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Helicobacter pylori infection in relation to E-cadherin gene promoter polymorphism and hypermethylation in sporadic gastric carcinomas

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World Journal of Gastroenterology 2005年第33期11卷 5174-5179页

作者： Yao-Chi Liu Chen-Yang Shen Hurng-Sheng Wu De-Chuan Chan cheng-Jueng Chen Jyh-Cherng yu cheng-ping yu Horng-Jyh Harn Rong-Yaun Shyu yu-Lueng Shih Chung-Bao Hsieh Huan-Mieng Hsu Division of General Surgery Department of Surgery Tri-Service General HospitalNational Defense Medical Center Taipei Taiwan China Division of Gastroenterology Department of Internal Medicine Tri-Service General HospitalNational Defense Medical Center Taipei Taiwan China Department of Pathology Tri-Service GeneralHospital National Defense Medical Center Taipei Taiwan China Department of Pathology Buddhist Tzu-Chi General Hospital Hualien Taiwan China Department of Surgery Show Chwan Memorial Hospital Changhua Taiwan China Institute of Biomedical Sciences Academia Sinica Taipei Taiwan China

AIM: To study Helicobacter pylori (H pylori) infection in relation to E-cadherin (E-cad) promoter polymorphism and hypermethylation in ***: Specimens were taken from representative cancerous lesions and adjacent non-cancerous epithelia of 67 resected GCs. Hpyloriwas detected by real-time PCR of the cagA gene from non-neoplastic epithelium.E-cad promoter polymorphism and hypermethylation were determined by restriction fragment length polymorphism analysis and methylation-specific PCR, respectively. Expression of E-cad protein was determined by ***: Hpyloriwas found in 57% of patients with GC.H pylori infection was more frequently found in tumors with the -160C/C genotype than those with the -160C/A and -160A/A genotypes (74% vs47%, P = 0.02). Hpylori infection was associated with E-cad methylation in nonneoplastic epithelium; however, no significant difference in H pylori was observed between methylated and unmethylated cancerous ***: Patients with the -160C/C genotype might require Hpyloriinfection to promote the inactivation of CDH1, suggesting that Hpylori infection might affect GC in an initial stage because polymorphism is germ *** of hypermethylation of CDH1 promoter in GC is complex, and Hpyloriinfection might affect it in an initial stage.

关键词： H pylort E-cadherirr -160 C→A polymorphism Hypermethylation Gastric carcinoma

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Mechanisms inactivating the gene for E-cadherin in sporadic gastric carcinomas

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World Journal of Gastroenterology 2006年第14期12卷 2168-2173页

作者： Yao-Chi Liu Chen-Yang Shen Hurng-Sheng Wu Tsai-yuan Hsieh De-Chuan Chan cheng-Jueng Chen Jyh-Cherng yu cheng-ping yu Horng-Jyh Harn Peng-Jen Chen Chung-Bao Hsieh Teng-Wei Chen Huan-Mieng Hsu Division of General Surgery Department of Surgery Tri-Service General Hospital National Defense Medical Center Taipei Taiwan China Division of Gastroenterology Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan China Department of Pathology Tri-Scrvice General Hospital National Defense Medical Center Taipei Taiwan China Department of Pathology Buddhist Tzu-Chi General Hospital Hualien Taiwan China Department of Surgery Show Chwan Memorial Hospital Changhua Taiwan China Institute of Biomedical Sciences Academia Sinica Taipei Taiwan China

AIM： To study the role of CDH1/E-cadherin （E-cad） gene alteration profiles including mutation, loss of heterozygosity （LOH）, promoter polymorphism and hypermethylation in mechanisms of CDH1 inactivation in gastric carcinoma （GC）. METHODS： Specimens were collected surgically from 70 patients with GC. Allelotyping PCR and detection of LOH, denaturing high pressure liquid chromatography and DNA sequencing, restriction fragment length polymorphism analysis, methylation specific PCR, and immunohistochemical staining were used. RESULTS： Promoter polymorphism was not a major mechanism of E-cad inactivation. Only one truncating mutation was found in a diffuse type tumor （3%）. Both LOH and promoter hypermethylation were major mechanisms of E-cad inactivation, but interestingly, there was a negative association between the fraction of allelic loss （LOH） in tumors and hypermethylation of CDH1. Therefore LOH and hypermethylation were two different tumorigenic pathways involved in GC. CONCLUSION： Given the findings that somatic mutation was extremely low and the relationship between LOH and hypermethylation was inverse, any two combinations of these three factors cannot fulfill the classical two-hit hypothesis of CDH1 inactivation. Thus, other mechanisms operating at the transcriptional level or at the post-translational level might be required to induce E-cadherin inactivation.

