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Sensitivity study of searching for τ^-→γμ^- at HIEPA

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Science Bulletin 2016年第4期61卷 307-312页

作者： Yu-Bo Li cheng-ping shen Chang-Zheng Yuan School of Physics and Nuclear Energy Engineering Beihang University Institute of High Energy Physics Chinese Academy of Sciences

The charged lepton flavor violation process is a clean and sensitive probe of new physics beyond the Standard Model. A sensitivity study is performed to the process τ^-→γμ^- based on a 3 fb^(-1) inclusive Monte Carlo sample of e^+e^- collisions at a center-of-mass energy of4.26 or 4.6 Ge V, in the framework of the BESIII software system. The 90 % confidence level upper limits on B(τ^-→γμ^-) are estimated assuming no signal is produced. We also obtain the sensitivity on B(τ^-→γμ^-) as a function of the integrated luminosity, to serve as a reference for the HIEPA being proposed in China. It is found that 6.34 ab^(-1) are needed to reach the current best upper limit of 4:4 10^(-8) and about 2510 ab^(-1) are needed to reach a sensitivity of 10^(-9) if the detector design is similar to that of BESIII.

关键词： Charged lepton flavor violation Branching fraction New physics

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鉴定最重QED原子的新方法

Science Bulletin 2024年第10期69卷 1386-1391页

作者：傅靖航贾森周兴玉张玉洁沈成平苑长征 School of Physics Beihang UniversityBeijing 100083China School of Physics Southeast UniversityNanjing 211189China School of Physics and Electronic Technology Liaoning Normal UniversityDalian 116029China Peng Huanwu Collaborative Center for Research and Education Beihang UniversityBeijing 100191China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE)and Institute of Modern Physics Fudan UniversityShanghai 200443China School of Physics Henan Normal UniversityXinxiang 453007China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China

QED atoms are composed of unstructured and point-like lepton pairs bound together by the electromag-netic *** smallest and heaviest QED atom is formed by a τ^(+)τ^(-)***,the only known atoms of this type are the e^(+)e^(-)and μ^(+)e^(-)atoms,which were discovered 64 years ago and remain the sole examples found thus *** demonstrate that the J_(τ)(τ^(+)τ^(-) atom with J^(PC)=1^(--))atom signal can be observed with a significance larger than 5o including both statistical and systematic uncertainties,*** process e^(+)e^(-)→X^(+)Y^(-)E(X,Y=e,μ,π,K,or ρ,and E is the missing energy due to unobserved neutri-nos)with 1.5 ab^(-1)data taken around the τ pair production *** τ lepton mass can be measured with a precision of 1 keV with the same data *** is within one year's running time of the pro-posed super tau-charm facility in China or super charm-tau factory in Russia.

关键词： QED atom Tau lepton e^(+)e^(-)annihilation STCF SCTF

艾宾浩斯记忆法在老年慢性阻塞性肺疾病患者健康教育中应用

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护理实践与研究 2017年第5期14卷 153-155页

作者：单萍承红沈鑫江苏省常州市第二人民医院20病区老年科常州市213003

目的:探讨艾宾浩斯记忆法在老年慢性阻塞性肺疾病综合健康教育中的应用效果。方法:选取2014年8月~2015年8月我院收治的老年慢性阻塞性肺疾病患者62例作为对照组,实施常规健康教育;选取2015年9月~2016年9月我院收治的老年慢性阻塞性肺疾... 详细信息

目的:探讨艾宾浩斯记忆法在老年慢性阻塞性肺疾病综合健康教育中的应用效果。方法:选取2014年8月~2015年8月我院收治的老年慢性阻塞性肺疾病患者62例作为对照组,实施常规健康教育;选取2015年9月~2016年9月我院收治的老年慢性阻塞性肺疾病患者62例作为观察组,根据艾宾浩斯记忆法实施综合健康教育。比较两组患者干预前后肺功能指标、运动能力和自我效能感评分。结果:观察组干预后FEV_1、FEV_1/FVC、MVV和PEFR高于对照组(P<0.05)。干预后运动能力分级优于对照组(P<0.05),自我效能感评分高于对照组(P<0.05)。结论:艾宾浩斯记忆法在老年慢性阻塞性肺疾病综合健康教育中效果显著,可明显改善患者肺功能,提高运动能力和自我效能感,值得推广。

