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Preliminary clinical experience in liver retransplantation

Hepatobiliary & Pancreatic Diseases International 2007年第2期6卷 152-156页

作者： Yan, Ji-Qi Peng, cheng-Hong Li, Hong-Wei Shen, Bai-Yong Zhou, Guang-Wen Yang, Wei-ping Chen, Hao Chen, Yong-Jun Shen, Chuan Jiao Tong Univ Dept Surg Ctr Organ Transplant Ruijin Hosp Shanghai 200025 Peoples R China

BACKGROUND: The past several decades have witnessed increasingly successful rates of liver transplantation. However, retransplantation remains the only choice for patients with irreversible graft failure after primary transplantation. This article aimed to summarize our clinical experience in liver retransplantation. METHODS: From June 2002 to December 2005, a total of 185 cases of liver transplantation including 8 cases of retransplantation were performed in our hospital. The clinical data were analyzed retrospectively. RESULTS: The rate of liver retransplantation was 4.32%. Retransplantation was indicated for the following reasons: biliary complication (3 cases), chronic rejection (2), hepatic artery thrombosis (1), uncontrollable acute rejection (1) and hepatitis B recurrence (1). The mean model of end-stage liver disease (MELD) scores before primary transplantation and retransplantation were 15.6 and 23.9, respectively (P < 0.05). The MELD score reflected the severity of liver disease more precisely than the Child classification. The mean interval between the first and second transplantation was 316 days (78-725 days). The first three patients, with mean interval of 101 days, died of severe infection combined with multiple organ failure after retransplantation. The patients who underwent retransplantation more than six months after the first transplant had better outcomes. The one-year survival rate for retransplantation in our group was 62.5%. CONCLUSIONS: Liver retransplantation is the only means of saving the patient with hepatic allograft failure. Understanding of the indications for retransplantation, careful selection of operation timing, excellent surgical skills and meticulous postoperative management all contribute to the success of each case of retransplantation.

关键词： liver transplantation retransplantation model of end-stage liver disease score

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HPLC同时测定杠板归及其蜜炙品中5个黄酮类成分含量

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中国现代应用药学 2022年第15期39卷 2006-2010页

作者：陈慧黄平江西医学高等专科学校江西上饶334000 浙江中医药大学杭州310053

目的建立杠板归药材及其蜜炙品中5个活性成分(金丝桃苷、山奈酚-3-O-芸香糖苷、槲皮素、山奈素、异鼠李素)的HPLC含量测定方法。方法采用Phenomonex~?-C18色谱柱(4.6 mm×250 mm,5μm),以甲醇(A)-0.4%的磷酸溶液(B)为流动相进行线性... 详细信息

目的建立杠板归药材及其蜜炙品中5个活性成分(金丝桃苷、山奈酚-3-O-芸香糖苷、槲皮素、山奈素、异鼠李素)的HPLC含量测定方法。方法采用Phenomonex~?-C18色谱柱(4.6 mm×250 mm,5μm),以甲醇(A)-0.4%的磷酸溶液(B)为流动相进行线性梯度洗脱,流速1.0 mL·min^(-1),柱温30℃,检测波长为360nm。结果金丝桃苷、山奈酚-3-O-芸香糖苷、槲皮素、山奈素和异鼠李素分别在浓度3.406~340.6,0.828~82.8,5.025~502.5,1.036~103.6,1.162~116.2μg·mL^(-1)内与峰面积呈良好的线性关系(r≥0.999 3),平均加样回收率分别为100.04%,99.67%,97.96%,102.50%和98.99%。杠板归蜜炙后,金丝桃苷和山奈酚-3-O-芸香糖苷含量明显降低、槲皮素、山奈素、异鼠李素的含量明显升高。结论该方法简便高效、专属性强,可为杠板归药材及其蜜炙品的质量控制和评价方法的建立提供依据。

关键词：杠板归蜜炙杠板归含量测定高效液相色谱法质量控制

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Characteristics of Chinese Families in Which Children and Both Parents Are Diagnosed with Malignant Tumors:A Retrospective Study

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Chinese Medical Sciences Journal 2021年第1期36卷 27-34页

作者： Ju Liu Zhijian Xu Xiaofeng Bi ping Sun Jiaqin huang Department of Cancer Prevention National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100021China

