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Modulation of Antiviral Immunity and Therapeutic Efficacy by 25-Hydroxycholesterol in Chronically SIV-Infected, ART-Treated Rhesus Macaques

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Virologica Sinica 2021年第5期36卷 1197-1209页

作者： Chunxiu Wu Jin Zhao Ruiting Li Fengling Feng Yizi He Yanjun Li Runhan Huang Guangye Li Heng Yang Genhong cheng Ling Chen Feng Ma Pingchao Li Caijun sun State Key Laboratory of Respiratory Disease Guangzhou Institutes of Biomedicine and Health(GIBH)Chinese Academy of SciencesGuangzhou 510530China School of Public Health(Shenzhen) Sun Yat-Sen UniversityGuangdong 518107China Key Laboratory of Tropical Disease Control Sun Yat-Sen UniversityMinistry of EducationGuangzhou 514400China University of Chinese Academy of Sciences Beijing 100049China Center for Systems Medicine Institute of Basic Medical SciencesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China Suzhou Institute of Systems Medicine Suzhou 215123China Department of Microbiology Immunology and Molecular GeneticsUniversity of CaliforniaLos Angeles 90095USA Guangdong Landau Biotechnology Co.Ltd Guangzhou 510700China

Cholesterol-25-hydroxylase(CH25 H)and its enzymatic product 25-hydroxy cholesterol(25 HC)exert broadly antiviral activity including inhibiting HIV-1 ***,their antiviral immunity and therapeutic efficacy in a nonhuman primate model are ***,we report that the regimen of 25 HC combined with antiretroviral therapy(ART),provides profound immunological modulation towards inhibiting viral replication in chronically SIVmac239-infected rhesus macaques(RMs).Compared to the ART alone,this regimen more effectively controlled SIV replication,enhanced SIVspecific cellular immune responses,restored the ratio of CD4/CD8 cells,reversed the hyperactivation state of CD4^(+)T cells,and inhibited the secretion of proinflammatory cytokines by CD4^(^(+))and CD8^(+)T lymphocytes in chronically SIVinfected ***,the in vivo safety and the preliminary pharmacokinetics of the 25 HC compound were assessed in this RM *** together,these assessments help explain the profound relationship between cholesterol metabolism,immune modulation,and antiviral activities by 25 *** results provide insight for developing novel therapeutic drug candidates against HIV-1 infection and other related diseases.

关键词： 25-hydroxycholesterol(25HC) HIV SIV Antiretroviral therapy(ART) Macaque

Elemental sulfur in northern South China Sea sediments and its significance

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Science China Earth Sciences 2015年第11期58卷 2271-2278页

作者： LIN qi WANG JiaSheng FU ShaoYing LU HongFeng BU qingTao LIN RongXiao sun Fei State Key Laboratory of Biogeology and Environmental Geology School of Earth Science China University of Geosciences Guangzhou Marine Geological Survey qingdao Institute of Marine Geology

Elemental sulfur(ES) is one of the intermediates in the inorganic sulfur cycle and thus plays a key role in the fractionation of stable sulfur isotopes in different reservoirs and the marine environment. In this study, solid ES is discovered in sediments near the Jiulong Methane Reef in the northern South China Sea by scanning electron microscopy and Raman spectroscopy. Combining the morphology and distribution of ES, pyrite concentrations, and sulfur isotopes, we conclude that:(1) solid ES coexists with pyrite microcrystals and sulfide(oxyhydr)oxides as well as clay minerals, and they are mainly distributed on the surface of mineral aggregates;(2) ES mainly occurs within and near the sulfate-methane transition zone(SMTZ) despite little morphological diversity;(3) ES formation might be related to hydrogen sulfide oxidation and is therefore linked with fluctuations in the SMTZ. Within the SMTZ, hydrogen sulfide is produced and pyrite precipitates because of enhanced anaerobic oxidation of methane coupled with dissimilatory sulfate reduction. This enhances the efficiency of the inorganic sulfur cycle and provides favorable conditions for ES formation. The discovery of solid ES in sediments near the Jiulong Methane Reef suggests an important relationship with SMTZ fluctuations that could have implications for the evolution of methane hydrate in the South China Sea.

