检索结果-南通市图书馆

Discovery of New Iridoids as Farnesoid X Receptor Agonists from Morinda officinalis: Agonistic Potentials and Molecular Stimulation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2021年第5期39卷 1288-1296页

作者： Zhi-Lin Luan Fei Qiao Wen-Yu Zhao Wen-Hua Ming Zhen-Long Yu Jie Liu Sheng-Yun Dai Shuang-Hui Jiang Chao-Jie Lian cheng-peng sun Bao-Jing Zhang Jian Zheng Shuang-cheng Ma Xiao-Chi Ma Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention College of PharmacyCollege of Integrative MedicineDalian Medical UniversityDalianLiaoning 116044China National Institutes for Food and Drug Control Beijing 102629China

The investigation of Morinda officinalis led to the isolation of twelve compounds(1-12),including three new iridoid glycosides morindallns A-C(1-3)and nine known compounds(4-12).Their structural identifications were conducted using HRMS,1D and 2D NMR,and electronic circular dichroism(ECD)spectra as well as quantum chemical *** 6 displayed the most significantly agonistic activity against farnesoid X receptor(FXR)with an EC_(50) value of 7.18 μM,and its agonistic effect was verified through the investigation of FXR downstream target genes including small heterodimer partner 1(SHP1),bile salt export pump(BSEP),and organic solute transporter subunit alpha and beta(OSTα and OSTβ).The potential interaction of compound 6 with FXR was analyzed by molecular docking and molecular dynamics stimulation,revealing that amino acid residues Leu287;Thr288,and Ser332 played a crucial role in the activation of compound 6 towards *** findings suggested that compound 6 could be regarded as a potential candidate for the development of FXR agonists.

关键词： Morinda officinalis Iridoid Farnesoid X receptor Agonistic effect

Uncarialins J-M from Uncaria rhynchophylla and Their Anti-depression Mechanism in Unpredictable Chronic Mild Stress-Induced Mice via Activating 5-HT_(1A) Receptor

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2021年第5期39卷 1331-1343页

作者： Zhen-Long Yu Rong Bai Jun-Jun Zhou Hui-Lian Huang Wen-Yu Zhao Xiao-Kui Huo Ya-Hui Yang Zhi-Lin Luan Bao-Jing Zhang cheng-peng sun Xiao-Chi Ma Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention National&Local Joint Engineering Research Center for Drug Development of Neurodegenerative DiseaseCollege of PharmacyCollege(Institute)of Integrative MedicineDalian Medical UniversityDalianLiaoning 116044China Department of Pharmacy Shanghai East HospitalTongji UniversityShanghai 200120China Laboratory of Modern Preparation of Traditional Chinese Medicine Ministry of EducationJiangxi University of Traditional Chinese MedicineNanchangJiangxi 330103China

Uncaria rhynchophylla has been widely used to treat central nervous system diseases for a long *** investigation of ***,eleven monoterpene indole alkaloids,including four new compounds uncarialins J-M(1-4)and seven known analogues(5-11),were isolated and *** structural characterization was conducted using HRESIMS,1D and 2D NMR,electronic circular dichroism(ECD)spectra,and quantum chemical *** 1,2,7,and 9-11 displayed significant ag-onistic effects towards 5-HT_(1A) receptor,and their EC_(50) values were 7.86,732,2.24,1.18,1.52,and 3.75μmol/L,***,in vivo experimental results fully revealed that hirsuteine(7)displayed a significant antidepression effect in unpredictable chronic mild stress(UCMS)-induced depression mice mainly via regulating 5-HT_(1A) signaling *** docking and site-directed amino acid mutation verified that amino acid residues Aspll6 and Asn386 were the binding sites of hirsuteine(7)with 5-HT_(1A) *** addition,pre-treatment of mice with WAY 100635 also blocked the anti-depression effect of hirsuteine(7),which further demonstrated that 5-HT_(1A) receptor was a potential target of hirsuteine(7)to effectively treat *** findings indicated the therapeutic material basis of *** and the anti-depression underlying mechanism of hirsuteine(7),and further provided the useful guidance for the development of hirsuteine(7)as a potential antidepressant candidate.

关键词： Monoterpene indole alkaloids Hirsuteine Depression 5-HT_(1A)receptor Site-directed amino acid mutation

In situ polymerization of poly(3,4-ethylenedioxythiophene)protective layer towards stable zinc anode

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2025年第1期18卷 382-394页

作者： Debin Luo peng Zhou Xiaowei Lv Panpan sun Xiaohua sun Hewei Zhao College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion MaterialsChina Three Gorges UniversityYichang 443002China Hubei Three Gorges Laboratory Yichang 443007China School of Chemistry Beihang UniversityBeijing 100191China