Objective To characterize Chinese families in which both parents and at least one child are diagnosed with malignant diseases and provide reference for cancer screening or early detection in people whose both parents are diagnosed with *** Medical records of all clients to the center of cancer screening and prevention of the National Cancer Center/Cancer Hospital between January 2008 and February 2018 were screened to select families in which both parents and at least one child were diagnosed with malignant *** cancer profiles of fathers,mothers,sons and daughters,their age distribution at diagnosis,and similarity of cancers between two generations were *** proportions of each cancer in males and females of the cohort were compared with corresponding data from the National Cancer Center Registry of China(NCCRC)in *** Totally 13S families were identified from records of 33200 *** of lung cancer in fathers(40/135,29.6%)and in mothers(38/135,28.1%)were higher than the national data(23.9%in males and 14.9%in females,respectively).The proportion of breast cancer in daughters(35/109,32.1%)was higher than that of mothers(14/135,10.4%)and the national data(17.1%),In 71 father-son pairs of cancer,46.5%(33/71)were of the same systematic disease,and 16.9%(12/71)were of the same *** two indexes were 31.2%(n=34)and 10.1%(n=l 1),respectively in the 109 father-daughter pairs of cancer,36.6%(n=26)and 8.5%(n=6)respectively in the 71 mother-son pairs of cancer,and 31.2%(n=34)and 20.2%(n=20)respectively in the 109 mother-daughter pairs of *** were more likely to suffer from cancers originated from the same system as father s cancer than daughters(χ^(2)=4.299,P<0.05),and daughters were more likely to suffer from the same cancer as their mother's cancer than sons(χ^(2)=4.506,P<0.05).The age(mean±standard deviation)of the daughters(52.4±12.7)and the sons(59.4±10.9)at diagnosis were significantly younger than the father

关键词： family history parents daughter son early detection malignant tumor

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外泌体在肺部疾病中的研究进展

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中国药理学通报 2023年第11期39卷 2006-2011页

作者：黄宁胡长平中南大学湘雅药学院药理学系湖南长沙410078 郑州大学第一附属医院药学部河南郑州450052 心血管研究湖南省重点实验室湖南长沙410078

多种细胞可分泌外泌体,外泌体含有丰富的内容物(包括蛋白质、脂质及核酸)。生理和病理条件下,外泌体及其内容物可介导细胞间物质传递与信号转导,参与细胞增殖与凋亡、迁移与分化、肿瘤侵袭与转移、炎症反应等过程。研究表明,外泌体可参... 详细信息

多种细胞可分泌外泌体,外泌体含有丰富的内容物(包括蛋白质、脂质及核酸)。生理和病理条件下,外泌体及其内容物可介导细胞间物质传递与信号转导,参与细胞增殖与凋亡、迁移与分化、肿瘤侵袭与转移、炎症反应等过程。研究表明,外泌体可参与多种肺部疾病的病理进程,外泌体及其内容物可以作为肺部疾病诊断、治疗及预后的新靶点。因此,外泌体在肺部疾病中具有广泛的临床应用潜能。

关键词：外泌体肺动脉高压慢性阻塞性肺疾病哮喘肺癌

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Characteristics and clinical role of bronchoscopy in diagnosis of childhood endobronchial tuberculosis

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World Journal of Pediatrics 2017年第6期13卷 599-603页

作者： An-Xia Jiao Lin Sun Fang Liu Xiao-Chun Rao Yu-Yan Ma Xi-cheng Liu Chen Shen Bao-ping Xu A-Dong Shen Kun-Ling Shen Key Laboratory of Major Diseases in Children Ministry of EducationNational Clinical Research Center for Respiratory DiseasesNational Key Discipline of Pediatrics(Capital Medical University)Department of Interventional PulmonologyBeijing Children's HospitalCapital Medical UniversityNational Center for Children's Health Beijing Key Laboratory of Pediatric Respiratory Infection Diseases Beijing Pediatric Research InstituteBeijing Children's HospitalCapital Medical UniversityNational Center for Children's Health Department of Respiratory Diseases Beijing Children's HospitalCapital Medical UniversityNational Center for Children's Health