关键词： elemental sulfur sulfate-methane transition zone shallow sediments northern South China Sea

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戊二醛交联优化脱细胞真皮基质的生物相容性

解剖学报 2010年第5期41卷 768-773页

作者：车鹏程孙红戚孟春闫博华北煤炭医学院附属医院整形科河北唐山063000 华北煤炭医学院基础医学部河北唐山063000

目的通过体内包埋实验将优化的脱细胞真皮基质(ADM)与成纤维细胞(FB)体外培养,探讨是否具有生物相容性。方法用高渗盐-NaOH消蚀法制备得到大鼠ADM,用低浓度戊二醛交联ADM,未交联A组(0min)作为对照,根据交联时间不同分成B组(10min)、C组(... 详细信息

目的通过体内包埋实验将优化的脱细胞真皮基质(ADM)与成纤维细胞(FB)体外培养,探讨是否具有生物相容性。方法用高渗盐-NaOH消蚀法制备得到大鼠ADM,用低浓度戊二醛交联ADM,未交联A组(0min)作为对照,根据交联时间不同分成B组(10min)、C组(15min)和D组(30min)。通过大鼠体内包埋实验对比各组ADM物理性状、包埋后面积、炎性反应、浸润生长的FB和毛细血管数目,选择出最佳交联时间。制备优化的人ADM,用四甲基偶氮唑盐(MTT)比色法检测ADM的细胞毒性;人FB与ADM复合培养检测其细胞相容性,用免疫组织化学和透射电镜观察FB的生长和增殖情况;反转录聚合酶链反应(RT-PCR)检测FBⅠ、Ⅲ型前胶原mRNA的表达。结果大鼠体内包埋实验显示,4周取材,未交联组不易触及移植物,植入物和周围的软组织基本融合难以分开;未交联组ADM的面积较包埋前缩小;未交联组ADM内有少量炎性细胞,胶原纤维嗜酸性弱;交联组ADM内未见炎性细胞,浸润生长的FB数目、血管数目与戊二醛交联时间的单因素相关性分析呈负相关;最佳的交联时间为10min。体外培养显示,优化ADM的细胞毒性反应0～1级;人FB能够很好地在优化的ADM表面贴附、生长和增殖;ADM内FBⅠ型、Ⅲ型前胶原mRNA的表达降低。结论高渗盐-NaOH消蚀法制备ADM,工艺简单、成本低、生物相容性好,可以提供细胞生长的空间,并可在细胞间转导通讯和信号,下调细胞外基质代谢系统。

关键词：脱细胞真皮基质戊二醛交联生物相容性 Ⅰ、Ⅲ型前胶原mRNA 高渗盐-NaOH消蚀法大鼠

The telomere-to-telomere genome of Fragaria vesca reveals the genomic evolution of Fragaria and the origin of cultivated octoploid strawberry

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Horticulture Research 2023年第4期10卷 101-109页

作者： Yuhan Zhou Jinsong Xiong Ziqiang Shu Chao Dong Tingting Gu Pengchuan sun Shuang He Mian Jiang Zhiqiang Xia Jiayu Xue Wasi Ullah Khan Fei Chen Zong-Ming cheng College of Horticulture Nanjing Agricultural UniversityNanjing 210095China Hainan Yazhou Bay Seed Laboratory Sanya 572024China Wuhan Benagen Tech Solutions Company Limited WuhanHubei 430021China Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education&State Key Laboratory of Hydraulics&Mountain River Engineering College of Life SciencesSichuan UniversityChengdu 610065China College of Tropical Crops Hainan UniversityHaikou 570228China Sanya Nanfan Research Institute from Hainan University Sanya 572025China

Fragaria vesca,commonly known as wild or woodland strawberry,is the most widely distributed diploid Fragaria species and is native to Europe and *** of its small plant size,low heterozygosity,and relative ease of genetic transformation,*** has been a model plant for fruit research since the publication of its Illumina-based genome in ***,its genomic contribution to octoploid cultivated strawberry remains a long-standing ***,we de novo assembled and annotated a telomere-to-telomere,gap-free genome of ***‘Hawaii 4’,with all seven chromosomes assembled into single contigs,providing the highest completeness and assembly quality to *** gap-free genome is 220785082 bp in length and encodes 36173 protein-coding gene models,including 1153 newly annotated *** 14 telomeres and seven centromeres were annotated within the seven *** the three previously recognized wild diploid strawberry ancestors,***,***,and ***,phylogenomic analysis showed that *** and *** are the ancestors of the cultivated octoploid strawberry F.×ananassa,and *** is its closest *** subgenomes of F.×ananassa belong to the *** group,and one is sister to *** anticipate that this high-quality,telomere-to-telomere,gap-free *** genome,combined with our phylogenomic inference of the origin of cultivated strawberry,will provide insight into the genomic evolution of Fragaria and facilitate strawberry genetics and molecular breeding.

