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Association between autoimmune gastritis and gastric polyps:Clinical characteristics and risk factors

World Journal of Gastrointestinal Oncology 2025年第1期17卷 73-87页

作者： Jing-Zheng Jin Xiao liang Shu-peng liu Rui-Lan Wang Qing-Wei Zhang Yu-Feng Shen Xiao-Bo li Division of Gastroenterology and Hepatology Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Division of Gastroenterology and Hepatology Shanghai Institute of Digestive DiseasesShanghai 200001China Division of Gastroenterology and Hepatology Renji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China Division of Gastroenterology and Hepatology Sichuan Armed Police Corps HospitalLeshan 610041Sichuan ProvinceChina Division of Gastroenterology and Hepatology NHC Key Laboratory of Digestive DiseasesRenji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Gastroenterology Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai Institute of Digestive DiseasesShanghai 200127China

BACKGROUND The relationship between autoimmune gastritis(AIG)and gastric polyps(GPs)is not well *** To explore the clinical characteristics and risk factors of AIG with GPs in *** This double center retrospective study included 530 patients diagnosed with AIG from July 2019 to July *** collected clinical,biochemical,serological,and demographic data were of each *** regression analyses,both multivariate and univariate,were conducted to pinpoint independent risk factors for GPs in patients with AIG *** operating characteristic curves were utilized to establish the optimal cutoff values,sensitivity,and specificity of these risk factors for predicting GPs in patients with *** Patients with GPs had a higher median age than those without GPs[61(52.25-69)years vs 58(47-66)years,P=0.006].The gastrin-17 levels were significantly elevated in patients with GPs compared with those without GPs[91.9(34.2-138.9)pmol/mL vs 60.9(12.6-98.4)pmol/mL,Plike cells hyperplasia(OR=3.116,Plike cells hyperplasia are significant risk factor for the development of GPs in patients with *** gastrin-17 levels may also play a role in this *** findings suggest potential targets for further research and therapeutic intervention in managing GPs in patients with AIG.

关键词： Autoimmune gastritis Gastric polyps Neuroendocrine tumor Risk factors Nomogram

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The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan liu Wei Wu Xuejuan li chengyan Wang Ke Chai Fanru Yuan Huijuan Zheng Yuxing Yao Chenlu li Zu-cheng Ye Daijun Zha Department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of Laboratory Animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

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电泳沉积功能陶瓷涂层技术

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中国陶瓷 2000年第6期36卷 36-40页

作者：张建民杨长春石秋芝程鹏里郑州大学化学化工学院郑州450052

本文评述了功能陶瓷悬浮液的稳定性、电泳沉积技术原理、以及该技术在制备生物陶瓷、超导陶瓷、铁电陶瓷、耐磨耐高温陶瓷等功能陶瓷涂层方面的应用。讨论了电流、电压。

关键词：电泳沉积功能陶瓷县浮液复合材料陶瓷涂层

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基于GSO-BP神经网络的城市轨道交通客流量短时间预测

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交通科技与经济 2017年第1期19卷 1-4,63页

作者：唐秋生程鹏李娜重庆交通大学交通运输学院重庆400041

城市轨道交通作为公共交通客流量的分担措施之一,能够解决因客流量预测不准确而带来的资源浪费和低效益问题。建立一种新的GSO-BPNN方法,该方法在BP网络的基础上植入GSO算法,优化网络的初始权值和阈值,并以某城市轨道交通客流量为例,对... 详细信息

城市轨道交通作为公共交通客流量的分担措施之一,能够解决因客流量预测不准确而带来的资源浪费和低效益问题。建立一种新的GSO-BPNN方法,该方法在BP网络的基础上植入GSO算法,优化网络的初始权值和阈值,并以某城市轨道交通客流量为例,对比普通BP网络预测模型,结果显示GSO-BPNN方法的预测精度较高。

关键词：城市轨道交通神经网络萤火虫算法客流量预测 Matlab仿真

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COX6c在疾病中差异表达及临床意义的研究进展

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生物医学工程与临床 2018年第2期22卷 221-224页

作者：程伟鹏庄丽维哈尔滨医科大学附属第四医院消化内科黑龙江哈尔滨150001

细胞色素c氧化酶(COX)是线粒体电子传递链的终末酶复合物,它在细胞的氧化磷酸化过程中起到了非常重要的调节作用。COX由13个亚基组成,其中细胞色素c氧化酶亚基6c(COX6c)是由细胞核基因组编码在核糖体中翻译后经过不同途径转运至线粒体... 详细信息

细胞色素c氧化酶(COX)是线粒体电子传递链的终末酶复合物,它在细胞的氧化磷酸化过程中起到了非常重要的调节作用。COX由13个亚基组成,其中细胞色素c氧化酶亚基6c(COX6c)是由细胞核基因组编码在核糖体中翻译后经过不同途径转运至线粒体最终形成COX复合体。近年来许多研究发现COX6c在家族性高胆固醇血症、慢性肾脏疾病、糖尿病、乳腺癌、前列腺癌、子宫平滑肌瘤、滤泡性甲状腺癌等多种疾病出现表达异常。其机制可能与组织损伤性疾病中细胞的氧化磷酸化途径有关。文章对COX6c在非肿瘤损伤性疾病和损伤性疾病中的表达差异分别作一综述。

关键词：细胞色素c氧化酶亚基6c 组织损伤肿瘤氧化磷酸化

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基于NI-LabVIEW环境加载板传输速率校准自动测试系统

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电子设计工程 2015年第20期23卷 106-109页

