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Diversity of bacterial lactase genes in intestinal contents of mice with antibiotics-induced diarrhea

World Journal of Gastroenterology 2017年第42期23卷 7584-7593页

作者： cheng-xing long Lu He Yan-Fang Guo Ya-Wei Liu Nen-Qun Xiao Zhou-Jin Tan Department of Microbiology Hunan University of Chinese Medicine College of Mathematics and Finance Hunan University of HumanitiesScience and Technology Loudi 417000Hunan Province China

AIM To investigate the diversity of bacterial lactase genes in the intestinal contents of mice with antibiotics-induced *** Following 2 d of adaptive feeding, 12 specific pathogenfree Kunming mice were randomly divided into the control group and model group. The mouse model of antibiotics-induced diarrhea was established by gastric perfusion with mixed antibiotics(23.33 m L·kg^(-1)·d^(-1)) composed of gentamicin sulfate and cephradine capsules administered for 5 days, and the control group was treated with an equal amount of sterile water. Contents of the jejunum and ileum were then collected and metagenomic DNA was extracted, after which analysis of bacterial lactase genes using operational taxonomic units(OTUs) was carried outafter amplification and *** OTUs were 871 and 963 in the model group and control group, respectively, and 690 of these were identical. There were significant differences in Chao1 and ACE indices between the two groups(P < 0.05). Principal component analysis, principal coordination analysis and nonmetric multidimensional scaling analyses showed that OTUs distribution in the control group was relatively intensive, and differences among individuals were small, while in the model group, they were widely dispersed and more diversified. Bacterial lactase genes from the intestinal contents of the control group were related to Proteobacteria, Actinobacteria, Firmicutes and unclassified bacteria. Of these, Proteobacteria was the most abundant phylum. In contrast, the bacterial population was less diverse and abundant in the model group, as the abundance of Bradyrhizobium sp. BTAi1, Agrobacterium sp. H13-3, Acidovorax sp. KKS102, Azoarcus sp. KH32 C and Aeromonas caviae was lower than that in the control group. In addition, of the known species, the control group and model group had their own unique genera, *** Antibiotics reduce the diversity of bacterial lactase genes in the intestinal contents, decreas

关键词： Antibiotics-induced diarrhea Lactase genes Gene diversity Intestinal bacteria High-throughput sequencing

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泄泻肝气乘脾造模对小鼠血常规及脏器的影响

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世界华人消化杂志 2020年第9期28卷 330-334页

作者：吴仪龙承星湖南中医药大学湖南省长沙市410208 湖南人文科技学院数学与金融学院湖南省娄底市417000

背景肝气乘脾是中医辩证施治泄泻最常见的证型.肝脏体阴用阳,若肝气疏泄功能不畅亦会影响肝藏血的功能.本研究采用复合因素造模,以血常规为载体,探究此模型对机体血液的影响,并为临床提供一定的指导和思路.目的探究泄泻肝气乘脾造模对... 详细信息

背景肝气乘脾是中医辩证施治泄泻最常见的证型.肝脏体阴用阳,若肝气疏泄功能不畅亦会影响肝藏血的功能.本研究采用复合因素造模,以血常规为载体,探究此模型对机体血液的影响,并为临床提供一定的指导和思路.目的探究泄泻肝气乘脾造模对小鼠血常规及脏器的影响.方法将20只实验小鼠随机分成正常组、模型组,模型组采用番泻叶-束缚夹尾法7 d制备泄泻肝气乘脾小鼠模型.实验期间观察小鼠一般状态及泄泻情况,造模成功后进行血常规检测及肝、脾、胸腺称重.结果造模7 d后番泻叶-束缚夹尾使模型小鼠出现情绪亢奋,腹泻程度严重,刺激腹泻明显的症状;与正常组相比,模型组血小板计数(platelet count,PLT)、血小板比容均下降且具有显著性差异(P<0.05),模型组小鼠白细胞降低且具有显著性差异,模型组胸腺系数降低有显著的统计学差异.结论泄泻肝气乘脾造模减少PLT,降低小鼠凝血功能,并减少白细胞数量和胸腺指数降低小鼠免疫功能.

关键词：泄泻肝气乘脾血常规免疫器官系数肝脾不调脾虚

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三元体系硼酸钾+硼酸铷+水和硼酸铷+硼酸镁+水323 K相平衡

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高校化学工程学报 2018年第3期32卷 514-521页

作者：于旭东刘敏王林程兴龙曾英成都理工大学材料与化学化工学院四川成都610059 四川省攀西战略矿产资源综合利用协同创新中心四川成都610059

含硼卤水中硼酸根存在形式多样,给硼酸盐的分离纯化带来一定难度,开展含硼体系相平衡研究,可为含硼卤水综合利用工艺制定提供支撑。采用等温溶解平衡法研究了323 K下三元体系硼酸钾+硼酸铷+水和硼酸铷+硼酸镁+水的相平衡关系,测定了上... 详细信息

