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Docosahexaenoic acid suppresses arachidonic acid-induced proliferation of LS-174T human colon carcinoma cells

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World Journal of Gastroenterology 2009年第9期15卷 1079-1084页

作者： Piet Habbel Karsten H Weylandt Katja Lichopoj Johannes Nowak Martin Purschke Jing-Dong Wang cheng-wei he Daniel C Baumgart Jing X Kang Department of Medicine Massachusetts General Hospital and Harvard Medical School Boston MA 02114 United States Department of Medicine Division of Gastroenterology and Hepatology Charité Medical Center-Virchow-Hospital Medical School of the Humboldt-University of Berlin 13344 Berlin Germany

AIM： To investigate the impact of arachidonic acid （AA） and docosahexaenoic acid （DHA） and their combination on colon cancer cell growth. METHODS： The LS-174T colon cancer cell line was used to study the role of the prostaglandin precursor AA and the omega-3 polyunsaturated fatty acid DHA on cell growth. Cell viability was assessed in XTT assays. For analysis of cell cycle and cell death, flow cytometry and DAPI staining were applied. Expression of cyclooxygenase-2 （COX-2）, p21 and bcl-2 in ceils incubated with AA or DHA was examined by real-time RT-PCR. Prostaglandin E2 （PGE2） generation in the presence of AA and DHA was measured using a PGE2- ELISA. RESULTS： AA increased cell growth, whereas DHA reduced viability of LS 174T cells in a time- and dosedependent manner. Furthermore, DHA down- regulated mRNA of bcl-2 and up-regulated p21. Interestingly, DHA was able to suppress AA-induced cell proliferation and significantly lowered AA-derived PGE2 formation. DHA also down-regulated COX-2 expression. In addition to the effect on PGE2 formation, DHA directly reduced PGE2-induced cell proliferation in a dosedependent manner. CONCLUSION： These results suggest that DHA can inhibit the pro-proliferative effect of abundant AA or PGE2.

关键词： Colorectal carcinoma Colon cancer Omega-3 Omega-6 Polyunsaturated fatty acids Arachidonic acid Docosahexaenoic acid ProstaglandinE2 Cyclooxygenase-2 Apoptosis

Three-dimensional fracture of UO2 ceramic pellets by phase field modeling

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 169-180页

作者： wei Xiong Xuan Ye Hongzhang cheng Xiaoming Liu Institute of Nuclear and New Energy Technology Collaborative Innovation Center of Advanced Nuclear Energy Technology Key Laboratory of Advanced Reactor Engineering and Safety of Ministry of Education Tsinghua University State Key Laboratory of Nonlinear Mechanics Institute of Mechanics Chinese Academy of Sciences School of Engineering Science University of Chinese Academy of Sciences

Fracture is the primary failure type for the UO2ceramic pellets,which are operated under irradiation and thermal processes,and physically confined by the *** this work,by combining closely coupled physical processes of heat conduction,heat transfer,and mechanical deformation with the cohesive phase field framework,we proposed a high-precision modeling of quasistatic cracking of three-dimensional （3D） UO2ceramic fuel pellets under high temperature and *** simulation results agree well with the experimental results,indicating that the proposed method has the potential to capture 3D crack modes in the interested time ***,we studied the relation of the 3D fracture patterns of fuel pellets with the peak power *** was found that the power level plays a critical role in determining the competition between radial and circumferential cracks,as well as transverse penetrating cracks.

关键词： phase field method nuclear fuel pellet coupled thermo-mechanical model thermal fracture

Synthesis and Antimicrobial Activities of Novel Sulfonamide-derived Aralkyl 1,2,3-Triazole Derivatives

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Synthesis and Antimicrobial Activities of Novel Sulfonamide-...

A mild, configurable, flexible CoNi-LDH（v）/Zn battery based on H-vacancy-induced reversible Zn2+ intercalation

第六届全国化学生物学学术会议

作者： Xian-Long Wang,Jin-Jian wei,cheng-he Zhou~* School of Chemistry and Chemical Engineering,Southwest University,Chongqing 400715

＜正＞The research and application of sulfonamides as antibacterial and antifungal agents are very widely used in medicinal chemistry *** their clinical use of sulfonamides was gradually limited as a result of the eme... 详细信息

关键词： Antimicrobial Sulfonamide 1,2,3-Triazole

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Journal of Energy Chemistry 2025年第1期100卷 498-508页

作者： Xinyue cheng Dingsheng Wu Hao Gao Qingqing Wang Pengfei Lv Sam S.Yoon Qufu wei Key Laboratory of Eco-textiles Ministry of Education Jiangnan University School of Mechanical Engineering Korea University