关键词： Gastric carcinoma E-cadherin gene alteration profiles Inactivation of E-cadherin

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Investigation of the measurement of murine airway hyperres-ponsiveness and the therapeutic effects of budesonide on ovalbumin sensitized and challenged mice

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Chinese Medical Journal 2005年第23期118卷 1959-1964页

作者： GONG Pi-hua GAO Zhan-cheng HU ping XU yu Departments of Respiratory ＆ Critical Care Medicine PekingUniversity People＇ s Hospital Beijing 100044 China

Background Airway hyperresponsiveness （AHR） is one of the most important characteristics of asthma. This study investigated the parameters, by which assess the airway responsiveness under tidal ventilation.Methods Female BALB/c mice were sensitized and challenged with ovalbumin （OVA）（group A）, and part of them were treated with budesonide aerosol （group B ）. All the mice were anaesthetized and mechanically ventilated, The values of tidal volume （Vt）, airway pressure （PA）, airway flow （F）, expiratory lung resistance （RL） and dynamic compliance of the thorax and lung （CT-L ） were recorded by the AniRes2003 animal lung function system. In addition, the expiratory volume in the first O. 1 second after the start of expiration （ EV0.1 ） was obtained according to the flow-volume （F-V） curve. The maximal or minimal values of EV0.1, RL and CT-L were documented after each dose of methacholine （MCH） and compared with values from negative control group （group C）.Results （1） When the dose of MCH reached 100 ng/g or 200 ng/g, the decrease of V, in group A was much more significant than group C （P =0. 001, 〈0. 001 respectively）, but not so between groups B and group C （P =0. 974, 0. 362 respectively）. （2） With the dose of 25, 50, 100 or 200 ng/g MCH, the decrease in percentage of EV0.1 in group A was much higher than group C （P = 0.012, 0.025, 0.001, 0.003 respectively）, while that in group B showed no significant difference as compared with group C （P = 0. 507, 0. 896,0. 972,0. 785）. （3） RE and CT-L： with the dose of 200 ng/g MCH, there was a statistically significant increase of RE in group A compared to group B or group C （ P 〈 0. 001, 〈 0. 001 respectively ）, but no significant difference between groups B and C （P =0. 266）. With doses of 100 ng/g and 200 ng/g MCH, there was a statistically significant decrease of CT.L in group A compared to group B （P =0. 001,=0. 001 ） and group C （P 〈 0. 001, 〈 0. 001 respectively）, but no significant difference between groups B and C （P

关键词： asthma airway hyperresponsiveness budesonide

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一种改进的非线性CS成像算法

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西安电子科技大学学报 2000年第3期27卷 273-277页

作者：程玉平西安电子科技大学雷达信号处理国家重点实验室陕西西安710071

文中分析了非线性ChirpScaling算法 (CS算法 )成像原理以及大斜视角下二次距离压缩随距离非线性变化产生的影响 ,提出了一种改进的非线性CS算法 ,该算法满足二次距离压缩随距离的非线性变化从而改善了散射点的聚焦性能 .经过理论分析和... 详细信息

文中分析了非线性ChirpScaling算法 (CS算法 )成像原理以及大斜视角下二次距离压缩随距离非线性变化产生的影响 ,提出了一种改进的非线性CS算法 ,该算法满足二次距离压缩随距离的非线性变化从而改善了散射点的聚焦性能 .经过理论分析和仿真实验验证了该方法的有效性 .

