检索结果-南通市图书馆

A Scd1-mediated metabolic alteration participates in liver responses to low-dose bavachin

Journal of Pharmaceutical Analysis 2023年第7期13卷 806-816页

作者： Pan Shen Zhi-Jie Bai Lei Zhou Ning-Ning Wang Zhe-Xin Ni De-Zhi Sun Cong-Shu Huang Yang-Yi Hu cheng-rong xiao Wei Zhou Bo-Li Zhang Yue Gao Department of Pharmaceutical Sciences Beijing Institute of Radiation MedicineBeijing100850China State Key Laboratory of Component-based Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin301617China

Hepatotoxicity induced by bioactive constituents in traditional Chinese medicines or herbs,such as bavachin(BV)in Fructus Psoraleae,has a prolonged latency to overt drug-induced liver injury in the *** studies have described BV-induced liver damage and underlying toxicity mechanisms,but little attention has been paid to the deciphering of organisms or cellular responses to BV at no-observed-adverse-effect level,and the underlying molecular mechanisms and specific indicators are also lacking during the asymptomatic phase,making it much harder for early recognition of ***,we treated mice with BV for 7 days and did not detect any abnormalities in biochemical tests,but found subtle steatosis in BV-treated *** then profiled the gene expression of hepatocytes and non-parenchymal cells at single-cell resolution and discovered three types of hepatocyte subsets in the BV-treated *** these,the hepa3 subtype suffered from a vast alteration in lipid metabolism,which was characterized by enhanced expression of apolipoproteins,carboxylesterases,and stearoyl-CoA desaturase 1(Scd1).In particular,increased Scd1 promoted monounsaturated fatty acids(MUFAs)synthesis and was considered to be related to BV-induced steatosis and polyunsaturated fatty acids(PUFAs)generation,which participates in the initiation of ***,we demonstrated that multiple intrinsic transcription factors,including Srebf1 and Hnf4a,and extrinsic signals from niche cells may regulate the above-mentioned molecular events in BV-treated ***,our study deciphered the features of hepatocytes in response to BV insult,decoded the underlying molecular mechanisms,and suggested that Scd1 could be a hub molecule for the prediction of hepatotoxicity at an early stage.

关键词： Bavachin Hepatotoxicity Scd1 Lipid metabolism Single-cell RNA-Seq

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

IMPACT OF CHINESE GUIDELINES FOR MANAGEMENT OF PATIENTS WITH ACUTE MYOCARDIAL INFARCTION ON OUTCOMES OF HOSPITALIZED PATIENTS

引用

Chinese Medical Journal 2006年第1期119卷 26-31页

作者： JIANG Shi-liang, JI xiao-ping, ZHANG cheng, WANG xiao-rong, ZHANG Mei and ZHANG YunDepartment of Cardiology, Qilu Hospital of Shandong University Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Public Health, Ji’nan 250012, China Department of Cardiology Qilu Hospital of Shandong University Ji'nan 250012 China.

Background The first Chinese guidelines for the diagnosis and management of patients with acute myocardial infarction （AMI） were issued by the Cardiovascular Branch of the Chinese Medical Association, the Editorial Board of the Chinese Journal of Cardiology, and the Editorial Board of the Chinese Circulation Journal in December 2001. However, it is still unclear whether these guidelines have produced a major impact on clinical practice and patient outcomes. The purpose of this study was to evaluate the impact of these guidelines on the management and prognosis of Chinese patients with AMI. Methods A retrospective study was carried out in patients with AMI who were admitted to Qilu Hospital of Shandong University from January 1994 to December 2004. Patients were divided into two groups： group A included patients admitted from January 1994 to December 2001, and group B comprised those admitted from January 2002 to December 2004. Therapeutic approaches and the occurrence rate of angina pectoris, reinfarction, heart failure and death during hospitalization were compared between two groups. Results A total of 1783 patients including 1208 cases in group A and 575 cases in group B were enrolled in this study. No significant difference was found in baseline characteristics between group A and group B patients （all P〉0.05）. There were more patients undergoing reperfusion therapy within the first 24 hours after symptom onset in group B than in group A （35.8% vs 21.7%, P〈0.001） . Administration of β-blockers, angiotensin-converting-enzyme inhibitors （ACEIs）, angiotensin receptor blockers （ARBs）, statins, and heparins were more commonly seen in group B than in group A （P〈 0.001）. There were no significant differences in the use of nitrates or antiplatelet drugs between groups A and B （98.8% vs. 97.9%, P=0.172, and 97.4% vs 98.6%, P=0.113, respectively）. In-hospital angina pectoris, heart failure and death were all lower in group B than in group A （ 32.2% vs 41.2%, P〈0.001;