Flexible Zn-based batteries have attracted increasing research interest as essential components of wearable energy storage ***,the advancement of flexible aqueous Zn-based batteries based on Co-Ni layered double hydroxide （CoNi-LDH） as the cathode material is hampered by their poor cycling stability and the corrosiveness of alkaline ***,CoNi-LDH nanosheets enriched with H vacancies (CoNi-LDH（v）) were constructed on a flexible carbon cloth （CC） substrate via electrochemical deposition and *** Zn-based battery comprising CoNi-LDH（v）@CC as the cathode exhibited highly reversible conversion reactions and stable operation in 3 M ZnSO4electrolyte （pH=4）.The battery delivered an excellent specific capacity (225 mA h g-1,0.26 mA h cm-2),acceptable cycling stability（53.9%,900 cycles）,and high discharging *** abundant H vacancies served as active sites for the reversible intercalation of Zn2+and the extravasation of NO3-generated channels and space for Zn2+transport and storage,together enabling an excellent Zn2+storage ***,a sandwich-structured solid-state CoNi-LDH（v）@CC//Zn@CC battery was fabricated and was found to exhibit a noteworthy electrochemical performance and mechanical *** a proof of concept,the unencapsulated battery powered a digital watch under various deformation conditions and operated stably for 80 ***,the flexible battery displayed outstanding customizability,maintaining an open-circuit voltage of 1.42 V even after being cut *** proposed engineering strategy contributes to the realization of textiles with truly wearable energy-storage devices.

关键词： CoNi/Zn battery H vacancies Mild aqueous electrolyte Tailorable battery Wearable energy storage device

RNA interference by expression of short hairpin RNAs suppresses bcl-xL gene expression in nasopharyngeal carcinoma cells

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Acta Pharmacologica Sinica 2005年第2期26卷 228-234页

作者： Fang LIU~2,cheng-wei he,Yue-fei ZHANG~4,Ke-yuan ZHOU~3~2Institute of Biochemistry and Molecular Biology ~4Department of Otorhinolaryngology,The First Affiliated Hospital,Guangdong MedicalCollege,Zhanjiang 524023,China Institute of Biochemistry and Molecular Biology The First Affiliated Hosptial Guangdong Medical College Zhanjiang 524023 China

Aim:To evaluate a new plasmid mediated RNA interference(RNAi)system andinvestigate whether knock-down of bcl-xL by short hairpin RNA(shRNA)caninduce apoptosis of human nasopharyngeal carcinoma(NPC)cell line CNE-2Z ***:The plasmid containing mU6 promoter was subcloned to yield thepmU6 plasmid,recombinant plasmid expressing shRNA targeting bcl-xL gene wasdesigned and constructed,and were co-transfected cells with green fluorescenceprotein expressing *** cytometry was used to evaluate transfectionefficiency,and RT-PCR and Western blot were applied to analyze bcl-xL mRNAand protein levels,***:The shRNA expressed by the recombi-nant plasmid efficiently suppressed bcl-xL gene expression and induced apoptosisof NPC cells in ***:The recombinant plasmid can sufficientlymediate RNAi in CNE-2Z cells,and knock-down of the bcl-xL expression by shRNAsignificantly induced apoptosis in CNE-2Z *** results suggest this newsystem,mediated RNAi can be used as a tool for the study of gene function andgene therapy.

关键词： RNAi plasmid gene transfection short hairpin RNA bcl-xL apoptosis nasopharyngeal carcinoma cells

Synthesis of Novel Benzimidazole Analogs and Their Biological Activities

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Synthesis of Novel Benzimidazole Analogs and Their Biologica...

肝素结合蛋白、1,25-二羟基维生素D_3、白三烯B4及炎性指标与慢性阻塞性肺疾病急性加重期患者肺功能的相关性研究

第六届全国化学生物学学术会议

作者： Wen-Tai Zhang,Yan-Hua Li,Jin-Jian wei,cheng-he Zhou~* School of Chemistry and Chemical Engineering,Southwest University,Chongqing 400715

＜正＞Benzimidazole and its derivatives exhibit extensive potential *** compounds are widely used by virtue of its broad-spectrum biological activities as drugs and artificial receptors for molecule and ion *** benzim... 详细信息

关键词： Benzimidazole Antibacterial Antifungal

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标记免疫分析与临床 2018年第3期25卷 403-406页

作者：张承何威双流区第一人民医院内四科四川成都610200

目的探讨肝素结合蛋白、1,25-二羟基维生素D3、白三烯B4及炎性指标与慢性阻塞性肺疾病急性加重期患者肺功能的相关性研究。方法选取360例2016年4月至2017年5月期间到我院呼吸科诊治的COPD和AECOPD患者作为研究对象。其中COPD患者167例,... 详细信息