Background:Endobronchial tuberculosis (EBTB) is the most frequent complication of primary pulmonary tuberculosis (PTB) in *** aim of the study was to analyze characteristics and clinical role of bronchoscopy in diagnosis of childhood ***:A retrospective,descriptive study was undertaken in 157 children with EBTB undergone flexible bronchoscopy (FB) between January 2006 and June ***:The median age of the enrolled patients was 3.4 years,with 73.2% of patients under five years *** most common subtype was tumorous type (145/157,92.4%).If only involved bronchus were considered,the common affected sites were right middle lobe bronchus (49/228,21.5%),left upper lobe bronchus (41/228,18.0%),right upper lobe bronchus (41/228,18.0%),right main bronchus (35/228,15.4%),*** younger than five years old were at higher risk to have multiple endobronchial lesions (P=0.044),with an odds ratio of 2.313 (95% confidence interval:1.009-5.299).Before the bronchoscopy,only 16 (10.2%)patients were highly suspected of EBTB,while the others were diagnosed as PTB without EBTB (69.4%),or misdiagnosed as pneumonia or foreign body aspiration (20.4%) on ***:The patients under five years old are at high risk to progress to EBTB and have multiple endobronchial *** most frequent subtype of EBTB in children is tumorous *** lesions are seen in the right bronchial system more *** should be performed to detect the endobronchial lesions in suspected patients as soon as possible.

关键词： diagnosis endobronchial tuberculosis flexible bronchoscopy

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Exogenous application of a low concentration of melatonin enhances salt tolerance in rapeseed(Brassica napus L.) seedlings

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Journal of Integrative Agriculture 2018年第2期17卷 328-335页

作者： ZENG Liu CAI Jun-song LI Jing-jing LU Guang-yuan LI Chun-sheng FU Gui-ping ZHANG Xue-kun MA Hai-qing LIU Qing-yun ZOU Xi-ling cheng Yong Key Laboratory of Biology and Genetic Improvement of Oil Crops Ministry of Agriculture/Oil Crops Research Institute Chinese Academy of Agricultural Sciences Wuhan 430062 P.R.China Hubei Province Oilseed Rape Office Wuhan 430060 P.R. China Hubei Engineering University Xiaogan 432000 P.R. China The Agricultural Bureau of Xishui County Huanggang 438200 P.R. China

Melatonin is a naturally occurring compound in plants. Here, we tested the effect of exogenous melatonin on rapeseed（Brassica napus L.） grown under salt stress. Application of 30 μmol L^-1 melatonin alleviated salt-induced growth inhibition, and the shoot fresh weight, the shoot dry weight, the root fresh weight, and the root dry weight of seedlings treated with exogenous melatonin increased by 128.2, 142.9, 122.2, and 124.2%, respectively, compared to those under salt stress. In addition, several physiological parameters were evaluated. The activities of antioxidant enzymes including peroxidase（POD）, catalase（CAT） and ascorbate peroxidase（APX） were enhanced by 16.5, 19.3, and 14.2% compared to their activities in plants without exogenous melatonin application under salt stress, while the H2O2 content was decreased by 11.2% by exogenous melatonin. Furthermore, melatonin treatment promoted solute accumulation by increasing the contents of proline（26.8%）, soluble sugars（15.1%） and proteins（58.8%）. The results also suggested that higher concentrations（〉50 μmol L^-1） of melatonin could attenuate or even prevent the beneficial effects on seedling development. In conclusion, application of a low concentration of exogenous melatonin to rapeseed plants under salt stress can improve the H2O2-scavenging capacity by enhancing the activities of antioxidant enzymes such as POD, CAT and APX, and can also alleviate osmotic stress by promoting the accumulation of osmoregulatory substances such as soluble proteins, proline, and water soluble glucan. Ultimately, exogenous melatonin facilitates root development and improves the biomass of rapeseed seedlings grown under salt stress, thereby effectively alleviating the damage of salt stress in rapeseed seedlings.

