检索结果-南通市图书馆

Efficacy of comprehensive remote ischemic conditioning in elderly patients with acute ST-segment elevation myocardial infarction underwent primary percutaneous coronary intervention

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2022年第6期19卷 435-444页

作者： yan-Ling WANG Qi yanG cheng-yan hu yan-yan Chu Zheng SUN huan ZHAO Zhi LIU Department of Cardiology Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Radiology Chaoyang HospitalCapital Medical UniversityBeijingChina Department of Radiology Xuanwu HospitalCapital Medical UniversityBeijingChina

BACKGROUND Remote ischemic conditioning(RIC)is used to protect against myocardial ***,there is no adequate evidence for comprehensive RIC in elderly patients with ST-segment elevation myocardial infarction(STEMI).This study aimed to test whether comprehensive RIC,started pre-primary percutaneous coronary intervention(PPCI)and repeated daily on 1-30 days post-PPCI,can improve myocardial salvage index(SI),left ventricular ejection fraction(LVEF),Kansas City Cardiomyopathy Questionnaire Clinical Summary Score(KCCQ-CSS)and 6-min walk test distance(6MWD)in elderly patients with acute STEMI during 12 months *** 328 consenting elderly patients were randomized to receive standard PPCI plus comprehensive RIC(the treatment group)or standard PPCI(the control group).SI at 5-7 days after PPCI,LVEF,left ventricular end-diastolic volume index(LVEDVI),left ventricular end-systolic volume index(LVESVI),KCCQ-CSS,6MWD and adverse events rates were measured and *** SI was significantly higher in the treatment group[interquartile range(IQR):0.38-0.66,P=0.037].There were no significant differences in major adverse events at 12 *** the differences of LVEDVI,LVESVI and LVEF between the treatment group and the control group did not reach statistical significance at 6 months and 12 months,LVEF tended to be higher,LVEDVI tended to be lower in the treatment *** KCCQ-CSS was significantly higher in the treatment group at 1 month(IQR:46.5-87,P=0.001)and 12 months(IQR:55-93,P=0.008).There was significant difference in 6MWD between the treatment group and the control group(IQR:258-360 ***:250-345,P=0.002)at 1 month and(IQR:360-445 ***:345-432,P=0.035)at 12 months.A modest correlation was found between SI and LVEF(r=0.452,P<0.01),KCCQ-CSS(r=0.440,P<0.01)and 6MWD(r=0.384,P<0.01)respectively at 12 *** The comprehensive RIC can improve SI,KCCQ-CSS and *** may be an adjunctive therapy to PPCI in elderly patients with STEMI

关键词： patients infarction coronary

Effect of cytochrome P4502C19(CYP2C19)gene polymorphism and clopidogrel reactivity on long term prognosis of patients with coronary heart disease after PCI

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2024年第1期21卷 90-103页

作者： cheng-yan hu yan-Ling WANG Zhen-Xing FAN Xi-Peng SUN Shuai WANG Zhi LIU Department of Geriatrics Fu Xing HospitalCapital Medical UniversityBeijingChina Department of Cardiology Xuanwu Hospital Capital Medical UniversityBeijingChina Emergency Department of Xuanwu Hospital Capital Medical UniversityBeijingChina

Objective To investigate the impact of CYP2C19 gene polymorphism on clopidogrel reactivity and its association with longterm clinical outcome in patients with coronary heart disease(CHD)undergoing percutaneous coronary intervention(PCI).Methods In total,675 patients were *** on the platelet inhibition rate,patients were categorized into two groups:clopidogrel low responsiveness(CLR)and normal clopidogrel responsiveness(NCR).The CLR group was divided into ticagrelor and clopidogrel group based on the antiplatelet drugs used in the follow-up *** were classified into three groups(normal metabolizer,intermediate metabolizer,and poor metabolizer)based on the CYP2C19 *** aimed to evaluate the impact of CYP2C19 gene polymorphism on clopidogrel *** cumulative rates of 12-month all-cause deaths,major adverse cardiovascular events(MACCEs),and bleeding events were *** CLR was observed in 44.4%of the overall *** differences were observed in the platelet inhibition rate of clopidogrel among the three metabolic genotypes(P0.05).Conclusions Low response to clopidogrel in CHD patients is correlated with CYP2C19 gene ***2C19 genotyping combined with platelet reactivity is an independent predictor of 12-months MACCEs in patients with clopidogrel treatment after PCI,which is better than either test alone.