目的探讨肝素结合蛋白、1,25-二羟基维生素D3、白三烯B4及炎性指标与慢性阻塞性肺疾病急性加重期患者肺功能的相关性研究。方法选取360例2016年4月至2017年5月期间到我院呼吸科诊治的COPD和AECOPD患者作为研究对象。其中COPD患者167例,作为稳定组,AECOPD患者193例,作为加重组。选取同期进行体检的健康人300例作为对照组。比较3组受试者HBP、1,25-(OH)2D3、LTB4、TNF-α、IL-8和IL-6水平。比较稳定组和加重组肺功能指标。分析HBP、1,25-(OH)2D3、LTB4、TNF-α、IL-8和IL-6与患者肺功能相关性。结果稳定组、加重组患者HBP和LTB4水平显著高于对照组,1,25-(OH)2D3显著低于对照组,加重组患者HBP和LTB4水平显著高于稳定组,1,25-(OH)2D3显著低于稳定组(P<0.05)。稳定组、加重组患者TNF-α、IL-8和IL-6水平显著高于对照组,加重组患者TNF-α、IL-8和IL-6水平显著高于稳定组(P<0.05)。加重组患者各肺功能指标(FEV1%Pred、FEV1/Fvc%、MMEF%Pred、V50%Pred、V25%Pred)均显著高于稳定组(P<0.05)。经过Pearson相关性分析,HBP、LTB4、TNF-α、IL-8、IL-6与患者肺功能呈负相关,1,25-(OH)2D3与患者肺功能呈正相关。结论 HBP、1,25-(OH)2D3、LTB4及炎性指标与AECOPD患者肺功能指标密切相关,可以评估患者的病情严重程度,指导临床治疗。

关键词：肝素结合蛋白 1,25-二羟维生素D3 白三烯B4 慢性阻塞性肺疾病急性加重期

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Relationship between longitudinal changes in lipid composition and ischemic stroke among hypertensive patients

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World Journal of Clinical Cases 2025年第4期13卷 18-27页

作者： cheng-cheng wei Yu-Qing Huang cheng-Hong Yu Department of Cardiology Tongxiang First People's HospitalTongxiang 314500Zhejiang ProvinceChina Department of Cardiology Guangdong Cardiovascular InstituteGuangzhou 510080Guangdong ProvinceChina

BACKGROUND Dyslipidemia was strongly linked to stroke,however the relationship between dyslipidemia and its components and ischemic stroke remained *** To investigate the link between longitudinal changes in lipid profiles and dyslipidemia and ischemic stroke in a hypertensive *** Between 2013 and 2014,6094 hypertension individuals were included in this,and ischemic stroke cases were documented to the end of *** changes of lipid were stratified into four groups:(1)Normal was transformed into normal group;(2)Abnormal was transformed into normal group;(3)Normal was transformed into abnormal group;and(4)Abnormal was transformed into abnormal *** examine the link between longitudinal changes in dyslipidemia along with its components and the risk of ischemic stroke,we utilized multivariate Cox proportional hazards models with hazard ratio(HR)and 95%*** The average age of the participants was 62.32 years±13.00 years,with 329 women making up 54.0%of the *** the course of a mean follow-up of 4.8 years,143 ischemic strokes *** normal was transformed into normal group was used as a reference,after full adjustments,the HR for dyslipidemia and ischemic stroke among abnormal was transformed into normal group,normal was transformed into abnormal group and abnormal was transformed into abnormal wei CC et *** changed and ischemic stroke WJCC https://*** 2 February 6,2025 Volume 13 Issue 4 group were 1.089(95%CI:0.598-1.982;P=0.779),2.369(95%CI:1.424-3.941;Phe risk of ischemic stroke.

关键词： Longitudinal change Hypertension Dyslipidemia Lipid profile Ischemic stroke

成人胶质瘤病人术前营养状况与临床预后的相关性研究

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肠外与肠内营养 2021年第2期28卷 104-108页

作者：程伟鹤李桂云袁媛曹炜李晋首都医科大学附属北京天坛医院北京100070

目的:调查成人恶性胶质瘤住院病人术前营养状况,分析病人营养状况与临床预后的相关性。方法:采用描述性研究,对2018年12月至2019年12月在北京天坛医院神经外科病房进行治疗的184例胶质瘤病人进行调查,应用NRS 2002对其进行营养风险筛查... 详细信息

目的:调查成人恶性胶质瘤住院病人术前营养状况,分析病人营养状况与临床预后的相关性。方法:采用描述性研究,对2018年12月至2019年12月在北京天坛医院神经外科病房进行治疗的184例胶质瘤病人进行调查,应用NRS 2002对其进行营养风险筛查,分析术前病人的营养状况与术后入住ICU时间、机械通气时间、住院时间、并发症、住院费用等的相关性。结果:184例胶质瘤病人营养风险发生率为43.48%(80/184),有营养风险的病人其术后入住ICU的天数、机械通气天数、总住院天数、肺部感染的发生率、住院费用均高于无营养风险的病人,差异有显著性统计学意义(P<0.05)。结论:胶质瘤病人的营养风险发生率较高,术前存在营养风险的病人临床预后显著差于无营养风险的病人。临床医护人员应重视胶质瘤病人的营养状况,将术前营养状态评估列为必要的评估内容,及早帮助有营养风险的病人进行营养支持,改善其临床预后,提高病人的生存质量。

关键词：胶质瘤营养状况临床预后

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