Aqueous zinc-ion devices are considered promising candidates for energy storage due to their high safety,low cost and relatively high energy ***,the dendrite growth,hydrogen evolution reaction(HER)and corrosion of the zinc anode significantly limit the development of Zn-ion ***,an inexpensive poly(3,4-ethylenedioxythiophene)(PEDOT)protective layer was constructed in situ on the Zn surface using electropolymerization to suppress dendrite growth and side reactions,thereby enhancing the reversibility of *** and theoretical calculations revealed that this hydrophilic protective layer promotes the desolvation process of hydrated Zn^(2+)and facilitates the transport of zinc ions,thus improving the thermodynamic and kinetic properties of Zn^(2+)deposition and inhibiting interfacial side ***,the optimized PEDOT@Zn symmetric battery exhibited a cycling stability exceeding 1250 h at 0.5 mA·cm^(-2)and 0.25 mAh·cm^(-2),with a significantly reduced overpotential(from 91.8 to 35 mV).With the assistance of the PEDOT protective layer,the PEDOT@Zn//Cu battery maintained approximately 99.5%Coulombic efficiency after 450 ***-situ scanning electron microscopy(SEM)and in situ optical microscopy characterizations further confirmed that the PEDOT protective layer can effectively suppress the growth of zinc ***,the Zn-ion capacitors assembled by the PEDOT@Zn and activated carbon also demonstrated outstanding cycling stability.

关键词： zinc-ion devices zinc anode poly(3 4-ethylenedioxythiophene)(PEDOT) dendrite desolvation process

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

压电陶瓷激振器定频激振能力的评价方法

东北大学学报（自然科学版） 2016年第10期37卷 1421-1425页

作者：李晖薛鹏程孙伟闻邦椿东北大学机械工程与自动化学院辽宁沈阳110819

提出了评价压电陶瓷激振信号的线性度指标,并基于自主研发的压电陶瓷激励反馈系统,对一款PZT陶瓷进行了实验研究.在分析其激振力的影响因素及影响规律的基础上,提出了压电陶瓷定频激振能力的评价方法.由实验数据建立了评价方程,得到了... 详细信息

提出了评价压电陶瓷激振信号的线性度指标,并基于自主研发的压电陶瓷激励反馈系统,对一款PZT陶瓷进行了实验研究.在分析其激振力的影响因素及影响规律的基础上,提出了压电陶瓷定频激振能力的评价方法.由实验数据建立了评价方程,得到了其定频激振的频率置信区间,使其可以更好地被应用到板壳类薄壁构件的高阶振动测试研究中.研究结果表明,压电陶瓷定频激振能力的总体特点是在低频状态下可实现高幅定频激励,而高频状态下仅能实现低幅定频激励.

关键词：压电陶瓷激振器定频激振评价方法激振能力线性度

Abietane and Tigliane Diterpenoids from the Roots of Euphorbia fischeriana

在线全文

学校读者我要写书评

暂无评论

Abietane and Tigliane Diterpenoids from the Roots of Euphorb...

Target Tracking with Guaranteed Coverage in Autonomous Mobile Sensor Networks

中国化学会第十一届全国天然有机化学学术会议

作者： Chun-Jie Wang Ping Li cheng-peng sun Xiao-Kui Huo Xiao-Chi Ma Sa Deng Chao Wang College of Pharmacy Academy of Integrative MedicineDalian Medical University

＜正＞Euphorbia fischeriana Steud is a perennial herbaceous plant of *** mainly in northeastern *** roots of *** named"Laiig-du".is a traditional Chinese Medicine for the treatments of edema,ascites,and *** China,the ...

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Target Tracking with Guaranteed Coverage in Autonomous Mobil...

Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder

第三十届中国控制会议

作者： BAI Jing,CAO Xianghui,cheng peng,CHEN Jiming,sun Youxian State Key Lab of Industrial Control Technology,Zhejiang University,Hangzhou 310027,P.R.China

＜正＞The advancements in robotics and wireless communication provide a good opportunity to combine the mobility and wireless sensor networks so that different objectives can be satisfied simultaneously with less required ***, mobility enables the sensors to dynamically adjust their positions for better sensing quality,and offers a higher probability for guaranteeing the coverage required at the same *** this paper,we propose a novel coordinating scheme for autonomous mobile sensor networks so that the target sensing quality is optimized while the coverage requirement of the field of interest is also *** whole problem is transformed into one finite horizon optimization problem,which is then solved efficiently. Extensive simulations demonstrate the effectiveness of the proposed method.