关键词： myocardial infarction treatment guidelines outcome

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Characteristics of gut microbiota dysbiosis in patients with colorectal polyps

引用

World Journal of Gastrointestinal Oncology 2025年第1期17卷 13-21页

作者： Xian-rong Wu xiao-Hong He Yong-Fang Xie School of Life Health Information Science and Engineering Chongqing Post and Communications UniversityChongqing 400065China

This editorial,inspired by a recent study published in the World Journal of Gastrointestinal Oncology,covers the research findings on microbiota changes in various *** recurrent colorectal polyps,the abundances of Klebsiella,Parvimonas,and Clostridium increase,while those of Bifidobacterium and Lactoba-cillus *** dysbiosis may promote the formation and recurrence of *** microbial changes have also been observed in colorectal cancer,inflammatory bowel disease,autism spectrum disorder,and metabolic syndrome,indicating the role of increased pathogens and decreased probiotics in these *** the gut microbiota,particularly by increasing probiotic levels,may help prevent polyp recurrence and promote gut *** microbial intervention strategy holds promise as an adjunctive treatment for patients with colorectal polyps.

关键词： Recurrent colorectal polyps Gut microbiota dysbiosis Klebsiella Probiotics Intestinal inflammation Microbial intervention strategy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cardioprotection of Shenfu preparata on cardiac myocytes through cytochrome P450 2J3

引用

Journal of Integrative Medicine 2013年第5期11卷 327-336页

作者： Yong xiao Zeng-chun Ma Yu-guang Wang Hong-ling Tan Xiang-ling Tang Qian-de Liang cheng-rong xiao Yue Gao Beijing Institute of Radiation Medicine Academy of Military Medical Sciences School of Pharmaceutical Sciences Central South University

To evaluate whether Shenfu injection （SFI） protects against cardiac myocyte injury induced by Fupian injection （FPI） in vitro. METHODS： H9c2 cells were separately treated with FPI, Renshen injection （RSI） and SFI. Cell viability, lactate dehydrogenase （LDH） release, spontaneous beating rate of primative cardical cells, caspase-3/7 activity, cell apoptosis, and cytochrome P450 2J3 （CYP2J3） mRNA expression were analyzed. RESULTS： The viability of H9c2 cells treated with SFI （37 and 75 mg/mL） was significantly higher than that of H9c2 cells treated with FPI （25 and 50 mg/mL）（P〈0.05, P〈0.01, respectively）. LDH activity of H9c2 cells treated with SFI （75 mg/mL） was significantly decreased （P〈0.01） compared with that of H9c2 cells treated with FPI （50 mg/mL）. SFI （150 mg/mL） significantly attenuated FPI （100 mg/mL）-induced spontaneous beating rate decrease in primary myocardial cells after 4-hour treatment. Compared with FPI （12 and 25 mg/mL）, SFI （18 and 37 mg/mL） treatment could effectively reverse the change of caspase-3/7 activity （P〈0.01 and P〈0.01, respectively）. Compared with FPI （6 and 25 mg/mL）, apoptotic cells decreased significantly （P〈0.05, P〈0.01, respectively） when H9c2 cells were incubated with SFI （9 and 37 mg/mL）. The expression of CYP2J3 mRNA was down-regulated by FPI, while RSI and SFI could up-regulate the expression of CYP2J3 （P〈0.01）, which suggested the potential mechanism of protection of RSI against cardiac myocyte damage induced by FPI treatment. CONCLUSION： These observations indicate that SFI has the potential to exert cardioprotective effects against FPI toxicity. The effect was possibly correlated with the activation of CYP2J3.

关键词： Shenfu decoction cardiotonic agents cytochrome P450 2J3 plant extracts in vitro

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Interleukin-17A facilitates tumor progression via upregulating programmed death ligand-1 expression in hepatocellular carcinoma