关键词：雷达成像成像算法二次距离压缩合成孔径雷达

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Limited Wegener's granulomatosis of the epididymis and testis

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Asian Journal of Andrology 2006年第6期8卷 737-739页

作者： Shang-Sen Lee Shou-Hung Tang Guang-Huan Sun cheng-ping yu Jong-Shiaw Jin Sun-Yran Chang Division of Urology Department of Surgery Tri-Service General Hospital National Defense Medical Center National Defense University Taipei Taiwan 114 China Department of Pathology Tri-Service General Hospital National Defense Medical Center National Defense University Taipei Taiwan 114 China

A case is presented of Wegener＇s granulomatosis limited to the testis and epididymis, simultaneously, in a 69-year-old man. Orchiectomy was carried out through an inguinal incision under the presumptive diagnosis of a right testicular tumor. A hard, irregular mass occupied the upper testicle and a portion of the epididymal head was visualized. Histopathologic examination of the specimen showed granulomatous inflammation of the testis and epididymis with prominent angiocentric granulomata in the walls of arteries, veins and foci of fibrinoid necrosis, surrounded by palisading inflammatory cells with a few giant cells. The diagnosis of limited Wegener＇s granulomatosis was considered, although antineutrophil cytoplasmic antibody （c-ANCA） test was negative 2 weeks after orchiectomy. The patient showed an excellent response after local complete excision. He remains free of disease 18 months after orchiectomy.

关键词： Wegener's granulomatosis testis epididymis

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韩非思想与秦兵马俑艺术刍议

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陕西师范大学学报（哲学社会科学版） 2019年第5期48卷 160-166页

作者：程玉萍高明陕西师范大学美术学院

秦政治受韩非思想影响很大,韩非思想对秦兵马俑艺术的影响主要体现在三个方面:韩非'势'的思想对秦兵马俑艺术宏伟气势的影响;韩非'质'的思想对秦兵马俑艺术写实风格的影响;韩非'严刑重罚'思想对秦兵马俑宁静、冷漠气质的影响。秦兵马俑... 详细信息

秦政治受韩非思想影响很大,韩非思想对秦兵马俑艺术的影响主要体现在三个方面:韩非'势'的思想对秦兵马俑艺术宏伟气势的影响;韩非'质'的思想对秦兵马俑艺术写实风格的影响;韩非'严刑重罚'思想对秦兵马俑宁静、冷漠气质的影响。秦兵马俑艺术的创造完全是出于政治目的,是为了展示一代君王中央集权、至高无上的权威。

关键词：秦朝政治兵马俑韩非思想写实风格

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上海市闵行区消除疟疾历程回顾

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中国热带医学 2021年第2期21卷 160-165页

作者：成玉萍王宙云上海市闵行区疾病预防控制中心上海201101

目的分析上海市闵行区不同时期疟疾流行状况和防治历程,总结闵行区消除疟疾工作,为维持消除疟疾状态提供依据。方法收集闵行区1950—2019年疟疾防治疫情相关报表、工作计划总结、防治文件和策略等资料,采用描述流行病学方法分析闵行区... 详细信息

目的分析上海市闵行区不同时期疟疾流行状况和防治历程,总结闵行区消除疟疾工作,为维持消除疟疾状态提供依据。方法收集闵行区1950—2019年疟疾防治疫情相关报表、工作计划总结、防治文件和策略等资料,采用描述流行病学方法分析闵行区疟疾流行特征与防治措施,总结评估闵行区消除疟疾历程。结果疟疾曾是闵行区危害最大的传染病,1954年和1961年先后发生过2次暴发流行,年发病率最高达7 824.98/10万,以间日疟为主,中华按蚊为唯一传播媒介。经过综合防治,1980年疟疾发病率逐步降低至10/10万,1985年达到了基本消灭疟疾的标准;2010年启动闵行区消除疟疾行动计划,实施以清除传染源、阻断传播为重点的综合技术措施,至2015年连续5年无本地感染病例,达到了消除疟疾考核标准;2016年后进入消除疟疾维持阶段。闵行区根据不同时期疟疾流行特点采取了针对性防控措施,经历疟疾流行、控制、监测、消除和消除后维持的不同阶段。2013年后病例均为境外输入性病例,以中青年流动人口为主,感染虫种和病例发病时间无明显特征,防控重点是及时发现和处置疟疾病例,防止引起续发传播。结论达到消除疟疾标准后,维持疟疾监测网络和监测能力,防止输入性病例再传播风险成为面临的新挑战。

关键词：疟疾流行消除监测

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Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

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Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： Shan ping yu Emily Choi Michael QJiang Ling Wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

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Relationship between longitudinal changes in lipid composition and ischemic stroke among hypertensive patients

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World Journal of Clinical Cases 2025年第4期13卷 18-27页