关键词：艾宾浩斯记忆法老年慢性阻塞性肺疾病综合健康教育肺功能运动能力自我效能

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棉酚的不同旋光异构体抗生育作用的研究

解剖学报 1989年第S1期20卷 37-42,112-113页

作者：卢清显陈啸梅刘平程凯沈晓明中国医学科学院基础医学研究所

本实验采用12种组织化学方法观察棉酚旋光异构体对灌喂(+),(±)棉酚每日30mg/kg及(-)棉酚每日15mg/kg的大鼠生殖系统的影响.结果表明:(+)棉酚无抗生育作用.(±),(-)棉酚均能引起大鼠精于发生过程出现动力学紊乱,抑制晚期精子细胞核蛋白... 详细信息

本实验采用12种组织化学方法观察棉酚旋光异构体对灌喂(+),(±)棉酚每日30mg/kg及(-)棉酚每日15mg/kg的大鼠生殖系统的影响.结果表明:(+)棉酚无抗生育作用.(±),(-)棉酚均能引起大鼠精于发生过程出现动力学紊乱,抑制晚期精子细胞核蛋白的替代与转换,使附睾尾精子头、尾断裂、线粒体酶反应颗粒变粗,数量减少,酶活性受抑制。但是,反映睾丸间质细胞雄激素合成功能的G6PDH和3β-HSDH以及表明附睾雄激素释放功能的ALP均未改变,说明棉酚对雄激素合成与分泌无影响。

关键词：棉酚旋光异构体抗生育作用组织化学

Cerebral fat embolism following autologous fat injection in facial reconstruction:A case report

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World Journal of Clinical Cases 2025年第2期13卷 50-58页

作者： Xiu-Ying Chen Fa shen Chang cheng Yu-Han Wang Wen-Chao cheng De-Zhi Yuan Wen Huang Department of Neurology Chongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400000China Department of Neurology Xinqiao HospitalThe Army Medical University(Third Military Medical University)Chongqing 400000China

BACKGROUND Autologous fat injection in facial reconstruction is a common cosmetic *** cerebral fat embolism(CFE)as a complication is rare,it carries serious health *** SUMMARY We present a case of a 29-year-old female patient who developed acute CFE following facial fat filling *** the surgery,the patient experienced symptoms including headache,nausea,vomiting,and difficulty breathing,which was followed by neurological symptoms such as slurred speech and left-sided *** physical examination and auxiliary investigations,including blood tests,head and neck computed tomography angiography,and cranial magnetic resonance diffusion-weighted imaging,were performed upon *** clinical diagnosis was acute cerebral embolism following facial fat filling *** included measures to improve cerebral circulation,dehydration for intracranial pressure reduction,nutritional support,and rehabilitation therapy for left limb *** patient showed a significant improvement in symptoms after 2 weeks of *** recovered left limb muscle strength to grade 5,had clear speech,and experienced complete relief of *** Our case highlights the potential occurrence of severe complications in patients undergoing fat injection in facial *** prevent these complications,plastic surgeons should enhance their professional knowledge and skills.

关键词： Cerebral fat embolism Mechanical thrombectomy Thrombolysis Steroid therapy Symptomatic treatment Case report

Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan cheng Zhaoli Han Bo Yan Pan Liao Zhenyu Yin Xintong Ge Dai Li Rongrong Zhong Qiang Liu Fanglian Chen ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

Loss of lncRNA SNHG8 promotes epithelial-mesenchymal transition by destabilizing CDH1 mRNA

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Science China(Life Sciences) 2021年第11期64卷 1858-1867页

作者： ping He cheng Zhang Guoqiang Chen Shaoming shen Department of Pathophysiology Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of EducationState Key Laboratory of Oncogenes and Related Genes and Chinese Academy of Medical Sciences Research Unit(NO.2019RU043)Shanghai Cancer InstituteRui-Jin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Long non-coding RNAs(lnc RNAs) are widely involved in a variety of biological processes, including epithelial-mesenchymal transition(EMT). In the current study, we found that lnc RNA small nucleolar RNA host gene 8(SNHG8) was tightly correlated with EMT-associated gene signatures, and was down-regulated by Zinc finger E-box-binding homeobox 1(ZEB1) during EMT progress. Functionally, knockdown of SNHG8 induced EMT in epithelial cells, through destabilizing the CDH1 m RNA dependent on a 17-nucleotide sequence shared by SNHG8 and CDH1. In addition, analysis with public database showed that SNHG8 tended to be down-regulated in different cancer types and the lower expression of SNHG8 predicted poorer *** together, our study reports a ZEB1-repressed lnc RNA SNHG8 which is important for stabilizing CDH1 m RNA, thereby maintaining the epithelial status of epithelial cells.