关键词： CYP2C19 drugs PCI

Acid-catalyzed chemoselective C-and O-prenylation of cyclic 1,3-diketones

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Catalysis 2020年第9期41卷 1401-1409页

作者： Ying Li yan-cheng hu Ding-Wei Ji Wei-Song Zhang Gu-cheng He Yu-Feng Cong Qing-An Chen Dalian Institute of Chemical Physics Chinese Academy of SciencesDalian 116023LiaoningChina College of Chemistry Chemical Engineering and Environmental EngineeringLiaoning Shihua UniversityFushun 113001LiaoningChina

The chemoselective C-and O-prenylation of cyclic 1,3-diketones was achieved by tuning the prenyl source and *** the presence of the solid acid Nafion,the coupling of 1,3-cyclohexanediones with isoprene gave C-prenylated ***,using prenol as the substrate with the Lewis acid Al Cl3 as the catalyst resulted in the exclusive O-prenylation of 1,***,the resulting products could easily undergo aromatization to deliver prenylated resorcinols that are otherwise difficult to *** methodology is highly selective,atom-economical,operationally simple,easily scalable,and has potential applications throughout organic synthesis.

关键词： 5-Chromenones 1 3-Cyclohexanediones O-Prenylation [3+3]Annulation Isoprene Prenol

Research on Adaptability of Construction Project from Point of Ecology

在线全文

学校读者我要写书评

暂无评论

工程科学（英文版） 2007年第3期5卷 95-100页

作者： Lu yan,cheng hu,Chen Shouke(Project Management Research Institute,Southeast University,Nanjing,210096)

Concept of zoology energy is advanced,zoology energy development trend line and zoology energy development curve of construction project are traced out in this *** the point of construction project itself,its adaptability can be shown in its own strong zoology energy,dominant in zoology energy sequence of its engineering population,great niche breath and less superpostion(overlap) in its engineering *** of construction project is researched from the angle of ecology which can be taken as basic research of consistent development of construction project,and enrich evaluation system of construction project.

关键词： ecology Construction project adaptability zoology energy niche

Catalytic C2 prenylation of unprotected indoles:Late‐stage diversification of peptides and two‐step total synthesis of tryprostatin B

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Catalysis 2021年第9期42卷 1593-1607页

作者： yan‐cheng hu Ying Li Ding‐Wei Ji Heng Liu Hao Zheng Gong Zhang Qing‐An Chen Dalian Institute of Chemical Physics Chinese Academy of SciencesDalian 116023LiaoningChina University of Chinese Academy of Sciences Beijing 100049China

C2 prenylated indoles are widespread in a variety of bioactive natural ***,theselective installation of prenyl group at C2 position of NH indoles is of great ***,the known protocols generally require a multi‐step procedure and stoichiometric *** develop a one‐step C2 prenylation of NH indole with cheap tert‐prenyl alcohol enabled by *** features include good regioselectivity,step‐and atom‐economy,broad substratescope,and simple catalytic *** mechanistic investigations demonstrate that both C2prenylation and C3 prenylation/migration pathways are engaged in the ***,this practicalstrategy can be applied to the late‐stage diversification of tryptophan‐based peptides and concisesynthesis of tryprostatin B.

关键词： Indole prenylation Step economy Atom economy Tryptophan Peptide diversification Total synthesis

Mapping Major Restore Genes for C-type Cytoplasmic Male Sterility in Maize with SSR Marker

在线全文

学校读者我要写书评

暂无评论

Agricultural Sciences in China 2002年第3期1卷 269-273页

作者： TANG Ji-hua, LIU Zong-hua, CHEN Wei-cheng, hu yan-min, JI Hong-qiang, JI Liang-yue, XIE hui-ling and huANG Xi-lin(Henan Agricultural University, Zhengzhou 450002 ) Henan Agricultural University Zhengzhou 450002

Through observation about the restoration of male fertility of F2 and BC, progeny, we found that the restoring line Fengkel had two duplicating restorer genes. The restorer gene R/5 in Fengkel background was located on chromosome 5L by SSR method; it linked with bnlg1711, bnlg1346 and phi058, the genetic distances with bnlg1711, bnlg1346, and phi058 were 7.51cM, 1.68cM, and 9.87cM respectively; the restorer gene Rf4 was mapped on chromosome 8S linked with bnlg2307.