含硼卤水中硼酸根存在形式多样,给硼酸盐的分离纯化带来一定难度,开展含硼体系相平衡研究,可为含硼卤水综合利用工艺制定提供支撑。采用等温溶解平衡法研究了323 K下三元体系硼酸钾+硼酸铷+水和硼酸铷+硼酸镁+水的相平衡关系,测定了上述两个体系平衡时各组分的溶解度和平衡液相密度、折光率,根据溶解度数据和固相组成绘制了三元体系相图、密度-组成图、折光率-组成图。研究发现:两个三元体系均为简单共饱和型,无复盐或固溶体生成。两个三元体系相图均为水合物Ⅰ型相图,由1个共饱点,2条单变量曲线和2个结晶区组成。研究还对三元体系硼酸铷+硼酸镁+水在323和348 K不同温度时的稳定相图作了对比分析和讨论。

关键词：相平衡溶解性水合物热力学铷盐硼酸盐

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Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong Li Hui-Min xing Hai-Dong Qian Qiao Gao Sheng-Lan Xu Hua Ma Zai-long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles

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An Unprecedented Efficiency with Approaching 21%Enabled by Additive‑Assisted Layer‑by‑Layer Processing in Organic Solar Cells

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Nano-Micro Letters 2025年第2期17卷 372-375页

作者： Shuai Xu Youdi Zhang Yanna Sun Pei cheng Zhaoyang Yao Ning Li long Ye Lijian Zuo Ke Gao Key Laboratory of Advanced Green Functional Materials College of ChemistryChangchun Normal UniversityChangchun 130032People’s Republic of China Shandong Provincial Key Laboratory for Science of Material Creation and Energy Conversion School of Chemistry and Chemical EngineeringShandong UniversityQingdao 266237People’s Republic of China College of Polymer Science and Engineering Sichuan UniversityChengdu 610065People’s Republic of China State Key Laboratory and Institute of Elemento‑Organic Chemistry Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer MaterialsRenewable Energy Conversion and Storage Center(RECAST)College of ChemistryNankai UniversityTianjin 300071People’s Republic of China Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and Devices South China University of TechnologyGuangzhou 510640People’s Republic of China Tianjin Key Laboratory of Molecular Optoelectronic Sciences School of Materials Science and EngineeringTianjin UniversityTianjin 300350People’s Republic of China State Key Laboratory of Silicon Materials MOE Key Laboratory of Macromolecular Synthesis and FunctionalizationDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China

Recently published in Joule,Feng Liu and colleagues from Shanghai Jiaotong University reported a record-breaking 20.8%power conversion efficiency in organic solar cells(OSCs)with an interpenetrating fibril network active layer morphology,featuring a bulk p-in structure and proper vertical segregation achieved through additive-assisted layer-by-layer *** optimized hierarchical gradient fibrillar morphology and optical management synergistically facilitates exciton diffusion,reduces recombination losses,and enhances light capture *** approach not only offers a solution to achieving high-efficiency devices but also demonstrates the potential for commercial applications of OSCs.

关键词： Organic solar cells Additive-assisted layer-by-layer processing Three-dimensional fibril morphology Bulk p-i-n structure Optical management

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Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen Chen Xiaolin Zeng Le Wang Wenwu Zhang Gang Li xing cheng Peiqiang Su Yong Wan Xiang Li Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

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Crystallization Modulation and Holistic Passivation Enables Efficient Two‑Terminal Perovskite/CuIn(Ga)Se_(2)Tandem Solar Cells

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Nano-Micro Letters 2025年第1期17卷 205-215页

作者： Cong Geng Kuanxiang Zhang Changhua Wang Chung Hsien Wu Jiwen Jiang Fei long Liyuan Han Qifeng Han Yi‑Bing cheng Yong Peng State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070People’s Republic of China Triumph Photovoltaic Materials Co. Ltd.No.1001 Yannan AvenueHigh‑Tech Development DistrictBengbuAnhui 233000People’s Republic of China College of Materials Science and Engineering Guilin University of TechnologyGuilin 541004People’s Republic of China State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Two-terminal(2-T)perovskite(PVK)/CuIn(Ga)Se_(2)(CIGS)tandem solar cells(TSCs)have been considered as an ideal tandem cell because of their best bandgap matching regarding to Shockley–Queisser(S–Q)***,the nature of the irregular rough morphology of commercial CIGS prevents people from improving tandem device *** this paper,D-homoserine lactone hydrochloride is proven to improve coverage of PVK materials on irregular rough CIGS surfaces and also passivate bulk defects by modulating the growth of PVK *** addition,the minority carriers near the PVK/C60 interface and the incompletely passivated trap states caused interface recombination.A surface reconstruction with 2-thiopheneethylammonium iodide and N,N-dimethylformamide assisted passivates the defect sites located at the surface and grain ***,LiF is used to create this field effect,repelling hole carriers away from the PVK and C60 interface and thus reducing *** a result,a 2-T PVK/CIGS tandem yielded a power conversion efficiency of 24.6%(0.16 cm^(2)),one of the highest results for 2-T PVK/CIGS TSCs to our *** validation underscores the potential of our methodology in achieving superior performance in PVK/CIGS tandem solar cells.