关键词： Mobile Sensor Networks Target Tracking Coverage

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1541-1554页

作者： Jinmei Ye Cong Duan Jiaxin Han Jinrong Chen Ning sun Yuan Li Tifei Yuan Daihui peng Division of Mood Disorder Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Shanghai Key Laboratory of Psychotic Disorders Brain Health InstituteNational Center for Mental DisordersShanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Co-Innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

In the pathogenesis of major depressive disorder, chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response. Mitochondrial DNA may be an inflammatory trigger, after its release from stress-induced dysfunctional central nervous system mitochondria into peripheral circulation. This evidence supports the potential use of peripheral mitochondrial DNA as a neuroinflammatory biomarker for the diagnosis and treatment of major depressive disorder. Herein, we critically review the neuroinflammation theory in major depressive disorder, providing compelling evidence that mitochondrial DNA release acts as a critical biological substrate, and that it constitutes the neuroinflammatory disease pathway. After its release, mitochondrial DNA can be carried in the exosomes and transported to extracellular spaces in the central nervous system and peripheral circulation. Detectable exosomes render encaged mitochondrial DNA relatively stable. This mitochondrial DNA in peripheral circulation can thus be directly detected in clinical practice. These characteristics illustrate the potential for mitochondrial DNA to serve as an innovative clinical biomarker and molecular treatment target for major depressive disorder. This review also highlights the future potential value of clinical applications combining mitochondrial DNA with a panel of other biomarkers, to improve diagnostic precision in major depressive disorder.

关键词： biomarker cytokine exosomes inflammasome major depressive disorder microglia mitochondrial DNA mitochondrial dysfunction neuroinflammation Toll-like receptor

An Unprecedented Efficiency with Approaching 21%Enabled by Additive‑Assisted Layer‑by‑Layer Processing in Organic Solar Cells

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第2期17卷 372-375页

作者： Shuai Xu Youdi Zhang Yanna sun Pei cheng Zhaoyang Yao Ning Li Long Ye Lijian Zuo Ke Gao Key Laboratory of Advanced Green Functional Materials College of ChemistryChangchun Normal UniversityChangchun 130032People’s Republic of China Shandong Provincial Key Laboratory for Science of Material Creation and Energy Conversion School of Chemistry and Chemical EngineeringShandong UniversityQingdao 266237People’s Republic of China College of Polymer Science and Engineering Sichuan UniversityChengdu 610065People’s Republic of China State Key Laboratory and Institute of Elemento‑Organic Chemistry Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer MaterialsRenewable Energy Conversion and Storage Center(RECAST)College of ChemistryNankai UniversityTianjin 300071People’s Republic of China Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and Devices South China University of TechnologyGuangzhou 510640People’s Republic of China Tianjin Key Laboratory of Molecular Optoelectronic Sciences School of Materials Science and EngineeringTianjin UniversityTianjin 300350People’s Republic of China State Key Laboratory of Silicon Materials MOE Key Laboratory of Macromolecular Synthesis and FunctionalizationDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China

Recently published in Joule,Feng Liu and colleagues from Shanghai Jiaotong University reported a record-breaking 20.8%power conversion efficiency in organic solar cells(OSCs)with an interpenetrating fibril network active layer morphology,featuring a bulk p-in structure and proper vertical segregation achieved through additive-assisted layer-by-layer *** optimized hierarchical gradient fibrillar morphology and optical management synergistically facilitates exciton diffusion,reduces recombination losses,and enhances light capture *** approach not only offers a solution to achieving high-efficiency devices but also demonstrates the potential for commercial applications of OSCs.

关键词： Organic solar cells Additive-assisted layer-by-layer processing Three-dimensional fibril morphology Bulk p-i-n structure Optical management

Crystallization Modulation and Holistic Passivation Enables Efficient Two‑Terminal Perovskite/CuIn(Ga)Se_(2)Tandem Solar Cells

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第1期17卷 205-215页

作者： Cong Geng Kuanxiang Zhang Changhua Wang Chung Hsien Wu Jiwen Jiang Fei Long Liyuan Han Qifeng Han Yi‑Bing cheng Yong peng State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070People’s Republic of China Triumph Photovoltaic Materials Co. Ltd.No.1001 Yannan AvenueHigh‑Tech Development DistrictBengbuAnhui 233000People’s Republic of China College of Materials Science and Engineering Guilin University of TechnologyGuilin 541004People’s Republic of China State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Two-terminal(2-T)perovskite(PVK)/CuIn(Ga)Se_(2)(CIGS)tandem solar cells(TSCs)have been considered as an ideal tandem cell because of their best bandgap matching regarding to Shockley–Queisser(S–Q)***,the nature of the irregular rough morphology of commercial CIGS prevents people from improving tandem device *** this paper,D-homoserine lactone hydrochloride is proven to improve coverage of PVK materials on irregular rough CIGS surfaces and also passivate bulk defects by modulating the growth of PVK *** addition,the minority carriers near the PVK/C60 interface and the incompletely passivated trap states caused interface recombination.A surface reconstruction with 2-thiopheneethylammonium iodide and N,N-dimethylformamide assisted passivates the defect sites located at the surface and grain ***,LiF is used to create this field effect,repelling hole carriers away from the PVK and C60 interface and thus reducing *** a result,a 2-T PVK/CIGS tandem yielded a power conversion efficiency of 24.6%(0.16 cm^(2)),one of the highest results for 2-T PVK/CIGS TSCs to our *** validation underscores the potential of our methodology in achieving superior performance in PVK/CIGS tandem solar cells.

关键词： PVK/CIGS TSCs Irregular rough surfaces Modulating the growth PVK/C60 interface recombination