicine Joint Laboratory for Molecular Medicine Northeastern University Shenyang 110000China Pharmacy College Shandong First Medical University&Shandong Academy of Medical SciencesJi’nan 250117China University of Chinese Academy of Sciences Beijing 100049China

Fluorescence lateral flow immunoassay(LFA)has emerged as a powerful tool for rapid screening of various biomarkers owing to its simplicity,sensitivity and *** is noteworthy that fluorescent probe mainly determines the analytical performance of *** to the emission and excitation wavelengths are located in the visible region,most fluorophores are inevitably subject to light scattering and background ***,we reported a novel LFA sensor based on the second near-infrared(NIR-Ⅱ)fluorescent probe with excellent anti-interference *** designed NIR-Ⅱprobe was the Nd^(3+)and Yb^(3+)doped rare earth nanoparticles(RENPs)by employing Nd^(3+)as energy donor and Yb^(3+)as energy acceptor,which of the donor-acceptor energy transfer(ET)efficiency reached up to 80.7%.Meanwhile,relying on the convenient and effective encapsulation strategy of poly(lactic-co-glycolic acid)(PLGA)microspheres to RENPs,the surface functionalized NIR-Ⅱprobe(RE@PLGA)was obtained for subsequent *** from the optical advantages of NIR-Ⅱprobe,this proposed NIR-ⅡLFA displayed a good linear relationship ranging from 7 ng/mL to 200 ng/mL for the detection ofα-fetoprotein(AFP),an important biomarker of hepatocellular carcinoma(HCC).The limit of detection(LOD)was determined as low as 3.0 ng/m L,which was of 8.3 times lower than clinical cutoff *** is promising that LFA sensor based on this efficient RENPs probe provides new opportunities for high sensitive detection of various biomarkers in biological samples.

关键词： Donor-acceptor energy transfer(ET) Lateral flow immunoassay(LFA) The second near-infrared(NIR-Ⅱ) fluorescence Rare-earth nanoparticles(RENPs) Poly(lactic acid-co-glycolic acid)(PLGA) Tumor biomarker