关键词： PVK/CIGS TSCs Irregular rough surfaces Modulating the growth PVK/C60 interface recombination

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四元含锂铷氯化物水盐体系298.2 K介稳相平衡研究

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四川大学学报（自然科学版） 2018年第3期55卷 579-584页

作者：陈杰曾英程兴龙于旭东成都理工大学材料与化学化工学院成都610059 攀西战略矿产资源综合利用协同创新中心成都610059

采用等温蒸发法研究了四元含锂铷氯化物体系Li+,Na+,Rb+//Cl--H2O 298.2K下的相平衡关系,测定了平衡液相的溶解度、密度和折光率.基于实验数据,绘制了该四元体系的立体图、干基图、密度-组成图和折光率-组成图.该四元体系298.2K下的介... 详细信息

采用等温蒸发法研究了四元含锂铷氯化物体系Li+,Na+,Rb+//Cl--H2O 298.2K下的相平衡关系,测定了平衡液相的溶解度、密度和折光率.基于实验数据,绘制了该四元体系的立体图、干基图、密度-组成图和折光率-组成图.该四元体系298.2K下的介稳相图由1个共饱和点,3条单变量曲线和3个结晶区(RbCl、NaCl、LiCl·H2O)组成.将研究的结果同LiCl+KCl+RbCl+H2O体系进行了对比和分析,总结Na+和K+对三元体系Li+,Rb+//Cl--H2O的影响.应用折光率计算的经验公式对实验测定的折光率进行了验证,其最大绝对误差小于-0.0090,从而证明了实验数据的可靠性.

关键词：地下卤水相平衡溶解度相图铷盐

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终端区进场航线交叉点通行能力研究

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科学技术与工程 2017年第10期17卷 62-67页

作者：王宽朱承元王兴隆中国民航大学空中交通管理学院天津300300

终端区航线交叉点是空中交通运行的瓶颈,其通行能力是表征交叉点运行状态的重要指标,深入研究交叉点的通行能力,能够为进离场航线优化及航线网规划提供理论指导,并为减少航班延误提供必要的技术支持。借鉴地面道路交叉口通行能力已有研... 详细信息

终端区航线交叉点是空中交通运行的瓶颈,其通行能力是表征交叉点运行状态的重要指标,深入研究交叉点的通行能力,能够为进离场航线优化及航线网规划提供理论指导,并为减少航班延误提供必要的技术支持。借鉴地面道路交叉口通行能力已有研究成果,依据终端区空域结构及航空器飞行特征,创新地提出终端区进场航线交叉点通行能力定义,建立了计算模型,深入分析了航空器飞行速度、机型组合、航线夹角对通行能力的影响。以天津机场终端区为例,计算进场航线交叉点CG点的通行能力,进行了实例验证及分析。

关键词：终端区航线交叉点通行能力航空器速度机型组合航线夹角仿真分析

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三元体系CsCl+MgCl_2+H_2O 298 K介稳相平衡研究

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化学工程 2018年第6期46卷 42-46页

作者：邬莉婷程兴龙曾英于旭东成都理工大学材料与化学化工学院四川成都610059 成都理工大学矿产资源化学四川省高校重点实验室四川成都610059

采用等温蒸发法研究三元体系CsCl+MgCl_2+H_2O 298 K的介稳相平衡。结果发现,相图包含2个共饱点,3条溶解度曲线和3个结晶相区。3个结晶区分别为单盐CsCl,MgCl_2·6H_2O和复盐CsCl·MgCl_2·6H_2O的结晶区。此体系有复盐铯光卤石形成,为... 详细信息

采用等温蒸发法研究三元体系CsCl+MgCl_2+H_2O 298 K的介稳相平衡。结果发现,相图包含2个共饱点,3条溶解度曲线和3个结晶相区。3个结晶区分别为单盐CsCl,MgCl_2·6H_2O和复盐CsCl·MgCl_2·6H_2O的结晶区。此体系有复盐铯光卤石形成,为复杂三元体系。由相图可知,铯光卤石CsCl·MgCl_2·6H_2O的复盐射线(CW)通过其溶解度曲线(E1E2),属同成分复盐。随着复盐的形成,相图中出现2个共饱点,在共饱点处,均有2种盐和一种平衡溶液达到共饱和。2个共饱点对应的饱和盐分别为MgCl_2·6H_2O+CsCl·MgCl_2·6H_2O和CsCl+CsCl·MgCl_2·6H_2O,且2个共饱点均位于其相应组分点构成的三角形之内,均属于相称共饱点。3种盐结晶区大小按以下顺序排列:CsCl·MgCl_2·6H_2O>CsCl>MgCl_2·6H_2O,其中CsCl·MgCl_2·6H_2O结晶区最大,意味着复盐CsCl·MgCl_2·6H_2O比其他盐更容易析出。

关键词：介稳相平衡铯盐光卤石 298 K

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