关键词： straw Fragaria origin

起伏地表条件下2.5维声波方程有限差分法数值模拟

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石油物探 2014年第5期53卷 509-515页

作者：齐鹏孙建国吉林大学地球探测科学与技术学院吉林长春130026

针对三维数值模拟难以应对的大尺度模拟或快速计算问题,2.5维数值模拟是一种能兼顾模拟精度和计算效率的有效折中手段。基于L型2.5维声波近似方程,通过纵向坐标变换,采用有限差分法实现了起伏地表条件下2.5维声波方程数值模拟。理论模... 详细信息

针对三维数值模拟难以应对的大尺度模拟或快速计算问题,2.5维数值模拟是一种能兼顾模拟精度和计算效率的有效折中手段。基于L型2.5维声波近似方程,通过纵向坐标变换,采用有限差分法实现了起伏地表条件下2.5维声波方程数值模拟。理论模型试算结果表明,2.5维声波方程有限差分数值模拟方法能够很好地处理起伏地表问题;与起伏地表二维声波方程数值模拟结果相比,两者在地震波运动学特征上基本一致,而在地震波动力学特征模拟上2.5维数值模拟更具优势;通过不同炮检距模拟记录的振幅对比,验证了2.5维声波方程数值模拟在时间和空间上的衰减特性。

关键词：起伏地表 2.5维声波方程数值模拟有限差分

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综合运输规划理论的基点

交通运输工程学报 2006年第3期6卷 122-126页

作者：吴群琪孙启鹏长安大学经济与管理学院陕西西安710064

为了实现市场经济条件下各种运输方式的协调发展,分析了现有综合运输理论由于无法体现需求者对运输供给多样化、多层次的要求和不同条件下运输供给满足程度的差异性,难以解决交通运输面临的提升运输能力、可持续发展、实现本质目标、协... 详细信息

为了实现市场经济条件下各种运输方式的协调发展,分析了现有综合运输理论由于无法体现需求者对运输供给多样化、多层次的要求和不同条件下运输供给满足程度的差异性,难以解决交通运输面临的提升运输能力、可持续发展、实现本质目标、协调发展等问题,提出各种运输方式的技术经济特性是形成综合运输规划理论的基点,强调以需求为主导,结合特定的运用条件,分析运输方式实现的技术经济特性,能够体现物量均衡和经济均衡的有机统一,属“动态技术经济特性”。

关键词：综合运输运输方式技术经济特性理论基点

Relative Contributions of Boundary-Layer Meteorological Factors to the Explosive Growth of PM2.5 during the Red-Alert Heavy Pollution Episodes in Beijing in December 2016

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Journal of Meteorological Research 2017年第5期31卷 809-819页

作者： junting zhong xiaoye zhang yaqiang wang junying sun yangmei zhang jizhi wang kaiyan tan xiaojing shen haochi che lu zhang zhouxiang zhang xuefei qi huarong zhao sanxue ren yang li state key laboratory of severe weather/key laboratory of atmospheric chemistry of china meteorological administration chinese academy of meteorological sciencesBeijing 100081 center for excellence in regional atmospheric environment institute of urban environmentchinese academy of sciencesBeijing 100081 integrated ecologica–meteorological observation and experimental station chinese academy of meteorological sciencesXiamen 361021 center for atmosphere watch and service meteorological observation centerchina meteorological administrationBeijing 100081