作者： cheng-cheng Wei yu-Qing Huang cheng-Hong yu Department of Cardiology Tongxiang First People's HospitalTongxiang 314500Zhejiang ProvinceChina Department of Cardiology Guangdong Cardiovascular InstituteGuangzhou 510080Guangdong ProvinceChina

BACKGROUND Dyslipidemia was strongly linked to stroke,however the relationship between dyslipidemia and its components and ischemic stroke remained *** To investigate the link between longitudinal changes in lipid profiles and dyslipidemia and ischemic stroke in a hypertensive *** Between 2013 and 2014,6094 hypertension individuals were included in this,and ischemic stroke cases were documented to the end of *** changes of lipid were stratified into four groups:(1)Normal was transformed into normal group;(2)Abnormal was transformed into normal group;(3)Normal was transformed into abnormal group;and(4)Abnormal was transformed into abnormal *** examine the link between longitudinal changes in dyslipidemia along with its components and the risk of ischemic stroke,we utilized multivariate Cox proportional hazards models with hazard ratio(HR)and 95%*** The average age of the participants was 62.32 years±13.00 years,with 329 women making up 54.0%of the *** the course of a mean follow-up of 4.8 years,143 ischemic strokes *** normal was transformed into normal group was used as a reference,after full adjustments,the HR for dyslipidemia and ischemic stroke among abnormal was transformed into normal group,normal was transformed into abnormal group and abnormal was transformed into abnormal Wei CC et *** changed and ischemic stroke WJCC https://*** 2 February 6,2025 Volume 13 Issue 4 group were 1.089(95%CI:0.598-1.982;P=0.779),2.369(95%CI:1.424-3.941;P<0.001)and 1.448(95%CI:1.002-2.298;P=0.047)(P for trend was 0.233),*** In individuals with hypertension,longitudinal shifts from normal to abnormal in dyslipidemia-particularly in total and low-density lipoprotein cholesterol-were significantly associated with the risk of ischemic stroke.

关键词： Longitudinal change Hypertension Dyslipidemia Lipid profile Ischemic stroke

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枯草芽胞杆菌TR21防控粉杂1号香蕉枯萎病的效果和对根系抗性相关信号物质累积的影响

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中国生物防治学报 2016年第5期32卷 627-634页

作者：张琳程萍喻国辉王燕仲恺农业工程学院生命科学学院广州510225 珠海市现代农业发展中心珠海519075 华中农业大学生命科学技术学院武汉430070

本文研究了枯草芽胞杆菌Bacillus subtilis TR21在大田对抗病品种粉杂1号枯萎病的防控效果及其与病原菌不同组合处理种苗根系抗性相关信号物质累积情况,评估了菌株TR21与粉杂1号结合减轻大田发病率的应用价值。田间试验设置清水对照区... 详细信息

本文研究了枯草芽胞杆菌Bacillus subtilis TR21在大田对抗病品种粉杂1号枯萎病的防控效果及其与病原菌不同组合处理种苗根系抗性相关信号物质累积情况,评估了菌株TR21与粉杂1号结合减轻大田发病率的应用价值。田间试验设置清水对照区、菌株TR21可湿性粉剂喷叶区、菌株TR21可湿性粉剂喷叶+叶腋接种1次胶囊剂型区、菌株TR21可湿性粉剂喷叶+叶腋接种1次栓剂剂型区,并统计田间发病率、抽蕾率、断蕾率和产量。室内采用清水处理、菌株TR21叶腋接种、香蕉枯萎病菌FOC004孢子根系接种、菌株TR21叶腋接种后再在根系接种FOC004孢子的挑战接种4种处理方式,测定接种后不同时间点根系NO、H_2O_2和水杨酸(SA)变化。结果表明,TR21可湿性粉剂的不同处理均能降低粉杂1号发病率,其中喷叶区防效达72%,此外增加1次栓剂处理可以显著增加单株产量,并显著缩短粉杂1号生育期。对抗性信号物质测定发现,只有挑战处理能够在接种早期(4 h)激发NO的显著升高,并维持较长时间(72 h);3种处理均能够在早期(4 h)显著减少根系产生H_2O_2;病原菌和挑战处理在早期(4 h)能够激发根系SA含量显著升高。TR21叶腋喷施通过提高粉杂1号对枯萎病的抗性来降低田间发病率。

关键词：粉杂1号香蕉枯萎病菌枯草芽胞杆菌TR21 诱导抗性

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