关键词： melatonin rapeseed(Brassica napus L.) salt seedlings

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Segmental Translocation Contributed to the Origin of the Brassica S-locus

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Horticultural Plant Journal 2020年第3期6卷 167-178页

作者： Yinan Cui Mu Zhuang Jian Wu Jisheng Liu Yiyue Zhang Lingkui Zhang Yile huang Xu Cai Jianli Liang Kang Zhang Xiaowu Wang Feng cheng Institute of Vegetables and Flowers Chinese Academy of Agricultural SciencesKey Laboratory of Biology and Genetic Improvement of Horticultural Crops of the Ministry of AgricultureSino-Dutch Joint Laboratory of Horticultural GenomicsBeijing 100081China

Self-incompatibility(SI),which has recurred during the evolution of plants,is one of the most important cross-pollination mating *** S-loci have been reported in Brassicaceae,namely,Arabidopsis lyrata(Al),Brassica(Br),and Leavenworthia alabamica(La)***,through multi-genomic comparative analysis of 20 species,we revealed that the most ancient S-locus was formed prior to the divergence of Brassicaceae lineage I and *** retained and inherited by Arabidopsis,as the Al S-locus in Brassicaceae lineage ***,we found that the Br S-locus,which has been widely used in the breeding of Brassica crops to generate hybrid seeds,was formed through segmental translocation(ST)in the hexaploid ancestor of Brassica in Brassicaceae lineage *** Br S-locus was evolved through a ST from one of the triplicated ancestral S-locus paralogs in the Brassica hexaploidy ancestor,while the other two S-locus paralogs were *** with the previous discovery that the La S-locus was formed through a secondary origin in Brassicaceae lineage I,we conclude the monophyletic origin of Al and Br S-loci and clarify the evolutionary route of S-loci in the Brassicaceae *** findings will contribute to evolutionary studies and breeding applications of the S-locus in Brassicaceae.

关键词： Self incompatibility SRK,SCR Gene evolution Brassicaceae

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The Infection and Pathogenicity of SARS-CoV-2 Variant B.1.351 in hACE2 Mice

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Virologica Sinica 2021年第5期36卷 1232-1235页

作者： Qi Chen Xing-Yao huang Ying Tian Changfa Fan Mengxu Sun Chao Zhou Ruiting Li Rong-Rong Zhang Guizhen Wu cheng-Feng Qin State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyAMMSBeijing 100071China School of Basic Medical Sciences Anhui Medical UniversityHefei 230032China Division of Animal Model Research Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug ControlBeijing 102629China National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China

Dear Editor,Since the outbreak of COVID-19 at the end of 2019,its causative agent SARS-Co V-2 has been spreading around the world for one and half a *** the long global circulation of SARS-Co V-2,mutations in the vira... 详细信息

关键词： emerged accumulated SARS

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变性高效液相色谱技术在视网膜母细胞瘤基因诊断中的应用

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中华眼科杂志 2007年第6期43卷 564-566页

作者：徐萍黄倩上海交通大学附属第一人民医院中心实验室 200080

视网膜母细胞瘤（RB）的发生与13q14的Rb1基因失活有关，其中约90％的Rb1基因失活是由于Rb1基因的缺失、点突变或甲基化所致。新近的变性高效液相色谱技术（DHPLC）可简便、快速、准确检测基因的点突变、甲基化状态及其含量。目前DHPLC... 详细信息

视网膜母细胞瘤（RB）的发生与13q14的Rb1基因失活有关，其中约90％的Rb1基因失活是由于Rb1基因的缺失、点突变或甲基化所致。新近的变性高效液相色谱技术（DHPLC）可简便、快速、准确检测基因的点突变、甲基化状态及其含量。目前DHPLC已经在RB患者及其家庭成员的基因诊断和遗传咨询中起重要作用。（中华眼科杂志，2007，43：564-566）

关键词：视网膜母细胞瘤基因,视网膜母细胞瘤色谱法,高压液相

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Reaction Ergodography and Transition State Analyses of the Addition of AIH_3 to Acetylene

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Chemical Research in Chinese Universities 1992年第4期8卷 422-427页

作者： SU Zhong-min, huang Jing-an and ZHAO cheng-da (Department of Chemistry, Northeast Normal University, Changchun, 130024)

The present paper covers the reaction ergodography for the addition of AlH3 to acetylene investigated by ab initio calculation with RHF/3-21G basis set. The changes in some physical properties along the reaction path (IRC) are presented. The formations of FMOs of the transition state have been analyzed according to the Fukui' s method. On the basis of the perturbation theory and Wolfsborg Helmholtz formula, we calculated the FMO' s energy orders of TS and its formation that shows the HOMO of TS consists of LUMO, HOMO of AlH3 and HOMO of HCCH.

关键词： Ergodography TS analysis Acetylene

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