关键词： Maize C-cytopIasmic male sterility Restorer genes SSR makers

A Novel Model for Describing Rail Weld Irregularities and Predicting Wheel-Rail Forces Using a Machine Learning Approach

在线全文

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2025年第1期142卷 555-577页

作者： Linlin Sun Zihui Wang Shukun Cui Ziquan yan Weiping hu Qingchun Meng State Key Laboratory of High-Speed Railway Track System China Academy of Railway Sciences Corporation LimitedBeijing100081China Railway Engineering Research Institute China Academy of Railway Sciences Corporation LimitedBeijing100081China School of Aeronautic Science and Engineering Beihang UniversityBeijing100191China

Rail weld irregularities are one of the primary excitation sources for vehicle-track interaction dynamics in modern high-speed *** can cause significant wheel-rail dynamic interactions,leading to wheel-rail noise,component damage,and *** researchers have employed the vehicle-track interaction dynamic model to study the dynamic interactions between wheel and rail induced by rail weld geometry ***,the cosine wave model used to simulate rail weld irregularities mainly focuses on the maximum value and neglects the geometric *** this study,novel theoretical models were developed for three categories of rail weld irregularities,based on measurements of the high-speed railway from Beijing to *** vertical dynamic forces in the time and frequency domains were compared under different running *** forces generated by the rail weld irregularities that were measured and modeled,respectively,were compared to validate the accuracy of the proposed ***,based on the numerical study,the impact force due to rail weld irrregularity is modeled using an Artificial Neural Network(ANN),and the optimum combination of parameters for this model is *** results showed that the proposed model provided a more accurate wheel/rail dynamic evaluation caused by rail weld irregularities than that established in the *** ANN model used in this paper can effectively predict the impact force due to rail weld irrregularity while reducing the computation time.

关键词： Rail weld irregularity high-speed railway vehicle-track coupled dynamics wheel/rail dynamic vertical force artificial neural networks

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

适用于折弯机的专用比例阀

液压与气动 2015年第3期39卷 80-82页

作者：杨敬强成沪燕伊顿流体动力(上海)有限公司产品工程部上海200131

介绍了一种通过改变阀芯机能而满足折弯机高速、平稳、准确和同步控制的专用比例阀解决方案。通过对折弯机的工况特点分析,得出了附带压力与阀芯机能的相互转化关系。试验结果表明,专用比例阀有效解决了附带压力问题,提高了控制效果。

关键词：折弯机比例阀芯典型应用同步控制

Repetitive transcranial magnetic stimulation in Alzheimer’s disease:effects on neural and synaptic rehabilitation

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 326-342页

作者： Yi Ji Chaoyi yang Xuerui Pang Yibing yan Yue Wu Zhi Geng Wenjie hu Panpan hu Xingqi Wu Kai Wang Department of Neurology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders HefeiAnhui ProvinceChina Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health HefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina Department of Psychology and Sleep Medicine The Second Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina

Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and *** Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neurodegeneration and ultimately disrupting the operational abilities in daily life,leaving patients *** transcranial magnetic stimulation is a cost-effective,neuro-modulatory technique used for multiple neurological *** the past two decades,it has been widely used to predict cognitive decline;identify pathophysiological markers;promote neuroplasticity;and assess brain excitability,plasticity,and *** has also been applied to patients with dementia,because it can yield facilitatory effects on cognition and promote brain recovery after a neurological ***,its therapeutic effectiveness at the molecular and synaptic levels has not been elucidated because of a limited number of *** study aimed to characterize the neurobiological changes following repetitive transcranial magnetic stimulation treatment,evaluate its effects on synaptic plasticity,and identify the associated *** review essentially focuses on changes in the pathology,amyloidogenesis,and clearance pathways,given that amyloid deposition is a major hypothesis in the pathogenesis of Alzheimer’s *** mechanisms associated with repetitive transcranial magnetic stimulation procedures and different pathways mediating gene transcription,which are closely related to the neural regeneration process,are also ***,we discuss the outcomes of animal studies in which neuroplasticity is modulated and assessed at the structural and functional levels by using repetitive transcranial magnetic stimulation,with the aim to highlight future directions for better clinical translations.

关键词： Alzheimer’s disease amyloid deposition apoptotic mechanisms biomarker neural regeneration neurodegeneration repetitive transcranial magnetic stimulation synaptic plasticity