引用

World Journal of Gastrointestinal Oncology 2025年第1期17卷 176-198页

作者： Zhong-Xia Yang Li-Ting Zhang xiao-Jun Liu Xue-Bin Peng xiao-rong Mao The First School of Clinical Medicine Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Infectious Diseases The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Radiotherapy Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is an inflammation-associated tumor with a dismal *** has become an important treatment strategy for HCC,as immunity is closely related to inflammation in the tumor *** regulates the expression of programmed death ligand-1(PD-L1)in the immunosuppressive tumor microenvironment and affects im-munotherapy ***-17A(IL-17A)is involved in the remodeling of the tumor microenvironment and plays a protumor or antitumor role in different *** hypothesized that IL-17A participates in tumor progression by affe-cting the level of immune checkpoint molecules in *** upregulation of PD-L1 expression in HCC cells by IL-17A was assessed by reverse transcription PCR,western blotting,and flow *** studies were conducted with gene knockout models and pathway *** function of IL-17A in immune evasion was explored through coculture of T cells and HCC *** effects of IL-17A on the malignant biological behaviors of HCC cells were evaluated in vitro,and the antitumor effects of an IL-17A inhibitor and its synergistic effects with a PD-L1 inhibitor were studied in *** IL-17A upregulated PD-L1 expression in HCC cells in a dose-dependent manner,whereas IL-17A receptor knockout or treatment with a small mothers against decapentaplegic 2 inhibitor diminished the PD-L1 expression induced by ***-17A enhanced the survival of HCC cells in the coculture ***-17A increased the viability,G2/M ratio,and migration of HCC cells and decreased the apoptotic *** D1,VEGF,MMP9,and Bcl-1 expression increased after IL-17A treatment,whereas BAX expression *** combination of IL-17A and PD-L1 inhibitors showed synergistic antitumor efficacy and increased cluster of differentiation 8+T lymphocyte infiltration in an HCC mouse *** IL-17A upregulates PD-L1 expression via the IL-17A receptor/phosphorylation-small mothers against

关键词： Interleukin-17A Programmed death ligand-1 Interleukin-17A receptor Small mothers against decapentaplegic 2 Hepatocellular carcinoma Immunotherapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

射干麻黄汤加减联合布地奈德对寒痰郁肺型小儿毛细支气管炎患者治疗效果观察

引用

中国中医基础医学杂志 2019年第8期25卷 1104-1107,1140页

作者：成小蓉杜丽贵州省人民医院

目的:分析寒痰郁肺型毛细支气管炎患儿中施予射干麻黄汤加减与布地奈德联用的疗效。方法:抽取2015年12月至2017年9月间进入本院儿科确诊的143例患毛细支气管炎患儿,按随机数字表法分为治疗组73例给予射干麻黄汤加减疗法与布地奈德联用,... 详细信息

目的:分析寒痰郁肺型毛细支气管炎患儿中施予射干麻黄汤加减与布地奈德联用的疗效。方法:抽取2015年12月至2017年9月间进入本院儿科确诊的143例患毛细支气管炎患儿,按随机数字表法分为治疗组73例给予射干麻黄汤加减疗法与布地奈德联用,对照组70例给予布地奈德单治,回顾性比较其疗效、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、白介素-8(IL-8)、降钙素原(PCT)及C-反应蛋白(hs-CRP)。结果:治疗组有效率97.26%,比对照组的84.29%更高;治疗组PCT(0.41±0.11)ng/ml、hs-CRP(0.50±0.09)mg/dl,比对照组的PCT(0.55±0.19)ng/ml、hs-CRP(0.65±0.20)mg/dl更低。治疗组患儿心率指数达到健康水平所用时间、气促现象消失时间、哮鸣音现象消失时间以及湿罗音现象消失时间均比对照组短,治疗组CD4^+、CD4^+/CD8^+比对照组高,而CD8^+比对照组低,治疗组TNF-α、IL-6及IL-8均比对照组低。结论:儿科给予毛细支气管炎患儿专业治疗时以射干麻黄汤加减疗法与布地奈德联用效果显著,值得临床推广。

关键词：射干麻黄汤加减布地奈德小儿毛细支气管炎血清PCT hs-CRP

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于活动轮廓模型的胃窦B超序列图象边缘轮廓的提取与跟踪

引用

小型微型计算机系统 2000年第9期21卷 958-961页

作者：张艳费耀平夏利民常小荣长沙铁道学院信息技术研究中心长沙410075

本文提出了一种基于活动轮廓模型的胃窦 B超序列图象边缘轮廓的提取与跟踪方法 .对于序列中的第一幅图象 ,通过人工取点 ,B样条拟合的方法 ,提取其初始轮廓 ,再运用活动轮廓模型 ,进行边缘轮廓的逼近 ,以获得比较精确的胃窦边缘轮廓 .... 详细信息

本文提出了一种基于活动轮廓模型的胃窦 B超序列图象边缘轮廓的提取与跟踪方法 .对于序列中的第一幅图象 ,通过人工取点 ,B样条拟合的方法 ,提取其初始轮廓 ,再运用活动轮廓模型 ,进行边缘轮廓的逼近 ,以获得比较精确的胃窦边缘轮廓 .在后续图象处理中 ,将活动轮廓模型与光流模型相结合 ,实现了轮廓的跟踪 .实验的结果证明了该方法的有效性 .