作者：陆春程金朋成立鹏刘向明武汉工程大学机电工程学院湖北武汉430073

针对加载板传输速率校准测试要求,开发了一种基于LAN接口组合仪器自动测试平台,该平台基于虚拟仪器技术中的LabVIEW图形化编程开发,将多台仪器有机组合. 并采用眼图六点法检测的方式,将预估眼图面积与理想状态的眼图面积之比与阈值比较... 详细信息

针对加载板传输速率校准测试要求,开发了一种基于LAN接口组合仪器自动测试平台,该平台基于虚拟仪器技术中的LabVIEW图形化编程开发,将多台仪器有机组合. 并采用眼图六点法检测的方式,将预估眼图面积与理想状态的眼图面积之比与阈值比较,通过这种方法对信号的传输速率质量进行评判,实现了对加载板传输速率校准的自动有序测试,自动存储,对加载板传输速率生产检验具有重大的实际工程意义.

关键词： LABVIEW LAN接口传输速率眼图六点法检测

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Extramedullary plasmacytoma with the uvula as first affected site:A case report

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World Journal of Clinical Oncology 2025年第1期16卷 53-58页

作者： Jing Yang Hui peng Sheng-Ke Tu Min li Kui Song Department of Hematology The First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina Department of Pharmacy The First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina

BACKGROUND Extramedullary plasmacytoma(EMP)represents one of the rarer forms of plasma cell malignancies,capable of impacting a variety of tissues and organs throughout the *** majority of EMP cases are predominantly found in the head and neck region,especially within the laryngopharynx,as well as in the gastrointestinal *** there have been documented instances of oropharyngeal involvement in EMP cases in the academic literature,it is important to note that EMP specifically affecting the uvula is exceedingly ***,it is noteworthy that over 60% of epithelial carcinomas in the upper respiratory tract and oropharynx tend to metastasize to the cervical lymph nodes,indicating a propensity for regional spread in these types of *** this context,we present a rare case of extramedullary plasmacytoma where the uvula served as the initially affected *** case emphasizes the need for heightened awareness among clinicians regarding such unusual comorbidities,as early recognition and diagnosis can significantly influence patient management and treatment *** addition,a review of the relevant literature is included to further educate and inform healthcare professionals about this rare presentation,ultimately aiming to enhance clinical understanding and improve patient care in similar *** SUMMARY A 51-year-old man was admitted to our hospital because of a slowly enlarging neck mass.A physical examination revealed a palpable left lymph node,and magnetic resonance imaging(MRI)of the oropharynx and the neck showed a soft tissue mass in the oropharynx and enlargement of multiple lymph nodes in the *** soft tissue mass was diagnosed as plasmacytoma by immunohistochemical *** immunoglobulins and bone marrow biopsy showed normal ***,we diagnosed that as EMP of the *** four cycles of adjuvant chemotherapy dominated by bortezomib,MRI reexamination showed a significant reduction of the mass

关键词： Extramedullary plasmacytoma Plasmacytoma Uvula Multiple myeloma Case report

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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma peng-peng li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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An Unprecedented Efficiency with Approaching 21%Enabled by Additive‑Assisted Layer‑by‑Layer Processing in Organic Solar Cells

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Nano-Micro Letters 2025年第2期17卷 372-375页

作者： Shuai Xu Youdi Zhang Yanna Sun Pei cheng Zhaoyang Yao Ning li Long Ye lijian Zuo Ke Gao Key Laboratory of Advanced Green Functional Materials College of ChemistryChangchun Normal UniversityChangchun 130032People’s Republic of China Shandong Provincial Key Laboratory for Science of Material Creation and Energy Conversion School of Chemistry and Chemical EngineeringShandong UniversityQingdao 266237People’s Republic of China College of Polymer Science and Engineering Sichuan UniversityChengdu 610065People’s Republic of China State Key Laboratory and Institute of Elemento‑Organic Chemistry Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer MaterialsRenewable Energy Conversion and Storage Center(RECAST)College of ChemistryNankai UniversityTianjin 300071People’s Republic of China Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and Devices South China University of TechnologyGuangzhou 510640People’s Republic of China Tianjin Key Laboratory of Molecular Optoelectronic Sciences School of Materials Science and EngineeringTianjin UniversityTianjin 300350People’s Republic of China State Key Laboratory of Silicon Materials MOE Key Laboratory of Macromolecular Synthesis and FunctionalizationDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China

Recently published in Joule,Feng liu and colleagues from Shanghai Jiaotong University reported a record-breaking 20.8%power conversion efficiency in organic solar cells(OSCs)with an interpenetrating fibril network active layer morphology,featuring a bulk p-in structure and proper vertical segregation achieved through additive-assisted layer-by-layer *** optimized hierarchical gradient fibrillar morphology and optical management synergistically facilitates exciton diffusion,reduces recombination losses,and enhances light capture *** approach not only offers a solution to achieving high-efficiency devices but also demonstrates the potential for commercial applications of OSCs.

关键词： Organic solar cells Additive-assisted layer-by-layer processing Three-dimensional fibril morphology Bulk p-i-n structure Optical management

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72例结核性毁损肺患者的围手术期护理

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中国临床护理 2010年第4期2卷 321-322页

作者：陈鲁玉曹莹彭成丽河南省胸科医院胸外二科郑州450003

术前加强护患沟通,注重患者心理护理,做好呼吸道准备;术后密切观察生命体征,加强呼吸道管理及胸腔引流管的护理,加强服药指导,对可能出现的并发症采取有效预防措施等。本组72例患者,70例治愈,术后随访1年,无复发病例。

关键词：结核肺肺切除术围手术期护理

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