关键词： SNHG8 epithelial-mesenchymal transition CDH1 mRNA stability

运动改善多发性硬化症患者生理功能的潜在生物学机制

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中国组织工程研究 2025年第20期29卷 4341-4350页

作者：沈闯蔺松程瑞娟重庆邮电大学体育学院重庆市400065 重庆邮电大学科技处重庆市400065 四川大学华西医院风湿免疫科四川省成都市610041

背景:研究证实运动对多发性硬化症具有潜在的改善作用,但具体机制尚不完全清楚。目的:总结多发性硬化症患者的生理功能变化,探讨运动改善多发性硬化症患者生理功能的机制。方法:应用计算机检索Web of Science、PubMed、中国知网、万方... 详细信息

背景:研究证实运动对多发性硬化症具有潜在的改善作用,但具体机制尚不完全清楚。目的:总结多发性硬化症患者的生理功能变化,探讨运动改善多发性硬化症患者生理功能的机制。方法:应用计算机检索Web of Science、PubMed、中国知网、万方和维普数据库等,中文检索词为“多发性硬化症,脱髓鞘自身免疫疾病,运动,体育锻炼,神经退行性疾病”等,英文检索词为“Multiple sclerosis,Demyelinating Autoimmune Diseases,Exercise,Physical activity,Neurodegenerative diseases”等,文献检索时限为各数据库建库至2024年6月,根据预定的纳入和排除标准,最终筛选出81篇文献进行综述。结果与结论:多发性硬化症患者的生理和功能变化复杂多样,严重影响患者的生活质量和独立生活能力。运动作为一种非药物干预方式,在改善多发性硬化症患者的生理和功能状态方面显示出显著潜力,运动可以缓解疲劳、调节免疫反应、降低压力激素水平、增强血脑屏障功能及促进神经可塑性。然而,当前关于运动治疗多发性硬化症的具体机制研究仍然不足,需要更多高质量、系统性的研究来进一步验证和完善相关结论。未来的研究应聚焦于以下几个方面:进一步探索不同类型和强度运动对多发性硬化症患者生理功能和病情进展的具体影响,找出最适合多发性硬化症患者的运动方案;开展大规模、长期随访的临床试验,验证运动对多发性硬化症患者的长期效果和安全性;结合现代科技手段,如功能性磁共振成像和神经电生理技术,深入揭示运动干预对多发性硬化症患者神经系统的具体作用机制;考虑患者个体差异,制定个性化的运动干预方案,以最大程度地提高干预效果和患者依从性。

关键词：多发性硬化症脱髓鞘自身免疫疾病运动神经退行性疾病生理功能工程化组织构建

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RGB-D salient object detection:A survey

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Computational Visual Media 2021年第1期7卷 37-69页

作者： Tao Zhou Deng-ping Fan Ming-Ming cheng Jianbing shen Ling Shao Inception Institute of Artificial Intelligence(IIAI) Abu DhabiUnited Arab Emirates

Salient object detection,which simulates human visual perception in locating the most significant object(s)in a scene,has been widely applied to various computer vision ***,the advent of depth sensors means that depth maps can easily be captured;this additional spatial information can boost the performance of salient object *** various RGB-D based salient object detection models with promising performance have been proposed over the past several years,an in-depth understanding of these models and the challenges in this field remains *** this paper,we provide a comprehensive survey of RGBD based salient object detection models from various perspectives,and review related benchmark datasets in ***,as light fields can also provide depth maps,we review salient object detection models and popular benchmark datasets from this domain ***,to investigate the ability of existing models to detect salient objects,we have carried out a comprehensive attribute-based evaluation of several representative RGB-D based salient object detection ***,we discuss several challenges and open directions of RGB-D based salient object detection for future *** collected models,benchmark datasets,datasets constructed for attribute-based evaluation,and related code are publicly available at https://***/taozh2017/RGBD-SODsurvey.

关键词： RGB-D saliency light fields benchmarks