关键词：活动轮廓模型 B样条胃窦 B超图像

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于移动代理的宽带电力线通信网络管理模型研究

引用

中国电机工程学报 2005年第9期25卷 74-79页

作者：程晓荣苑津莎侯思祖赵惠兰华北电力大学河北省保定市071003

随着宽带电力线通信网络的不断扩大和普及,宽带电力线通信网络管理的研究已成为新的问题。该文首先简要分析宽带电力线通信网络管理范围以及宽带电力线通信网络系统中网元类型和所具有的特性,然后对几种新型的网络管理方式进行了比较,... 详细信息

随着宽带电力线通信网络的不断扩大和普及,宽带电力线通信网络管理的研究已成为新的问题。该文首先简要分析宽带电力线通信网络管理范围以及宽带电力线通信网络系统中网元类型和所具有的特性,然后对几种新型的网络管理方式进行了比较,根据移动代理技术和Web 技术的思想以及其在网络管理的应用,采用了基于移动代理的网管平台,使用了三种不同的Agent,即常驻代理(Stationary Agent)和信使代理(MessengerAgent) 及负责激活Stationary Agent和调度Messenger Agent 的网管中心Agent,给出了基于Agent 平台的网管系统结构,并在此基础上提出了基于Web和移动代理的宽带电力线通信网络管理结构模型,并且从响应时间和流量两个方面分析并验证了该模型相对于传统的SNMP 模型在性能上的优越性。所设计的模型提高了宽带电力线网络的性能,增强了网管功能的灵活性,为电力线宽带网络管理系统设计提供了技术支持和依据。

关键词：网络管理模型宽带电力线通信网络 Messenger 网络管理系统设计通信网络管理 Agent平台通信网络系统网络管理方式移动代理技术 Web技术基于Web 电力线网络管理范围网管平台网管中心系统结构结构模型 MP模型

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ginsenoside Rg1 inhibits proliferation of vascular smooth muscle cells stimulated by tumor necrosis factor-α

引用

Acta Pharmacologica Sinica 2006年第8期27卷 1000-1006页

作者： Zeng-chun MA Yue GAO~2 Yu-guang WANG Hong-ling TAN cheng-rong xiao Sheng-qi WANG Institute of Radiation Medicine Sciences,Academy of Military Medical Sciences,Beijing 100850,China Institute of Radiation Medicine Sciences Academy of Military Medical Sciences Beijing 100850 China

Aim:To investigate the proliferation of vascular smooth muscle cells(VSMC)affected by ginsenoside Rg1 and further explore the molecular mechanism ofginsenoside Rg1 using ***:The proliferation of VSMC wasmeasured by MTS assay kit and flow *** alterations were ana-lyzed using two-dimensional electrophoresis and peptide mass *** proteins found in proteomics were confirmed by ***:The proliferation of VSMC was enhanced significantly after tumor necrosis fac-tor-α(TNF-α)treatment,and ginsenoside Rg1 treatment inhibited proliferation ina dose-dependent *** analysis showed 24 protein spots werechanged,including 17 spots that were increased and 7 spots that were *** Rg1 could restore the expression levels of these proteins,at leastpartly,to basic levels of untreated *** expression of G-protein coupledreceptor kinase,protein kinase C(PKC)-ζ,N-ras protein were decreased,whilecycle related protein p21 was increased by ginsenoside Rgl in TNF-α ***:PKC-ζ and p21 pathway might be the mechanism for inhibi-tory effects of ginsenoside Rg1 on proliferation of VSMC.

关键词： cell cycle ginsenoside Rg1 proteomics tumor necrosis factor-α vascular smooth muscle cells

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中压宽带电力线通信接入及信道特性测试与分析

引用

电力系统自动化 2005年第14期29卷 69-72页

作者：程晓荣苑津莎侯思祖康恩婷华北电力大学计算机学院河北省保定市071003

针对国内中压电网的结构和特性进行了分析,给出了国内中压线路的宽带电力线通信(PLC)接入方式及其接入原理,对中压线路的接入设备、接入接口进行了归纳,在此基础上完成了国内第1条实际的中压PLC信道的测试,给出了反映信道特性的测试结... 详细信息

针对国内中压电网的结构和特性进行了分析,给出了国内中压线路的宽带电力线通信(PLC)接入方式及其接入原理,对中压线路的接入设备、接入接口进行了归纳,在此基础上完成了国内第1条实际的中压PLC信道的测试,给出了反映信道特性的测试结果并进行了分析与研究。所完成的中压PLC信号的传输实验和测试研究,为宽带PLC进一步向中压电力线发展提供了设计依据和技术储备,为未来中压线路全程长距离接入提供了参考数据和资料。

关键词：中压电力线通信接入方式信道特性测试

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：