Based on observations of urban mass concentration of fine particulate matter smaller than 2.5 μm in diameter （PM2.5）, ground meteorological data, vertical measurements of winds, temperature, and relative humidity （RH）, and ECMWF reanalysis data, the major changes in the vertical structures of meteorological factors in the boundary layer （BL） during the heavy aerosol pollution episodes （HPEs） that occurred in winter 2016 in the urban Beijing area were analyzed. The HPEs are divided into two stages： the transport of pollutants under prevailing southerly winds, known as the transport stage （TS）, and the PM2.5 explosive growth and pollution accumulation period characterized by a temperature inversion with low winds and high RH in the lower BL, known as the cumulative stage （CS）. During the TS, a surface high lies south of Beijing, and pollutants are transported northwards. During the CS, a stable BL forms and is characterized by weak winds, temperature inversion, and moisture accumulation. Stable atmospheric stratifica- tion featured with light/calm winds and accumulated moisture （RH 〉 80%） below 250 m at the beginning of the CS is closely associated with the inversion, which is strengthened by the considerable decrease in near-surface air temperat- ure due to the interaction between aerosols and radiation after the aerosol pollution occurs. A significant increase in the PLAM （Parameter Linking Aerosol Pollution and Meteorological Elements） index is found, which is linearly re- lated to PM mass change. During the first 10 h of the CS, the more stable BL contributes approximately 84% of the explosive growth of PM2.5 mass. Additional accumulated near-surface moisture caused by the ground temperature de- crease, weak turbulent diffusion, low BL height, and inhibited vertical mixing of water vapor is conducive to the sec- ondary aerosol formation through chemical reactions, including liquid phase and heterogeneous reactions, which fur- ther increases the PM2.5 concentration

关键词： explosive growth of PM2.5 pollutant transport anomalous temperature inversion moisture accumula-tion light or calm winds

NSVS 1908107, an EB-type eclipsing binary in the open cluster NGC 869

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Research in Astronomy and Astrophysics 2016年第7期16卷 77-82页

作者： Yang Pan Zhi-Quan Luo Xiao-Bin Zhang Li-Cai Deng Kun Wang Yang-Ping Luo Wei-Jing Fang Yin-Jiang Peng Jin-Jiang sun qi-Li Liu qiang Zhou Physics and Space Science College China West Normal University Key Laboratory of Optical Astronomy National Astronomical Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

We present a time-series BV CCD photometry for an EB-type eclipsing binary NSVS 1908107, a member of the young open cluster NGC 869. The photometric solution was obtained by using the 2003 version of the Wilson-Devinney code. It reveals that the system is a semi-detached binary with the secondary component filling its Roche lobe. The mass ratio was determined to be 0.059±0.001. With the physical parameters of the cluster, the masses, radii and luminosities of the two components of NSVS 1908107 are estimated to be M1 = 10.34±2.29 M⊙, R1 = 4.65re±0.34 Rspectivel⊙, L1 = 8076 y. The results s±371 L = 2.40 how tha⊙and M2 = 0.61 t the secondary co±0.13M⊙, R2±0.17 R⊙, L2 = 1054±48 L⊙mponent could be a giant or subgiant star with the outer envelope being stripped.

关键词： binaries eclipsing binaries semi-detached stars giant stars individual(NSVS 1908107)

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多个大股东与企业金融化

管理工程学报 2022年第3期36卷 62-77页

作者：孙泽宇齐保垒西安交通大学管理学院陕西西安710049 西安交通大学管理国家级实验教学示范中心陕西西安710049

本文聚焦于中国经济“脱实向虚”背景下实体企业金融化问题,从多个大股东这一股权结构安排的视角实证检验了其与企业金融化决策间关系。研究结果表明,多个大股东并存显著抑制了企业金融化程度。该结论在控制内生性的情况下依然成立。机... 详细信息

本文聚焦于中国经济“脱实向虚”背景下实体企业金融化问题,从多个大股东这一股权结构安排的视角实证检验了其与企业金融化决策间关系。研究结果表明,多个大股东并存显著抑制了企业金融化程度。该结论在控制内生性的情况下依然成立。机制检验表明,多个大股东通过缓解融资约束与提高主业经营业绩的途径抑制了企业金融化,发挥了积极治理作用。进一步研究发现,多个大股东对企业金融化行为的抑制作用在非国企、机构持股、分析师关注、管理层持股较少以及行业竞争程度较低的样本中更为显著,多个大股东的存在还促进了企业实体投资。本研究不仅丰富了企业金融化影响因素以及多个大股东经济后果领域的文献,对现实中如何优化公司治理结构、遏制实体企业金融化以及改善实体经济“脱实向虚”等均具有较强的启示意义。

关键词：多个大股东企业金融化融资约束经营业绩